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Molecules, Volume 29, Issue 4

2024 February-2 - 174 articles

Cover Story: By incorperating high-valence metals as an electron reservoir with various ionic electronegativity, the ratio of surface Ru4+/Ru3+ species in rutile RuO2 is successfully regulated and optimized for activity and stability of catalysts. It has been found that Re with the highest ionic electronegativity attracted a mass of electrons from Ru in the pre-catalyst and replenished electrons to Ru under the operating potential, resulting in high activity and outstanding stability. View this paper
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Articles (174)

  • Article
  • Open Access
10 Citations
2,843 Views
20 Pages

Broad Spectral Response FeOOH/BiO2−x Photocatalyst with Efficient Charge Transfer for Enhanced Photo-Fenton Synergistic Catalytic Activity

  • Pengfei Wu,
  • Yufei Qin,
  • Mengyuan Gao,
  • Rui Zheng and ,
  • Yixin Zhang,
  • Xinli Li,
  • Zhaolong Liu,
  • Yingkun Zhang,
  • Zhen Cao and
  • Qingling Liu
  • + 5 authors+ 0 author

19 February 2024

In this work, to promote the separation of photogenerated carriers, prevent the catalyst from photo-corrosion, and improve the photo-Fenton synergistic degradation of organic pollutants, the coating structure of FeOOH/BiO2−x rich in oxygen vaca...

(This article belongs to the Special Issue Advanced Photocatalysts for Energy Conversion and Environmental Applications, 2nd Edition)
  • Article
  • Open Access
1 Citations
3,608 Views
12 Pages

19 February 2024

This article presents a thorough investigation into the synthesis of trimethylolpropane triacrylate (TMPTA) via the esterification reaction of trimethylolpropane (TMP) with acrylic acid using Amberlite™ 120 IR (H+), Amberlyst® 15, and Dowex...

(This article belongs to the Special Issue Research on Heterogeneous Catalysis)
  • Article
  • Open Access
9 Citations
4,320 Views
15 Pages

Bioactive Potential of Carrot-Based Products Enriched with Lactobacillus plantarum

  • Monica Boev,
  • Cristina Stănescu,
  • Mihaela Turturică,
  • Mihaela Cotârleţ and ,
  • Denisa Batîr-Marin,
  • Nicoleta Maftei,
  • Carmen Chiţescu,
  • Leontina Grigore-Gurgu,
  • Vasilica Barbu and
  • Elena Lăcrămioara Lisă
  • + 6 authors+ 1 author

19 February 2024

The primary goal of this study was to generate different kinds of functional products based on carrots that were supplemented with lactic acid bacteria. The fact that carrots (Daucus carota sp.) rank among the most popular vegetables in our country l...

(This article belongs to the Section Food Chemistry)
  • Article
  • Open Access
4 Citations
2,529 Views
12 Pages

19 February 2024

Although nano SiO2 exhibits excellent application potential in the field of oil and gas exploration and development, such as drilling fluid, enhanced oil/gas recovery, etc., it is prone to agglomeration and loses its effectiveness due to the action o...

  • Article
  • Open Access
1 Citations
5,020 Views
43 Pages

19 February 2024

I propose a new strategy to suppress human cancer completely with two entirely new drug compounds exploiting cancer’s Warburg effect characterized by a defective mitochondrial aerobic respiration, substituted by cytosolic aerobic fermentation/g...

(This article belongs to the Section Medicinal Chemistry)
  • Article
  • Open Access
9 Citations
3,705 Views
16 Pages

19 February 2024

Medium- and long-chain triacylglycerol (MLCT), as a novel functional lipid, is valuable due to its special nutritional properties. Its low content in natural resources and inefficient synthesis during preparation have limited its practical applicatio...

