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426 Results Found

  • Article
  • Open Access
87 Citations
15,437 Views
19 Pages

Menopause is an inevitable developmental event that women encounter at an age of 42–54 years. The drop of estrogen levels that accompanies cessation of menstruation is associated with multiple vasomotor, physical, neuropsychological, and sexual...

  • Article
  • Open Access
5 Citations
6,300 Views
18 Pages

Association Between Protein-Rich Foods, Nutritional Supplements, and Age of Natural Menopause and Its Symptoms

  • Yilin Yang,
  • Yehuan Yang,
  • Zhenghua Yong,
  • Li Yang,
  • Yanxia Zhao,
  • Mengke Yan,
  • Ruimin Zheng and
  • Xiaomin Luo

20 January 2025

Objective: To investigate the relationship between protein-rich foods, various nutritional supplements, and age of natural menopause and its symptoms. Methods: This study was a large-scale cross-sectional survey. A multi-stage stratified random sampl...

  • Article
  • Open Access
30 Citations
5,658 Views
13 Pages

Female Sexual Function and Its Association with the Severity of Menopause-Related Symptoms

  • Isabel Pérez-Herrezuelo,
  • Agustín Aibar-Almazán,
  • Antonio Martínez-Amat,
  • Raquel Fábrega-Cuadros,
  • Esther Díaz-Mohedo,
  • Rosemary Wangensteen and
  • Fidel Hita-Contreras

The aim of this study was to examine female sexual functioning and its association with the impact of the symptoms of menopause among Spanish postmenopausal women. A total of 182 postmenopausal women (65.59 ± 7.93 years) participated in this c...

  • Article
  • Open Access
4 Citations
2,433 Views
9 Pages

Urinary tract infection (UTI) is a common cause for prescription of antibiotics among women in general practice. Diagnosis is often established by inquiry into clinical history and symptoms, and these may be experienced differently depending on menop...

  • Article
  • Open Access
1,716 Views
16 Pages

30 June 2025

Background and Objectives: This study investigated changes in quality of life (QOL), depression, and menopausal symptoms after surgical menopause, and the efficacy of hormone replacement therapy (HRT) in gynecological cancer survivors (GCS). Material...

  • Article
  • Open Access
6 Citations
4,216 Views
13 Pages

24 May 2023

Menopause is a hormone-deficiency state that causes facial flushing, vaginal dryness, depression, anxiety, insomnia, obesity, osteoporosis, and cardiovascular disease as ovarian function decreases. Hormone-replacement therapy is mainly used to treat...

  • Systematic Review
  • Open Access
1,122 Views
15 Pages

Efficacy and Safety of Placental Extract on Menopausal Symptoms: A Systematic Review

  • Sára Papp,
  • László Tűű,
  • Katalin Nas,
  • Zsófia Telkes,
  • Lotti Keszthelyi,
  • Márton Keszthelyi,
  • Nándor Ács,
  • Szabolcs Várbíró and
  • Marianna Török

10 December 2025

Background: Menopause affects every woman worldwide, with varying degrees of severity. In addition to traditional treatments such as hormone replacement therapy, there is also a growing interest in alternative treatments. One possible way to address...

  • Article
  • Open Access
2 Citations
1,248 Views
10 Pages

Objective. The current study determined the association between menopausal symptoms and marital quality of life, and explored the role of several demographic variables (education, occupation, and income) on these symptoms. Materials and Methods. The...

  • Article
  • Open Access
1 Citations
1,808 Views
14 Pages

Assessing the Relationship Between Depressive Symptoms and Menopausal Quality of Life Among Academic Women in Saudi Arabia

  • Sally Mohammed Farghaly Abdelaliem,
  • Noha Mohamed Mahmoud Hassan,
  • Aljory Alqahtani,
  • Lama Alamer,
  • Noura Alhomaid,
  • Hessa Alsubaie,
  • Rania Alsaeed,
  • Dalal Al-Qahtani and
  • Mudhawi Alenazi

Background/Objective: Menopause marks a significant life transition for women, signaling the end of reproductive ability and triggering various physiological and psychological changes. During this phase, women may experience a range of physical and e...

