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30 Results Found

  • Article
  • Open Access
6 Citations
2,773 Views
10 Pages

29 October 2023

Background and Objectives: A potential role of vascular endothelial growth factor (VEGF) in the pathophysiology of infantile hemangiomas (IH) is thought to be plausible. The primary objective of this study was to investigate the importance of determi...

  • Review
  • Open Access
68 Citations
12,556 Views
14 Pages

Since seminal descriptions of signal transducer and activator of transcription 3 (STAT3) as a signal transducer and transcriptional regulator, which is most usually activated by phosphorylation of a specific tyrosine residue, a staggering wealth of r...

(This article belongs to the Special Issue Advances in Biological Functions of STAT3)
  • Review
  • Open Access
522 Views
22 Pages

Research Progress on Angiogenesis and Involution Mechanisms of Infantile Hemangioma and Its Regulation by Active Components of Salvia miltiorrhiza

  • Yuan Lu,
  • Yamin Wu,
  • Nan Gu,
  • Ke Wen and ,
  • Chao Yang,
  • Xuetao Huang,
  • Dedong Zeng,
  • Lu Huang,
  • Shimin Wu and
  • Qian Liu
  • + 6 authors+ 1 author

2 September 2026

Infantile hemangioma (IH) is the most common benign vascular tumor of infancy, characterized by a unique life cycle encompassing a rapid proliferative phase followed by spontaneous involution. Although the majority of cases exhibit a favorable progno...

(This article belongs to the Section Molecular Pharmacology)
  • Article
  • Open Access
3 Citations
2,523 Views
13 Pages

CD26 Is Differentially Expressed throughout the Life Cycle of Infantile Hemangiomas and Characterizes the Proliferative Phase

  • Bruno Lorusso,
  • Antonella Nogara,
  • Rodanthi Fioretzaki,
  • Emilia Corradini and ,
  • Roberta Bove,
  • Giovanni Roti,
  • Andrea Gherli,
  • Anna Montanaro,
  • Gregorio Monica and
  • Costanza Anna Maria Lagrasta
  • + 13 authors+ 8 authors

10 September 2024

Infantile hemangiomas (IHs) are benign vascular neoplasms of childhood (prevalence 5–10%) due to the abnormal proliferation of endothelial cells. IHs are characterized by a peculiar natural life cycle enclosing three phases: proliferative (≤...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Review
  • Open Access
13 Citations
6,565 Views
21 Pages

25 February 2025

The mammary gland undergoes significant changes throughout a woman’s life; from embryonic development to transformations after breastfeeding and during aging. These processes, while essential for normal breast physiology, can increase breast ca...

(This article belongs to the Section Cancer Epidemiology and Prevention)
  • Article
  • Open Access
26 Citations
5,333 Views
29 Pages

Transcriptome Analysis of Goat Mammary Gland Tissue Reveals the Adaptive Strategies and Molecular Mechanisms of Lactation and Involution

  • Rong Xuan,
  • Jianmin Wang,
  • Xiaodong Zhao,
  • Qing Li and ,
  • Yanyan Wang,
  • Shanfeng Du,
  • Qingling Duan,
  • Yanfei Guo,
  • Zhibin Ji and
  • Tianle Chao
  • + 5 authors+ 0 author

20 November 2022

To understand how genes precisely regulate lactation physiological activity and the molecular genetic mechanisms underlying mammary gland involution, this study investigated the transcriptome characteristics of goat mammary gland tissues at the late...

(This article belongs to the Special Issue mRNAs in Biology)
  • Article
  • Open Access
9 Citations
4,164 Views
20 Pages

Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy

  • Manila Hada,
  • Hannah Oh,
  • Shaoqi Fan,
  • Roni T. Falk and ,
  • Berta Geller,
  • Pamela Vacek,
  • Donald Weaver,
  • John Shepherd,
  • Jeff Wang and
  • Gretchen L. Gierach
  • + 11 authors+ 6 authors

17 January 2020

The association of progesterone/progesterone metabolites with elevated mammographic breast density (MBD) and delayed age-related terminal duct lobular unit (TDLU) involution, strong breast cancer risk factors, has received limited attention. Using a...

