This paper presents an image-processing technique for cabin delivery employing local localization and docking in a mobile station, which is a mobile vertiport for the use of dual-mode flying cars. A dual-mode flying automobile with an aerial electric...
The clinical success of chimeric antigen receptor (CAR) T cell immunotherapy in the treatment of haematological cancers has encouraged the extensive development of CAR design to improve their function and increase their applicability. Advancements in...
The Reverse Chimeric Antigen Receptor (RevCAR) system is an adapter CAR T cell technology that allows the precise tuning of T cell activity and, thus, improved safety management. RevCAR T cells recognize and eradicate tumor cells via a bispecific ada...
In order to improve the yaw stability of a front-wheel dual-motor-driven driverless vehicle, a yaw stability control strategy is proposed for a front-wheel dual-motor-driven formula student driverless racing car. A hierarchical control structure is a...
Single-targeted chimeric antigen receptor (CAR) T cells tremendously improve outcomes for patients with relapsed/refractory hematological malignancies and are considered a breakthrough therapy. However, over half of treated patients experience relaps...
Chimeric antigen receptor (CAR)-T cell-based therapies have achieved substantial success against B-cell malignancies, which has led to a growing scientific and clinical interest in extending their use to solid cancers. However, results for solid tumo...
Leukemia is a prevalent pediatric cancer with significant challenges, particularly in relapsed or refractory cases. Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a personalized cancer treatment, modifying patients’ T cells to...
In the last decade, anti-CD19 CAR-T cell therapy has led to a treatment paradigm shift for B-cell non-Hodgkin lymphomas, first with the approval for relapsed/refractory (R/R) large B-cell lymphomas and subsequently for R/R mantle cell and follicular...
Novel therapeutic approaches against ovarian cancer (OC) are urgently needed because of its high rate of recurrence even after extensive surgery and multi-agent chemotherapy. We aimed to develop a novel anti-CD24 chimeric antigen receptor (CAR) as an...
A friction-driven forestry electric monorail car based on a wheel hub motor is designed with the aim of solving the problems of the low transportation capacity, low running speed, large turning radius, and poor stability of low-slope mountain forestr...
Nowadays, hybrid electric vehicles represent one of the main solutions for the reduction of greenhouse gases in the automotive sector. Alongside the reduction of CO2, hybrid electric vehicles serve as a strong alternative on drivability and performan...
Recent clinical trials have shown that adoptive chimeric antigen receptor (CAR) T cell therapy is a very potent and possibly curative option in the treatment of B cell leukemias and lymphomas. However, targeting a single antigen may not be sufficient...
The national targets of reaching carbon peak in 2030 and carbon neutrality in 2060 propose higher requirements for energy conservation and emission reduction of China’s automobile industry. As an important measure for the government, the fuel consump...
Several immune checkpoint molecules and immune targets in leukemic cells have been investigated. Recent studies have suggested the potential clinical benefits of immuno-oncology (IO) therapy against acute myeloid leukemia (AML), especially targeting...
6 July 2021
The large sales volume and a great number of passenger car ownership in China have brought a series of environmental and energy problems. In response to these problems, Corporate Average Fuel Consumption and New Energy Vehicle Dual-credit Regulation...
The utilization of “green” hydrogen in transportation areas gives rise to production- and supply infrastructure-related challenges; therefore, its wider application in automotive transport would lead to higher demand with cost reduction a...
In the last few decades, chimeric antigen receptor (CAR) T-cell therapy has led to a paradigm shift in the treatment of hematological malignancies, including various subtypes of B-cell non-Hodgkin’s lymphoma, B-cell acute lymphoblastic leukemia...
Signaling Lymphocyte Activation Molecule Family member 7 (SLAMF7) represents a potential target for CAR T-cell therapy in the treatment of multiple myeloma (MM), and it is a promising alternative to classic BCMA-CAR therapy. The receptor is expressed...
NKG2D is an activating receptor of natural killer cells that recognizes stress-induced ligands (NKG2DL) expressed by many tumor cells. Nevertheless, NKG2DL downregulation or shedding can still allow cancer cells to evade immune surveillance. Here, we...
The decrease of emissions from vehicle operation is connected mainly to the reduction of the car’s body weight. The high strength and good formability of the dual phase steel grades predetermine these to be used in the structural parts of the car’s b...
Chimeric antigen receptor (CAR) T-cell therapy has shown promising clinical impact against hematologic malignancies. CD19 is a marker on the surface of normal B cells as well as most B-cell malignancies, and thus has a role as an effective target for...
To ensure food safety and prevent the toxic effects of paclobutrazol (PBZ) and carbofuran (CAR) on humans, a sensitive and rapid method for the detection of PBZ and CAR in fruits and vegetables is required. Herein, a highly sensitive PBZ monoclonal a...
Chimeric antigen receptor (CAR) modified T cell therapy offers a targeted immunotherapeutic approach to patients with refractory hematological malignancies. This technology is most advanced in B cell malignancies and multiple myeloma and is rapidly e...
22 September 2023
CAR-T cell therapy involves genetically engineering T cells to recognize and attack tumour cells by adding a chimeric antigen receptor (CAR) to their surface. In this study, we have used dual transduction with AAV serotype 6 (AAV6) to integrate an an...
Visible/near-infrared spectroscopy is widely used for non-destructive fruit quality detection, but the high cost of spectrometers (400–1100 nm range) in sorting equipment limits its accessibility. This study proposes a dual-channel co-spectrosc...
