Heterochromatin and euchromatin form different spatial compartments in the interphase nucleus, with heterochromatin being localized mainly at the nuclear periphery. The mechanisms responsible for peripheral localization of heterochromatin are still n...
Protoparvoviruses target the nucleus due to their dependence on the cellular reproduction machinery during the replication and expression of their single-stranded DNA genome. In recent years, our understanding of the multistep process of the capsid n...
Nuclear power can replace fossil fuels and will have a decisive impact on the change in the approach to conventional energy. However, nuclear (or radioactive) wastes are produced by the operation of the nuclear reactors should be safely and properly...
Any given cell type has an associated “normal” nuclear morphology, which is important to maintain proper cellular functioning and safeguard genomic integrity. Deviations from this can be indicative of diseases such as cancer or premature...
Nuclear energy can help stop climate change by generating large amounts of emission-free electricity. Nuclear reactor designs are continually being developed to be more fuel efficient, safer, easier to construct, and to produce less nuclear waste. Th...
Nuclear power has been questioned almost since its beginnings and one of the major issues concerning its social acceptability around the world is nuclear waste management. In recent years, these issues have led to a rise in public opposition in some...
The necessity of coolant flow consumption measurement accuracy increase in the nuclear reactor primary circuit has been substantiated. Additionally, the need to control the coolant condition in the current flow inside the pipeline is shown. Nowadays,...
There are two primary challenges for establishing nuclear third party liability (TPL) regimes within multilateral nuclear approaches (MNA) to nuclear fuel cycle facilities in the Asian region. The first challenge is to ensure secure and prompt compen...
The nuclear envelope (NE) surrounds the nucleus with a double membrane in eukaryotic cells. The double membranes are embedded with proteins that are synthesized on the endoplasmic reticulum and often destined specifically for either the outer nuclear...
Multilateral Nuclear Approaches (MNAs) is a concept of international and/or multilateral control of nuclear material and/or nuclear fuel cycle facilities. It is a strategy for contributing to and promoting the sustainability of nuclear energy while e...
During the Cold War, two basic schools of thought emerged among U.S. Christian leaders and ethicists concerning the implications of the nuclear revolution for the use of force by the United States. The just war thinkers held that nuclear war could in...
In eukaryotic cells, the organization of the genome within the nucleus requires the nuclear envelope (NE) and its associated proteins. The nucleus is subjected to mechanical forces produced by the cytoskeleton. The physical properties of the NE and t...
Small Modular Reactors (SMRs) are becoming one of the key trends in the development of nuclear technology, offering a flexible, safe and cost-effective alternative to large nuclear power plants. This review defines the “driving force” of...
The design of a country’s nuclear energy development policy and legal system is crucial to the development of its nuclear energy industry, and thus also affects international issues such as climate change and energy green and low-carbon transfo...
Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues. Many studies have shown that alteration of the components of the nuclear lamina is a...
Nuclear energy is proposed as part of the solution to a net-zero carbon future. However, environmental issues with nuclear energy remain. In this study, a total of 1616 participants from across the U.S. stated their position on the following statemen...
The nuclear lamina is the main component of the nuclear cytoskeleton that maintains the integrity of the nucleus. However, it represents a natural barrier for viruses replicating in the cell nucleus. The lamina blocks viruses from being trafficked to...
The continued use of nuclear energy has come into question due to the difficulties in managing radioactive waste, and public opposition has increased since the Fukushima nuclear disaster in March 2011. Nonetheless, the novel spent nuclear fuel (SNF)...
Herpesvirus capsids are assembled in the nucleus and undergo a two-step process to cross the nuclear envelope. Capsids bud into the inner nuclear membrane (INM) aided by the nuclear egress complex (NEC) proteins UL31/34. At that stage of egress, enve...
There is accumulating evidence that the nuclear periphery is a transcriptionally repressive compartment. A surprisingly large fraction of the genome is either in transient or permanent contact with nuclear envelope, where the majority of genes are ma...
The delivery of the HIV-1 genome into the nucleus is an indispensable step in retroviral infection of non-dividing cells, but the mechanism of HIV-1 nuclear import has been a longstanding debate due to controversial experimental evidence. It was comm...
The legacy of the early days of the Atomic Age consists of many problematic sites worldwide, including radioactive waste dumps, uranium mines, spent fuel reprocessing plants, and defunct processing and enrichment plants. Although nature quickly recla...
Baculoviruses are one of the largest viruses that replicate in the nucleus of their host cells. During infection, the rod-shape, 250-nm long nucleocapsid delivers its genome into the nucleus. Electron microscopy evidence suggests that baculoviruses,...
Although international law forbids nuclear attacks, only nine states have mutually assured destruction available to prevent direct attacks against themselves, while non-nuclear states have few substantive options to deter a nuclear attack. This study...
In the last decades, the study of many nuclear envelope components in Dictyostelium amoebae has revealed conserved mechanisms of nuclear envelope dynamics that root back unexpectedly deep into the eukaryotic tree of life. In this review, we describe...
Yes-associated Protein (YAP) and its paralog Transcriptional Coactivator with PDZ-binding Motif (TAZ) are major regulators of gene transcription/expression, primarily controlled by the Hippo pathway and the cytoskeleton. Integrating an array of chemi...
