Biosensing with terahertz (THz) waves has received large amounts of attention due to its potential to detect the functional expression of biomolecules in a label-free fashion. However, many practical challenges against the diffraction limit of THz wa...
Highly efficient surface acoustic wave (SAW) transducers offer significant advantages for microfluidic atomization. Aiming at highly efficient atomization, we innovatively accomplish dual-surface simultaneous atomization by strategically positioning...
Polyurethanes (PU) are a broad class of polymers that offer good solvent compatibility and a wide range of properties that can be used to generate microfluidic layers. Here, we report the first characterization of a commercially available Shore 80D p...
Nanoparticles (NPs) are used in various medicinal applications. Exosomes, bio-derived NPs, are promising biomarkers obtained through separation and concentration from body fluids. Polydimethylsiloxane (PDMS)-based microchannels are well-suited for pr...
The concept and feasibility of producing liposomes by rehydrating engineered lipid nanoconstructs are demonstrated in this study. Nanoconstructs of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) were produced using a microfluidic delivery pr...
Droplet microarrays are increasingly used for miniaturized, high-throughput biochemical assays, yet their fabrication commonly relies on complex lithographic processes, custom masks, or specialized coatings. Here we present a simple method for genera...
The ability to characterize the microscale mechanical properties of biological materials has the potential for great utility in the field of tissue engineering. The development and morphogenesis of mammalian tissues are known to be guided in part by...
To manipulate liquid matter at the nanometer scale, we have developed a robotic assembly equipped with a hollow atomic force microscope (AFM) cantilever that can handle femtolitre volumes of liquid. The assembly consists of four independent robots, e...
Advances in micro and nano fabrication technologies have enabled fabrication of smaller and more sensitive devices for applications not only in solid-state physics but also in medicine and biology. The demand for devices that can precisely transport...
The exclusion zone (EZ) is a boundary region devoid of macromolecules and microscopic particles formed spontaneously in the vicinity of hydrophilic surfaces. The exact mechanisms behind this remarkable phenomenon are still not fully understood and ar...
Since the cell was discovered by humans, it has been an important research subject for researchers. The mechanical response of cells to external stimuli and the biomechanical response inside cells are of great significance for maintaining the life ac...
In this paper, we present the first microfluidic junctions for droplet generation directly engraved on lithium niobate crystals by micromachining techniques, preparatory to a fully integrated opto-microfluidics lab-on-chip system. In particular, lase...
This study involved the preparation of an all-solid-state ion-selective electrode (ASS-ISE) with copper and a poly(3,4-ethylenedioxythiophene) and polystyrene sulfonate (PEDOT/PSS) conversion layer through electrode deposition. The morphology of the...
Arsenic contamination of drinking water is a global concern. Standard laboratory methods that are commonly used for arsenic detection in water, such as atomic absorption spectroscopy and mass spectroscopy, are not suitable for mass monitoring purpose...
Microfluidic technologies have recently been applied as innovative methods for the production of a variety of nanomedicines (NMeds), demonstrating their potential on a global scale. The capacity to precisely control variables, such as the flow rate r...
Heavy metal ion (HMI) contamination poses significant threats to public health and environmental safety, necessitating advanced detection technologies that are rapid, sensitive, and field-deployable. While conventional methods like atomic absorption...
Microfluidic structures and devices have been studied over decades for the transport of liquid through internal channels using versatile microfabrication schemes such as surface and bulk micromachining technologies. One challenge in consideration of...
Since the discovery of graphene, there has been increasing interest in two-dimensional (2D) materials. To realize practical applications of 2D materials, it is essential to isolate mono- or few-layered 2D nanosheets from unexfoliated counterparts. Li...
Microbubbles have various applications including their use as carrier agents for localized delivery of genes and drugs and in medical diagnostic imagery. Various techniques are used for the production of monodisperse microbubbles including the Gyrato...
Lead pollution has increasingly become the focus of environmental pollution, which is a great harm to the ecological environment and human health. Strict control of the emission of lead pollutants and accurate monitoring of lead are very important. T...
Advances in microfabrication and biomaterials have enabled the development of microfluidic chips for studying tissue and organ models. While these platforms have been developed primarily for modeling human diseases, they are also used to uncover cell...
Microfluidic chips and optical elements can be fabricated based on the nonlinear photosensitivity in photo–thermo–refractive (PTR) glass by controlling the growth of nanocrystals in the femtosecond (fs) laser–irradiated region. Here, we focus on CeO2...
Magnetophoresis-based microfluidic devices offer simple and reliable manipulation of micro-scale objects and provide a large panel of applications, from selective trapping to high-throughput sorting. However, the fabrication and integration of micro-...
Microfluidics cell-based assays require strong cell-substrate adhesion for cell viability, proliferation, and differentiation. The intrinsic properties of PDMS, a commonly used polymer in microfluidics systems, regarding cell-substrate interactions h...
21 May 2019
Chromium contamination of drinking water has become a global problem due to its extensive use in industry. The most commonly used methods for chromium detection in water are laboratory-based methods, such as atomic absorption spectroscopy and mass sp...
