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  • Perspective
  • Open Access
551 Views
15 Pages

5 August 2026

In the context of artificial intelligence in chemistry, the first applications that come to mind are widely discussed ones, such as building surrogate models to replace costly numerical simulations or designing new compounds. However, one area where...

  • Review
  • Open Access
29 Citations
14,247 Views
17 Pages

27 November 2017

Contemporary peptide science exploits methods and tools of bioinformatics, and cheminformatics. These approaches use different languages to describe peptide structures—amino acid sequences and chemical codes (especially SMILES), respectively. The lat...

(This article belongs to the Section Bioorganic Chemistry)
  • Article
  • Open Access
3 Citations
3,444 Views
14 Pages

CrystalShift is an open-source computational tool tailored for the analysis, transformation, and conversion of crystallographic data, with a particular emphasis on organic crystal structures. It offers a comprehensive suite of features valuable for t...

(This article belongs to the Special Issue Feature Papers in Computational Chemistry)
  • Letter
  • Open Access
4 Citations
3,625 Views
2 Pages

Letter to the Editor: “Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques”

  • Angelica M. Merlot,
  • Sumit Sahni,
  • Darius J. R. Lane,
  • Vera Richardson,
  • Michael L. H. Huang,
  • Danuta S. Kalinowski and
  • Des R. Richardson

16 November 2016

In reading the article by Xu, Z., et al. entitled “Analysis of the Interaction of Dp44mT with Human Serum Albumin and Calf Thymus DNA Using Molecular Docking and Spectroscopic Techniques” [1], there is evidence that some of the key methods and compar...

  • Editorial
  • Open Access
1 Citations
2,078 Views
3 Pages

According to the traditional definition of the concept of “simple substance” adopted in chemistry, it is as a chemical compound, the structural unit of which (molecule, ion, radical, the link of the polymer chain, the unit cell of the cry...

(This article belongs to the Special Issue Simple Substances of Non-metals: Molecular Structures Modeling with Using DFT and More Advanced Methods of Quantum Chemistry)
  • Editorial
  • Open Access
7 Citations
11,518 Views
5 Pages

International Journal of Molecular Sciences 2016 Best Paper Award

  • International Journal of Molecular Sciences Editorial Office

The Editors of the International Journal of Molecular Sciences have established the Best Paper Award to recognize the most outstanding articles published in the areas of molecular biology, molecular physics and chemistry that have been published in t...

  • Editorial
  • Open Access
2 Citations
12,627 Views
8 Pages

International Journal of Molecular Science 2019 Best Paper Award

  • International Journal of Molecular Science Editorial Office

The Editors of the International Journal of Molecular Sciences have established the Best Paper Award to recognize the most outstanding articles published in the areas of molecular biology, molecular physics, and chemistry that have been published in...

  • Editorial
  • Open Access
3 Citations
10,458 Views
6 Pages

International Journal of Molecular Science 2018 Best Paper Award

  • International Journal of Molecular Science Editorial Office

21 November 2018

The Editors of the International Journal of Molecular Sciences have established the Best Paper Award to recognize the most outstanding articles published in the areas of molecular biology, molecular physics, and chemistry that have been published in...

  • Editorial
  • Open Access
193 Views
2 Pages

Stepping into the role of Section Editor-in-Chief for Molecular Pharmacology at Current Issues in Molecular Biology (CIMB) comes at a pivotal moment for the discipline [...]

(This article belongs to the Section Molecular Pharmacology)
  • Editorial
  • Open Access
6,052 Views
2 Pages

22 November 2011

Microarrays covers research where microarrays are applied to address complex biological questions. This new open access journal publishes articles where novel applications or state-of-the art technology developments in the field are reported. In addi...

  • Editorial
  • Open Access
4 Citations
8,387 Views
6 Pages

International Journal of Molecular Science 2017 Best Paper Award

  • International Journal of Molecular Science Editorial Office

2 November 2017

The Editors of the International Journal of Molecular Sciences have established the Best Paper Award to recognize the most outstanding articles published in the areas of molecular biology, molecular physics and chemistry that have been published in t...

  • Editorial
  • Open Access
6 Citations
11,442 Views
3 Pages

International Journal of Molecular Science Best Paper Award 2014

  • Stephen A. Bustin,
  • Ian A. Nicholls and
  • Michael Iba

22 January 2014

International Journal of Molecular Science is instituting an annual award to recognize outstanding papers in the area of chemistry, molecular physics and molecular biology published in International Journal of Molecular Science. We are pleased to...

  • Editorial
  • Open Access
4,098 Views
6 Pages

It is a great honor and a pleasure for me to serve as Guest Editor for this Issue of the “International Journal of Molecular Sciences”, dedicated to our mentor and colleague, Professor Dr [...]

