Next Article in Journal
Role of Brain Derived Extracellular Vesicles in Decoding Sex Differences Associated with Nicotine Self-Administration
Next Article in Special Issue
ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA
Previous Article in Journal
Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited Disorders of the One Carbon Metabolism
Previous Article in Special Issue
In Vivo Assembly of a Dictyostelium Lamin Mutant Induced by Light, Mechanical Stress, and pH
Open AccessReview

Structural and Mechanical Aberrations of the Nuclear Lamina in Disease

1
Department of Genetics and Cell Biology, Maastricht University Medical Centre, NL-6200 MD Maastricht, The Netherlands
2
GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre, NL-6200 MD Maastricht, The Netherlands
3
CARIM-School for Cardiovascular Diseases, Maastricht University Medical Centre, NL-6200 MD Maastricht, The Netherlands
4
Institute for Molecular Cardiovascular Research IMCAR, RWTH Aachen University, 52074 Aachen, Germany
*
Author to whom correspondence should be addressed.
Cells 2020, 9(8), 1884; https://doi.org/10.3390/cells9081884
Received: 10 July 2020 / Revised: 2 August 2020 / Accepted: 10 August 2020 / Published: 11 August 2020
(This article belongs to the Collection Lamins and Laminopathies)
The nuclear lamins are the major components of the nuclear lamina in the nuclear envelope. Lamins are involved in numerous functions, including a role in providing structural support to the cell and the mechanosensing of the cell. Mutations in the genes encoding for lamins lead to the rare diseases termed laminopathies. However, not only laminopathies show alterations in the nuclear lamina. Deregulation of lamin expression is reported in multiple cancers and several viral infections lead to a disrupted nuclear lamina. The structural and mechanical effects of alterations in the nuclear lamina can partly explain the phenotypes seen in disease, such as muscular weakness in certain laminopathies and transmigration of cancer cells. However, a lot of answers to questions about the relation between changes in the nuclear lamina and disease development remain elusive. Here, we review the current understandings of the contribution of the nuclear lamina in the structural support and mechanosensing of healthy and diseased cells. View Full-Text
Keywords: nuclear lamina; mechanosensing; mechanoresponse; nuclear rupture; nuclear stiffness; laminopathy; lamins in cancer; lamins and viruses nuclear lamina; mechanosensing; mechanoresponse; nuclear rupture; nuclear stiffness; laminopathy; lamins in cancer; lamins and viruses
Show Figures

Figure 1

MDPI and ACS Style

Stiekema, M.; van Zandvoort, M.A.M.J.; Ramaekers, F.C.S.; Broers, J.L.V. Structural and Mechanical Aberrations of the Nuclear Lamina in Disease. Cells 2020, 9, 1884. https://doi.org/10.3390/cells9081884

AMA Style

Stiekema M, van Zandvoort MAMJ, Ramaekers FCS, Broers JLV. Structural and Mechanical Aberrations of the Nuclear Lamina in Disease. Cells. 2020; 9(8):1884. https://doi.org/10.3390/cells9081884

Chicago/Turabian Style

Stiekema, Merel; van Zandvoort, Marc A.M.J.; Ramaekers, Frans C.S.; Broers, Jos L.V. 2020. "Structural and Mechanical Aberrations of the Nuclear Lamina in Disease" Cells 9, no. 8: 1884. https://doi.org/10.3390/cells9081884

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop