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26 Results Found

  • Article
  • Open Access
765 Views
19 Pages

Dillapiole Dampens the Expression of the Major Virulence Genes of Francisella tularensis

  • Elliot M. Collins,
  • Anthony Sako,
  • Kristen Sikorsky,
  • James Denvir,
  • Jun Fan,
  • Donald A. Primerano,
  • Deanna M. Schmitt,
  • Stuart Cantlay,
  • Roger Seeber and
  • Joseph Horzempa
  • + 1 author

6 October 2025

Francisella tularensis is a pathogenic bacterium and the causative agent of the disease tularemia. Because of the virulence of this bacterium and the potential for weaponization, the Centers for Disease Control and Prevention (CDC) has classified F....

  • Article
  • Open Access
11 Citations
6,315 Views
15 Pages

13 June 2014

We examined the cytotoxic effects of dillapiole, a phenylpropanoid with antileishmanial, anti-inflammatory, antifungal, and acaricidal activities, on the blastocyst stage of mouse embryos, subsequent embryonic attachment and outgrowth in vitro, and i...

  • Article
  • Open Access
41 Citations
10,282 Views
11 Pages

Dillapiole, Isolated from Peperomia pellucida, Shows Gastroprotector Activity against Ethanol-Induced Gastric Lesions in Wistar Rats

  • Raúl Rojas-Martínez,
  • Jesús Arrieta,
  • Leticia Cruz-Antonio,
  • Daniel Arrieta-Baez,
  • Antonio Magdiel Velázquez-Méndez and
  • María Elena Sánchez-Mendoza

13 September 2013

Peperomia pellucida is a plant used in traditional medicine to treat gastric ulcers. Although this gastroprotective activity was reported, the active compounds have not been identified. Therefore, the aim herein was to identify the most active compou...

  • Article
  • Open Access
7 Citations
3,233 Views
16 Pages

14 July 2023

Agastache urticifolia (Benth.) Kuntze (horsemint), Achillea millefolium L. (yarrow), and Perideridia gairdneri (Hook. & Arn.) Mathias (yampah) are native, culturally important plants that grow in the subalpine meadows of Montana. Analysis of the...

  • Article
  • Open Access
15 Citations
4,193 Views
20 Pages

Piper aduncum Essential Oil Rich in Dillapiole: Development of Hydrogel-Thickened Nanoemulsion and Nanostructured Lipid Carrier Intended for Skin Delivery

  • Simone Braga Carneiro,
  • Tainá Kreutz,
  • Renata Pereira Limberger,
  • Helder Ferreira Teixeira,
  • Valdir Florêncio da Veiga Júnior and
  • Letícia Scherer Koester

The essential oil extracted from the leaves of Piper aduncum, an aromatic plant from the Amazon region, is rich in dillapiole and presents anti-inflammatory activity. In this study, nanoemulsions (NE) and nanostructured lipid carriers (NLC), which ar...

  • Article
  • Open Access
1 Citations
1,052 Views
18 Pages

Oviposition Deterrence and Larvicidal Activity of Propyl Ether Dillapiole and Piperidyl Dillapiole Against Aedes (Stegomyia) aegypti (Diptera: Culicidae)

  • Junielson Soares da Silva,
  • Ana Cristina da Silva Pinto,
  • Samara Silva de Souza,
  • Francisco Célio Maia Chaves,
  • Sabrina da Fonseca Meireles,
  • Rosalina Pinheiro Pereira,
  • Rosemary Aparecida Roque,
  • João Marcelo de Castro e Sousa and
  • Míriam Silva Rafael

8 April 2025

The study of substances of botanical origin is fundamental for the development of new effective alternatives for the control of Aedes (Stegomyia) aegypti (Culicidae), a vector of arboviruses in humans. In this study, the potential of two new dillapio...