  • Article
  • Open Access
2 Citations
3,524 Views
11 Pages

Menopause is a physiological change in which the menstrual period permanently ends. Every woman experiences this transition in different ways between the ages of 40 and 55. Women may have menopausal symptoms as a result of low estrogen levels. Self-c...

  • Article
  • Open Access
11 Citations
3,558 Views
10 Pages

Menopausal Symptoms, Postural Balance, and Functional Mobility in Middle-Aged Postmenopausal Women

  • João Espírito Santo,
  • Agustín Aibar-Almazán,
  • Antonio Martínez-Amat,
  • Nuno Eduardo Marques de Loureiro,
  • Vânia Brandão-Loureiro,
  • María Leyre Lavilla-Lerma and
  • Fidel Hita-Contreras

24 November 2021

The aim of the present study was to determine the associations between the severity of the menopausal symptoms and postural balance and functional mobility in middle-aged postmenopausal women. A cross-sectional study was performed (171 participants,...

  • Article
  • Open Access
4,578 Views
18 Pages

18 October 2025

Background: Menopause is often accompanied by menopausal symptoms and reduced quality of life. Studies on the combined effects of time-restricted eating and exercise in this population are lacking. This approach may provide additive preventive benefi...

  • Review
  • Open Access
84 Citations
24,933 Views
19 Pages

Menopausal symptoms are associated with deterioration in physical, mental, and sexual health, lowering women’s quality of life (QoL). Our study objective is to examine the effect of exercise on QoL in women with menopausal symptoms. After initi...

  • Article
  • Open Access
19 Citations
8,970 Views
16 Pages

The Effect of Lactobacillus acidophilus YT1 (MENOLACTO) on Improving Menopausal Symptoms: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

  • Eun Yeong Lim,
  • So-Young Lee,
  • Hee Soon Shin,
  • Jaekwang Lee,
  • Young-Do Nam,
  • Dong Ock Lee,
  • Ji Young Lee,
  • Sung Hum Yeon,
  • Rak Ho Son and
  • Yun Tai Kim
  • + 1 author

This study evaluated the efficacy of Lactobacillus acidophilus YT1 (MENOLACTO) for alleviating menopausal symptoms. This study was a multi-center, randomized, double-blinded, placebo-controlled clinical trial involving female subjects (ages: 40&ndash...

  • Article
  • Open Access
6 Citations
4,032 Views
11 Pages

Introduction: Current UKHSA UTI diagnostic guidance advises empirical antibiotics if two of the following symptoms are present: cloudy urine, dysuria, and new onset nocturia. Hormonal changes during menopause may impact UTI symptoms, and qualitative...

  • Article
  • Open Access
11 Citations
4,951 Views
14 Pages

(1) Background: The increasing presence of employed women undergoing menopause has stimulated a growing corpus of research highlighting the complex relationship between menopause and work. Nevertheless, little is known regarding the mechanism by whic...

  • Review
  • Open Access
4 Citations
3,191 Views
12 Pages

Danggui Liuhuang (DLH) decoctions are traditional herbal medicines that are widely used for menopausal symptoms. The objective of this systematic review was to investigate evidence of the efficacy of DLH decoctions for menopausal symptoms. Fifteen da...

  • Article
  • Open Access
10 Citations
5,503 Views
12 Pages

Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial

  • Yuka Enokuchi,
  • Atsushi Suzuki,
  • Tohru Yamaguchi,
  • Ryuji Ochiai,
  • Masakazu Terauchi and
  • Kiyoshi Kataoka

7 December 2020

A reduction in estrogen levels in the perimenopausal and postmenopausal periods causes various symptoms in women, such as hot flushes, sweats, depression, anxiety, and insomnia. Chlorogenic acids (CGAs), which are phenolic compounds widely present in...

  • Article
  • Open Access
4,706 Views
15 Pages

Royal Jelly and Fermented Soy Extracts—A Holistic Approach to Menopausal Symptoms That Increase the Quality of Life in Pre- and Post-menopausal Women: An Observational Study

  • Andreea Balan,
  • Marius Alexandru Moga,
  • Andrea Elena Neculau,
  • Maria Mitrica,
  • Liliana Rogozea,
  • Petru Ifteni and
  • Lorena Dima

26 February 2024

Background: The objective of this study was to determine the effects of royal jelly and fermented soy extracts on menopausal symptoms and on quality of life in pre- and post-menopausal women. Materials and method: This prospective observational study...

