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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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High Consequence Viral Transmission

edited by

Olivier Escaffre

submission deadline 17 Jul 2026 | 2 articles | Viewed by 2130 | Submission Open

Keywords: high-consequence viruses; zoonotic viruses; spillover events; natural reservoirs; wildlife vectors; pandemic; outbreaks; airborne transmission; droplet transmission; sexual transmission; high fatality rates; Filoviridae; Orthoebolavirus; Orthomarbugvirus; Paramyxoviridae; Orthoparamyxovirinae; Arenaviridae; Mammarenavirus; Peribunyaviridae; Orthobunyavirus; Nairoviridae; Orthonairovirus; Hantaviridae; Orthohantavirus; Coronaviridae; Betacoronavirus

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advancing Hepatitis Elimination: HBV, HDV, and HCV

edited by

Federico García

submission deadline 31 Jul 2026 | 13 articles | Viewed by 21095 | Submission Open

Keywords: hepatitis elimination; HBV; HCV; HDV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Rodent-Borne Viruses 2026

edited by

Renata Carvalho De Oliveira

and

Jorlan Fernandes

submission deadline 31 Jul 2026 | 4 articles | Viewed by 15004 | Submission Open

Keywords: rodent-borne viruses; hantaviridae; arenaviridae; poxviridae; zoonosis; virus ecology and evolution; virus–host interaction; virus discovery; animal model; rodents

(This special issue belongs to the Section Animal Viruses)

Molecular Epidemiology of SARS-CoV-2, 4th Edition

edited by

Marta Giovanetti

submission deadline 31 Jul 2026 | 10 articles | Viewed by 14320 | Submission Open

Keywords: SARS-CoV-2; genomic monitoring; phylodynamic; molecular epidemiology

(This special issue belongs to the Section Coronaviruses)

Coronavirus Pathogenesis and Virus-Host Interaction

edited by

Hin Chu

submission deadline 31 Jul 2026 | 4 articles | Viewed by 7341 | Submission Open

Keywords: COVID-19; SARS-CoV-2; SARS-CoV-1; MERS-CoV; pathogenesis; virus–host interaction; virus entry; host factors; animal models; SARS-CoV-2 variants

(This special issue belongs to the Section General Virology)

HIV in the Context of Chronic Disorders and Aging

edited by

Maria Mazzitelli

Andrea De Vito

and Mattia Trunfio

submission deadline 31 Jul 2026 | 5 articles | Viewed by 6998 | Submission Open

(This special issue belongs to the Section Human Virology and Viral Diseases)

Translational Research in Virology

edited by

Kenneth Lundstrom

and

Alaa A. A. Aljabali

submission deadline 31 Jul 2026 | 2 articles | Viewed by 6172 | Submission Open

Keywords: vaccines; antiviral drugs; monoclonal antibodies; viral vectors; self-amplifying RNA; clinical trials; translational medicine; proteomic analysis; antiviral resistance; bioinformatics; structural virology; immune escape mechanisms; viral evolution; diagnostic virology; high-throughput screening; nanotechnology in virology; viral assembly and disassembly; host-pathogen interactions; emerging viral infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Infection in Airway Epithelial Cells

edited by Camille Ehré and Raymond J. Pickles

submission deadline 31 Jul 2026 | 2 articles | Viewed by 5533 | Submission Open

Keywords: respiratory viral infections; airway epithelial cells; virus–host interactions; viral pathogenesis; immune responses; Influenza viruses; respiratory syncytial virus (rsv); coronaviruses; SARS-CoV-2; respiratory tract

(This special issue belongs to the Section Animal Viruses)

RSV Epidemiological Surveillance: 3rd Edition

edited by Emanuele Castagno and Irene Raffaldi

submission deadline 31 Jul 2026 | 3 articles | Viewed by 5377 | Submission Open

Keywords: respiratory syncytial virus (RSV); epidemiological surveillance; bronchiolitis; children; newborns; infants

(This special issue belongs to the Section Human Virology and Viral Diseases)

Vaccines and Antiviral Drugs Against Viral Diseases in Domestic Animals

edited by

Jing Zhang

submission deadline 31 Jul 2026 | 4 articles | Viewed by 5069 | Submission Open

Keywords: vaccines; antiviral drugs; domestic animals; virus

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virus-Host Interactions: From Mechanisms to Therapeutics

edited by

Leike Zhang

and

Ke Xu

submission deadline 31 Jul 2026 | 2 articles | Viewed by 5067 | Submission Open

Keywords: host-directed antivirals; antiviral agents; drug resistance; host factors; viral–host interplay

