2,232 Results Found

Fragmentation is a design technique widely used in multimedia databases, because it produces substantial benefits in reducing response times, causing lower execution costs in each operation performed. Multimedia databases include data whose main char...

The proper storage and management of multimedia data is a topic of great interest to industry and academia. Database fragmentation plays a fundamental role as a mechanism to guarantee cost reduction and improve response time performance in distribute...

Ecological land is a land use category provided with considerable ecological value and a vital indicator reflecting regional eco-environmental quality. However, it has experienced severe fragmentation during the rapid urbanization in China which stro...

In previously reported experimental studies, a yield of double-walled carbon nanotubes (DWCNTs) at C₇₀@Single-walled carbon nanotubes (SWCNTs) is higher than C₆₀@SWCNTs due to the higher sensitivity to photolysis of the former. From the perspective o...

Antibodies have been increasingly used as pharmaceuticals in clinical treatment. Thermal stability and unfolding process are important properties that must be considered in antibody design. In this paper, the structure-encoded dynamical properties an...

An interesting format in the development of therapeutic monoclonal antibodies uses the crystallizable fragment of IgG1 as starting scaffold. Engineering of its structural loops allows generation of an antigen binding site. However, this might impair...

Among landscapes, rural landscapes are important because they simultaneously present functional and cultural aspects. Rural landscapes are often created to modify the Earth’s surface according to different human needs and, among these modifying...

The production of non-toxic and homogeneous colloidal solutions of nanoparticles (NPs) for biomedical applications is of extreme importance nowadays. Among the various methods for generation of NPs, pulsed laser ablation in liquids (PLAL) has proven...

As the primary method used in open-pit mining, blasting has a direct impact on the efficiency and cost of subsequent operations. Therefore, dynamic identification of rock fragment size after blasting is essential for evaluating blasting quality and o...

Structure-driven fragment-based (SDFB) approaches have provided efficient methods for the identification of novel drug candidates. This strategy has been largely applied in discovering several pharmacological ligand classes, including enzyme inhibito...

Immunoassay for pesticides is an emerging analytical method since it is rapid, efficient, sensitive, and inexpensive. In this study, a recombinant antigen-binding fragment (Fab) against a broad set of O,O-diethyl organophosphorus pesticides (DOPs) wa...

TRAF6 is an E3 ubiquitin ligase that plays a crucial role in cell signaling. It is known that MMP is involved in tumor metastasis, and TRAF6 induces MMP-9 expression by binding to BSG. However, inhibiting TRAF6’s ubiquitinase activity without d...

Dynamic fracture and fragmentation characteristics of explosively driven rings and cylinders are important issues in the field of weapon effectiveness and protection. However, the comparison of fracture characteristics between metal cylinder and ring...

Blocking the interaction between programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) by directly targeting the PD-L1 dimer has emerged as a hot topic in the field of cancer immunotherapy. Epigallocatechin gallate (EGCG), a natur...

The dynamic behavior and biologically mediated transformation of microplastics (MPs) in crustaceans remain insufficiently explored in aquatic ecotoxicology. In this study, we employed the red swamp crayfish (Procambarus clarkii) as a model organism t...

To clearly realize the dynamic process as well as the dynamic fragmentation behavior of a long run-out rockslide, a novel numerical method for landslide simulation of the coupled finite-discrete element method (FDEM) was applied and the Jichang rocks...

Fragment-Based Drug Discovery (FBDD) approaches have gained popularity not only in industry but also in academic research institutes. However, the computational prediction of the binding mode adopted by fragment-like molecules within a protein bindin...

The dynamic fracture process of iron ore under blast loading is an important manifestation of ore fragmentation. To investigate the dynamic fracturing process of iron ore, Hopkinson bar experiments were conducted under different impact loads. The res...

Understanding the dynamic mechanical behaviors and microstructural properties of outburst-prone coal is significant for preventing coal and gas outbursts during underground mining. In this paper, the split Hopkinson pressure bar (SHPB) tests were com...

Solution nuclear magnetic resonance (NMR) spectroscopy is a powerful tool to study structures and dynamics of biomolecules under physiological conditions. As there are numerous NMR-derived methods applicable to probe protein–ligand interactions...

This paper proposes a target damage calculation method based on the profit-loss value of a warhead fragment group. The group is discretized into a fan-shaped column warhead fragment dispersion arrangement model, and the angle of its intersection with...

In this paper, we propose a grouping-based dynamic routing, core, and spectrum allocation (RCSA) method for preventing spectrum fragmentation and inter-core crosstalk in elastic optical path networks based on multi-core fiber environments. Multi-core...

During severe plastic deformation (SPD), the processes of lattice defect formation as well as their relaxation (annihilation) compete with each other. As a result, a dynamic equilibrium is established, and a steady state is reached after a certain st...

The dynamic response behavior of concrete is constantly concerned because of seismic, impact and explosion events in the service of constructions. As a classic device for testing the dynamic mechanical properties of materials, the splitting Hopkinson...

Preformed fragments can deform or even fracture when subjected to contact blasts, which might lead to a reduction of the terminal effect. Therefore, to solve this problem, the effect of surface electroplating on the fragment deformation behavior unde...

