Mosaic loss of the Y chromosome (mLOY) is a common karyotype alteration. The accumulation of LOY cells leads to genetic mosaicism and affects the development of pathological conditions in elderly men. Emerging data suggest that this phenomenon might...
Bone is a dynamic organ that can adapt its structure to meet the demands of its biochemical and biophysical environment. Osteocytes form a sensory network throughout the tissue and orchestrate tissue adaptation via the release of soluble factors such...
Long cytoplasmic processes of osteocytes orchestrate bone activity by integration of biochemical and mechanical signals and regulate load-induced bone adaptation. Low-Intensity Pulsed Ultrasound (LIPUS) is a clinically used technique for fracture hea...
Mosaic loss of chromosome Y (mLOY) is a common ageing-related somatic event and has been previously associated with Alzheimer’s disease (AD). However, mLOY estimation from genotype microarray data only reflects the mLOY degree of subjects at th...
Until a few years ago, it was believed that the gradual mosaic loss of the Y chromosome (mLOY) was a normal age-related process. However, it is now known that mLOY is associated with a wide variety of pathologies in men, such as cardiovascular diseas...
31 October 2023
Osteocytes play an important role as regulators of both osteoclasts and osteoblasts, and some proteins that are secreted from them play a role in bone remodeling and modeling. LPS affects bone structure because it is an inflammatory factor, despite v...
The differentiation and function of osteocytes are controlled by surrounding cells and mechanical stress; however, the detailed mechanisms are unknown. Recent findings suggest that IL-33 is highly expressed in periodontal tissues in orthodontic tooth...
Bone substitute materials loaded with mediators that stimulate fracture healing are demanded in the clinical treatment in trauma surgery and orthopedics. Brain-derived neurotrophic factor (BDNF) enhances the proliferation and differentiation of mesen...
Background/Objective: Osteocytes are the most abundant cell type in the skeleton, with key endocrine functions, particularly in regulating osteoblast and osteoclast activity to maintain bone quality. Angiotensin II (Ang II), a critical component of t...
The osteocyte network inside the bone matrix is of functional importance and osteocyte cell death is a characteristic feature of pathological bone diseases. Osteocytes have emerged as key regulators of bone tissue maintenance, yet maintaining their p...
Finding and constructing an osteogenic microenvironment similar to natural bone tissue has always been a frontier topic in orthopedics. We found that osteocytes are targeting cells controlling bone anabolism produced by PTH (JBMR 2017, PMID: 27704638...
Regulation of the human IGF2 gene displays multiple layers of control, which secures a genetically and epigenetically predetermined gene expression pattern throughout embryonal growth and postnatal life. These predominantly nuclear regulatory mechani...
The discovery that osteocytes secrete phosphaturic fibroblast growth factor 23 (FGF23) has defined bone as an endocrine organ. However, the autocrine and paracrine functions of FGF23 are still unknown. The present study focuses on the cellular and mo...
Bone remodeling is maintained through the coordinated actions of osteoblasts, osteoclasts, and osteocytes, among which osteocytes serve as major regulators of osteoclast-mediated bone resorption through the receptor activator of the nuclear factor-&k...
Periprosthetic osteolysis (PPO) induced by wear particles is the most severe complication of total joint replacement; however, the mechanism behind PPO remains elusive. Previous studies have shown that osteocytes play important roles in wear-particle...
Introduction The use of scaffolds in tissue engineering is becoming increasingly important as solutions need to be found to preserve human tissues such as bone or cartilage. Various factors, including cells, biomaterials, cell and tissue culture cond...
Osteocytes, the most important regulators of bone processes, are producers of molecules (usually proteins) that act as signals in order to communicate with nearby cells. These factors control cell division (proliferation), differentiation, and surviv...
Heparin has been proven to enhance bone resorption and induce bone loss. Since osteoclasts play a pivotal role in bone resorption, the effect of heparin on osteoclastogenesis needs to be clarified. Since osteocytes are the key modulator during osteoc...
One of the methods of municipal solid waste (MSW) treatment is biodrying. The literature describes mainly the results obtained in a laboratory- and a pilot-scale reactor. The manuscript presents the results of MSW treatment in a full-scale bio-drying...
Bisphosphonates are one of the most widely used synthetic pyrophosphate analogues for the treatment of bone resorbing diseases such as osteoporosis, multiple myeloma, and bone metastases. Although the therapeutic usefulness of bisphosphonates mainly...
The fire performance of epoxy and carbon-fiber-reinforced polymer (CFRP) composites with and without fire retardants (FR) (i.e., ammonium polyphosphate (APP), aluminum trihydroxide (ATH), melamine (MEL), expandable graphite (EG)) was investigated. A...
A series of novel flame retardants (aluminum diethylphosphinate and melamine) were used to improve the fire performance of phenolic resin. Fourier transform infrared spectroscopy (FTIR) was used to characterize the modification results. Thermo-gravim...
The flame-retardant polyamide 66 composites (FR-PA66) were prepared by in situ loading of amino-functionalized polyphosphazene microspheres (HCNP), which were synthesized in the laboratory and confirmed by a Fourier transform infrared spectrometer (F...
Ecofriendly flame-retardant polystyrene (PS) composites were developed using the synergistic effects of phytic acid (PA), polyethyleneimine (PEI), and expandable graphite (EG). PA was chemically hybridized with PEI, and the hybrid (PAE) was incorpora...
Thermally conductive and flame-retardant polyolefin composites are facing great challenges in meeting the increasing demands for fire safety and thermal management. Aiming at simultaneously enhancing thermal conductivity and flame retardancy, hexagon...
