Next Article in Journal
Control of Arms of Au Stars Size and its Dependent Cytotoxicity and Photosensitizer Effects in Photothermal Anticancer Therapy
Previous Article in Journal
Effects of Membrane and Biological Target on the Structural and Allosteric Properties of Recoverin: A Computational Approach
Previous Article in Special Issue
The SUMO Pathway in Hematomalignancies and Their Response to Therapies
Open AccessReview

Resistance Mechanisms to CAR T-Cell Therapy and Overcoming Strategy in B-Cell Hematologic Malignancies

Department of Hemato-Oncology, Hanyang University Hanmaeum Changwon Hospital, Changwon 51497, Korea
Division of Hematology-Oncology, Department of Internal Medicine, Hanyang University College of Medicine, Hanyang University Seoul Hospital, Seoul 04763, Korea
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5010;
Received: 24 August 2019 / Revised: 3 October 2019 / Accepted: 9 October 2019 / Published: 10 October 2019
(This article belongs to the Special Issue Drug Resistance in Hematologic Malignancies)
Chimeric antigen receptor (CAR) T-cell therapy has shown promising clinical impact against hematologic malignancies. CD19 is a marker on the surface of normal B cells as well as most B-cell malignancies, and thus has a role as an effective target for CAR T-cell therapy. In numerous clinical data, successes with cell therapy have provided anticancer therapy as a potential therapeutic option for patients who are resistant to standard chemotherapies. However, recent growing evidence showed the limitations of the treatment such as antigen-positive relapse due to poor CAR T-cell persistence and antigen-negative relapses associated with CAR-driven mutations, alternative splicing, epitope masking, low antigen density, and lineage switching. The understanding of the resistance mechanisms to the cell therapy has developed novel potential treatment strategies, including dual-targeting therapy (dual and tandem CAR), and armored and universal CAR T-cell therapies. In this review, we provide an overview of resistance mechanisms to CD19 CAR T-cell therapy in B-cell malignancies and also review therapeutic strategies to overcome these resistances. View Full-Text
Keywords: CAR T-cell; drug resistance; B cell hematologic malignancies CAR T-cell; drug resistance; B cell hematologic malignancies
Show Figures

Figure 1

MDPI and ACS Style

Song, M.-K.; Park, B.-B.; Uhm, J.-E. Resistance Mechanisms to CAR T-Cell Therapy and Overcoming Strategy in B-Cell Hematologic Malignancies. Int. J. Mol. Sci. 2019, 20, 5010.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop