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Open AccessArticle

The Effect of Lactobacillus acidophilus YT1 (MENOLACTO) on Improving Menopausal Symptoms: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

1
Division of Food Functionality Research, Korea Food Research Institute, Wanju 55365, Korea
2
Department of Food Biotechnology, Korea University of Science & Technology, Daejeon 34113, Korea
3
Center for Gynecologic Cancer, National Cancer Center Korea, Goyang-si 10408, Korea
4
Department of Obstetrics and Gynecology, Konkuk University Hospital, Konkuk University School of Medicine, Seoul 05030, Korea
5
R&D Center, Huons Co., Ltd., Ansan 15588, Korea
6
Clinical Operation Team, Huons Co., Ltd., Seongnam-si 13486, Korea
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(7), 2173; https://doi.org/10.3390/jcm9072173
Received: 20 May 2020 / Revised: 2 July 2020 / Accepted: 7 July 2020 / Published: 9 July 2020
(This article belongs to the Section Obstetrics & Gynecology)
This study evaluated the efficacy of Lactobacillus acidophilus YT1 (MENOLACTO) for alleviating menopausal symptoms. This study was a multi-center, randomized, double-blinded, placebo-controlled clinical trial involving female subjects (ages: 40–60 years) with menopausal symptoms and a Kupperman index (KMI) score ≥ 20. Subjects were administered 1 × 108 CFU/day MENOLACTO or placebo, with the primary endpoint being total KMI score, and the effect of secondary endpoints on alleviating menopausal symptoms according to individual categories of the modified KMI, as well as a quality of life questionnaire (MENQOL questionnaire). After 12 weeks, total KMI scores decreased significantly, demonstrating improved menopausal symptoms relative to placebo along with improved modified KMI scores. Additionally, quality of life, according to the MENQOL questionnaire, significantly improved in all four symptoms—physical, psychosocial, vasomotor, and sexual symptoms. Moreover, we observed no significant difference between the two groups or significant changes in blood follicle-stimulating hormone and estradiol levels or endometrial thickness. These results demonstrated that MENOLACTO alleviated menopausal symptoms without notable side effects and improved quality of life, suggesting its efficacy as an alternative supplement to alleviate menopausal symptoms in women ineligible for hormonal therapy. View Full-Text
Keywords: MENOLACTO; Lactobacillus acidophilus YT1; menopausal symptoms; clinical trial; Kupperman index MENOLACTO; Lactobacillus acidophilus YT1; menopausal symptoms; clinical trial; Kupperman index
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Lim, E.Y.; Lee, S.-Y.; Shin, H.S.; Lee, J.; Nam, Y.-D.; Lee, D.O.; Lee, J.Y.; Yeon, S.H.; Son, R.H.; Park, C.L.; Heo, Y.H.; Kim, Y.T. The Effect of Lactobacillus acidophilus YT1 (MENOLACTO) on Improving Menopausal Symptoms: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. J. Clin. Med. 2020, 9, 2173.

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