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Open AccessArticle

Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial

1
Health & Wellness Products Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan
2
Department of Research & Development, Kao Corporation, Tokyo 131-8501, Japan
3
Biological Science Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan
4
Department of Woman’s Health, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
5
Personal Health Care Products Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3757; https://doi.org/10.3390/nu12123757
Received: 30 October 2020 / Revised: 27 November 2020 / Accepted: 4 December 2020 / Published: 7 December 2020
(This article belongs to the Special Issue Nutrition Challenges for Middle-Aged and Older Women)
A reduction in estrogen levels in the perimenopausal and postmenopausal periods causes various symptoms in women, such as hot flushes, sweats, depression, anxiety, and insomnia. Chlorogenic acids (CGAs), which are phenolic compounds widely present in plants such as coffee beans, have various physiological functions. However, the effects of CGAs on menopausal symptoms are unknown. To examine the effects of CGAs on menopausal symptoms, especially hot flushes, a randomized, placebo-controlled, double-blind, parallel-group trial was conducted in healthy women. Eighty-two subjects were randomized and assigned to receive CGAs (270 mg) tablets or the placebo for 4 weeks. After 4 weeks of intake, the number of hot flushes, the severity of hot flushes during sleep, and the severity of daytime sweats decreased significantly in the CGA group compared to the placebo group. The modified Kupperman index for menopausal symptoms decreased significantly after 2 weeks in the CGA group compared to the placebo group. Adverse effects caused by CGAs were not observed. The results show that continuous intake of CGAs resulted in improvements in menopausal symptoms, especially hot flushes, in healthy women. View Full-Text
Keywords: chlorogenic acid; hot flushes; menopausal symptoms chlorogenic acid; hot flushes; menopausal symptoms
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MDPI and ACS Style

Enokuchi, Y.; Suzuki, A.; Yamaguchi, T.; Ochiai, R.; Terauchi, M.; Kataoka, K. Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial. Nutrients 2020, 12, 3757. https://doi.org/10.3390/nu12123757

AMA Style

Enokuchi Y, Suzuki A, Yamaguchi T, Ochiai R, Terauchi M, Kataoka K. Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial. Nutrients. 2020; 12(12):3757. https://doi.org/10.3390/nu12123757

Chicago/Turabian Style

Enokuchi, Yuka; Suzuki, Atsushi; Yamaguchi, Tohru; Ochiai, Ryuji; Terauchi, Masakazu; Kataoka, Kiyoshi. 2020. "Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial" Nutrients 12, no. 12: 3757. https://doi.org/10.3390/nu12123757

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