The large majority of electric cars have a single-speed gearbox, because electrified powertrains provide maximal power across a wide operating range, and single-speed simplifies construction and reduces capital costs. Nevertheless, multi-speed transm...
In this study, a novel and simple strategy is proposed based on 3D network formed by easily blending polysaccharide carrageenan (Car) and fucoidan (Fuc) without a crosslinker. The Fuc/Car dual coating effectively assists the self-assembly of soy prot...
To improve the upright balancing performance of the two-wheeled self-balancing car, this paper proposes an attitude estimation algorithm based on fuzzy Kalman filtering. Fuzzy logic is used to correct the inclination angle and angular velocity of the...
Chimeric antigen receptor (CAR) gene-modified T cells (CAR T cells) can eradicate B cell malignancies via recognition of surface-expressed B lineage antigens. Antigen escape remains a major mechanism of relapse and is a key barrier for expanding the...
The metabolic milieu of solid tumors provides a barrier to chimeric antigen receptor (CAR) T-cell therapies. Excessive lactate or hypoxia suppresses T-cell growth, through mechanisms including NADH buildup and the depletion of oxidized metabolites. N...
The implementation of the dual-credit policy has had a significant impact on the development of new energy vehicles. Considering the background of the dual-credit policy, this paper examines the concept that demand is influenced by price, consumer lo...
CD19CAR T cells facilitate a transformational treatment in various relapsed and refractory aggressive B-lineage cancers. In general, encouraging response rates have been observed in B-lineage-derived non-Hodgkin’s lymphomas treated with CD19CAR...
Adoptive cell therapies have transformed the treatment landscape for hematologic malignancies. Yet, translation to solid tumors remains constrained by antigen heterogeneity, an immunosuppressive tumor microenvironment (TME), and poor persistence of c...
Faced with the current situation of high rates of microbial resistance, together with the scarcity of new antibiotics, it is necessary to search for and identify new antimicrobials, preferably natural, to alleviate this situation. The aim of this wor...
Chimeric antigen receptor-engineered mesenchymal stem cells (CAR-MSCs) represent a novel and highly adaptable platform for the targeted treatment of inflammatory and autoimmune diseases. By integrating the inflammation-homing and immunomodulatory pro...
In this paper, a variable gear ratio for active steering systems with a double planetary gear configuration is presented to optimize the steering performance of commercial vehicles. First, a variable transmission ratio system with a dual-row planetar...
Patients with metastatic melanoma have a historically poor prognosis, but recent advances in treatment options, including targeted therapy and immunotherapy, have drastically improved the outcomes for some of these patients. However, not all patients...
Recent times have witnessed remarkable progress in cancer immunotherapy, drastically changing the cancer treatment landscape. Among the various immunotherapeutic approaches, adoptive cell therapy (ACT), particularly chimeric antigen receptor (CAR) T...
Introduction: Treatment of relapsed and refractory (R/R) B acute lymphoblastic leukemia (B-ALL) represents an unmet medical need in children and adults. Adoptive T cells engineered to express a chimeric antigen receptor (CAR-T) is emerging as an effe...
In this paper, we extended the Hamy mean (HM) operator, the Dombi Hamy mean (DHM) operator, the Dombi dual Hamy mean (DDHM), with the intuitionistic fuzzy numbers (IFNs) to propose the intuitionistic fuzzy Dombi Hamy mean (IFDHM) operator, intuitioni...
Acute myeloid leukemia (AML) is a heterogeneous and aggressive hematologic malignancy with poor prognosis despite multiple available therapies. While chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of B-cell malignancies,...
In order to achieve the safe and efficient navigation of mobile robots, it is essential to consider both the environmental geometry and kinodynamic constraints of robots. We propose a trajectory planner for car-like robots on the basis of the Dual-Tr...
The current study aimed to produce a material that has dual effects of healing and anti-inflammatory activity. For this purpose, a κ-carrageenan/polyacrylamide film loaded with cetrimide (κ-CAR/PAAm/CI) was developed using the manual cast...
Chimeric antigen receptor (CAR)-T and T-cell receptor (TCR)-engineered T-cell (TCR-T) therapies have revolutionized the treatment of hematological malignancies; however, their application to solid tumors remains a formidable challenge. The immunosupp...
Promoter choice is an essential consideration for transgene expression in gene therapy. The expression of multiple genes requires ribosomal entry or skip sites, or the use of multiple promoters. Promoter systems comprised of two separate, divergent p...
The configuration under investigation consists of a car and a trailer connected by a coupling mechanism at a hinge point. Due to the dual-unit design, car–trailer combinations are prone to poor lateral stability at high speeds, often resulting...
Despite the improvement in survival outcomes, multiple myeloma (MM) remains an incurable disease. Chimeric antigen receptor (CAR) T-cell therapy targeting B-cell maturation antigen (BCMA) represents a new strategy for the treatment of relapsed/refrac...
The application of vehicle-to-everything (V2X) technology has resulted in the traffic environment being different from how it was in the past. In the V2X environment, the information perception ability of the driver–vehicle unit is greatly enha...
Chimeric antigen receptor (CAR) T-cell therapy has brought hope for patients with cancer and showed promising results and a high cure rate in various types of hematological malignancies. However, cellular therapy can lead to profound immunodeficiency...
Background: Chimeric Antigen Receptor (CAR) T-cell therapy has transformed the treatment of hematological malignancies, yet its application in solid tumors remains constrained by unique biological and logistical barriers. Objective: This review criti...
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