  • Article
  • Open Access
4 Citations
3,198 Views
15 Pages

A Versatile Approach for the Synthesis of Antimicrobial Polymer Brushes on Natural Rubber/Graphene Oxide Composite Films via Surface-Initiated Atom-Transfer Radical Polymerization

  • Wenya Zhu,
  • Bangsen Li,
  • Jinrui Liu,
  • Shishu Sun and ,
  • Yan Zhang,
  • Dashuai Zhang,
  • Chen Li,
  • Tianyi Sun,
  • Huaide Qin and
  • Zaifeng Shi
  • + 6 authors+ 1 author

19 February 2024

A simple strategy was adopted for the preparation of an antimicrobial natural rubber/graphene oxide (NR/GO) composite film modified through the use of zwitterionic polymer brushes. An NR/GO composite film with antibacterial properties was prepared us...

(This article belongs to the Section Macromolecular Chemistry)
  • Article
  • Open Access
13 Citations
4,380 Views
19 Pages

Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for Parkinson’s Disease

  • Mingjie Zhang,
  • Congyan Duan,
  • Weifang Lin,
  • Honghua Wu and ,
  • Lu Chen,
  • Hong Guo,
  • Minyu Yu,
  • Qi Liu,
  • Yaling Nie and
  • Shaoxia Wang
  • + 6 authors+ 1 author

19 February 2024

The microglia, displaying diverse phenotypes, play a significant regulatory role in the development, progression, and prognosis of Parkinson’s disease. Research has established that glycolytic reprogramming serves as a critical regulator of inf...

(This article belongs to the Section Natural Products Chemistry)
  • Article
  • Open Access
16 Citations
3,696 Views
26 Pages

19 February 2024

Lignocellulosic biomass such as canola straw is produced as low-value residue from the canola processing industry. Its high cellulose and hemicellulose content makes it a suitable candidate for the production of hydrogen via supercritical water gasif...

(This article belongs to the Section Green Chemistry)
  • Review
  • Open Access
10 Citations
4,546 Views
28 Pages

Exploring Four Atraphaxis Species: Traditional Medicinal Uses, Phytochemistry, and Pharmacological Activities

  • Alima Abilkassymova,
  • Aknur Turgumbayeva,
  • Lazzat Sarsenova,
  • Kuanysh Tastambek and ,
  • Nazym Altynbay,
  • Gulnar Ziyaeva,
  • Ravil Blatov,
  • Gulmira Altynbayeva,
  • Kuralay Bekesheva and
  • Assem Kalykova
  • + 8 authors+ 3 authors

19 February 2024

Atraphaxis is a genus of flowering plants in the family Polygonaceae, with approximately 60 species. Species of Atraphaxis are much-branched woody plants, forming shrubs or shrubby tufts, primarily inhabiting arid zones across the temperate steppe an...

(This article belongs to the Special Issue Study on the Bioactive Compounds from Plant Extraction)
  • Article
  • Open Access
3 Citations
2,174 Views
12 Pages

Anti-Inflammatory Peroxidized Chlorahololide-Type Dimers Are Artifacts of Shizukaol-Type Dimers: From Phenomena Discovery and Confirmation to Potential Underlying Mechanism

  • Xiu-Wen Yin,
  • Ming Zhang,
  • Lan Wu,
  • Fu-Cai Ren and ,
  • Fu-Rong Yang,
  • Xiang-Dong Pu,
  • Zhi-Jun Zhang and
  • Chuan-Pu Shen
  • + 3 authors+ 0 author

19 February 2024

In our research on naturally occurring sesquiterpenes, eight shizukaol-type dimers, one chlorahololide-type dimer, and one sarcanolide-type dimer were isolated from the roots of Chloranthus fortunei. As the project was implemented, we accidentally di...

  • Article
  • Open Access
15 Citations
3,745 Views
18 Pages

Dendrobium Nobile Alcohol Extract Extends the Lifespan of Caenorhabditis elegans via hsf-1 and daf-16

  • Linfeng Li,
  • Zhen Liu,
  • Huiling Hu,
  • Renming Cai and ,
  • Jingdou Bi,
  • Qin Wang,
  • Xiaogang Zhou,
  • Huairong Luo,
  • Chun Zhang and
  • Runlan Wan
  • + 5 authors+ 0 author

19 February 2024

Dendrobium nobile is a traditional Chinese herb with anti-inflammatory, antioxidant, and neuroprotective properties. However, its antiaging effects are unclear. Herein, we studied the aging-related functions and the mechanism of action of the alcohol...

