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Open AccessArticle

Viruses in Horses with Neurologic and Respiratory Diseases

1
Vitalant Research Institute, San Francisco, CA 94118, USA
2
Department of Laboratory Medicine, University of California, San Francisco, CA 94118, USA
3
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(10), 942; https://doi.org/10.3390/v11100942
Received: 29 August 2019 / Revised: 2 October 2019 / Accepted: 7 October 2019 / Published: 14 October 2019
(This article belongs to the Special Issue Equine Viruses)
Metagenomics was used to identify viral sequences in the plasma and CSF (cerobrospinal fluid) of 13 horses with unexplained neurological signs and in the plasma and respiratory swabs of 14 horses with unexplained respiratory signs. Equine hepacivirus and two copiparvoviruses (horse parvovirus-CSF and a novel parvovirus) were detected in plasma from neurological cases. Plasma from horses with respiratory signs contained the same two copiparvoviruses plus equine pegivirus D and respiratory swabs contained equine herpes virus 2 and 5. Based on genetic distances the novel copiparvovirus qualified as a member of a new parvovirus species we named Eqcopivirus. These samples plus another 41 plasma samples from healthy horses were tested by real-time PCRs for multiple equine parvoviruses and hepacivirus. Over half the samples tested were positive for one to three viruses with eqcopivirus DNA detected in 20.5%, equine hepacivirus RNA and equine parvovirus-H DNA in 16% each, and horse parvovirus-CSF DNA in 12% of horses. Comparing viral prevalence in plasma none of the now three genetically characterized equine parvoviruses (all in the copiparvovirus genus) was significantly associated with neurological and respiratory signs in this limited sampling. View Full-Text
Keywords: Parvoviridae; Eqcopivirus; horse parvovirus-CSF; equine hepacivirus; equine parvovirus H; bosavirus; virome Parvoviridae; Eqcopivirus; horse parvovirus-CSF; equine hepacivirus; equine parvovirus H; bosavirus; virome
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MDPI and ACS Style

Altan, E.; Li, Y.; Sabino-Santos Jr, G.; Sawaswong, V.; Barnum, S.; Pusterla, N.; Deng, X.; Delwart, E. Viruses in Horses with Neurologic and Respiratory Diseases. Viruses 2019, 11, 942. https://doi.org/10.3390/v11100942

AMA Style

Altan E, Li Y, Sabino-Santos Jr G, Sawaswong V, Barnum S, Pusterla N, Deng X, Delwart E. Viruses in Horses with Neurologic and Respiratory Diseases. Viruses. 2019; 11(10):942. https://doi.org/10.3390/v11100942

Chicago/Turabian Style

Altan, Eda; Li, Yanpeng; Sabino-Santos Jr, Gilberto; Sawaswong, Vorthon; Barnum, Samantha; Pusterla, Nicola; Deng, Xutao; Delwart, Eric. 2019. "Viruses in Horses with Neurologic and Respiratory Diseases" Viruses 11, no. 10: 942. https://doi.org/10.3390/v11100942

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