Forests play an irreplaceable role in preserving soil and water, as well as realizing carbon neutrality. However, logging and urban expansion have caused widespread forest fragmentation globally, resulting in biodiversity loss and carbon emissions. T...

Two isoforms of extracellular regulated kinase (ERK), namely ERK-1 and ERK-2, are associated with several cellular processes, the aberration of which leads to cancer. The ERK-1/2 inhibitors are thus considered as potential agents for cancer therapy....

Clusterin is one of the many known proteins implicated in cancer chemoresistance, which hinders the effectiveness of chemotherapy. This study aimed to design novel inhibitors targeting clusterin using fragment-based drug discovery (FBDD). This approa...

In this study, novel experimental total electron detachment cross sections for O₂⁻ collisions with benzene molecules are reported for the impact energy range (10–1000 eV), as measured with a transmission beam apparatus. By analysing the p...

Solution NMR spectroscopy is a powerful tool to study protein structures and dynamics under physiological conditions. This technique is particularly useful in target-based drug discovery projects as it provides protein-ligand binding information in s...

The Niger Delta Region is the largest river delta in Africa and features the fifth largest mangrove forest on Earth. It provides numerous ecosystem services to the local populations and holds a wealth of biodiversity. However, due to the oil and gas...

The pathogen of COVID-19, SARS-CoV-2, has caused a severe global health crisis. So far, while COVID-19 has been suppressed, the continuous evolution of SARS-CoV-2 variants has reduced the effectiveness of vaccines such as mRNA-1273 and drugs such as...

DNA carries the genetic information required for the synthesis of RNA and proteins and plays an important role in many processes of biological development. Understanding the three-dimensional (3D) structures and dynamics of DNA is crucial for underst...

Island ecosystems have distinct and unique vulnerabilities that place them at risk from threats to their ecology and socioeconomics. Spatially exhibiting the fragmentation process of island landscapes and identifying their driving factors are the fun...

Laser induced opening of the C₆₀ cage is studied by a semiclassical electron-radiation-ion dynamics technique. The simulation results indicate that the C₆₀ cage is abruptly opened immediately after laser excitation. The opening of the C₆₀ cage induce...

Habitat fragmentation is one of the most critical threats to species conservation, particularly for those with strict habitat preferences and specialized feeding and reproductive behaviors. In such cases, dispersal is essential for gene flow, playing...

Heat Shock Protein 70s (HSP70s) are key molecular chaperones that are overexpressed in many cancers and often associated with metastasis and poor prognosis. It has proven difficult to develop ATP-competitive, drug-like small molecule inhibitors of HS...

The dynamic properties of the heart differ based on the regions that effectively circulate blood throughout the body with each heartbeat. These properties, including the inter-beat interval (IBI) of autonomous beat activity, are retained even in in v...

There is an urgent need for a thorough assessment of forest landscape fragmentation to inform forest protection and restoration, and reforestation policies. However, there is currently a lack of an effective comprehensive index for forest landscape f...

The effect of different constitutive modelling choices is crucial under a high strain rate as encountered in ballistic applications. Natural fragmentation of explosively driven cylinder rings is chosen as a simplified example to describe the ability...

Monkeypox is a serious public health issue in tropical and subtropical areas. Antivirals that target monkeypox proteins might lead to more effective and efficient therapy. The F13 protein is essential for the growth and maturation of the monkeypox vi...

Fullerenes, such as C₆₀, are ideal systems to investigate energy redistribution following substantial excitation. Ultra-short and ultra-intense free electron lasers (FELs) have allowed molecular research in a new photon energy regime. FELs have allow...

In the following paper, we present the results of our studies on the interactions of the Aβ_1-42 peptide and its three short fragments, namely Aβ_5-16 (RHDSGYEVHHQK; HZ1), Aβ_8-13 (SGYEVH; HZ2), and Aβ_8-12 (SGYEV; HZ3) with selected...

Forest fragmentation and urban shrinkage have become the focus of attention in global ecological conservation, with the goal of achieving sustainable development. However, few studies have been concerned with urban forest patterns in shrinking cities...

Assessing the dynamics between native forests and exotic tree plantations is key to understanding the drivers of native forest transformation and conservation challenges. We examined these dynamics across four zones in the Los Ríos and Los Lag...

The spike protein is key to SARS-CoV-2 high infectivity because it facilitates the receptor binding domain (RBD) encounter with ACE2. As targeting subunit S1 has not yet delivered an ACE2-binding inhibitor, we have assessed the druggability of the co...

The search for anticancer drugs that target ferroptosis is a promising avenue of research. SLC7A11, a key protein involved in ferroptosis, has been identified as a potential target for drug development. Through screening efforts, novel inhibitors of...

Artificial reservoirs formed by hydroelectric dams are young ecosystems requiring water quality monitoring, as they often serve local populations. Traditionally, this is performed through hydrochemical and sanitary assessments, alongside phytoplankto...

The dopamine D4 receptor (D4R) is a promising therapeutic target in widespread diseases, and the search for novel agonists and antagonists appears to be clinically relevant. The mechanism of binding to the receptor (R) for antagonists and agonists va...

Infection of hosts by morbilliviruses is facilitated by the interaction between viral hemagglutinin (H-protein) and the signaling lymphocytic activation molecule (SLAM). Recently, the functional importance of the n-terminal region of human SLAM as a...