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Volume 14
Issue 22
10.3390/cells14221832
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Review

Integrin αvβ3 as a Non-Genomic Estrogen Receptor in Breast Cancer for Signaling Pathways and Crosstalk

by
Kuan Wang
1,†,
Zi-Lin Li
1,2,†,
Lin-Yi Huang
3,†,
Chih-Jung Yao
4,5,
Dana R. Crawford
6,
Chih-Yang Wang
2,7,8,
Ju-Ku Mo
1,2,
Ya-Jung Shih
1,2,
Hung-Yun Lin
2,9,10,* and
Jacqueline Whang-Peng
2,11
1
Graduate Institute of Nanomedicine and Medical Engineering, College of Medical Engineering, Taipei Medical University, Taipei 11031, Taiwan
2
Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
3
Department of Pediatrics, E-DA Hospital, I-Shou University, Kaohsiung 82445, Taiwan
4
Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
5
Department of Medical Education and Research, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan
6
Department of Immunology and Microbial Disease, Albany Medical College, 43 New Scotland Avenue, Albany, NY 12208, USA
7
Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan
8
TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 11031, Taiwan
9
Lung Cancer Research Team, Taipei Cancer Center, Taipei Medical University, Taipei 11031, Taiwan
10
Traditional Herbal Medicine Research Center of Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan
11
Cancer Center, Wan Fang Hospital, Taipei Medical University, Taipei 11031, Taiwan
 
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*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Cells 2025, 14(22), 1832; https://doi.org/10.3390/cells14221832 (registering DOI)
Submission received: 2 September 2025 / Revised: 11 November 2025 / Accepted: 14 November 2025 / Published: 20 November 2025
(This article belongs to the Special Issue Hormone Receptors in Cancers: From Molecular Insights to Clinical Applications)
Versions Notes

Abstract

Integrin αvβ3, a key member of the integrin family, plays a crucial role in cell localization, mobilization, and signal transduction through collaborating with extracellular proteins. Its unique expression and activation in tumor cells and rapidly dividing endothelial cells suggest its potential role in cancer cell growth and metastasis, making it a promising therapeutic target. In genomic pathways, estrogen binds to its receptors to form transcription complexes that bind to the promoters of steroid hormone-receptive genes. Conversely, G protein-coupled estrogen receptor 1 (GPER) and integrin αvβ3 have been shown to play oles in non-genomic actions that contribute to estrogen-induced cancer growth. The molecular mechanisms of these non-genomic functions involve signal transduction via focal activated kinase (FAK), mitogen-activated protein kinase (ERK1/2), and phosphatidylinositol 3-kinase (PI3K), as well as the differential expression of multiple genes associated with various cellular processes. As a hormone receptor, integrin αvβ3, collaborating with ER-α and GPER, exhibits a wide range of cellular effects relevant to cancer biology.
Keywords: breast cancer; estrogen; estrogen receptor; GPER; integrin αvβ3 breast cancer; estrogen; estrogen receptor; GPER; integrin αvβ3

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MDPI and ACS Style

Wang, K.; Li, Z.-L.; Huang, L.-Y.; Yao, C.-J.; Crawford, D.R.; Wang, C.-Y.; Mo, J.-K.; Shih, Y.-J.; Lin, H.-Y.; Whang-Peng, J. Integrin αvβ3 as a Non-Genomic Estrogen Receptor in Breast Cancer for Signaling Pathways and Crosstalk. Cells 2025, 14, 1832. https://doi.org/10.3390/cells14221832

AMA Style

Wang K, Li Z-L, Huang L-Y, Yao C-J, Crawford DR, Wang C-Y, Mo J-K, Shih Y-J, Lin H-Y, Whang-Peng J. Integrin αvβ3 as a Non-Genomic Estrogen Receptor in Breast Cancer for Signaling Pathways and Crosstalk. Cells. 2025; 14(22):1832. https://doi.org/10.3390/cells14221832

Chicago/Turabian Style

Wang, Kuan, Zi-Lin Li, Lin-Yi Huang, Chih-Jung Yao, Dana R. Crawford, Chih-Yang Wang, Ju-Ku Mo, Ya-Jung Shih, Hung-Yun Lin, and Jacqueline Whang-Peng. 2025. "Integrin αvβ3 as a Non-Genomic Estrogen Receptor in Breast Cancer for Signaling Pathways and Crosstalk" Cells 14, no. 22: 1832. https://doi.org/10.3390/cells14221832

APA Style

Wang, K., Li, Z.-L., Huang, L.-Y., Yao, C.-J., Crawford, D. R., Wang, C.-Y., Mo, J.-K., Shih, Y.-J., Lin, H.-Y., & Whang-Peng, J. (2025). Integrin αvβ3 as a Non-Genomic Estrogen Receptor in Breast Cancer for Signaling Pathways and Crosstalk. Cells, 14(22), 1832. https://doi.org/10.3390/cells14221832

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