(This article belongs to the Special Issue Theme Issue Honoring Prof. Dr. Ludger Wessjohann’s 60th Birthday: Natural Products in Modern Drug Discovery)
  • Expression of Concern
  • Open Access
514 Views
1 Page

The Editor-in-Chief of the International Journal of Molecular Sciences wishes to alert readers to concerns regarding apparent irregularities in the images presented in Figure 6B,C of this article [...]

(This article belongs to the Section Biochemistry)
  • Editorial
  • Open Access
1 Citations
6,318 Views
4 Pages

Non-Coding RNAs in Cancer: An Interview with Dr. Martin Pichler

  • International Journal of Molecular Sciences Editorial Office

In this issue, we are pleased and honored to have an interview with Professor Martin Pichler, who is the Collection Editor for the International Journal of Molecular Sciences Topical Collection of “Regulation by Non-Coding RNAs” [1].[...]

(This article belongs to the Collection Regulation by Non-coding RNAs)
  • Editorial
  • Open Access
6 Citations
9,579 Views
3 Pages

22 February 2013

Since 2012, International Journal of Molecular Science has instituted an annual award to recognize outstanding papers in the area of chemistry, molecular physics and molecular biology that meet the aims, scope and high standards of this journal [1]....

  • Letter
  • Open Access
1 Citations
3,593 Views
2 Pages

To the Editor, We read with great interest the article by Kobori and colleagues [1], “Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E,” which appeared on 30 March 2017 in In...

  • Review
  • Open Access
777 Views
31 Pages

Reversible genetic medicines are emerging as controllable alternatives to permanent genome editing by enabling programmable modulation of RNA sequence, transcript abundance, chromatin state, and gene expression without irreversible genomic alteration...

(This article belongs to the Special Issue CRISPR/Cas Systems and Genome Editing—3rd Edition)
  • Editorial
  • Open Access
3,613 Views
5 Pages

A Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to mechanisms mediated at the molecular and cellular levels to respond to adverse genomic perturbations and DNA replication stress (https://www [...]

(This article belongs to the Special Issue DNA Replication Stress)
  • Review
  • Open Access
17 Citations
4,548 Views
19 Pages

Advances and Applications of Plant Base Editing Technologies

  • Hao Peng,
  • Jiajun Li,
  • Kehui Sun,
  • Huali Tang,
  • Weihong Huang,
  • Xi Li,
  • Surong Wang,
  • Ke Ding,
  • Zhiyang Han and
  • Ke Wang
  • + 2 authors

27 September 2025

Base editing represents a major breakthrough in the field of genome editing in recent years. By fusing deaminases with the CRISPR/Cas system, it enables precise single-base modifications of DNA. This review systematically summarizes the development o...

(This article belongs to the Special Issue Gene Editing for Cereal Crops)
  • Letter
  • Open Access
4,043 Views
2 Pages

To the Editor, We read with great interest the article “Circulating Cell-Free DNA and Circulating Tumor Cells as Prognostic and Predictive Biomarkers in Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line Chemotherapy” published by C...

  • Review
  • Open Access
15 Citations
7,467 Views
15 Pages

12 March 2025

Recent years have witnessed remarkable progress in plant biology, driven largely by the rapid evolution of CRISPR/Cas-based genome editing (GE) technologies. These tools, including versatile CRISPR/Cas systems and their derivatives, such as base edit...

(This article belongs to the Section Plant Genetics, Genomics and Biotechnology)
  • Review
  • Open Access
2 Citations
3,340 Views
32 Pages

9 January 2026

The rapid evolution of CRISPR/Cas technology has transformed genome editing across biological systems in which zebrafish have emerged as a powerful vertebrate model for functional genomics and disease research. Due to its transparency, genetic simila...

(This article belongs to the Section Genetics and Biotechnology)
  • Review
  • Open Access
2,010 Views
25 Pages

Application of Gene Editing Technology in Poultry

  • Ruyu Liao,
  • Rong Ran,
  • Yixin Liu,
  • Xinyi Zhou,
  • Min Tan,
  • Qigui Wang,
  • Haiwei Wang and
  • Xi Lan

Gene editing technology, a revolutionary tool in molecular biology, enables precise modifications of genomic sequences and gene expression patterns, thereby conferring desired traits to cells or organisms. Since 2014, CRISPR/Cas9 has rapidly become t...

  • Editorial
  • Open Access
945 Views
7 Pages

4 February 2026

This year, the selection criteria for highly cited articles in the ‘Molecular and Cellular Neuroscience’ section of Brain Sciences were focused on publications that achieved a citation count of 10 or more during 2024. Applying this metric...