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Nuclear Architecture in Viral Infection

edited by Veronica Sanchez and Elizabeth White

submission deadline 31 Jul 2026 | 3 articles | Viewed by 4466 | Submission Open

Keywords: nuclear architecture; viral transcription; viral replication; viral assembly

(This special issue belongs to the Section General Virology)

Dual Nature of Bacteriophages: Friends or Enemies in the Food Industry?—2nd Edition

edited by

Michał Wójcicki

Barbara Sokolowska

and

Ewa Jończyk-Matysiak

submission deadline 31 Jul 2026 | 3 articles | Viewed by 4160 | Submission Open

Keywords: bacteriophages; biocontrol; biosensors; food safety; foodborne bacterial pathogens; food quality; foodborne saprophytic bacteria

(This special issue belongs to the Section Bacterial Viruses)

Foot-and-Mouth Disease Virus

edited by

Satya Parida

Zhidong Zhang

and

Madhanmohan Muthukrishnan

submission deadline 31 Jul 2026 | 3 articles | Viewed by 3770 | Submission Open

Keywords: foot-and-mouth disease; foot-and-mouth disease virus; hoof-and-mouth disease; FMD; FMD virus; foot-and-mouth disease vaccines

(This special issue belongs to the Section Animal Viruses)

Zika Virus and Congenital Zika Syndrome, 2nd Edition

edited by Marcos Vinicius da Silva Pone and Sheila Moura Pone

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3663 | Submission Open

Keywords: viral infections; Zika virus; congenital Zika syndrome

(This special issue belongs to the Section Human Virology and Viral Diseases)

Congenital Cytomegalovirus Infection, 3rd Edition

edited by

Giovanni Nigro

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3335 | Submission Open

Keywords: primary cytomegalovirus infection; pregnancy; CMV screening; hyperimmune globulin; valaciclovir

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virology and Immunology of Gene Therapy 2026

edited by Weidong Xiao and

Jianming Qiu

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2899 | Submission Open

Keywords: gene therapy; viral vector; vaccine; immune responses; viruses; AAV; lentiviral vectors; neutralizing antibody

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viroinformatics and Viral Diseases

edited by

Hernan Garcia-Ruiz

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2727 | Submission Open

Keywords: viral genomics; virus variation; genome-wide variation; gene silencing; antiviral defense; virus replication; host factors; high-throughput sequencing; small RNA sequencing

(This special issue belongs to the Section General Virology)

Structural and Mechanistic Advances in Retroviral Biology

edited by Yong Xiong,

Swapnil Chandrakant Devarkar

and

Luiza Mendonca

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1775 | Submission Open

Keywords: retroviruses; capsid structure and assembly; host-viral interactions; in situ cryo EM; reverse transcription; integration; genome packaging

(This special issue belongs to the Section Human Virology and Viral Diseases)

Human Adenovirus (HAdV) Infection in Children

edited by Adriana Kajon and

Glen R. Nemerow

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1571 | Submission Open

Keywords: epidemiology; pediatric; transplant recipients; antivirals; outbreak; acute respiratory illness; gastroenteritis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Strategies for the Discovery of Antivirals Against Respiratory RNA Viruses 2026

edited by Yuanwei Pan, Badri Parshad and

Xinyi Liu

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1398 | Submission Open

Keywords: antiviral discovery; respiratory RNA viruses; drug repurposing; high-throughput screening; nanomaterials-based antivirals; antiviral drug delivery; viral polymerase inhibitors; preclinical models

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Oncolytic Virus Engineering for Tumor Immunotherapy

edited by

Stefan Weger

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1165 | Submission Open

Keywords: oncolytic viruses (OV); cancer immunotherapy; cancer treatment; genetic engineering; tumor-specificity; tumor-specific promoters; immunosuppressive; tumor micro environment (TME)

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

The Role of Adjuvants in Viral Vaccines and Vaccination

edited by

Zoltan Vajo

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1152 | Submission Open

Keywords: aluminum hydroxide; oil-in-water emulsion adjuvants; TLR agonists; combination adjuvants

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Giant, Jumbo and Mega Phages

edited by

Julie Thomas

submission deadline 31 Jul 2026 | Viewed by 943 | Submission Open

Keywords: long-genome phage; giant phage; jumbo phage; mega phage; genomes; structure/assembly; infection strategies; ecology; evolution; applications

(This special issue belongs to the Section Bacterial Viruses)

Intrinsic Immunity vs. Viral Antagonism: Which One Bites the Dust?

edited by

Akatsuki Saito

and

Kenzo Tokunaga

submission deadline 31 Jul 2026 | Viewed by 450 | Submission Open

Keywords: host restriction factors; viral antagonists; replication cycle; interferon-inducible pathways; ubiquitination; membrane trafficking