(This article belongs to the Special Issue Mammographic Density: Biology and Clinical Applications)
  • Article
  • Open Access
4 Citations
3,152 Views
13 Pages

miR-152-3p Represses the Proliferation of the Thymic Epithelial Cells by Targeting Smad2

  • Ying Li,
  • Xintong Wang,
  • Qingru Wu,
  • Fenfen Liu and ,
  • Lin Yang,
  • Bishuang Gong,
  • Kaizhao Zhang,
  • Yongjiang Ma and
  • Yugu Li
  • + 4 authors+ 0 author

24 March 2022

MicroRNAs (miRNAs) control the proliferation of thymic epithelial cells (TECs) for thymic involution. Previous studies have shown that expression levels of miR-152-3p were significantly increased in the thymus and TECs during the involution of the mo...

(This article belongs to the Topic MicroRNA: Mechanisms of Action, Physio-Pathological Implications, and Disease Biomarkers)
  • Article
  • Open Access
3 Citations
2,942 Views
11 Pages

The Role of Ewes’ Udder Health on Echotexture and Blood Flow Changes during the Dry and Lactation Periods

  • Aikaterini Ntemka,
  • Ioannis Tsakmakidis,
  • Constantin Boscos,
  • Alexandros Theodoridis and
  • Evangelos Kiossis

30 August 2022

The objective of the current study was to investigate the echotextural and hemodynamic changes of ewes entering the dry period with or without subclinical mastitis. B-mode and color Doppler ultrasonography were applied to 12 Chios ewes (6 with health...

(This article belongs to the Special Issue Modern Technology in Farm Animals’ Reproductive Services)
  • Review
  • Open Access
8 Citations
4,109 Views
11 Pages

Cellular Plasticity and Heterotypic Interactions during Breast Morphogenesis and Cancer Initiation

  • Saevar Ingthorsson,
  • Gunnhildur Asta Traustadottir and
  • Thorarinn Gudjonsson

24 October 2022

The human breast gland is a unique organ as most of its development occurs postnatally between menarche and menopause, a period ranging from 30 to 40 years. During this period, the monthly menstruation cycle drives the mammary gland through phases of...

(This article belongs to the Special Issue Breast Development and Cancer)
  • Case Report
  • Open Access
5 Citations
1 Views
3 Pages

A Mixed Neoplasm of Intraosseous Hemangioma with an Ameloblastoma: A Case of Collision Tumor or a Rare Variant?

  • Harshvardhan S. Jois,
  • Mohan Kumar K.P,
  • Mandali Satish Kumar and
  • Shefali Waghrey

30 December 2011

Hemangiomas of the head and neck are considered to be benign tumors of infancy that are characterized by a rapid growth phase with endothelial cell proliferation, followed by gradual involution. Central hemangiomas are a rare occurrence and even rare...

  • Article
  • Open Access
1 Citations
1,560 Views
51 Pages

30 November 2025

Many of the most fundamental observables—position, momentum, phase point, and spin direction—cannot be measured by an instrument that obeys the orthogonal projection postulate. Continuous-in-time measurements provide the missing theoretic...

  • Article
  • Open Access
1 Citations
1,302 Views
18 Pages

1 December 2025

Planetary gears consisting of simple external gear wheels and an internal ring gear are widely used in industry in various fields. This type of drive is most commonly found in robots, and it is also frequently used in the automotive industry, such as...

(This article belongs to the Special Issue Interdisciplinary Insights in Engineering Research)
  • Article
  • Open Access
9 Citations
2,236 Views
13 Pages

Investigation of the Mechanical Properties of Spur Involute Gearing by Infrared Thermography

  • Milan Sapieta,
  • Vladimír Dekýš,
  • Michal Kaco,
  • Miroslav Pástor and ,
  • Alžbeta Sapietová and
  • Barbora Drvárová
  • + 1 author+ 0 author

12 May 2023

The work aims at validating a methodology for 3D printing of gears with involute gearing and evaluating their mechanical properties using infrared camera. A general methodology for the setup of 3D printing of gears made of polymeric materials has bee...

