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  • Review
  • Open Access
2 Citations
1,629 Views
14 Pages

Winter Storms Within: Climate-Driven Stressors Undermine Honey Bee Gut Microbiome

  • Gagandeep Brar,
  • Ramandeep Kaur,
  • Mandeep Kaur Gill,
  • Navjot Singh and
  • Rupinderjeet Kaur

Climate change is intensifying winters in temperate regions, posing a serious threat to Apis mellifera health. The gut microbiome, a distinct community of core bacterial species, is central to overwintering success by supporting immune function, nutr...

(This article belongs to the Special Issue The Animal Microbiome in Health and Disease: From Insights to Innovations)
  • Review
  • Open Access
7 Citations
2,367 Views
26 Pages

19 March 2026

Honey bees are exposed to a wide range of environmental and ecological stressors that threaten individual health and colony sustainability. Growing evidence suggests that many of these stressors converge on a common target: the gut microbiome and its...

(This article belongs to the Special Issue Honeybee and Other Pollinators: Physiology and Biochemistry Across Environmental Conditions)
  • Article
  • Open Access
45 Citations
7,406 Views
16 Pages

Microbial Ecology of European Foul Brood Disease in the Honey Bee (Apis mellifera): Towards a Microbiome Understanding of Disease Susceptibility

  • Amy S. Floyd,
  • Brendon M. Mott,
  • Patrick Maes,
  • Duan C. Copeland,
  • Quinn S. McFrederick and
  • Kirk E. Anderson

20 August 2020

European honey bees (Apis mellifera Linnaeus) are beneficial insects that provide essential pollination services for agriculture and ecosystems worldwide. Modern commercial beekeeping is plagued by a variety of pathogenic and environmental stressors...

(This article belongs to the Collection Bees and Their Symbionts)
  • Article
  • Open Access
37 Citations
9,050 Views
14 Pages

Characterization of the Kenyan Honey Bee (Apis mellifera) Gut Microbiota: A First Look at Tropical and Sub-Saharan African Bee Associated Microbiomes

  • Yosef Hamba Tola,
  • Jacqueline Wahura Waweru,
  • Gregory D. D. Hurst,
  • Bernard Slippers and
  • Juan C. Paredes

Gut microbiota plays important roles in many physiological processes of the host including digestion, protection, detoxification, and development of immune responses. The honey bee (Apis mellifera) has emerged as model for gut-microbiota host interac...

(This article belongs to the Section Gut Microbiota)
  • Article
  • Open Access
40 Citations
9,016 Views
12 Pages

Propolis Envelope Promotes Beneficial Bacteria in the Honey Bee (Apis mellifera) Mouthpart Microbiome

  • Hollie Dalenberg,
  • Patrick Maes,
  • Brendon Mott,
  • Kirk E. Anderson and
  • Marla Spivak

18 July 2020

Honey bees collect and apply plant resins to the interior of their nest cavity, in order to form a layer around the nest cavity called a propolis envelope. Propolis displays antimicrobial activity against honey bee pathogens, but the effect of propol...

(This article belongs to the Collection Bees and Their Symbionts)
  • Review
  • Open Access
36 Citations
9,604 Views
25 Pages

16 October 2023

Bees are important pollinators worldwide, promoting sustainability in agriculture and natural ecosystems. Moreover, honey bees produce a variety of honey bee products (beehive products). Honey is the main edible bee product. The consumption of pollen...

(This article belongs to the Special Issue Pseudomonas Biology and Biodiversity)
  • Article
  • Open Access
7 Citations
3,382 Views
12 Pages

Paromomycin is a naturally occurring aminoglycoside antibiotic that has effects on both prokaryotic and eukaryotic microbes. However, previous reports have indicated that it has little effect on microsporidia, including Vairimorpha (Nosema) ceranae,...

(This article belongs to the Section Parasitology)
  • Brief Report
  • Open Access
33 Citations
13,032 Views
11 Pages

Two Novel Strains of Torulaspora delbrueckii Isolated from the Honey Bee Microbiome and Their Use in Honey Fermentation

  • Joseph P. Barry,
  • Mindy S. Metz,
  • Justin Hughey,
  • Adam Quirk and
  • Matthew L. Bochman

Yeasts are ubiquitous microbes found in virtually all environments. Many yeast species can ferment sugar into ethanol and CO2, and humans have taken advantage of these characteristics to produce fermented beverages for thousands of years. As a natura...

