CRISPR/Cas Systems and Genome Editing—3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 25 August 2025 | Viewed by 100
Special Issue Editor
Interests: CRISPR/Cas; genome editing; yeast; intracellular proteolysis; transcription regulation; bacillii; stress responses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The harnessing of CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated genes) systems for the detection, chemical modification, and sequence editing of nucleic acids has dramatically changed many fields of fundamental science, biotechnology, and biomedicine. It is thus no wonder that the inventors of the technology, Emmanuelle Charpentier and Jennifer Doudna, were awarded the Nobel Prize in 2020. Natural CRISPR/Cas systems are well suited to disrupting coding and non-coding sequences in the genome, are much less effective at distinguishing and editing sequences with single-nucleotide differences, and are prone to recognizing similar sequences in the genome. Therefore, further exploration of the CRISPR/Cas field continues both to find new genome and epigenome editors, and to engineer known editors to overcome their shortcomings to make their applications more efficient, predictable, and safe. Notably, in late 2023, the FDA approved a cellular product obtained by CRISPR/Cas9-based genome editing—CasgevyTM—for the treatment of sickle cell disease. Thus, ten years after the first application of the CRISPR/Cas9 system for genome editing in mammalian cells, the first CRISPR/Cas9-based cellular product for curing human disease marked the beginning of the era of CRISPR/Cas therapies for humans.
The aim of this Special Issue is to gather knowledge on the current state of the rapidly growing field of CRIPSR/Cas systems and other genome editing tools in fundamental science, biotechnology, and biomedicine.
Dr. Dmitry Karpov
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- CRISPR/Cas
- bacterial argonauts
- transcription regulation
- genome editing
- genome editing tools
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