Background: Next-generation sequencing (NGS) technology is revolutionizing diagnostic screening for mitochondrial diseases (MDs). Moreover, an investigation by NGS still requires analyzing the mitochondrial genome and nuclear genes separately, with l...
Ab initio molecular dynamics combines a classical description of nuclear motion with a density-functional description of the electronic cloud. This approach nicely describes chemical reactions. A possible conclusion is that a quantum mechanical descr...
The organization of eukaryotic genome in the nucleus, a double-membraned organelle separated from the cytoplasm, is highly complex and dynamic. The functional architecture of the nucleus is confined by the layers of internal and cytoplasmic elements,...
Marine reactors have been applied to floating nuclear power plants, naval vessels such as submarines, and civilian ships such as icebreakers. Nuclear-powered shipping is gaining increased interest because of decarbonization goals motivated by climate...
The nuclear phase of herpesvirus replication is regulated through the formation of regulatory multi-component protein complexes. Viral genomic replication is followed by nuclear capsid assembly, DNA encapsidation and nuclear egress. The latter has be...
The p38 mitogen-activated protein kinase (p38MAPK, termed here p38) cascade is a central signaling pathway that transmits stress and other signals to various intracellular targets in the cytoplasm and nucleus. More than 150 substrates of p38α/&...
The adequacy of legal and regulatory framework relating to nuclear energy in Bangladesh has sparked many questions since the government took the formal decision to establish a nuclear power plant (NPP) at Rooppur. Consequently, the government has tak...
One of primary challenges for ensuring effective and efficient functions of the multilateral nuclear approaches (MNA) to nuclear fuel cycle facilities is harmonization between a MNA framework and existing nuclear cooperation agreements (NCA). A metho...
Polyphosphoinositides (PPIns) are signalling messengers representing less than five per cent of the total phospholipid concentration within the cell. Despite their low concentration, these lipids are critical regulators of various cellular processes,...
The popularity of nuclear power as a high-availability energy source is increasing in countries that currently rely on coal-based energy. The growing use of renewable energy sources emphasizes the need for greater energy supply security and grid stab...
This study determines the nuclear pragmatic limit where the direct physical negative consequences of nuclear weapons use are counter to national interests, by assuming all unknowns are conservatively optimistic. The only effect considered is nuclear...
The nuclear lamins are the major components of the nuclear lamina in the nuclear envelope. Lamins are involved in numerous functions, including a role in providing structural support to the cell and the mechanosensing of the cell. Mutations in the ge...
The transport of host proteins into and out of the nucleus is key to host function. However, nuclear transport is restricted by nuclear pores that perforate the nuclear envelope. Protein intrinsic disorder is an inherent feature of this selective tra...
The nuclear envelope (NE) of eukaryotic cells provides a physical barrier for messenger RNA (mRNA) and the associated proteins (mRNPs) traveling from sites of transcription in the nucleus to locations of translation processing in the cytoplasm. Nucle...
Lamins are the best characterized cytoskeletal components of the cell nucleus that help to maintain the nuclear shape and participate in diverse nuclear processes including replication or transcription. Nuclear actin is now widely accepted to be anot...
This paper provides a review and analysis of the challenges that nuclear power must overcome in order to be considered sustainable. The results make it clear that not only do innovative technical solutions need to be generated for the fundamental inh...
Polybrominated diphenyl ethers (PBDEs) are natural products with potent antimicrobial and antineoplastic activity. We have previously shown that the polybrominated diphenyl ether bromoxib (4,5,6-tribromo-2-(2′,4′-dibromophenoxy) phenol),...
Nanomedicine 2.0 refers to the next generation of nanotechnology-based medical therapies and diagnostic tools. This field focuses on the development of more sophisticated and precise nanoparticles (NPs) for targeted drug delivery, imaging, and sensin...
Nuclear waste (like radioactive waste) is waste that contains, or is contaminated with, radionuclides, at activity concentrations greater than clearance levels set by the regulators, beyond which no further use is foreseen. Disposal is the emplacemen...
Replication of the RNA genome of influenza A virus occurs in the nucleus of infected cells. The influenza nucleoprotein (NP) associated with the viral RNA into ribonucleoprotein complexes (vRNPs) is involved in the nuclear import of the viral genome....
The cell nucleus contains a number of membrane-less organelles or intra-nuclear compartments. These compartments are dynamic structures representing liquid-droplet phases which are only slightly denser than the bulk intra-nuclear fluid. They possess...
Regulator of TElomere Length Helicase 1 (RTEL1) is a helicase required for telomere maintenance and genome replication and repair. RTEL1 has been previously shown to participate in the nuclear export of small nuclear RNAs. Here we show that RTEL1 def...
While atomic scale structural and dynamic information are hallmarks of nuclear magnetic resonance (NMR) methodologies, sensitivity is a fundamental limitation in NMR studies. Fully exploiting NMR capabilities to study membrane proteins is further ham...
Marine nuclear power plants (MNPPs) represent items of forward-looking high-end engineering equipment combining nuclear power and ocean engineering, with unique advantages and broad application prospects. When a nuclear accident occurs, it causes con...
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