(This article belongs to the Special Issue Yeast Biotechnology 2.0)
  • Article
  • Open Access
1 Citations
1,712 Views
28 Pages

First Molecular and Metagenomic Investigation of the Italian Honey Bee (Apis mellifera) Microbiome

  • Fulvio Bordin,
  • Arianna Peruzzo,
  • Gianpiero Zamperin,
  • Elisa Palumbo,
  • Adelaide Milani,
  • Massimiliano Orsini,
  • Alice Fusaro,
  • Michela Bertola,
  • Paola Mogliotti and
  • Anna Granato
  • + 8 authors

3 April 2026

The western honey bee (Apis mellifera) represents a key pollinator for both crops and wild plants, and its global decline raises serious concerns for ecosystem stability and agricultural productivity. Several biotic and abiotic factors are responsibl...

(This article belongs to the Special Issue Advances in Honeybee and Their Biological and Environmental Threats)
  • Correction
  • Open Access
144 Views
1 Page
  • Article
  • Open Access
2 Citations
1,291 Views
14 Pages

1 January 2026

Honey bees, as vital pollinators and essential contributors to terrestrial ecosystems, play a critical role in maintaining biodiversity and ecological stability. Beyond their role as pollinators, honey bees are increasingly recognized as bioindicator...

(This article belongs to the Special Issue Current Advances in Pollinator Insects)
  • Article
  • Open Access
18 Citations
5,059 Views
20 Pages

Honey bee (Apis mellifera L.) health is crucial for honey bee products and effective pollination, and it is closely associated with gut bacteria. Various factors such as reduced habitat, temperature, disease, and diet affect the health of honey bees...

(This article belongs to the Section Veterinary Microbiology)
  • Article
  • Open Access
3 Citations
3,616 Views
14 Pages

The Phytochemical Properties of Low-Grade Longan Syrup and Its Potential Use as a Dietary Supplement for Honey Bees

  • Phurichaya Lertlakkanawat,
  • Sarana Rose Sommano,
  • Khanchai Danmek,
  • Surat Hongsibsong,
  • Chuleui Jung,
  • Saeed Mohamadzade Namin,
  • Malaiporn Wongkaew and
  • Bajaree Chuttong

29 November 2024

Climate change significantly affects honey bee populations and their access to natural food sources, demanding alternative economic feed sources. Longan stands out as the most important fruit crop in Southeast Asia, but with a surplus of low-grade fr...

(This article belongs to the Special Issue Bee Conservation: Behavior, Health and Pollination Ecology)
  • Communication
  • Open Access
38 Citations
8,689 Views
12 Pages

Chronic Exposure to Polystyrene Microplastic Fragments Has No Effect on Honey Bee Survival, but Reduces Feeding Rate and Body Weight

  • Yahya Al Naggar,
  • Christie M. Sayes,
  • Clancy Collom,
  • Taiwo Ayorinde,
  • Suzhen Qi,
  • Hesham R. El-Seedi,
  • Robert J. Paxton and
  • Kai Wang

21 January 2023

Microplastics (MPs), in the form of fragments and fibers, were recently found in honey samples collected in Ecuador as well as in honey bees collected from Denmark and China. However, little is known about how MPs impact bee health. To fill this know...

(This article belongs to the Special Issue Quantification and Identification of Micro- and Nanoplastics in Environmental Matrices)
  • Review
  • Open Access
447 Views
24 Pages

2 October 2026

Honey bees provide a tractable model for studying the gut–brain axis in social insects. Unlike mammalian systems, the gut–brain axis in honey bees is jointly shaped by a relatively simple yet functionally specialized microbiota, physiolog...