(This article belongs to the Special Issue Plants Extractions in Health Care)
  • Article
  • Open Access
1 Citations
2,925 Views
18 Pages

19 February 2024

Nicotinic acid adenine dinucleotide phosphate (NAADP), identified as one of the most potent calcium-mobilizing second messengers, has been studied in different eukaryotic cell types, including lymphocytes. Although aspects of NAADP-mediated calcium r...

(This article belongs to the Section Chemical Biology)
  • Article
  • Open Access
10 Citations
3,208 Views
15 Pages

19 February 2024

Melanoma is the most aggressive and difficult to treat of all skin cancers. Despite advances in the treatment of melanoma, the prognosis for melanoma patients remains poor, and the recurrence rate remains high. There is substantial evidence that Chin...

  • Correction
  • Open Access
1 Citations
1,689 Views
2 Pages

Correction: Eid et al. Interference with TGFβ1-Mediated Inflammation and Fibrosis Underlies Reno-Protective Effects of the CB1 Receptor Neutral Antagonists AM6545 and AM4113 in a Rat Model of Metabolic Syndrome. Molecules 2021, 26, 866

  • Basma G. Eid,
  • Thikryat Neamatallah,
  • Abeer Hanafy,
  • Hany M. El-Bassossy and ,
  • Lenah Binmahfouz,
  • Hibah M. Aldawsari,
  • Atif Hasan,
  • Gamal Abd El-Aziz,
  • Kiran Vemuri and
  • Alexandros Makriyannis
  • + 5 authors+ 0 author

19 February 2024

The authors wish to make the following changes to the paper [...]

(This article belongs to the Special Issue Cannabinergic Ligands: Chemistry, Pharmacology and Therapeutic Potential)
  • Article
  • Open Access
6 Citations
3,214 Views
15 Pages

18 February 2024

A novel process for the synthesis of hydrated silica derived from ferronickel slag (FNS)-leaching residue was proposed in this study. The products of the purification of hydrated silica with 99.68% grade and 95.11% recovery can be obtained through am...

  • Article
  • Open Access
6 Citations
3,156 Views
12 Pages

18 February 2024

Bread is a basic element of the human diet. To counteract the process of its going stale, semi-finished bakery products are subjected to cooling or freezing. This process is called postponed baking. The aim of this work was to investigate the effect...

(This article belongs to the Section Food Chemistry)
  • Review
  • Open Access
66 Citations
21,883 Views
20 Pages

Machine Learning Empowering Drug Discovery: Applications, Opportunities and Challenges

  • Xin Qi,
  • Yuanchun Zhao,
  • Zhuang Qi,
  • Siyu Hou and
  • Jiajia Chen

18 February 2024

Drug discovery plays a critical role in advancing human health by developing new medications and treatments to combat diseases. How to accelerate the pace and reduce the costs of new drug discovery has long been a key concern for the pharmaceutical i...

(This article belongs to the Special Issue Computational Approaches in Drug Discovery and Design)
  • Article
  • Open Access
4 Citations
3,140 Views
15 Pages

18 February 2024

The objective of this study is to determine the effect of endogenous plant matrix components, dose and digestion-related factors on the bioaccessibility of rosmarinic acid and basil co-compounds in in vitro digestion conditions. Different forms of ad...

(This article belongs to the Special Issue Bio-Accessibility/Availability of Bioactive Compounds from Natural Food Sources)
  • Article
  • Open Access
9 Citations
7,293 Views
16 Pages

18 February 2024

The development of selective extraction protocols for Cannabis-inflorescence constituents is still a significant challenge. The characteristic Cannabis fragrance can be mainly ascribed to monoterpenes, sesquiterpenes and oxygenated terpenoids. This w...

