Probiotics and Their Health Benefits
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 686
Special Issue Editor
Interests: animal internal medicine and toxic diseases; animal nutritional metabolic diseases and immunity; intestinal microbes; probiotic fermentation; obesity; liver fibrosis; cholestatic liver injury
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Probiotics refer to live microorganisms, predominantly bacteria and yeast, that confer health benefits to the host when administered via oral or topical routes. Dysbiosis, characterized by an imbalance in pathogenic bacteria within the gut microbiome, has been implicated in inflammatory responses, metabolic disturbances, and malabsorption issues. Probiotics can enhance gut health by promoting the proliferation of beneficial microbiota, inhibiting the growth of pathogens, and maintaining gut homeostasis.
Research has demonstrated that probiotics possess therapeutic potential in managing various gastrointestinal disorders such as diarrhea, irritable bowel syndrome, ulcerative colitis, and Crohn’s disease. Their beneficial properties are associated with immunomodulatory mechanisms that reduce harmful bacteria and their toxic metabolites, including lipopolysaccharides (LPSS), while downregulating pro-inflammatory cytokines and upregulating the populations of mucus-producing bacteria like Akkermansia muciniphila.
Recent studies demonstrate the role of probiotics in metabolic health, particularly through the gut–liver axis, which links gut microbiota to lipid metabolism. This interaction has lowered cholesterol levels, mitigated weight gain, and improved insulin sensitivity. Although the precise mechanisms are still being elucidated, current findings support the potential of probiotics in fostering gastrointestinal, immunological, and metabolic health. However, further clinical trials are essential to clarify their therapeutic applications and optimize their use in clinical practice.
Dr. Yunhuan Liu
Guest Editor
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Keywords
- probiotics
- beneficial microbiota
- host health
- diseases
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