Background: Standard single-cell RNA sequencing (scRNA-seq) analysis workflows face significant limitations, particularly the rigidity of clustering-dependent methods that can obscure subtle cellular heterogeneity and the potential loss of biological...
Single cell RNA sequencing (scRNA-seq) allows researchers to explore tissue heterogeneity, distinguish unusual cell identities, and find novel cellular subtypes by providing transcriptome profiling for individual cells. Clustering analysis is usually...
Individual cells have many unique properties that can be quantified to develop a holistic understanding of a population. This can include understanding population characteristics, identifying subpopulations, or elucidating outlier characteristics tha...
We present an analytic framework based on Self-Organizing Map (SOM) machine learning to study large scale patient data sets. The potency of the approach is demonstrated in a case study using gene expression data of more than 200 mature aggressive B-c...
This paper investigates a use case of robust anomaly detection applied to the scenario of a photovoltaic production factory—namely, Enel Green Power’s 3SUN solar cell production plant in Catania, Italy—by considering a Monte Carlo based pre-processin...
Single-cell RNA-sequencing (scRNA-seq) is a recent high-throughput technique that can measure gene expression, reveal cell heterogeneity, rare and complex cell populations, and discover cell types and their relationships. The analysis of scRNA-seq da...
We apply hierarchical clustering (HC) of DNA k-mer counts on multiple Fastq files. The tree structures produced by HC may reflect experimental groups and thereby indicate experimental effects, but clustering of preparation groups indicates the presen...
Technology opportunity discovery (TOD) is an important technique to help fuel cell vehicle (FCV) firms keep market advantage and sustainable development. Under fierce competition in the new energy industry, there is an urgent necessity for innovative...
During the manufacturing process of the lithium-ion battery, metal foreign matter is likely to be mixed into the battery, which seriously influences the safety performance of the battery. In order to reduce the outflow of such foreign matter defect c...
Cellular organisms store heritable information in two forms, genetic and epigenetic, the latter being largely dependent on cytosine methylation (5mC). Chargaff’s Second Parity Rule (CSPR) describes the nucleotide composition of cellular genomes...
Proteomic analysis of extracellular vesicles presents several challenges due to the unique nature of these small membrane-bound structures. Alternative analyses could reveal outcomes hidden from standard statistics to explore and develop potential ne...
Lithium-ion batteries, with their high energy density, long cycle life, and non-polluting advantages, are widely used in energy storage stations. Connecting lithium batteries in series to form a battery pack can achieve the required capacity and volt...
This paper explores the spatial impact of green infrastructure (GI) location on the resilience of urban drainage systems by the application of exploratory spatial data analysis (ESDA). A framework that integrates resilience assessment, location sensi...
Hematologic and biochemical data are useful for indicating disease diagnosis and growth performance in swine. However, the assessment of these parameters in healthy commercial pigs is rare in China. Thus, blood samples were collected from 107 nursery...
Live virus neutralization is the gold standard to investigate immunity. This prospective observational study aimed to determine the magnitude of response against the original B.1 lineage and against the BA.5 lineage six months after the third BNT162b...
Background/Objectives: Severe COVID-19 pneumonia damages alveolar type II cells and disrupts surfactant homeostasis, contributing to acute respiratory distress syndrome (ARDS). Surfactant proteins (SP-A, SP-B, SP-C, SP-D) are critical for reducing al...
Competitive athletes are often exposed to extreme physiological loading, resulting in over excessive mechanotransduction during their acute intensive training sessions and competitions. Individual differences in their genetics often affect how they c...
This paper proposes a novel unsupervised multi-model fusion framework for robust cell-level anomaly detection in grid-scale battery energy storage systems (BESSs). Addressing the complex nonlinearity and prevalent data quality issues (e.g., asynchron...
The complexity of cancer diseases demands bioinformatic techniques and translational research based on big data and personalized medicine. Open data enables researchers to accelerate cancer studies, save resources and foster collaboration. Several to...
7 June 2024
Background: Diffuse large B-cell lymphoma (DLBCL) is one of the most frequent lymphomas. DLBCL is phenotypically, genetically, and clinically heterogeneous. Aim: We aim to identify new prognostic markers. Methods: We performed anomaly detection analy...
Observational studies indicate that variations in peripheral blood mononuclear cell (PBMC) subsets are associated with an increased risk of pulmonary tuberculosis (PTB) and coronavirus disease 2019 (COVID-19), but causal validation is lacking. Here,...
The retinal structure is generally conserved across vertebrates; however, variations occur due to the relationship between environmental factors and visual perception. Birds have adapted to diverse ecological contexts, evolving specialized visual cha...
Protein kinases are vital regulators in cell biology, modifying protein functions through phosphorylation. Protein kinase inhibitors (PKIs), which impede these kinases’ activities, have broadened their therapeutic scope from cancer treatment to...