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viral Aerosol Transmission, Host Environmental Exposures, and Antiviral Intervention Strategies

edited by

St Patrick Reid

submission deadline 31 Jul 2026 | Viewed by 423 | Submission Open

Keywords: viral aerosol transmission; host–environment interactions; emerging cellular mechanisms; antiviral therapeutics; immune defense mechanisms

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viral Immune Imprinting and Vaccine Design

edited by

Deborah H. Fuller

submission deadline 31 Jul 2026 | Viewed by 414 | Submission Open

Keywords: viral imprinting; original antigenic sin; trained immunity; viral interference; cross-protective immunity; vaccine design

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Antiviral Drugs and Biologics Targeting HIV: Drug Resistance to Newer Treatment and Pre-Exposure Prophylaxis (PrEP) Options: 2nd Edition

edited by

Bluma G. Brenner

submission deadline 31 Jul 2026 | Viewed by 386 | Submission Open

Keywords: HIV; antiretroviral therapy (ART); pre-exposure prophylaxis (PrEP); antiviral drugs; drug resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viral Regulation of Cell Death and Stress Responses

edited by

Jiann-Ruey Hong

submission deadline 31 Jul 2026 | Viewed by 321 | Submission Open

Keywords: virus; cell death; stress response; viral gene; viral controlling; viral therapy

(This special issue belongs to the Section General Virology)

The 13th Wisc-e-sota Symposium

edited by

Louis M. Mansky

and

Paul F. Lambert

submission deadline 31 Jul 2026 | Viewed by 287 | Submission Open

Keywords: HIV; retrovirus; adeno-associated virus; Epstein–Barr virus; pichinde virus; porcine reproductive and respiratory syndrome virus

(This special issue belongs to the Section General Virology)

Phages in the Battle Against Antimicrobial Resistance

edited by

Bożena Nejman-Faleńczyk

submission deadline 31 Jul 2026 | Viewed by 284 | Submission Open

Keywords: antimicrobial resistance (AMR); multidrug-resistant bacteria (MDR); non-antibiotic strategies; phage therapy; phage characteristics

(This special issue belongs to the Section Bacterial Viruses)

Immune Modulation by Human Cytomegalovirus: 2nd Edition

edited by

Davide Abate

submission deadline 1 Aug 2026 | Viewed by 337 | Submission Open

Keywords: human cytomegalovirus (CMV); molecular and cellular mechanisms; cell-intrinsic immunity; adaptive immunity; innate immunity

(This special issue belongs to the Section Human Virology and Viral Diseases)

Control and Contributions of Transposable Elements: Implications for Development and Disease

edited by Suzanne B. Sandmeyer and Henry L. Levin

submission deadline 14 Aug 2026 | Viewed by 2595 | Submission Open

Keywords: transposable elements; endogenous viruses; transcription factors; neurotransmission; aging

(This special issue belongs to the Section General Virology)

Infectious Disease Epidemiology: Current Updates and Perspectives

edited by

Agata Skrzat-Klapaczynska

and

Justyna Dominika Kowalska

submission deadline 15 Aug 2026 | Viewed by 498 | Submission Open

Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments

(This special issue belongs to the Section General Virology)

Rift Valley Fever Virus: New Insights into a One Health Archetype

edited by

Rebekah C. Kading

, Juliette Lewis and Brian H. Bird

submission deadline 16 Aug 2026 | 3 articles | Viewed by 6572 | Submission Open

Keywords: One Health; emerging infectious diseases; mosquito; bunyavirus; arbovirus; medical entomology; medical countermeasures; livestock

(This special issue belongs to the Section Animal Viruses)

Spotlight on Bocavirus and Other Parvoviruses, and Overlooked Respiratory Viruses

edited by

Suncanica Ljubin‐Sternak

and

Tatjana Vilibic-Cavlek

submission deadline 30 Aug 2026 | 4 articles | Viewed by 4341 | Submission Open

Keywords: bocavirus; Parvovirus B19; canine parvovirus; porcine parvovirus; metapneumovirus; rhinovirus

(This special issue belongs to the Section Animal Viruses)

Avian Viral Pathogenesis and Host Interactions

edited by Ping Wei and Xiumiao He

submission deadline 30 Aug 2026 | 1 articles | Viewed by 1716 | Submission Open

Keywords: avian virus; molecular mechanisms; epidemiology and evolution; molecular biology; pathogenesis; virus–host interaction; diagnostic; vaccine

(This special issue belongs to the Section Animal Viruses)

Porcine Epidemic Diarrhea Virus (PEDV): A Persistent Threat to the Global Swine Industry

edited by

Ke Liu

submission deadline 31 Aug 2026 | 4 articles | Viewed by 7843 | Submission Open

Keywords: porcine epidemic diarrhea virus; global epidemiology; economic loss; vaccines and drugs; molecular mechanism; transmission and pathogenic mechanisms