(This article belongs to the Section Social Insects and Apiculture)
  • Article
  • Open Access
21 Citations
7,495 Views
15 Pages

Impacts of Diverse Natural Products on Honey Bee Viral Loads and Health

  • Dawn L. Boncristiani,
  • James P. Tauber,
  • Evan C. Palmer-Young,
  • Lianfei Cao,
  • William Collins,
  • Kyle Grubbs,
  • Jillian A. Lopez,
  • Lyndel W. Meinhardt,
  • Vy Nguyen and
  • Jay D. Evans
  • + 4 authors

13 November 2021

Western honey bees (Apis mellifera), a cornerstone to crop pollination in the U.S., are faced with an onslaught of challenges from diseases caused by parasites, pathogens, and pests that affect this economically valuable pollinator. Natural products...

(This article belongs to the Special Issue Frontier Research in Apiculture (Diagnosis and Control of Bee Diseases, Bee Products, Environmental Monitoring))
  • Article
  • Open Access
33 Citations
6,919 Views
15 Pages

Antimicrobial Activity from Putative Probiotic Lactic Acid Bacteria for the Biological Control of American and European Foulbrood Diseases

  • Massimo Iorizzo,
  • Sonia Ganassi,
  • Gianluca Albanese,
  • Francesco Letizia,
  • Bruno Testa,
  • Cosimo Tedino,
  • Sonia Petrarca,
  • Franco Mutinelli,
  • Alessandra Mazzeo and
  • Antonio De Cristofaro

The balance of the gut microbiome is important for the honey bee’s growth and development, immune function and defense against pathogens. The use of a beneficial bacteria-based strategy for the prevention and biocontrol of American foulbrood (A...

(This article belongs to the Special Issue Challenges and Advances in Bee Health and Diseases)
  • Review
  • Open Access
28 Citations
10,119 Views
31 Pages

Exploring the Potential of Bee-Derived Antioxidants for Maintaining Oral Hygiene and Dental Health: A Comprehensive Review

  • Poonam Choudhary,
  • Surya Tushir,
  • Manju Bala,
  • Sanjula Sharma,
  • Manjeet Kaur Sangha,
  • Heena Rani,
  • Nileshwari Raju Yewle,
  • Parminder Kumar,
  • Diksha Singla and
  • Mohamed Mekhemar
  • + 2 authors

Honey bee products comprise various compounds, including honey, propolis, royal jelly, bee pollen, bee wax and bee venom, which have long been recognized for their pharmacological and health-promoting benefits. Scientists have discovered that periodo...

(This article belongs to the Special Issue Antioxidant Activity of Honey Bee Products)
  • Viewpoint
  • Open Access
3 Citations
5,685 Views
5 Pages

Examples of urban restoration and rewilding are critical in promoting grass roots efforts to restore ecosystems diversity in built environments. Honey bees are a vital part of many ecosystems, and urban beekeeping is a growing initiative with multipl...

(This article belongs to the Special Issue The Emerging Concept of Planetary Health: Connecting People, Place, Purpose and Planet)
  • Article
  • Open Access
470 Views
35 Pages

Honey Bees as Bioindicators of Environmental PFASs Contamination and Potential Effects on Gut-Microbial Communities

  • Laura Zulian,
  • Arianna Peruzzo,
  • Michela Bertola,
  • Gioele Scopel,
  • Elena Albertin,
  • Marianna Martinello,
  • Chiara Manzinello,
  • Alessandra Moressa,
  • Sara Petrin and
  • Anna Granato
  • + 5 authors

6 October 2026

Honey bees are valuable bioindicators of environmental contamination due to their wide foraging range and exposure to diverse biotic and abiotic stressors. This study evaluates the use of honey bees as bioindicators for detecting per- and polyfluoroa...

(This article belongs to the Section Social Insects and Apiculture)
  • Review
  • Open Access
17 Citations
8,571 Views
17 Pages

Bee Products and Colorectal Cancer—Active Components and Mechanism of Action

  • Justyna Moskwa,
  • Sylwia Katarzyna Naliwajko,
  • Dominika Dobiecka and
  • Katarzyna Socha

27 March 2023

Colorectal cancer is one of the most common malignancies in the world. Lifestyle and eating patterns may have a significant impact on the prevention of this type of cancer. Bioactive food ingredients influence the gut microbiome and can have a protec...

