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Nuclear Mechanics in the Fission Yeast

Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-Consejo Superior de Investigaciones Científicas, Junta de Andalucia, 41010 Seville, Spain
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Cells 2019, 8(10), 1285; https://doi.org/10.3390/cells8101285
Received: 18 September 2019 / Revised: 14 October 2019 / Accepted: 17 October 2019 / Published: 20 October 2019
(This article belongs to the Special Issue Nuclear Organisation)
In eukaryotic cells, the organization of the genome within the nucleus requires the nuclear envelope (NE) and its associated proteins. The nucleus is subjected to mechanical forces produced by the cytoskeleton. The physical properties of the NE and the linkage of chromatin in compacted conformation at sites of cytoskeleton contacts seem to be key for withstanding nuclear mechanical stress. Mechanical perturbations of the nucleus normally occur during nuclear positioning and migration. In addition, cell contraction or expansion occurring for instance during cell migration or upon changes in osmotic conditions also result innuclear mechanical stress. Recent studies in Schizosaccharomyces pombe (fission yeast) have revealed unexpected functions of cytoplasmic microtubules in nuclear architecture and chromosome behavior, and have pointed to NE-chromatin tethers as protective elements during nuclear mechanics. Here, we review and discuss how fission yeast cells can be used to understand principles underlying the dynamic interplay between genome organization and function and the effect of forces applied to the nucleus by the microtubule cytoskeleton. View Full-Text
Keywords: nucleus; genome 3D organization; nuclear architecture; nuclear envelope; inner nuclear membrane (INM) proteins; linker of nucleoskeleton and cytoskeleton (LINC) complex; chromatin; chromatin domains; microtubule (MT) cytoskeleton; MT pushing forces; nuclear mechanics nucleus; genome 3D organization; nuclear architecture; nuclear envelope; inner nuclear membrane (INM) proteins; linker of nucleoskeleton and cytoskeleton (LINC) complex; chromatin; chromatin domains; microtubule (MT) cytoskeleton; MT pushing forces; nuclear mechanics
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MDPI and ACS Style

Gallardo, P.; Barrales, R.R.; Daga, R.R.; Salas-Pino, S. Nuclear Mechanics in the Fission Yeast. Cells 2019, 8, 1285.

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