  • Article
  • Open Access
2,315 Views
17 Pages

Purification, Characterization, cDNA Cloning, and Bioinformatic Analysis of Zinc-Binding Protein from Magallana hongkongensis

  • Citing Chen,
  • Wan Li,
  • Jialong Gao,
  • Wenhong Cao and ,
  • Xiaoming Qin,
  • Huina Zheng,
  • Haisheng Lin and
  • Zhongqin Chen
  • + 3 authors+ 0 author

18 February 2024

Oysters contain significant amounts of the zinc element, which may also be found in their proteins. In this study, a novel zinc-binding protein was purified from the mantle of the oyster Magallana hongkongensis using two kinds of gel filtration chrom...

(This article belongs to the Section Food Chemistry)
  • Article
  • Open Access
5 Citations
2,168 Views
15 Pages

18 February 2024

A new ionic liquid modified polymer gel containing methylimidazolium groups (poly(MIA)) is proposed as a sorbent for the separation and enrichment of trace inorganic and organic arsenic species in surface waters. The poly(MIA) was synthesized by chem...

  • Article
  • Open Access
5 Citations
3,058 Views
14 Pages

Investigation on Gold Dissolution Performance and Mechanism in Imidazolium Cyanate Ionic Liquids

  • Na Zhang,
  • Yuxin Zhang,
  • Zhengyu Liu,
  • Ziyuan Liu and ,
  • Chunbao Sun,
  • N. Emre Altun and
  • Jue Kou
  • + 2 authors+ 0 author

18 February 2024

To explore green gold leaching reagents, a series of imidazolium cyanate ionic liquids (ILs), 1-ethyl-3-methyl-imidazolium cyanate ([C2MIM][OCN]), 1-propyl-3-methyl-imidazolium cyanate ([C3MIM][OCN]) and 1-butyl-3-methyl-imidazolcyanate ([C4MIM][OCN]...

(This article belongs to the Section Electrochemistry)
  • Article
  • Open Access
3 Citations
3,328 Views
12 Pages

18 February 2024

Amyloidosis is a group of protein misfolding diseases, which include spongiform encephalopathies, Alzheimer’s disease and transthyretin (TTR) amyloidosis; all of them are characterized by extracellular deposits of an insoluble fibrillar protein...

(This article belongs to the Section Molecular Structure)
  • Review
  • Open Access
19 Citations
6,594 Views
15 Pages

Therapeutic Potential of Pectin and Its Derivatives in Chronic Diseases

  • Anathi Dambuza,
  • Pamela Rungqu,
  • Adebola Omowunmi Oyedeji,
  • Gugulethu Miya and ,
  • Ayodeji Oluwabunmi Oriola,
  • Yiseyon Sunday Hosu and
  • Opeoluwa Oyehan Oyedeji
  • + 2 authors+ 0 author

18 February 2024

Non-communicable diseases (NCDs) are described as a collection of chronic diseases that do not typically develop from an acute infection, have long-term health effects, and frequently require ongoing care and therapy. These diseases include heart dis...

  • Communication
  • Open Access
7 Citations
7,845 Views
15 Pages

Microwave-Mediated, Catalyst-Free Synthesis of 1,2,4-Triazolo[1,5-a]pyridines from Enaminonitriles

  • Kwanghee Lee,
  • Young-Ah Kim,
  • Chanhyun Jung,
  • Jaeuk Sim and ,
  • Shanmugam Rajasekar,
  • Jae-Hwan Kwak,
  • Mayavan Viji and
  • Jae-Kyung Jung
  • + 3 authors+ 0 author

18 February 2024

A catalyst-free, additive-free, and eco-friendly method for synthesizing 1,2,4-triazolo[1,5-a]pyridines under microwave conditions has been established. This tandem reaction involves the use of enaminonitriles and benzohydrazides, a transamidation me...

(This article belongs to the Section Organic Chemistry)
  • Correction
  • Open Access
1,400 Views
1 Page

Correction: Ghani et al. Multi-Dimensional Antioxidant Screening of Selected Australian Native Plants and Putative Annotation of Active Compounds. Molecules 2023, 28, 3106

  • Md. Ahsan Ghani,
  • Celia Barril,
  • Danny R. Bedgood,
  • Geoffrey E. Burrows and ,
  • Danielle Ryan and
  • Paul D. Prenzler
  • + 1 author+ 0 author

18 February 2024

In the original publication [...]

(This article belongs to the Section Natural Products Chemistry)
  • Review
  • Open Access
25 Citations
11,915 Views
31 Pages

An Umbrella Insight into the Phytochemistry Features and Biological Activities of Corn Silk: A Narrative Review

  • Yumei Wang,
  • Jialin Mao,
  • Meng Zhang,
  • Lei Liu and ,
  • Yu Zhu,
  • Meiling Gu,
  • Jinling Zhang,
  • Hongzhou Bu,
  • Yu Sun and
  • Qi Liu
  • + 9 authors+ 4 authors

18 February 2024

Corn silk (Zea mays L.) is the stigma of an annual gramineous plant named corn, which is distributed in many regions worldwide and has a long history of medicinal use. In recent years, with the sustainable development of traditional Chinese medicine,...

  • Article
  • Open Access
3 Citations
2,551 Views
16 Pages

17 February 2024

We have described a new route for the preparation of partially methylated polygalacturonic acid containing hydrolyzed (acidic) and unhydrolyzed (methyl esterified) carboxylate groups in a ratio of 1:1 (PGA, compound 1), and one of its basic FeIII&mda...

(This article belongs to the Special Issue Synthesis, Structure, Molecular Modeling, and Bioactivity of Metal Complexes)
  • Article
  • Open Access
5 Citations
2,268 Views
12 Pages

17 February 2024

In a previous study, we proposed an open quantum network model of a quantum battery (QB) that possesses dark states owing to its structural exchange symmetries. While in a dark state, the QB is capable of storing an exciton without any environment-in...

(This article belongs to the Special Issue Molecular Simulations of Energy Materials)
  • Article
  • Open Access
2 Citations
2,768 Views
13 Pages

Synthesis and Dynamic Behavior of Ce(IV) Double-Decker Complexes of Sterically Hindered Phthalocyanines

  • Jeevithra Dewi Subramaniam,
  • Toshio Nishino,
  • Kazuma Yasuhara and
  • Gwénaël Rapenne

17 February 2024

Phthalocyanines and their double-decker complexes are interesting in designing rotative molecular machines, which are crucial for the development of molecular motors and gears. This study explores the design and synthesis of three bulky phthalocyanin...

(This article belongs to the Special Issue Macrocyclic Compounds: Derivatives and Applications)
  • Article
  • Open Access
3 Citations
2,845 Views
15 Pages

Functionalized 2,3′-Bipyrroles and Pyrrolo[1,2-c]imidazoles from Acylethynylpyrroles and Tosylmethylisocyanide

  • Maxim D. Gotsko,
  • Ivan V. Saliy,
  • Igor A. Ushakov,
  • Lyubov N. Sobenina and
  • Boris A. Trofimov

17 February 2024

An efficient method for the synthesis of pharmaceutically prospective but still rare functionalized 2,3′-bipyrroles (in up to 80% yield) by the cycloaddition of easily available acylethynylpyrroles with tosylmethylisocyanide (TosMIC) has been d...

