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A Novel Enzootic Nasal Tumor Virus Circulating in Goats from Southern China

1
Animal Disease Diagnostic Center, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Key Laboratory of Animal Disease Prevention of Guangdong province, Guangzhou 510640, China
2
Department of Biology and Microbiology, South Dakota State University, Brookings, SD 57007, USA
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State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China
4
Department of Microbiology, The University of Hong Kong, Hong Kong, China
5
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong, China
*
Authors to whom correspondence should be addressed.
Viruses 2019, 11(10), 956; https://doi.org/10.3390/v11100956
Received: 5 September 2019 / Revised: 4 October 2019 / Accepted: 14 October 2019 / Published: 17 October 2019
(This article belongs to the Section Animal Viruses)
Enzootic nasal tumor virus (ENTV) has two types, ENTV-1 in sheep and ENTV-2 in goats, respectively. In China, the incidence of ENTV-2 related diseases has increased year by year. In this study, we reported an outbreak of ENTV-2 in a commercial goat farm in Qingyuan city, Guangdong province, southern China. A full-length genome of ENTV-2 (designated GDQY2017), with 7479 base pairs, was sequenced. Although GDQY2017 shared the highest nucleotide identity with a Chinese ENTV-2 isolate (ENTV-2CHN4, GenBank accession number KU258873), it possesses distinct genome characteristics undescribed, including a non-continuous 21-nucleotide insertion in the gag gene and a non-continuous 12-nucleotide deletion in the env gene. Notably, most of these indel nucleotide sequences were originated from a Chinese jaagsiekte sheep retrovirus (JSRV) isolate (GenBank accession number DQ838494). In the gag and env genes, GDQY2017 was phylogenetically related to those Chinese ENTV-2 isolates and a Chinese JSRV isolate (DQ838494). For GDQY2017-like viruses, more surveillance work should be made to explain their pathogenicity in goat herds. To our knowledge, this study represents the first to demonstrate the circulating pattern of ENTV-2 in Guangdong province, China, which will help to better understand the epidemiology and genetic diversity of ENTV-2. View Full-Text
Keywords: enzootic nasal tumor virus; ENTV-2; novel variation; genetic diversity; goats; Guangdong province enzootic nasal tumor virus; ENTV-2; novel variation; genetic diversity; goats; Guangdong province
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Zhai, S.-L.; Lv, D.-H.; Xu, Z.-H.; Yu, J.-S.; Wen, X.-H.; Zhang, H.; Chen, Q.-L.; Jia, C.-L.; Zhou, X.-R.; Zhai, Q.; Li, F.; Woo, P.C.Y.; Lau, S.K.P.; Wang, D.; Wei, W.-K. A Novel Enzootic Nasal Tumor Virus Circulating in Goats from Southern China. Viruses 2019, 11, 956.

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