Performance of the current battery management systems is limited by the on-board embedded systems as the number of battery cells increases in the large-scale lithium-ion (Li-ion) battery energy storage systems (BESSs). Moreover, an expensive supervis...
Commercial vehicle operation (CVO) has been a popular application of intelligent transportation systems. Location determination and route tracing of an on-board unit (OBU) in a vehicle is an important capability for CVO. However, large location error...
Mutations in the GBA1 gene represent the major genetic risk factor for Parkinson’s disease (PD). The lysosomal enzyme beta-glucocerebrosidase (GCase) encoded by the GBA1 gene participates in both the endolysosomal pathway and the immune respons...
Nowadays, mangoes and other fruits are classified according to human perception of low productivity, which is a poor quality of classification. Therefore, in this study, we suggest a novel evaluation of internal quality focused on external features o...
Annual river discharge is a critical variable for water resources planning and management. Tree rings are widely used to reconstruct annual discharge, but errors can be large when tree growth fails to respond commensurately to hydrologically importan...
Assessing complex environmental mixtures and their effects is challenging. In this study, we evaluate the utility of an avian in vitro screening approach to determine the effects of passive air sampler extracts collected from different global megacit...
Background/Objectives: Predicting whether a compound is subject to active transport is crucial in drug development. We propose a simple threshold for passive membrane permeability (Pm), derived from the cell’s energy limitation, to identify com...
In this study we examine the relationship between remotely sensed, in situ and modelled land surface temperature (LST) over a heterogeneous land-cover (LC) enclosed in alpine terrain. This relationship can help to understand to what extent the remote...
The Fourier transform infrared (FTIR) imaging technique was used in a transmission model for the evaluation of twelve oral hyperkeratosis (HK), eleven oral epithelial dysplasia (OED), and eleven oral squamous cell carcinoma (OSCC) biopsy samples in t...
Background/Objectives: Host cell protein (HCP) content is a major attribute for biological and vaccine products that must be extensively characterized prior to product licensure. Enzyme Linked Immunosorbent Assay (ELISA) and Mass Spectrometry (MS) ar...
Crisp grass carp products from China are becoming more prevalent in the worldwide fish market because muscle hardness is the primary desirable characteristic for consumer satisfaction of fish fillet products. Unfortunately, current instrumental metho...
Sperm morphology assessment plays a vital role in semen analysis and the diagnosis of male infertility. By quantitatively analyzing the morphological characteristics of the sperm head, midpiece, and tail, it provides essential insights for assisted r...
Human dihydrofolate reductase (hDHFR) is a crucial cellular enzyme in folate metabolic pathway, where it catalyzes the reduction of dihydrofolate into tetrahydrofolate (THF) and an important cofactor involved in DNA, RNA, protein biosynthesis and cel...
Numerical modelling increasingly generates massive, high-dimensional spatio-temporal datasets. Exploring such datasets relies on effective visualization. This study presents a generic workflow to (i) project high-dimensional spatio-temporal data on a...
Virophages are a group of small double-stranded DNA viruses that replicate and proliferate with the help of the viral factory of large host viruses. They are widely distributed in aquatic environments but are more abundant in freshwater ecosystems. H...
Background and objective: Obstructive sleep apnea (OSA) can be related to changes in the levels of adipokines and neuropeptides, which in turn may affect the energy balance components of neuronal cells. Herein, a systematic review and meta-analysis c...
Background: Cancer cell lines are frequently used in research as in-vitro tumor models. Genomic data and large-scale drug screening have accelerated the right drug selection for cancer patients. Accuracy in drug response prediction is crucial for suc...
Patients undergoing myeloablative conditioning regimens and autologous stem-cell transplantation (ASCT) are at high risk of malnutrition. This randomized study aimed to determine if early nutrition support (commenced when oral intake is less than 80%...
Three passive microwave-based sea ice products archived at the National Snow and Ice Data Center (NSIDC) are compared: (1) the NASA Team (NT) algorithm product, (2) Bootstrap (BT) algorithm product, and (3) a new version (Version 4) of the NOAA/NSIDC...
Oestrogen receptor expression in breast cancer (BC) cells is a marker of high cellular differentiation and allows the identification of two BC groups (ER-positive and ER-negative) that, although not completely homogeneous, differ in biological charac...
Anomaly Detection (AD) in telecommunication networks is critical for maintaining service reliability and performance. However, operational networks present significant challenges: high-dimensional Key Performance Indicator (KPI) data collected from t...
Forest trees growing in high altitude conditions offer a convenient model for studying adaptation processes. They are subject to a whole range of adverse factors that are likely to cause local adaptation and related genetic changes. Siberian larch (L...
Background: Developing patient-centric baseline standards that enable the detection of clinically significant outlier gene products on a genome-scale remains an unaddressed challenge required for advancing personalized medicine beyond the small pools...