(This article belongs to the Special Issue Synthesis, Functionalization and Applications of Nitrogen-Containing Compounds)
  • Article
  • Open Access
7 Citations
4,011 Views
18 Pages

Chemical-Vapor-Deposition-Synthesized Two-Dimensional Non-Stoichiometric Copper Selenide (β-Cu2−xSe) for Ultra-Fast Tetracycline Hydrochloride Degradation under Solar Light

  • Srijith,
  • Rajashree Konar,
  • Eti Teblum,
  • Vivek Kumar Singh and ,
  • Madina Telkhozhayeva,
  • Michelangelo Paiardi and
  • Gilbert Daniel Nessim
  • + 2 authors+ 0 author

17 February 2024

The high concentration of antibiotics in aquatic environments is a serious environmental issue. In response, researchers have explored photocatalytic degradation as a potential solution. Through chemical vapor deposition (CVD), we synthesized copper...

(This article belongs to the Special Issue Feature Papers in Photochemistry and Photocatalysis)
  • Article
  • Open Access
5 Citations
2,767 Views
16 Pages

17 February 2024

Several types of pollutants have acute adverse effects on living bodies, and the effective removal of these pollutants remains a challenge. Safranin O (a biological dye) and merbromin (a topical mercury-containing antiseptic) are considered organic p...

(This article belongs to the Special Issue Metal Organic Frameworks: Synthesis and Application II)
  • Article
  • Open Access
7 Citations
4,142 Views
17 Pages

Quantitative Analysis of Cenobamate and Concomitant Anti-Seizure Medications in Human Plasma via Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry

  • Linda Molteni,
  • Bruno Charlier,
  • Albino Coglianese,
  • Viviana Izzo and ,
  • Giovanni Assenza,
  • Pierantonio Menna,
  • Ugo de Grazia and
  • Annachiara D’Urso
  • + 3 authors+ 0 author

17 February 2024

Cenobamate (CNB) is a new anti-seizure medication (ASM) recently introduced in clinical practice after approval by the FDA and EMA for the add-on treatment of focal onset seizures in adult patients. Although its mechanism of action has not been fully...

(This article belongs to the Topic Chromatography–Mass Spectrometry Analysis in Biomedical Research and Clinical Laboratory)
  • Review
  • Open Access
28 Citations
7,752 Views
30 Pages

Biodegradable Polymers in Veterinary Medicine—A Review

  • Magdalena Broda,
  • Daniel J. Yelle and
  • Katarzyna Serwańska-Leja

17 February 2024

During the past two decades, tremendous progress has been made in the development of biodegradable polymeric materials for various industrial applications, including human and veterinary medicine. They are promising alternatives to commonly used non-...

(This article belongs to the Special Issue Application of Synthetic and Natural Polymers in Medicine)
  • Article
  • Open Access
8 Citations
3,037 Views
10 Pages

Design, Synthesis of Hydrogen Peroxide Response AIE Fluorescence Probes Based on Imidazo [1,2-a] Pyridine

  • Luan Tong,
  • Yulong Yang,
  • Likang Zhang,
  • Jiali Tao and ,
  • Bin Sun,
  • Cairong Song,
  • Mengchen Qi,
  • Fengqing Yang,
  • Mingxia Zhao and
  • Junbing Jiang
  • + 5 authors+ 0 author

16 February 2024

Hydrogen peroxide (H2O2), a significant member of reactive oxygen species, plays a crucial role in oxidative stress and cell signaling. Abnormal levels of H2O2 in the body can induce damage or even impair body function, leading to the development of...

(This article belongs to the Section Organic Chemistry)
  • Article
  • Open Access
7 Citations
3,344 Views
15 Pages

An Efficient Approach to the Accurate Prediction of Mutational Effects in Antigen Binding to the MHC1

  • Mengchen Zhou,
  • Fanyu Zhao,
  • Lan Yu,
  • Jinfeng Liu and ,
  • Jian Wang and
  • John Z. H. Zhang
  • + 1 author+ 0 author

16 February 2024

The major histocompatibility complex (MHC) can recognize and bind to external peptides to generate effective immune responses by presenting the peptides to T cells. Therefore, understanding the binding modes of peptide–MHC complexes (pMHC) and...

