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Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation

Department of Integrated Biomedical Science and Soonchunhyang Institute of Medi-Bioscience, Soonchunhyang University, Cheon-an 31151, Korea
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Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2020, 9(3), 718; https://doi.org/10.3390/cells9030718 (registering DOI)
Received: 24 February 2020 / Revised: 11 March 2020 / Accepted: 12 March 2020 / Published: 14 March 2020
(This article belongs to the Special Issue Nuclear Architecture, Lipids, and Phase Separation)
Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues. Many studies have shown that alteration of the components of the nuclear lamina is associated with inflammation, both in vivo and in vitro. However, the mechanism by which the nuclear lamina regulates inflammation is largely unknown. Recent studies have suggested that the nuclear lamina regulates both organization of the three-dimensional chromatin structure at the nuclear periphery and global gene expression, such as the expression of inflammatory response genes. Here, we discuss the current updates in the research on nuclear lamina alteration, activation of inflammation, and nuclear reorganization in models of cellular senescence and organismal aging. View Full-Text
Keywords: nuclear lamina; lamins; aging; cellular senescence; chronic inflammation; 3D chromatin structure; Hi-C nuclear lamina; lamins; aging; cellular senescence; chronic inflammation; 3D chromatin structure; Hi-C
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Kristiani, L.; Kim, M.; Kim, Y. Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation. Cells 2020, 9, 718.

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