(This article belongs to the Section Molecular and Cellular Neuroscience)
  • Article
  • Open Access
14 Citations
5,198 Views
13 Pages

Counteracting the Common Shwachman–Diamond Syndrome-Causing SBDS c.258+2T>C Mutation by RNA Therapeutics and Base/Prime Editing

  • Laura Peretto,
  • Elena Tonetto,
  • Iva Maestri,
  • Valentino Bezzerri,
  • Roberto Valli,
  • Marco Cipolli,
  • Mirko Pinotti and
  • Dario Balestra

16 February 2023

Shwachman–Diamond syndrome (SDS) represents one of the most common inherited bone marrow failure syndromes and is mainly caused by SBDS gene mutations. Only supportive treatments are available, with hematopoietic cell transplantation required w...

(This article belongs to the Special Issue Advances in Gene and Cell Therapy)
  • Article
  • Open Access
3 Citations
3,789 Views
11 Pages

29 January 2023

In this work, computer-assisted writing techniques for linear expressions of the structure of polycyclic molecules, branched molecules and clusters, based on formal languages, are tested. The techniques used only require the ability to process writte...

(This article belongs to the Special Issue Reactions, Structures, and Properties of Small Clusters: Experiments and Theory)
  • Feature Paper
  • Article
  • Open Access
45 Citations
6,685 Views
14 Pages

18 June 2019

Biochemistry has been broadly defined as “chemistry of molecules included or related to living systems”, but is becoming increasingly hard to be distinguished from other related fields. Targets of its studies evolve rapidly; some newly em...

(This article belongs to the Special Issue Performance Measurement and Optimization for Sustainable Production Processes Improvement)
  • Commentary
  • Open Access
2,719 Views
11 Pages

17 June 2022

My laboratory’s research on lipids has focused on phospholipases and lipidomics and in many ways has evolved in parallel to the evolution of the lipid field over the past half century. I have reviewed our research elsewhere. Herein, I describe...

(This article belongs to the Special Issue Lipids–Lipolytic Enzymes–Lipid Analysis: A Themed Issue Dedicated to Prof. Edward A. Dennis for His 80th Birthday)
  • Article
  • Open Access
284 Views
12 Pages

CRISPR/Cas12a-Based Aptasensor for Cas9 Protein Detection in Spiked Food Matrices

  • Zizhao Wang,
  • Jing Wang,
  • Ling Li,
  • Guofeng Chen,
  • Hongtao Wen,
  • Baohai Liu and
  • Yiyang Dong

10 October 2026

Residual gene editors are a concern associated with the widespread application of CRISPR/Cas9 technology. Here, we developed a CRISPR/Cas12a-based fluorescent aptasensor for the qualitative and quantitative detection of Cas9 protein. Secondary struct...

(This article belongs to the Special Issue Recent Advances in DNA/Protein Biosensors)
  • Review
  • Open Access
1 Citations
1,894 Views
23 Pages

CRISPR and the Future of Cardiac Disease Therapy: A New Genetic Frontier

  • Sem Sterckel,
  • Imelda Lizeth Chávez Martínez and
  • Verena Schwach

CRISPR technologies are transforming cardiovascular therapy development by creating an increasingly seamless pipeline from potential target discovery to clinical translation. What began as a genome-editing tool has evolved into a versatile platform t...

(This article belongs to the Special Issue Cardiovascular Research: From Molecular Mechanisms to Novel Therapies)
  • Article
  • Open Access
6 Citations
2,212 Views
23 Pages

New molecular predictors for the response to treatment in HBV (hepatitis B virus) infection are assessed. Among them is miR-122. Our article searches the connection between miR-122 and the counts of lymphocytes in chronic HBV patients receiving treat...

(This article belongs to the Special Issue Control of Viral Infections: Pathogenesis, Immunity, Vaccines and Antivirals)
  • Review
  • Open Access
28 Citations
5,699 Views
12 Pages

Association between Periodontal Diseases and Polycystic Ovary Syndrome: A Systematic Review

  • Cecilia Fabiana Márquez-Arrico,
  • Javier Silvestre-Rangil,
  • Laura Gutiérrez-Castillo,
  • Mayte Martinez-Herrera,
  • Francisco Javier Silvestre and
  • Milagros Rocha

Background: A convergent association between polycystic ovary syndrome (PCOS) and periodontal disease, in particular chronic periodontitis (CP), has recently been proposed. The underlying molecular mechanisms of this association are not fully underst...

(This article belongs to the Special Issue Oral Health and Systemic Diseases)

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