(This article belongs to the Special Issue Feature Papers in Computational and Theoretical Chemistry)
  • Article
  • Open Access
20 Citations
4,531 Views
20 Pages

Dendrobium officinale Polysaccharides as a Natural Functional Component for Acetic-Acid-Induced Gastric Ulcers in Rats

  • Miao Zhang,
  • Liba Xu,
  • Long Chen,
  • Huan Wu and ,
  • Li Jia and
  • Hua Zhu
  • + 1 author+ 0 author

16 February 2024

Dendrobium officinale is an important edible and medicinal plant, with the Dendrobium officinale polysaccharide (DOP) being its primary active constituent, known for its diverse biological activities. In this study, DOP was extracted and characterize...

  • Article
  • Open Access
12 Citations
4,157 Views
13 Pages

Electrolyte Optimization Strategy: Enabling Stable and Eco-Friendly Zinc Adaptive Interfacial Layer in Zinc Ion Batteries

  • Bozhong Cao,
  • Chunyan Xu,
  • Bingchun Jiang,
  • Biao Jin and ,
  • Jincheng Zhang,
  • Lei Ling,
  • Yusheng Lu,
  • Tianyu Zou and
  • Tong Zhang
  • + 4 authors+ 0 author

16 February 2024

Aqueous zinc ion batteries (AZIBs) have emerged as a promising battery technology due to their excellent safety, high capacity, low cost, and eco-friendliness. However, the cycle life of AZIBs is limited by severe side reactions and zinc dendrite gro...

  • Article
  • Open Access
45 Citations
7,478 Views
16 Pages

Antibacterial Activity of Plant Polyphenols Belonging to the Tannins against Streptococcus mutans—Potential against Dental Caries

  • Krzysztof Czerkas,
  • Ewa Olchowik-Grabarek,
  • Magdalena Łomanowska,
  • Nodira Abdulladjanova and
  • Szymon Sękowski

16 February 2024

Dental caries (DC) is the most common oral pathology. The main bacteria responsible for DC is Streptococcus mutans. One of the strategies that can decrease or eliminate the risk of DC development is using compounds that will inhibit both the growth a...

  • Article
  • Open Access
12 Citations
3,328 Views
22 Pages

Strophanthidin Induces Apoptosis of Human Lung Adenocarcinoma Cells by Promoting TRAIL-DR5 Signaling

  • Xiao Tian,
  • Liangzhen Gu,
  • Fangang Zeng,
  • Xingkai Liu and ,
  • Yang Zhou,
  • Yang Dou,
  • Juanjuan Han,
  • Yao Zhao,
  • Yanyan Zhang and
  • Fuyi Wang
  • + 6 authors+ 1 author

16 February 2024

Strophanthidin (SPTD), one of the cardiac glycosides, is refined from traditional Chinese medicines such as Semen Lepidii and Antiaris toxicaria, and was initially used for the treatment of heart failure disease in clinic. Recently, SPTD has been sho...

(This article belongs to the Special Issue Anti-tumor Effects of Natural Products)
  • Article
  • Open Access
7 Citations
2,913 Views
17 Pages

A New Potent Inhibitor against α-Glucosidase Based on an In Vitro Enzymatic Synthesis Approach

  • Huanyu Zhang,
  • Xiance Che,
  • Hongyan Jing,
  • Yaowu Su and ,
  • Wenqi Yang,
  • Rubing Wang,
  • Guoqi Zhang,
  • Jie Meng,
  • Wei Yuan and
  • Wenyuan Gao
  • + 6 authors+ 1 author

16 February 2024

Inhibiting the activity of intestinal α-glucosidase is considered an effective approach for treating type II diabetes mellitus (T2DM). In this study, we employed an in vitro enzymatic synthesis approach to synthesize four derivatives of natural...

