CRISPR/Cas Systems and Genome Editing—3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 25 August 2025 | Viewed by 52
Special Issue Editor
Interests: CRISPR/Cas; genome editing; yeast; intracellular proteolysis; transcription regulation; bacillii; stress responses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The harnessing of CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated genes) systems for the detection, chemical modification, and sequence editing of nucleic acids has dramatically changed many fields of fundamental science, biotechnology, and biomedicine. It is thus no wonder that the inventors of the technology, Emmanuelle Charpentier and Jennifer Doudna, were awarded the Nobel Prize in 2020. Natural CRISPR/Cas systems are well suited to disrupting coding and non-coding sequences in the genome, are much less effective at distinguishing and editing sequences with single-nucleotide differences, and are prone to recognizing similar sequences in the genome. Therefore, further exploration of the CRISPR/Cas field continues both to find new genome and epigenome editors, and to engineer known editors to overcome their shortcomings to make their applications more efficient, predictable, and safe. Notably, in late 2023, the FDA approved a cellular product obtained by CRISPR/Cas9-based genome editing—CasgevyTM—for the treatment of sickle cell disease. Thus, ten years after the first application of the CRISPR/Cas9 system for genome editing in mammalian cells, the first CRISPR/Cas9-based cellular product for curing human disease marked the beginning of the era of CRISPR/Cas therapies for humans.
The aim of this Special Issue is to gather knowledge on the current state of the rapidly growing field of CRIPSR/Cas systems and other genome editing tools in fundamental science, biotechnology, and biomedicine.
Dr. Dmitry Karpov
Guest Editor
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Keywords
- CRISPR/Cas
- bacterial argonauts
- transcription regulation
- genome editing
- genome editing tools
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