  • Article
  • Open Access
69 Citations
10,354 Views
12 Pages

The aim of the study was to specify prevalence and severity of menopausal symptoms among middle-aged women and to understand the factors associated with women’s perimenopausal healthcare-seeking behavior in Shanghai, China. A community-based cr...

  • Article
  • Open Access
609 Views
13 Pages

Workplace Impact of Menopause Symptoms Among Canadian Women Physicians

  • Shannon E. Brent,
  • Lindsay Shirreff,
  • Natalie L. Yanchar and
  • Marie Christakis

25 October 2025

Background/Objectives: Menopause is a significant, universal hormonal transition, with symptoms impacting ~80% of women. Research shows that menopause can be professionally disruptive, contributing to decreased productivity, absenteeism, and early ex...

  • Article
  • Open Access
1,454 Views
16 Pages

Nutrient Intake and Menopausal Symptoms in Perimenopausal Women

  • Miriam Bernadette Murphy,
  • Geraldine Cuskelly and
  • Patricia Heavey

12 December 2025

Background/Objective: Perimenopause, the final years of a woman’s reproductive life, may be symptomatic, affecting health and wellbeing. Lifestyle factors, such as diet, may alleviate these symptoms and improve health. Understanding nutrient in...

  • Article
  • Open Access
8 Citations
13,444 Views
11 Pages

4 April 2024

Background and Objectives: Hormonal changes physiologically occurring in menopausal women may increase the risk of developing metabolic and vasomotor disturbances, which contribute to increase the risk of developing other concomitant pathologies, suc...

  • Review
  • Open Access
24 Citations
20,218 Views
14 Pages

11 April 2021

The meta-analysis presented in this article covered the efficacy of red clover isoflavones in relieving hot flushes and menopausal symptoms in perimenopausal and postmenopausal women. Studies were identified by MEDLINE (PubMed), Embase, and the Cochr...

  • Article
  • Open Access
7,219 Views
9 Pages

14 September 2022

Clary sage oil is commonly used in complementary and alternative medicine to treat menopausal symptoms. However, whether sclareol, which is considered to have estrogen-like effects, can be absorbed transdermally remains unknown. Therefore, in this st...

  • Article
  • Open Access
15,775 Views
21 Pages

Breast cancer survivors experience numerous chronic symptoms linked to autonomic dysfunction including anxiety, stress, insomnia, menopausal symptoms, and cognitive impairment. Effective non-pharmacological solutions to address these are currently la...

  • Review
  • Open Access
27 Citations
28,464 Views
14 Pages

The Efficacy of Strength Exercises for Reducing the Symptoms of Menopause: A Systematic Review

  • Ana María Capel-Alcaraz,
  • Héctor García-López,
  • Adelaida María Castro-Sánchez,
  • Manuel Fernández-Sánchez and
  • Inmaculada Carmen Lara-Palomo

9 January 2023

Background: The aim of this systematic review was to determine whether strength exercises improve the symptoms of menopause and to provide an update on the most recent scientific evidence on the type and regimen of exercise that help reduce the sympt...

  • Article
  • Open Access
1 Citations
6,900 Views
11 Pages

30 October 2013

Hormone replacement therapy has been proven efficacious for controlling vasomotor symptoms such as hot flushes associated with menopause. Drospirenone is a progestin with antiandrogenic and antimineralocorticoid activity that may be used in combinati...

  • Review
  • Open Access
76 Citations
20,973 Views
17 Pages

A Nutraceutical Approach to Menopausal Complaints

  • Pasquale De Franciscis,
  • Nicola Colacurci,
  • Gaetano Riemma,
  • Anna Conte,
  • Erika Pittana,
  • Maurizio Guida and
  • Antonio Schiattarella

28 August 2019

The menopausal transition, or perimenopause, is characterized by menstrual irregularities, vasomotor symptoms, sleep disturbances, mood symptoms, and urogenital tract atrophy. These changes can also affect the quality of life and one’s self-est...