(This article belongs to the Special Issue Antidiabetic Natural Products)
  • Article
  • Open Access
11 Citations
3,237 Views
20 Pages

Cyclodextrin-Enabled Enantioselective Complexation Study of Cathinone Analogs

  • András Dohárszky,
  • Eszter Kalydi,
  • Gergely Völgyi,
  • Szabolcs Béni and
  • Ida Fejős

16 February 2024

The characteristic alkaloid component of the leaves of the catnip shrub (Catha edulis) is cathinone, and its synthetic analogs form a major group of recreational drugs. Cathinone derivatives are chiral compounds. In the literature, several chiral met...

(This article belongs to the Special Issue Advances in Chiral Analysis)
  • Review
  • Open Access
44 Citations
7,453 Views
22 Pages

Recent Advances in Structural Optimization of Quinazoline-Based Protein Kinase Inhibitors for Cancer Therapy (2021–Present)

  • Heba T. Abdel-Mohsen,
  • Manal M. Anwar,
  • Nesreen S. Ahmed,
  • Somaia S. Abd El-Karim and
  • Sameh H. Abdelwahed

16 February 2024

Cancer is a complicated, multifaceted disease that can impact any organ in the body. Various chemotherapeutic agents have a low selectivity and are very toxic when used alone or in combination with others. Resistance is one of the most important hurd...

(This article belongs to the Section Organic Chemistry)
  • Article
  • Open Access
5 Citations
2,935 Views
12 Pages

16 February 2024

We conducted ab initio valence bond (VB) calculations employing the valence bond self-consistent field (VBSCF) and breathing orbital valence bond (BOVB) methods to investigate the nature of the coordination bonding between ferrous heme and carbon mon...

(This article belongs to the Special Issue Cytochrome P450)
  • Article
  • Open Access
1 Citations
3,189 Views
13 Pages

Teadenol B as a Component of Microorganism-Fermented Tea Extract Inhibited Breast Cancers by Promoting Autophagy

  • Ying Zhao,
  • Zhang-Gui Ding,
  • Yu-Jie Yan,
  • Rui Yang and ,
  • Miao-Miao Qi,
  • Shu-Kang Pan,
  • Ji-Ling Xie,
  • Yu-Hui Sun and
  • Jin Xiang
  • + 4 authors+ 0 author

16 February 2024

Breast cancer is a significant threat to life and health, which needs more safe and effective drugs to be explored. Teadenol B is a characteristic chemical component of microbial fermented tea. This study discovered that teadenol B could exhibit obvi...

(This article belongs to the Special Issue Research on Chemical Composition and Activity of Natural Products)
  • Article
  • Open Access
19 Citations
6,509 Views
15 Pages

Extraction of High Value Products from Zingiber officinale Roscoe (Ginger) and Utilization of Residual Biomass

  • Alexandra Spyrou,
  • Marcelle G. F. Batista,
  • Marcos L. Corazza,
  • Maria Papadaki and
  • Maria Antonopoulou

16 February 2024

Zingiber officinale Roscoe (ginger) is a plant from the Zingiberaceae family, and its extracts have been found to contain several compounds with beneficial bioactivities. Nowadays, the use of environmentally friendly and sustainable extraction method...

(This article belongs to the Special Issue Biomass and Waste Conversion and Valorization to Chemicals, Energy and Fuels)
  • Article
  • Open Access
2 Citations
2,540 Views
13 Pages

CO2-Driven N-Formylation/N-Methylation of Amines Using C-Scorpionate Metal Complexes

  • Inês A. S. Matias,
  • Anna M. Trzeciak,
  • Paulina Pąchalska,
  • Ana P. C. Ribeiro and
  • Luísa M. D. R. S. Martins

16 February 2024

C-scorpionate metal complexes, specifically, [NiCl2(tpm)]·3H2O, [CoCl2(tpm)]·3H2O and [PdCl2(tpm)] [tpm = hydrotris(1H-pyrazol-1-yl)methane], were effective in the N-formylation and N-methylation of amines using carbon dioxide, as carbo...

(This article belongs to the Special Issue Green Chemistry in Portugal)

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Molecules - ISSN 1420-3049