(This article belongs to the Section Optics and Lasers)
  • Feature Paper
  • Article
  • Open Access
1,109 Views
19 Pages

13 April 2026

The responsiveness of the stress axis is fundamental for maintaining health and sustaining productive performance; however, the effect of modulating this stress axis with bovine appeasing substance and its effects on biochemical, immunological, oxida...

(This article belongs to the Special Issue Nutrition and Metabolism of Cows and Stress Responses)
  • Article
  • Open Access
1,367 Views
35 Pages

The Dry Secretion Metabolome: LC-MS Profiling Distinguishes Subclinical Mastitis from Healthy Udder Quarters Across the Dry Period in Dairy Cows

  • Barjam Hasanllari,
  • Memet Kaja,
  • Shuang Zhao,
  • Xian Luo and ,
  • Liang Li and
  • Burim N. Ametaj
  • + 1 author+ 0 author

2 April 2026

The dry period is a critical window of susceptibility to intramammary infection in dairy cows, yet the metabolic environment of the mammary gland during this phase remains largely uncharacterized. The objective of this study was to profile the metabo...

(This article belongs to the Section Veterinary Biomedical Sciences)
  • Article
  • Open Access
1,347 Views
23 Pages

Effect of Tooth Count and Rim Thickness on the Operational Durability of Cylindrical Involute Gears

  • Milan Perkušić,
  • Stipe Pleština,
  • Vjekoslav Tvrdić and
  • Karlo Dvornik

This paper presents a numerical assessment of bending-fatigue durability in the tooth root region of cylindrical involute gears. Multiple gear pairs were modelled with different numbers of teeth and varying gear rim thicknesses. The generated geometr...

(This article belongs to the Special Issue Service Behaviour and Applied Mechanics of Mechanical Equipment Surfaces and Interfaces)
  • Article
  • Open Access
17 Citations
3,101 Views
18 Pages

4 July 2021

Currently, in nonlinear optics, models associated with various types of the nonlinear Schrödinger equation (scalar (NLS), vector (VNLS), derivative (DNLS)), as well as with higher and mixed equations from the corresponding hierarchies are usually stu...

(This article belongs to the Special Issue Symmetry of Hamiltonian Systems: Classical and Quantum Aspects)
  • Article
  • Open Access
39 Citations
7,746 Views
16 Pages

25 March 2019

The demand for rapid online optical inspection of gear tooth surfaces is increasing, especially for precision gears. In this study, a non-contact optical measurement method was established for the inspection of gear tooth surfaces. For the system arc...

(This article belongs to the Special Issue I3S 2018 Selected Papers)
  • Review
  • Open Access
12 Citations
7,895 Views
17 Pages

15 July 2021

Bovine perinatal mortality due to infection may result either from the direct effects of intrauterine infection and/or the fetal response to such infection, leading to the fetal inflammatory response syndrome (FIRS). Both intrauterine infection and F...

(This article belongs to the Special Issue The Neonate: Care and Immunity)
  • Article
  • Open Access
5 Citations
3,405 Views
13 Pages

Histological Correlation between Tonsillar and Glomerular Lesions in Patients with IgA Nephropathy Justifying Tonsillectomy: A Retrospective Cohort Study

  • Kensuke Joh,
  • Hiroyuki Ueda,
  • Kan Katayama,
  • Hiroshi Kitamura and ,
  • Kenichi Watanabe and
  • Osamu Hotta
  • + 1 author+ 0 author

Tonsillectomy with steroid pulse therapy (SPT) has been established as an effective treatment for immunoglobulin A nephropathy (IgAN) in Japan. However, the underlying mechanisms supporting tonsillectomy remain unclear. This study assessed palatine t...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Article
  • Open Access
7 Citations
2,367 Views
22 Pages

31 December 2024

Variable tooth thickness gears have significant effects on the characteristics of the flow field inside the gearbox and the lubrication efficiency under high-speed operating conditions due to their complex parameters, such as tooth profile, cone angl...

  • Article
  • Open Access
19 Citations
5,849 Views
13 Pages

PDGFA in Cashmere Goat: A Motivation for the Hair Follicle Stem Cells to Activate

  • Irene Pazzaglia,
  • Francesca Mercati,
  • Marco Antonini,
  • Stefano Capomaccio and ,
  • Katia Cappelli,
  • Cecilia Dall’Aglio,
  • Antonietta La Terza,
  • Matteo Mozzicafreddo,
  • Cristina Nocelli and
  • Carlo Renieri
  • + 7 authors+ 2 authors

28 January 2019

The cashmere hair follicle (HF) perpetually goes through cycles of growth, involution and rest. The photoperiod is the main factor in the control of seasonal coat change in cashmere goats while stem cells play a crucial role in the HF growth. Several...