  • Article
  • Open Access
2 Citations
9,477 Views
12 Pages

The Different Phytochemical Profiles of Salvia officinalis Dietary Supplements Labelled for Menopause Symptoms

  • Valentina Maggini,
  • Gianpaolo Bertazza,
  • Eugenia Gallo,
  • Vittorio Mascherini,
  • Lorenzo Calvi,
  • Chiara Marra,
  • Francesca Michelucci,
  • Chiara Liberati,
  • Anna Trassi and
  • Fabio Firenzuoli

22 December 2023

Phytochemical screening of four commercial products containing Salvia officinalis was carried out. Total phenolic content was estimated spectrophotometrically through the use of the Folin–Ciocalteau method, flavonoid content was measured throug...

  • Article
  • Open Access
23 Citations
4,152 Views
10 Pages

Background: The study investigated the effects of regular leisure-time physical activity on the parameters of cognitive function (plasma brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and cathepsin B) and menopausal symptoms (th...

  • Article
  • Open Access
5 Citations
4,809 Views
17 Pages

Effects of Hormonal Replacement Therapy and Mindfulness-Based Stress Reduction on Climacteric Symptoms Following Risk-Reducing Salpingo-Oophorectomy

  • Amira Mohammed Ali,
  • Saeed A. Al-Dossary,
  • Carlos Laranjeira,
  • Faten Amer,
  • Souheil Hallit,
  • Abdulmajeed A. Alkhamees,
  • Aljawharah Fahad Aljubilah,
  • Musheer A. Aljaberi,
  • Ebtesam Abdullah Alzeiby and
  • Haitham Khatatbeh
  • + 1 author

13 August 2024

Breast Cancer Associated Susceptibility Proteins Type 1/2 (BRCA1/2) promote cellular functioning by modulating NRF2-mediated antioxidant signaling. Redox failure in women with BRCA1/2 insufficiency increases the risk for breast/ovarian/uterine cancer...

  • Article
  • Open Access
2 Citations
3,550 Views
19 Pages

Effects of Integrated Extracts of Trigonella foenum-graecum and Asparagus racemosus on Hot Flash-like Symptoms in Ovariectomized Rats

  • Fusun Erten,
  • Besir Er,
  • Ramazan Ozmen,
  • Muhammed Tokmak,
  • Ebru Gokdere,
  • Cemal Orhan,
  • Abhijeet A. Morde,
  • Muralidhara Padigaru and
  • Kazim Sahin

Vasomotor symptoms, such as hot flashes (HFs), commonly affect women during menopause, leading to a reduced quality of life. The current study evaluates the combined effect of active components Asparagus racemosus (AR) and Trigonella foenum-graecum (...

  • Perspective
  • Open Access
1,454 Views
21 Pages

Neurokinin Antagonists to Treat Vasomotor Symptoms—Possible Implications for Long-Term Health and Disease

  • Angelo Cagnacci,
  • Anjeza Xholli,
  • Marta Fiamberti and
  • Ambrogio Pietro Londero

27 September 2025

In women in post-menopause, the presence of severe vasomotor symptoms is associated with sleep disorders and a depressive mood. Vasomotor symptoms, sleep disorders, and a depressive mood are all related to an increased risk of cardiovascular events a...

  • Article
  • Open Access
19 Citations
4,535 Views
16 Pages

Depressive Symptoms among Middle-Aged Women—Understanding the Cause

  • Anna M. Cybulska,
  • Małgorzata Szkup,
  • Daria Schneider-Matyka,
  • Karolina Skonieczna-Żydecka,
  • Mariusz Kaczmarczyk,
  • Anna Jurczak,
  • Sylwia Wieder-Huszla,
  • Beata Karakiewicz and
  • Elżbieta Grochans

28 December 2020

Menopause is an important event in a woman’s life associated with hormonal changes that play a substantial role in the functioning of her body. A decline in the level of estrogens contributes to depressive symptoms and mood disorders during thi...