Plastin-3 (PLS3) encodes T-plastin, an actin-bundling protein mediating the formation of actin filaments by which numerous cellular processes are regulated. Loss-of-function genetic defects in PLS3 are reported to cause X-linked osteoporosis and chil...
Banana peel powder (BPP) was used to prepare poly(lactic acid) (PLA) bio-based composites and the flame retardancy was enhanced by introducing silica-gel microencapsulated ammonium polyphosphate (MCAPP). The results showed that the limiting oxygen in...
In order to develop flame retardant and relatively green cable coating materials, polyethylene (PE) was melt blended with 5, 7.5, or 10 wt. % of a natural calcium montmorillonite (C–Ca) pre-dispersed in EBA (ethylene-butyl acrylate copolymer),...
The continuous emergence of New Psychoactive Substances (NPS) poses a significant challenge to public health and forensic toxicology due to their unpredictable pharmacology and rapid turnover on the illicit market. This study describes the developmen...
Fly-ash, a kind of large solid waste in energy industry, has brought about serious environmental problems and safety consequences. No efficient way has been found yet to deal with it worldwide. The focus of contemporary research are mainly placed on...
In recent years, industrial explosion accidents are frequent, causing serious negative influences on society. Mechanical shock waves, as a typical destructive factor in explosion accidents, can cause serious personal injury and building damage. In ad...
Cellular senescence and its senescence-associated secretory phenotype (SASP) are widely regarded as promising therapeutic targets for aging-related diseases, such as osteoporosis. However, the expression pattern of cellular senescence and multiple SA...
Rigid polyurethane (RPUF) was widely used in external wall insulation materials due to its good thermal insulation performance. In this study, a series of RPUF and RPUF-R composites were prepared using steel slag (SS) and dimelamine pyrophosphate (DM...
Conventional polyurethane (PU) grouting materials face a severe trade-off between curing exotherm safety, flame retardancy, and mechanical performance in deep coal mining. Herein, we propose a synergistic strategy combining chemical prepolymerization...
Oats contain unique bioactive compounds known as avenanthramides (AVAs) with antioxidant properties. AVAs might enhance the endogenous antioxidant cellular response by activation of the transcription factor Nrf2. Accumulation of reactive oxygen speci...
Background/Objectives: Osteotoxicity is a severe complication of Methotrexate (MTX) chemotherapy, characterized by oxidative stress and disrupted bone remodeling. The primary objective of this study was to investigate the cytoprotective mechanisms of...
In this paper, the 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO)-containing diblock copolymer poly[(p-hydroxybenzaldehyde methacrylate)m-b-(2-((6-oxidodibenzo[c,e][1,2]oxaphosphinin-6-yl)oxy)ethyl methacrylate)n] (abbrev. poly(HAMAm-b-HEP...
Combinations of multiple inorganic fillers have emerged as viable synergistic agents for boosting the flame retardancy of intumescent flame retardant (IFR) polymer materials. However, few studies on the effect of multiple inorganic fillers on the fla...
Phosphating sesbania gum (DESG) was obtained by modifying sesbania gum (SG) with 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) and endic anhydride (EA). The structure of DESG was determined using Fourier transform infrared (FTIR) spectros...
A new expandable graphite (EG) type was studied as a flame retardant additive in Polyamide 6 (PA6). The fire behavior was characterized by a cone calorimeter using external heat fluxes of 35, 50 and 65 kW/m2, limiting the oxygen index (LOI) and UL-94...
As part of the work, polymer composites dedicated to rapid prototyping were developed, especially for 3D printing using the material extrusion technique. For this purpose, a polymer matrix was selected, which was an acrylonitrile-butadiene-styrene (A...
Expandable graphite (EG) and graphite (G) were assessed as multifunctional additives improving both flame retardancy and thermal conductivity in highly filled, thermal conductive polymeric materials based on polyamide 6 (PA6). Fire testing was conduc...
Low viscosity, potentially renewable aliphatic epoxy resins, appropriate for processing with injection techniques were flame retarded with the use of resorcinol bis(diphenyl phosphate) (RDP), acting predominantly in the gas phase, ammonium polyphosph...
In this study, sodium alginate (SA) aerogel cross-linked with Ca2+ was selected as the basic skeleton to construct a lightweight, flame retardant, and thermal insulating composite aerogel via modification with melamine and phytic acid. The resulting...
As a result of the conducted studies, the method of combining components and foaming parameters for obtaining foam epoxides has been selected. The relationship between the structure of the foam epoxide and the amount of the added blowing agent—...
Rigid polyurethane foam (PUF) was successfully prepared from a novel oligo-ester-ether-diol obtained from the glycolysis of waste poly(ethylene terephthalate) (PET) bottles via reaction with diethylene glycol (DEG) in the presence of ZnSO4·7H2...
Due to their ability to prevent or slow the spread of fires, fire-retardant coatings are utilized as the main means of fire protection for steel structures, combining easy application and high economic efficiency. This study investigates the effects...
This study produces high-purity nano-silica from corn straw ash (biomass power plants) using an alkaline fusion-derived sodium silicate solution. CO2 replaces traditional acids in the carbonation reaction, enabling high extraction yield (93.11%). The...
The preparation of novel polymer aerogel materials with enhanced flame-retardancy, superior thermal insulation and mechanical strength is of great practical significance in energy-savings and fire-prevention for buildings. Herein, we reported the fib...
It remains a challenge to prepare flame-retardant composites via the addition of a low content of flame retardant. In this work, a novel DOPO-functionalized reduced graphene oxide hybrid (DOPO-M-rGO) flame-retardant system was synthesized for epoxy r...
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