(This article belongs to the Section Small Ruminants)
  • Article
  • Open Access
7 Citations
3,471 Views
28 Pages

17 March 2022

The effect of the cam profile on the nonlinear dynamics phenomenon of the follower is studied at three involutes’ profiles for the cam. The value of the Lyapunov exponent parameter is calculated at different internal distances of the follower g...

(This article belongs to the Special Issue Numerical Simulation of Nonlinear Dynamical Systems)
  • Article
  • Open Access
281 Citations
24,290 Views
14 Pages

Plant Disease Recognition Model Based on Improved YOLOv5

  • Zhaoyi Chen,
  • Ruhui Wu,
  • Yiyan Lin,
  • Chuyu Li and ,
  • Siyu Chen,
  • Zhineng Yuan,
  • Shiwei Chen and
  • Xiangjun Zou
  • + 3 authors+ 0 author

31 January 2022

To accurately recognize plant diseases under complex natural conditions, an improved plant disease-recognition model based on the original YOLOv5 network model was established. First, a new InvolutionBottleneck module was used to reduce the numbers o...

(This article belongs to the Topic Grand Challenges of Advanced Technologies in Sustainable Agriculture 4.0: Future Farming, Harvesting and Preservation)
  • Article
  • Open Access
5 Citations
2,666 Views
8 Pages

OCT Analysis of Retinal Pigment Epithelium in Myopic Choroidal Neovascularization: Correlation Analysis with Different Treatments

  • Davide Allegrini,
  • Diego Vezzola,
  • Alfredo Borgia,
  • Raffaele Raimondi and ,
  • Tania Sorrentino,
  • Domenico Tripepi,
  • Elisa Stradiotto,
  • Marco Alì,
  • Giovanni Montesano and
  • Mario R. Romano
  • + 5 authors+ 0 author

26 August 2022

Objective: The objective of this study was to analyze the status of the retinal pigment epithelium (RPE) by means of the spectral domain optical coherence tomography (SD-OCT) overlying the myopic neovascular lesions in the involutive phase, looking f...

(This article belongs to the Special Issue Imaging in Ophthalmology—Volume I)
  • Review
  • Open Access
36 Citations
11,790 Views
22 Pages

Critical Review on Physiological and Molecular Features during Bovine Mammary Gland Development: Recent Advances

  • Shalini Jaswal,
  • Manoj Kumar Jena,
  • Vijay Anand,
  • Avinash Jaswal and ,
  • Sudhakar Kancharla,
  • Prachetha Kolli,
  • Gowtham Mandadapu,
  • Sudarshan Kumar and
  • Ashok Kumar Mohanty
  • + 4 authors+ 0 author

21 October 2022

The mammary gland is a unique organ with the ability to undergo repeated cyclic changes throughout the life of mammals. Among domesticated livestock species, ruminants (cattle and buffalo) constitute a distinct class of livestock species that are kno...

  • Article
  • Open Access
15 Citations
3,823 Views
24 Pages

30 November 2022

In previous studies, the meshing force of a gear system is usually treated as being uniformly distributed for the convenience of analysis. In practical applications, however, it is nonuniformly distributed along the line of action due to machining er...

  • Article
  • Open Access
410 Views
26 Pages

21 June 2026

Asymmetric quantum codes are useful for quantum channels in which phase and bit errors occur with different probabilities, since the two distances, dz and dx, can be controlled separately. We develop a permutation-paired matrix-product construction f...

  • Review
  • Open Access
16 Citations
7,553 Views
85 Pages

30 October 2024

Background/Objectives. Obesity, type 2 diabetes (T2D), and Alzheimer’s disease (AD) are pathologies that affect millions of people worldwide. They have no effective therapy and are difficult to prevent and control when they develop. It has been...

(This article belongs to the Section Molecular and Cellular Neuroscience)