  • Systematic Review
  • Open Access
1 Citations
2,946 Views
22 Pages

Background/Objectives: Dance intervention, as a non-pharmacological therapy, has shown promising potential in alleviating menopausal symptoms among perimenopausal, menopausal, and postmenopausal women. However, a systematic evaluation of its overall...

  • Review
  • Open Access
38 Citations
14,789 Views
12 Pages

Neuroendocrine Changes during Menopausal Transition

  • Andrea Giannini,
  • Marta Caretto,
  • Andrea R. Genazzani and
  • Tommaso Simoncini

14 October 2021

Menopause is the permanent cessation of menstrual cycles following the loss of ovarian follicular activity. Quality of life of postmenopausal woman is the result of a series of psychobiological transformations, that see in the reduction of sex hormon...

  • Systematic Review
  • Open Access
8 Citations
7,362 Views
12 Pages

11 January 2024

(1) Background: Women in their middle years undergoing perimenopause encounter a range of physical and psychological alterations attributed to hormonal changes. The prominent symptoms among menopausal women are depressive symptoms and sleep-related p...

  • Feature Paper
  • Review
  • Open Access
5 Citations
6,832 Views
12 Pages

A New Hope for Woman with Vasomotor Symptoms: Neurokinin B Antagonists

  • Blazej Meczekalski,
  • Anna Kostrzak,
  • Christian Unogu,
  • Stefania Bochynska,
  • Marzena Maciejewska-Jeske,
  • Gregory Bala and
  • Anna Szeliga

21 February 2025

KNDy (kisspeptine, neurokinin B, dynorphin) neurons, located in the hypothalamus, play a crucial role in the development of vasomotor symptoms (VSM) in menopausal women. Estrogen withdrawal during menopause leads to the hyperactivation of kisspeptin...

  • Article
  • Open Access
5 Citations
7,429 Views
14 Pages

Nutritional Risk Factors Associated with Vasomotor Symptoms in Women Aged 40–65 Years

  • Alexandra Tijerina,
  • Yamile Barrera,
  • Elizabeth Solis-Pérez,
  • Rogelio Salas,
  • José L. Jasso,
  • Verónica López,
  • Erik Ramírez,
  • Rosario Pastor,
  • Josep A. Tur and
  • Cristina Bouzas

22 June 2022

Vasomotor symptoms (VMS) are the most common symptoms among menopausal women; these include hot flashes and night sweats, and palpitations often occur along with hot flashes. Some studies in Mexico reported that around 50% of women presented with VMS...

  • Article
  • Open Access
7 Citations
14,259 Views
11 Pages

Antimüllerian Hormone as a Tool to Predict the Age at Menopause

  • Efstathia Chatziandreou,
  • Andreas Eustathiou,
  • Areti Augoulea,
  • Eleni Armeni,
  • Nikoletta Mili,
  • Ioannis Boutas,
  • Nikolaos Tsoltos,
  • Antigoni Kapetanaki and
  • Sofia Kalantaridou

This study aimed to assess an eligible cut-off value of anti-Müllerian hormone (AMH) to detect ovarian senescence in a group of premenopausal Greek women to evaluate the possible link between AMH-values and the severity of climacteric symptoms d...

  • Review
  • Open Access
6 Citations
13,386 Views
15 Pages

Update on Genitourinary Syndrome of Menopause: A Scoping Review of a Tailored Treatment-Based Approach

  • Ilaria Cuccu,
  • Tullio Golia D’Augè,
  • Ilaria Firulli,
  • Emanuele De Angelis,
  • Giovanni Buzzaccarini,
  • Ottavia D’Oria,
  • Aris Raad Besharat,
  • Donatella Caserta,
  • Giorgio Bogani and
  • Andrea Giannini
  • + 1 author

19 November 2024

This scoping review explores the therapeutic strategies available for managing genitourinary syndrome of menopause (GSM), a condition often underdiagnosed and undertreated despite significantly affecting women’s quality of life. GSM results fro...

