Lipids–Lipolytic Enzymes–Lipid Analysis: A Themed Issue Dedicated to Prof. Edward A. Dennis for His 80th Birthday

Edward A. Dennis received his B.A. from Yale University in 1963 and his Ph.D. from Harvard University in 1968. Following the completion of his postdoctoral fellowship at Harvard Medical School, he was appointed (1970) assistant professor at the University of California, San Diego (UCSD). He became Professor in 1981 and then Distinguished Professor in 2004 in the Department of Chemistry and Biochemistry and Department of Pharmacology at the School of Medicine of UCSD. He has since served as Chair of the Department of Chemistry and Biochemistry, Editor-in-Chief of the Journal of Lipid Research (2003–2018) and Director of the LIPID MAPS NIH Glue Grant Consortium (2003–2014). He was the recipient of the American Society of Biochemistry and Molecular Biology’s Avanti Award in Lipid Enzymology in 2000, the European Federation for Lipid Science and Technology’s European Lipid Science Award in 2008, the American Chemical Society, San Diego Section, Distinguished Scientist Award in 2016, and the Bert Vallee Award in Biomedical Science from the American Society of Biochemistry and Molecular Biology (2020).

Prof. Dennis’ career research focus has been on the structure, function, mechanism, and inhibition of the enzyme phospholipase A₂ as well as on signal transduction, inflammation, lipid metabolism, eicosanoid action, and lipidomics. Since phospholipase A₂ releases arachidonic acid, it is partially responsible for the regulation of eicosanoid cascade and prostaglandin production. The regulation of the production of these compounds has been shown to be important in inflammatory diseases, including cancer, diabetes, and degenerative diseases. Thus, understanding how phospholipase A₂ functions and how to control its activity offer important avenues for developing novel pharmacological agents for controlling numerous diseases.

Molecules is pleased to announce a Special Issue honoring Prof. Edward A. Dennis, on the occasion of his 80th birthday, for his outstanding achievements in lipid chemistry and biochemistry. This Special Issue is dedicated to all aspects of lipid chemistry and biochemistry, in particular to lipid metabolizing enzymes, such as phospholipases and lipases, lipid analysis including cutting-edge lipidomics, lipid signaling, and bioactive lipids, and lipids in health and disease.

It is a pleasure to invite you to submit a manuscript to this Honorary Special Issue. Regular articles, communications, and reviews are all welcome.

Prof. Dr. George Kokotos
Prof. Dr. Jesús Balsinde 
Guest Editors

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