During the demolding process, the interfacial interaction between the polymer and the metal mold insert will lead to the deformation of the micro-structure, which will directly affect the molding quality and performance of injection molded microfluid...
Electrochemical analysis is an efficient way to study various materials. However, nanoparticles are challenging due to the difficulty in fabricating a uniform electrode containing nanoparticles. We developed novel approaches to incorporate nanopartic...
The contamination of air, water and soil by heavy metal ions is one of the most serious problems plaguing the environment. These metal ions are characterized by a low biodegradability and high chemical stability and can affect humans and animals, cau...
A traditional SAW (surface acoustic wave) atomizer directly supplies liquid to the surface of the atomized chip through a paper strip located in the path of the acoustic beam, resulting in irregular distribution of the liquid film, which generates an...
Pumping is an essential component in many microfluidic applications. Developing simple, small-footprint, and flexible pumping methods is of great importance to achieve truly lab-on-a-chip systems. Here, we report a novel acoustic pump based on the at...
In this work, we developed 3D ionic liquid (IL) functionalized graphene assemblies (GAs) decorated by ultrafine RuCu alloy nanoparticles (RuCu-ANPs) via a one-step synthesis process, and integrated it into a microfluidic sensor chip for in situ elect...
Polydimethylsiloxane (PDMS) is a silicone-based synthetic material used in various biomedical applications due to its properties, including transparency, flexibility, permeability to gases, and ease of use. Though PDMS facilitates and assists the fab...
Cell mechanical properties have been identified to characterize cells pathologic states. Here, we report our work on high-throughput mechanical phenotyping of androgen-sensitive and non-sensitive human prostate cancer cell lines based on a morphologi...
3,4-dihydroquinolone and its derivatives are structural motifs found in diverse pharmacologically active compounds. Direct oxidation of tetrahydroquinolines represents the most efficient synthetic route to 3,4-dihydroquinolone. However, the reaction...
The combination of multiplex polymerase chain reaction (mPCR) and microfluidic technologies demonstrates great significance in biomedical applications. However, current microfluidics-based molecular diagnostics face challenges in multi-target detecti...
In this work we report on a rapid, easy-to-operate, lossless, room temperature heterogeneous H2O plasma treatment process for the bonding of poly(methyl methacrylate) (PMMA) and double-sided polished (DSP) silicon substrates by for utilization in san...
In the development of micro/nano fluid control systems, fluid resistance has always been one of the key factors restricting its development. According to previous studies, it is found that the boundary slip effect of the solid-liquid interface can ef...
Carbon nanomaterials have received increased attention in the last few years due to their potential applications in several areas. In medicine, for example, these nanomaterials could be used as contrast agents, drug transporters, and tissue regenerat...
We present a sensor platform associated to silicon-nanowire chemical field effect transistors (Si-nw-ChemFET). Innovations concern the use of networks of suspended silicon N+/P/N+ nanowires as conducting channel, the realization by thermal oxidation...
Polysaccharide-based microgels have broad applications in multi-parametric cell cultures, cell-free biotechnology, and drug delivery. Multicomponent reactions like the Passerini three-component and the Ugi four-component reaction are shown in here to...
Physicochemical properties of immunolatex, prepared by incubation of negatively charged polystyrene microparticles with polyclonal rabbit IgGs, were determined by a variety of experimental techniques. These comprised dynamic light scattering (DLS), l...
Leukocytes, including neutrophils, propelled by blood flow, can roll on inflamed endothelium using transient bonds between selectins and their ligands, and integrins and their ligands. When such receptor–ligand bonds last long enough, the leukocyte m...
Magnetic levitation (MagLev) has recently emerged as a powerful method to develop diagnostic technologies based on the exploitation of the nanoparticle (NP)–protein corona. However, experimental procedures improving the robustness, reproducibil...
Mechanical models are capable of simulating the deformation and stress distribution of oocytes under external forces, thereby providing insights into the underlying mechanisms of intracellular mechanical responses. Interactions with micromanipulation...
Hierarchical surface structures were fabricated on fused silica by using a fs-laser with a pulse duration τ = 300 fs and a wavelength λ = 512 nm. The resulting surface structures were characterized by scanning electron microscopy, atomic f...
Surfactant films on solid surfaces have attracted much attention because of their scientific interest and applications, such as surface treatment agent, or for micro- or nano-scale templates for microfluidic devices. In this study, anionic surfactant...
Atomic force microscopy (AFM) in conjunction with microfluidic delivery was utilized to produce three-dimensional (3D) lipid structures following a custom design. While AFM is well-known for its spatial precision in imaging and 2D nanolithography, th...
Colloidal quantum dots (CQDs) have attracted significant attention in optoelectronics due to their size-tunable bandgap, high photoluminescence quantum yield, and solution processability, which enable integration into compact and energy-efficient sys...
Pesticides are unavoidable in agriculture to protect crops from pests and insects. Organophosphates (OPs) are a class of pesticides that are more harmful because of the irreversible inhibition reaction with acetylcholinesterase enzyme, thereby posing...
Despite decades of studies on symmetric impinging-jet atomization, the combined role of controlled pre-impingement asymmetry and viscosity in setting the instability pathways and droplet statistics of laminar microjets remains insufficiently quantifi...
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