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Cardiovascular Research: From Molecular Mechanisms to Novel Therapies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 684

Special Issue Editors


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Guest Editor
Department of Cardiac and Vascular Diseases, Jagiellonian University, Krakow, Poland
Interests: carotid artery revascularization; cardiovascular
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, Amsterdam, The Netherlands
Interests: heart; cardiovascular

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Guest Editor
John Paul II Hospital, Krakow, Poland
Interests: coronary artery disease; hypertension; heart defects; pulmonary hypertension; heart failure

Special Issue Information

Dear Colleagues,

Advances in molecular medicine have represented a driving force in the development of innovative therapies for cardiovascular diseases. This Special Issue will explore cutting-edge research in cardiac and vascular biology, focusing on both fundamental molecular mechanisms and novel therapeutic strategies.

We welcome original research and review articles covering a broad spectrum of topics related to cardiovascular pathology and diseases, including, but not limited to, the following:

  • Molecular and cellular mechanisms behind cardiovascular diseases;
  • Molecular diagnostics and biomarkers;
  • Mechanistic insights from bench models, organoids, and in vivo studies;
  • Gene therapy and regenerative medicine;
  • Innovative pharmacological and non-pharmacological therapies;
  • Translational studies, preclinical models, and clinical trials.

This Special Issue will provide a broad update on new discoveries and advances in therapies, supporting the transition of molecular research into clinical practice.

We invite contributions from researchers and clinician–scientists working across molecular biology, cardiovascular medicine, bioengineering, and pharmacology.

Dr. Piotr Musiałek
Dr. Monika M. Gladká
Dr. Lukasz Tekieli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • cardiovascular diseases
  • cardiovascular repair and regeneration
  • molecular cardiology
  • gene and stem cell therapy
  • drug and gene delivery
  • advanced imaging
  • biomarkers
  • tissue engineering
  • thrombosis and clotting abnormalities
  • animal models of human disease

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Published Papers (1 paper)

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Research

17 pages, 2287 KB  
Article
Evaluation of Potential Molecular Targets of the Alkaloid Epiisopiloturine, Involved in Cardioprotective Effects, Using Computational Molecular Docking in an Animal Model of Cardiac Ischemia and Reperfusion
by Francisco Sandro Menezes-Rodrigues, Elisa Andrade Costa, Pedro Ivo De Marqui Moraes, Erisvaldo Amarante de Araújo, Carlos Eduardo Braga Filho, Leiz Maria Costa Véras, Paulo Sérgio de Araujo Sousa, Jefferson Almeida Rocha, Nelson Americo Hossne Junior, Solange Guizilini, Isadora S. Rocco, Walter José Gomes, Afonso Caricati-Neto, Marcelo Pires-Oliveira, Célia Maria Camelo Silva, Almir Gonçalves Wanderley and Fernando Sabia Tallo
Int. J. Mol. Sci. 2025, 26(19), 9488; https://doi.org/10.3390/ijms26199488 - 28 Sep 2025
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Abstract
The most common cause of morbidity and death worldwide is acute myocardial infarction (AMI), which is typified by severe and deadly arrhythmias resulting from cardiac ischemia and reperfusion (CIR). We chose to investigate the possible cardioprotective activity of epiisopiloturine (EPI), an imidazole alkaloid [...] Read more.
The most common cause of morbidity and death worldwide is acute myocardial infarction (AMI), which is typified by severe and deadly arrhythmias resulting from cardiac ischemia and reperfusion (CIR). We chose to investigate the possible cardioprotective activity of epiisopiloturine (EPI), an imidazole alkaloid presents in the leaves of Pilocarpus microphyllus, in an animal model of CIR in rats. Control rats were treated with 0.9% saline solution and then subjected to CIR (SS + CIR); they were compared to rats pretreated with either 10 mg/kg (EPI10 + CIR group) or 15 mg/kg EPI (EPI15 + CIR) before CIR. ECG analysis was used to assess the incidence of ventricular arrhythmias (VAs), atrioventricular block (AVB), and lethality (LET) brought on by CIR in these rats. Serum creatine kinase-MB (CK-MB) was assessed using a colorimetric assay. In comparison to the SS + CIR group, animals treated with EPI15 + CIR had lower AVB incidence, which decreased from 85.7% to 21.4%, while LET incidence decreased from 71.4% to 21.4%. In both EPI10 + CIR and EPI15 + CIR groups, serum CK-MB was lower than in SS + CIR positive controls. These findings suggest that administration of EPI (15 mg/kg) before CIR could reduce the incidences of AVB and LET, as well as cardiac injury markers, which suggests that, likely due to its antioxidant effects, EPI may be a promising drug to reduce LET in patients with severe and fatal arrhythmia due to AMI. Full article
(This article belongs to the Special Issue Cardiovascular Research: From Molecular Mechanisms to Novel Therapies)
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