  • Article
  • Open Access
12 Citations
2,950 Views
11 Pages

Synergism in Two-Component Insecticides with Dillapiole against Fall Armyworm

  • Murilo Fazolin,
  • Humberto R. Bizzo,
  • André F. M. Monteiro,
  • Maria E. C. Lima,
  • Natália S. Maisforte and
  • Paola E. Gama

24 August 2023

The fall armyworm (Spodoptera frugiperda), a polyphagous insect pest, is a major threat to food production, rapidly spreading through all the tropical areas in the world. Resistance has developed to the control protocols used so far (pyrethroids, org...

  • Article
  • Open Access
7 Citations
3,333 Views
15 Pages

Effects of Piper aduncum (Piperales: Piperaceae) Essential Oil and Its Main Component Dillapiole on Detoxifying Enzymes and Acetylcholinesterase Activity of Amblyomma sculptum (Acari: Ixodidae)

  • Adalberto Alves Pereira Filho,
  • Vladimir Fazito do Vale,
  • Caio Marcio de Oliveira Monteiro,
  • Mayara Macedo Barrozo,
  • Mariana Alves Stanton,
  • Lydia Fumiko Yamaguchi,
  • Massuo Jorge Kato and
  • Ricardo Nascimento Araújo

Amblyomma sculptum is a species of tick in the family Ixodidae, with equids and capybaras among its preferred hosts. In this study, the acaricidal activity of the essential oil (EO) from Piper aduncum and its main component, Dillapiole, were evaluate...

  • Article
  • Open Access
7 Citations
1,850 Views
17 Pages

Variability in Crithmum maritimum L. Essential Oils’ Chemical Composition: PCA Analysis, Food Safety, and Sustainability

  • Antonella Porrello,
  • Alessandro Vaglica,
  • Dario Savoca,
  • Maurizio Bruno and
  • Francesco Sottile

20 March 2024

In this study, four accessions of Crithmum maritimum L., not previously studied, collected in Isola delle Femmine (Italy) (S43), Croatia (S44), Montenegro (S45), and Israel (S46) were investigated. The volatile profile of essential oils was evaluated...

  • Article
  • Open Access
9 Citations
2,560 Views
22 Pages

Considering the COVID-19 pandemic, this research aims to investigate some herbs as probable therapies for this disease. Achillea millefolium (Yarrow), Alkanet, Rumex patientia (Patience dock), Dill, Tarragon, and sweet fennel, including some principa...

  • Article
  • Open Access
624 Views
12 Pages

Chemical Composition and Selective Bioactivities of Piper platylobum Sodiro Essential Oil

  • Jairo Jaime-Carvajal,
  • Nicole Pesántez,
  • José Ballesteros,
  • Vladimir Morocho and
  • Omar Malagón

27 October 2025

Essential oils from the genus Piper are recognized for their chemical diversity and biological potential, yet Piper platylobum has been scarcely investigated. This study aimed to characterize the chemical composition of the leaf essential oil of P. p...

  • Article
  • Open Access
2 Citations
2,991 Views
13 Pages

Diversity of Crithmum maritimum L. from Salento Coastal Area: A Suitable Species for Domestication

  • Rita Accogli,
  • Eliana Nutricati,
  • Luigi De Bellis,
  • Massimiliano Renna,
  • Andrea Luvisi and
  • Carmine Negro

Crithmum maritimum L., known as sea fennel, is an aromatic halophyte typical of the cliffs and coastal areas of the Mediterranean Sea and Atlantic Ocean. Their phytochemicals have been of great interest in the food and pharmaceutical industry. In thi...

  • Article
  • Open Access
7 Citations
2,506 Views
23 Pages

12 April 2024

The repellent capacity against Sitophilus zeamais and the in vitro inhibition on AChE of 11 essential oils, isolated from six plants of the northern region of Colombia, were assessed using a modified tunnel-type device and the Ellman colorimetric met...

  • Article
  • Open Access
17 Citations
2,704 Views
15 Pages

Volatiles from French and Croatian Sea Fennel Ecotypes: Chemical Profiles and the Antioxidant, Antimicrobial and Antiageing Activity of Essential Oils and Hydrolates

  • Olivera Politeo,
  • Pavao Ćurlin,
  • Petra Brzović,
  • Killian Auzende,
  • Christian Magné and
  • Ivana Generalić Mekinić

24 February 2024

Sea fennel is a halophytic plant rich in valuable nutritional components and is characterized by pleasant organoleptic properties. While its essential oils (EOs) are well investigated, there are no reports on the volatiles from their corresponding hy...

