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Viruses, Volume 11, Issue 10

October 2019 - 93 articles

Cover Story: The phenomenon of “selective neuronal vulnerability” has been associated with conformational variants of rogue prion proteins, so-called prion strains, but their disease pathways remain unknown. To facilitate the search for molecular targets of prion strains, we established a novel neuroblastoma cell model with selectivity to distinct prion strains. Strikingly, the passage of prion strains in susceptible neuronal cells extends their host range to otherwise nonpermissive cell lines. View this paper.
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Articles (93)

  • Review
  • Open Access
48 Citations
11,236 Views
19 Pages

22 October 2019

The Zika virus (ZIKV) is a recently emerged mosquito-borne flavivirus that, while typically asymptomatic, can cause neurological symptoms in adults and birth defects in babies born to infected mothers. The interactions of ZIKV with many different pat...

  • Article
  • Open Access
23 Citations
6,641 Views
19 Pages

High Diversity and Novel Enteric Viruses in Fecal Viromes of Healthy Wild and Captive Thai Cynomolgus Macaques (Macaca fascicularis)

  • Vorthon Sawaswong,
  • Elizabeth Fahsbender,
  • Eda Altan,
  • Taratorn Kemthong,
  • Xutao Deng,
  • Suchinda Malaivijitnond,
  • Sunchai Payungporn and
  • Eric Delwart

22 October 2019

Cynomolgus macaques are common across South East Asian countries including Thailand. The National Primate Research Center of Thailand, Chulalongkorn University (NPRCT-CU) captures wild-borne cynomolgus macaque for research use. Limited information is...

  • Article
  • Open Access
46 Citations
14,037 Views
14 Pages

The S2 Subunit of QX-type Infectious Bronchitis Coronavirus Spike Protein Is an Essential Determinant of Neurotropism

  • Jinlong Cheng,
  • Ye Zhao,
  • Gang Xu,
  • Keran Zhang,
  • Wenfeng Jia,
  • Yali Sun,
  • Jing Zhao,
  • Jia Xue,
  • Yanxin Hu and
  • Guozhong Zhang

22 October 2019

Some coronaviruses (CoVs) have an extra furin cleavage site (RRKR/S, furin-S2′ site) upstream of the fusion peptide in the spike protein, which plays roles in virion adsorption and fusion. Mutation of the S2′ site of QX genotype (QX-type)...

  • Article
  • Open Access
44 Citations
11,099 Views
23 Pages

Gut DNA Virome Diversity and Its Association with Host Bacteria Regulate Inflammatory Phenotype and Neuronal Immunotoxicity in Experimental Gulf War Illness

  • Ratanesh K. Seth,
  • Rabia Maqsood,
  • Ayan Mondal,
  • Dipro Bose,
  • Diana Kimono,
  • LaRinda A. Holland,
  • Patricia Janulewicz Lloyd,
  • Nancy Klimas,
  • Ronnie D. Horner and
  • Kimberly Sullivan
  • + 2 authors

21 October 2019

Gulf War illness (GWI) is characterized by the persistence of inflammatory bowel disease, chronic fatigue, neuroinflammation, headache, cognitive impairment, and other medically unexplained conditions. Results using a murine model show that enteric v...

  • Article
  • Open Access
49 Citations
9,556 Views
8 Pages

A Novel Hepadnavirus is Associated with Chronic Hepatitis and Hepatocellular Carcinoma in Cats

  • Patricia A. Pesavento,
  • Kenneth Jackson,
  • Timothy Scase,
  • Tiffany Tse,
  • Bronte Hampson,
  • John S. Munday,
  • Vanessa R. Barrs and
  • Julia A. Beatty

21 October 2019

In 2015, over 850,000 people died from chronic hepatitis and hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV). A novel hepatitis B-like virus has recently been identified in domestic cats. The pathogenic potential of domestic cat hepa...

  • Review
  • Open Access
39 Citations
12,483 Views
22 Pages

20 October 2019

Increasing attention has focused on the contributions of persistent microbial infections with the manifestation of disease later in life, including neurodegenerative conditions such as Alzheimer’s disease (AD). Current data has shown the presen...

  • Review
  • Open Access
12 Citations
4,155 Views
15 Pages

Simian Foamy Viruses in Central and South America: A New World of Discovery

  • André F. Santos,
  • Liliane T. F. Cavalcante,
  • Cláudia P. Muniz,
  • William M. Switzer and
  • Marcelo A. Soares

20 October 2019

Foamy viruses (FVs) are the only exogenous retrovirus to date known to infect neotropical primates (NPs). In the last decade, an increasing number of strains have been completely or partially sequenced, and molecular evolution analyses have identifie...

  • Review
  • Open Access
188 Citations
18,070 Views
23 Pages

18 October 2019

Positive-sense single-stranded RNA (+ssRNA) viruses comprise many (re-)emerging human pathogens that pose a public health problem. Our innate immune system and, in particular, the interferon response form the important first line of defence against t...

  • Article
  • Open Access
27 Citations
4,468 Views
14 Pages

In Vitro and In Vivo Metabolomic Profiling after Infection with Virulent Newcastle Disease Virus

  • Panrao Liu,
  • Yuncong Yin,
  • Yabin Gong,
  • Xusheng Qiu,
  • Yingjie Sun,
  • Lei Tan,
  • Cuiping Song,
  • Weiwei Liu,
  • Ying Liao and
  • Chunchun Meng
  • + 1 author

18 October 2019

Newcastle disease (ND) is an acute, febrile, highly contagious disease caused by the virulent Newcastle disease virus (vNDV). The disease causes serious economic losses to the poultry industry. However, the metabolic changes caused by vNDV infection...

  • Communication
  • Open Access
12 Citations
4,621 Views
8 Pages

18 October 2019

The aim of this study was to identify respiratory viruses circulating amongst elite racehorses in a training yard by serological testing of serial samples and to determine their impact on health status and ability to race. A six-month longitudinal st...

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Viruses - ISSN 1999-4915