(This special issue belongs to the Section Animal Viruses)

Long-Acting Antiretrovirals

edited by Camilla Muccini and Antonella Castagna

submission deadline 31 Aug 2026 | 3 articles | Viewed by 6684 | Submission Open

Keywords: HIV infection; HIV prevention; long-acting; antiretroviral therapy; clinical studies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Polyomavirus

edited by

Sunnie R. Thompson

and Patrick S. Moore

submission deadline 31 Aug 2026 | 3 articles | Viewed by 5271 | Submission Open

Keywords: virus–host interactions; viral life cycle; viral replication; pathogenesis; phylogeny; structure; transcription; packaging; trafficking; persistence; re-arrangements; gene regulation; reactivation; miRNA; viral immune evasion; vaccines

(This special issue belongs to the Section Animal Viruses)

Pathogenesis and Persistence in Flavivirus Infections: Mechanisms, Biomarkers, and Clinical Implications

edited by

Aleksandra Drelich

and

Barbara Judy

submission deadline 31 Aug 2026 | 3 articles | Viewed by 3211 | Submission Open

Keywords: tropical infectious diseases; flaviviruses; co-infection; cross-reactivity; long-term sequelae; neurological symptoms; autoimmunity; pathogenesis; molecular virology; diagnosis; biomarkers

(This special issue belongs to the Section Human Virology and Viral Diseases)

Contribution of the Host Cell Integrated Stress Response (ISR) to Immunopathogenesis of Human RNA Viral Infections

edited by

Qiyi Tang

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2692 | Submission Open

Keywords: RNA viruses; immunopathogenesis; unfolded protein response; organelle stress; innate immunity

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Japanese Encephalitis Virus and Other Closely Related Clinically Important Orthoflaviviruses—a Persistent Threat to Public and Animal Health

edited by

Ke Liu

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2436 | Submission Open

Keywords: Japanese encephalitis virus; mosquito-borne; orthoflaviviruses; public and animal health; transmission; infection; host

(This special issue belongs to the Section General Virology)

Hepatitis Viruses: Detection, Diagnosis and Treatment

edited by

Daryl Lau

submission deadline 31 Aug 2026 | 2 articles | Viewed by 2357 | Submission Open

Keywords: molecular virology; virus–host interactions; epidemiology; novel biomarkers and therapy; HBV; HCV; HDV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Arboviruses and Climate, 2nd Edition

edited by José Lourenço and

Marta Giovanetti

submission deadline 31 Aug 2026 | 1 articles | Viewed by 2118 | Submission Open

Keywords: arbovirus; climate; climate change; arthropods; vectors; epidemiology; evolution; ecology; public health

(This special issue belongs to the Section Invertebrate Viruses)

Advancing Understanding of Filoviruses

edited by John Misasi and

Adam Hume

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1967 | Submission Open

Keywords: filoviruses; Ebola virus; Marburg virus; Sudan virus; Tai Forest virus; Bundibugyo virus; Reston virus; Lloviu virus; Bombali virus; Mengla virus; Dehong virus

(This special issue belongs to the Section Animal Viruses)

Mosquito-Borne Encephalitis Viruses: 2nd Edition

edited by

Megan Lloyd

and

Allison Imrie

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1532 | Submission Open

Keywords: mosquito-borne arboviruses; encephalitic togaviruses; encephalitic flaviviruses; encephalitic bunyaviruses; mosquito vectors; laboratory diagnostics; one health approaches to arbovirus ecology; arbovirus surveillance; vaccines to encephalitic arboviruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Insights into Feline Viruses: Molecular, Structural, Pathogenic, and Clinical Aspects

edited by

Barbara Di Martino

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1279 | Submission Open

Keywords: cats; feline viruses; emerging viruses; molecular virology; pathogenesis; clinical virology; molecular and serological diagnostics; metagenomics; therapeutic and control strategies; One Health

(This special issue belongs to the Section Animal Viruses)

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus: 2nd Edition

edited by Tongqing An and Xingyang Cui

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1117 | Submission Open

Keywords: PRRSV; genetic evolution; replication regulation; immunological or pathogenic mechanism; vaccine development; prevention and control

(This special issue belongs to the Section Animal Viruses)

Rotaviruses and Rotavirus Vaccines: 2nd Edition

edited by

Lijuan Yuan

and

Viviana Parreño

submission deadline 31 Aug 2026 | 1 articles | Viewed by 950 | Submission Open

Keywords: rotaviruses; molecular biology; reverse genetics; molecular epidemiology; vaccine development; human intestinal organoid models

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

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