(This article belongs to the Special Issue Bee Products in Human Health)
  • Review
  • Open Access
42 Citations
7,117 Views
13 Pages

Micro”bee”ota: Honey Bee Normal Microbiota as a Part of Superorganism

  • Daniil Smutin,
  • Egor Lebedev,
  • Maxim Selitskiy,
  • Nick Panyushev and
  • Leonid Adonin

Honey bees are model organisms for microbiota research. Gut microbiomes are very interesting for surveys due to their simple structure and relationship with hive production. Long-term studies reveal the gut microbiota patterns of various hive members...

(This article belongs to the Section Veterinary Microbiology)
  • Review
  • Open Access
104 Citations
14,004 Views
29 Pages

Antimicrobial Activity of Bee-Collected Pollen and Beebread: State of the Art and Future Perspectives

  • Nikos Asoutis Didaras,
  • Katerina Karatasou,
  • Tilemachos G Dimitriou,
  • Grigoris D. Amoutzias and
  • Dimitris Mossialos

14 November 2020

Bee-collected pollen (BCP) is a well-known functional food. Honey bees process the collected pollen and store it in the hive, inside the comb cells. The processed pollen is called bee- bread or ambrosia and it is the main source of proteins, lipids,...

(This article belongs to the Special Issue Honey Bee Products as an Alternative or Complement to Classical Antibiotics)
  • Article
  • Open Access
6 Citations
2,691 Views
26 Pages

Diverse Sublethal Effects of a Common Fungicide Impact the Behavior and Physiology of Honey Bees

  • Xufeng Zhang,
  • Qian Cao,
  • Feng Wang,
  • Yinyin Du,
  • Wen Zhao,
  • Yuan Guo and
  • Olav Rueppell

8 June 2025

Honey bees and other pollinators are key to functioning natural and managed ecosystems. However, their health is threatened by many factors, including pesticides. Spraying fungicides during flowering of fruit trees is widespread even though it direct...

(This article belongs to the Special Issue Biology and Conservation of Honey Bees)
  • Article
  • Open Access
32 Citations
5,952 Views
16 Pages

Overwintering Honey Bee Colonies: Effect of Worker Age and Climate on the Hindgut Microbiota

  • Patrick W. Maes,
  • Amy S. Floyd,
  • Brendon M. Mott and
  • Kirk E. Anderson

5 March 2021

Honey bee overwintering health is essential to meet the demands of spring pollination. Managed honey bee colonies are overwintered in a variety of climates, and increasing rates of winter colony loss have prompted investigations into overwintering ma...

(This article belongs to the Collection Bees and Their Symbionts)
  • Article
  • Open Access
4 Citations
1,801 Views
17 Pages

Effect of Diet Compositions on Colony Strength Parameters, and the Enzymatic Activity of Apis mellifera L. During Floral Scarcity

  • Shams Ul Islam,
  • Javeria Liaquat,
  • Muhammad Anjum Aqueel,
  • Asim Abbasi,
  • Muhammad Arshad,
  • Muhammad Shahid Rizwan,
  • Muhammad Saqib,
  • Nasir Masood,
  • Nyasha J. Kavhiza and
  • Abeer Hashem
  • + 4 authors

16 September 2025

Dearth periods associated with less floral resources negatively impact Apis mellifera colony performance. Artificial diets offer nutritional supplements to sustain bee colonies under stressful conditions. An eight-week feeding trial was conducted usi...

(This article belongs to the Section Insect Behavior and Pathology)
  • Article
  • Open Access
31 Citations
8,185 Views
16 Pages

Microbial Diversity Associated with the Pollen Stores of Captive-Bred Bumble Bee Colonies

  • Prarthana S. Dharampal,
  • Luis Diaz-Garcia,
  • Max A. B. Haase,
  • Juan Zalapa,
  • Cameron R. Currie,
  • Chris Todd Hittinger and
  • Shawn A. Steffan

16 April 2020

The pollen stores of bumble bees host diverse microbiota that influence overall colony fitness. Yet, the taxonomic identity of these symbiotic microbes is relatively unknown. In this descriptive study, we characterized the microbial community of poll...

