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Pre-Transplantation Assessment of BK Virus Serostatus: Significance, Current Methods, and Obstacles

1
Agents Infectieux, Résistance et Chimiothérapie Research Unit, EA 4294, Jules Verne University of Picardie, 80000 Amiens, France
2
Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences-I, Lebanese University, Hadath 21219, Lebanon
3
Infectiologie et Santé Publique “Biologie des Infections à polyomavirus” team, UMR INRA 1282, University of Tours, 37082 Tours, France
4
Department of Virology, Amiens University Medical Center, 80000 Amiens, France
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(10), 945; https://doi.org/10.3390/v11100945
Received: 19 August 2019 / Revised: 26 September 2019 / Accepted: 13 October 2019 / Published: 14 October 2019
(This article belongs to the Section Animal Viruses)
The immunosuppression required for graft tolerance in kidney transplant patients can trigger latent BK polyomavirus (BKPyV) reactivation, and the infection can progress to nephropathy and graft rejection. It has been suggested that pre-transplantation BKPyV serostatus in donors and recipients is a predictive marker for post-transplantation BKPyV replication. The fact that research laboratories have used many different assay techniques to determine BKPyV serostatus complicates these data analysis. Even studies based on the same technique differed in their standard controls choice, the antigenic structure type used for detection, and the cut-off for seropositivity. Here, we review the different BKPyV VP1 antigens types used for detection and consider the various BKPyV serostatus assay techniques’ advantages and disadvantages. Lastly, we highlight the obstacles in the implementation of a consensual BKPyV serologic assay in clinics (e.g., the guidelines absence in this field). View Full-Text
Keywords: BK virus; serological technique; BK virus serology; kidney transplantation BK virus; serological technique; BK virus serology; kidney transplantation
MDPI and ACS Style

Dakroub, F.; Touzé, A.; Akl, H.; Brochot, E. Pre-Transplantation Assessment of BK Virus Serostatus: Significance, Current Methods, and Obstacles. Viruses 2019, 11, 945.

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