  • Article
  • Open Access
4 Citations
2,473 Views
11 Pages

The Impact of Systemic Sclerosis on Sexual Health: An Italian Survey

  • Alessandro Ferdinando Ruffolo,
  • Maurizio Serati,
  • Arianna Casiraghi,
  • Vittoria Benini,
  • Chiara Scancarello,
  • Maria Carmela Di Dedda,
  • Carla Garbagnati,
  • Andrea Braga,
  • Massimo Candiani and
  • Stefano Salvatore

20 August 2023

Objective: To evaluate the impact of systemic sclerosis (SSc) on vulvovaginal atrophy (VVA) and sexual health in an Italian population. Methods: An Italian survey about the prevalence and severity of VVA (on a 0 to 10 scale) and sexual dysfunction (u...

  • Article
  • Open Access
9 Citations
3,931 Views
14 Pages

Changes in Food Consumption in Postmenopausal Women during the COVID-19 Pandemic: A Longitudinal Study

  • Priscilla Rayanne E. Silva Noll,
  • Monique G. Nascimento,
  • Luiza Helena Costa Moreira Bayer,
  • Juliana Zangirolami-Raimundo,
  • José Antonio Orellana Turri,
  • Matias Noll,
  • Edmund Chada Baracat,
  • José Maria Soares Junior and
  • Isabel Cristina Esposito Sorpreso

7 August 2023

Studying the dietary habits and symptoms of postmenopausal women during situations such as the COVID-19 pandemic is important to mitigate long-term post-pandemic health problems. We compared the menopausal symptoms and food consumption in postmenopau...

  • Systematic Review
  • Open Access
3 Citations
4,089 Views
9 Pages

Background and Objectives: Vaginitis causes vulvovaginal symptoms, including itching, irritation, vaginal discharge, burning, or foul odor. It is one of the most common diseases encountered in gynecologic practice. Hypoestrogenism due to menopause ha...

  • Review
  • Open Access
47 Citations
13,708 Views
22 Pages

Royal Jelly—A Traditional and Natural Remedy for Postmenopausal Symptoms and Aging-Related Pathologies

  • Andreea Bălan,
  • Marius Alexandru Moga,
  • Lorena Dima,
  • Sebastian Toma,
  • Andrea Elena Neculau and
  • Costin Vlad Anastasiu

20 July 2020

Women’s life stages are based on their reproductive cycle. This cycle begins with menstruation and ends with menopause. Aging is a natural phenomenon that affects all humans, and it is associated with a decrease in the overall function of the o...

  • Review
  • Open Access
5,319 Views
17 Pages

Estradiol and Micronized Progesterone: A Narrative Review About Their Use as Hormone Replacement Therapy

  • Martina Foschi,
  • Giulia Groccia,
  • Maria Laura Rusce,
  • Celeste Medaglia,
  • Claudia Aio,
  • Alessandra Sponzilli,
  • Veronica Setti,
  • Christian Battipaglia and
  • Alessandro D. Genazzani

16 October 2025

Hormone replacement therapy (HRT) currently represents the first-line treatment to manage and reduce menopausal symptoms. Standard regimens generally combine 17β-estradiol (E2) or conjugated equine estrogens (CEEs) with micronized progesterone (...

  • Article
  • Open Access
76 Citations
14,198 Views
12 Pages

High Physical Activity Level May Reduce Menopausal Symptoms

  • Magdalena Dąbrowska-Galas,
  • Jolanta Dąbrowska,
  • Kuba Ptaszkowski and
  • Ryszard Plinta

11 August 2019

Background and Objectives: Menopause is a normal physiological change occurring at a woman’s mid-life. During this time, women experience vasomotor, physical and physiological problems, which reduce their quality of life. Many women are searchi...

  • Article
  • Open Access
4 Citations
4,429 Views
16 Pages

23 August 2024

Lower urinary tract symptoms (LUTS) are common in postmenopausal women. These symptoms are often linked to decreased estrogen levels following menopause. This study investigated the relationship between estrogen levels, alterations in bladder tissue...

  • Article
  • Open Access
966 Views
17 Pages

8 November 2025

Background: The purpose of this study was to evaluate the effects of a structured barefoot walking program on menopausal symptoms, sleep quality, stress, and quality of life in middle-aged women experiencing menopausal symptoms. Methods: A quasi-expe...

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