(This article belongs to the Collection Bees and Their Symbionts)
  • Article
  • Open Access
5 Citations
1,244 Views
24 Pages

Probiotic Assessment of Lactic Acid Bacteria Strains and Consortia for Enhancing Honey Bee Health and Nutrition

  • Gianluca Albanese,
  • Alexandru Ioan Giurgiu,
  • Adriana Cristina Urcan,
  • Claudia Pașca,
  • Tudor Nicolas Ternar,
  • Victorița Bonta,
  • Dalila Di Criscio,
  • Massimo Iorizzo,
  • Antonio De Cristofaro and
  • Daniel Severus Dezmirean

The decline of honey bee health has intensified interest in microbiome-based strategies to support colony resilience and reduce reliance on chemical interventions. In this study, we performed an in vitro probiotic screening of five lactic acid bacter...

(This article belongs to the Special Issue Probiotics and Their Health Benefits)
  • Article
  • Open Access
4 Citations
3,797 Views
19 Pages

Antibiotic Use in Beekeeping: Implications for Health and Environment from a One-Health Perspective

  • Michela Mosca,
  • Andrea Gyorffy,
  • Marcella Milito,
  • Camilla Di Ruggiero,
  • Alessandra De Carolis,
  • Marco Pietropaoli,
  • Luigi Giannetti,
  • Francesco Necci,
  • Francesca Marini and
  • Giovanni Formato
  • + 6 authors

Background: The use of antibiotics in beekeeping has potential implications for honeybee health and environmental contamination. Recent research indicates that extensive antibiotic use in beekeeping, especially oxytetracycline, promotes antimicrobial...

(This article belongs to the Section Antibiotics in Animal Health)
  • Review
  • Open Access
111 Citations
18,949 Views
29 Pages

22 March 2021

Numerous honeybee (Apis mellifera) products, such as honey, propolis, and bee venom, are used in traditional medicine to prevent illness and promote healing. Therefore, this insect has a huge impact on humans’ way of life and the environment. While t...

(This article belongs to the Collection Gut Microbiota-Derived Metabolites and Host Gut-Brain Communication)
  • Review
  • Open Access
20 Citations
10,988 Views
23 Pages

Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies

  • Manoj Kumar,
  • Suraj Prakash,
  • Radha,
  • José M. Lorenzo,
  • Deepak Chandran,
  • Sangram Dhumal,
  • Abhijit Dey,
  • Marisennayya Senapathy,
  • Nadeem Rais and
  • Mohamed Mekhemar
  • + 14 authors

Periodontal diseases are caused mainly by inflammation of the gums and bones surrounding the teeth or by dysbiosis of the oral microbiome, and the Global Burden of Disease study (2019) reported that periodontal disease affects 20–50% of the glo...

(This article belongs to the Special Issue Natural Antioxidants and Oral Health)
  • Article
  • Open Access
3 Citations
4,213 Views
20 Pages

Bacterial Agents for Biocontrol of American Foulbrood (AFB) of Larvae Honey Bee

  • Piotr Nowotnik,
  • Paweł Chorbiński,
  • Paweł Migdał and
  • Bogusław Górski

24 November 2024

Bee colonies are constantly threatened by a bacterial larvae disease called American foulbrood, caused by the Gram-positive bacterium Paenibacillus larvae. This is a highly specialized pathogen with only one established host, the honey bee larvae. Th...

  • Article
  • Open Access
4 Citations
3,356 Views
11 Pages

Microbiota Analysis of Ejaculated Honey Bee Drone Semen and the Effect of Semen Collection Method on Bacterial Loads

  • Jesús Yániz,
  • Marion Toquet,
  • Pilar Santolaria,
  • Miguel Angel Silvestre,
  • Raquel Toledo-Perona and
  • Ángel Gómez-Martín

22 May 2024

Artificial insemination in queen honey bees is the only tool that provides complete control over mating for research and breeding purposes, making it essential in genetic improvement and conservation programs in this species. The aims of this study w...

(This article belongs to the Section Insect Physiology, Reproduction and Development)