  • Article
  • Open Access
12 Citations
5,687 Views
18 Pages

Isolation and Characterization of Phenylpropanoid and Lignan Compounds from Peperomia pellucida [L.] Kunth with Estrogenic Activities

  • I Gusti Agung Ayu Kartika,
  • In Jae Bang,
  • Catur Riani,
  • Muhamad Insanu,
  • Jong Hwan Kwak,
  • Kyu Hyuck Chung and
  • I Ketut Adnyana

23 October 2020

Extracts of Peperomia pellucida [L.] Kunth have previously been demonstrated to have in vivo estrogenic-like effects, thereby functioning as an anti-osteoporotic agent. However, the compounds responsible for these effects have not yet been determined...

  • Article
  • Open Access
5 Citations
3,089 Views
10 Pages

In Vitro Activity of Essential Oils from Piper Species (Piperaceae) against Tachyzoites of Toxoplasma gondii

  • Adalberto Alves Pereira Filho,
  • Mariana Maciel Cunha,
  • Mariana Alves Stanton,
  • Lydia Fumiko Yamaguchi,
  • Massuo Jorge Kato and
  • Érica S. Martins-Duarte

6 January 2023

Toxoplasmosis is a tropical and neglected disease caused by the parasitic protozoa Toxplasma gondii. Conventional treatment with sulfadiazine and pyrimethamine plus folinic acid, has some drawbacks, such as inefficacy in the chronic phase, toxic side...

  • Article
  • Open Access
7 Citations
4,687 Views
18 Pages

1 May 2020

Phenylpropanoid volatile components in plants are useful and valuable not only as flavorings, but also as medicines and food supplements. The pharmacological actions and toxicities of these compounds have been well studied but their synthetic pathway...

  • Article
  • Open Access
9 Citations
4,198 Views
18 Pages

Ontogenetic Changes in the Chemical Profiles of Piper Species

  • Anderson Melo Gaia,
  • Lydia Fumiko Yamaguchi,
  • Camilo Guerrero-Perilla and
  • Massuo Jorge Kato

28 May 2021

The chemical composition of seedlings and adult plants of several Piper species were analyzed by 1H NMR spectroscopy combined with principal component analysis (PCA) and HPLC-DAD, HPLC-HRESIMS and GC-MS data. The chromatographic profile of crude extr...

  • Systematic Review
  • Open Access
1,122 Views
26 Pages

Essential Oils and Bioproducts for Flea Control: A Critical Review

  • Diefrey Ribeiro Campos,
  • Ingrid Lins Raquel de Jesus,
  • Fabio Barbour Scott,
  • Thais Ribeiro Correia and
  • Yara Peluso Cid

16 December 2025

Fleas have major veterinary and public health relevance by causing dermatopathies and transmitting zoonotic agents. The limitations and environmental impact of synthetic insecticides have driven the search for safer and more sustainable tick control...

  • Article
  • Open Access
6 Citations
3,493 Views
16 Pages

Deverra triradiata Hochst. ex Boiss. from the Northern Region of Saudi Arabia: Essential Oil Profiling, Plant Extracts and Biological Activities

  • Arbi Guetat,
  • Abdelrahman T. Abdelwahab,
  • Yassine Yahia,
  • Wafa Rhimi,
  • A. Khuzaim Alzahrani,
  • Abdennacer Boulila,
  • Claudia Cafarchia and
  • Mohamed Boussaid

9 June 2022

Devrra triradiata Hochst. ex Boiss is an occasional plant species in the Northern region of Saudi Arabia. The shrub is favored on sandy desert wadis, gypsaceous substrate, and sandy gravel desert. In folk medicine, the plant is used for many purposes...

  • Article
  • Open Access
1,511 Views
21 Pages

13 August 2025

Moniliophthora roreri, the causal agent of moniliasis, severely affects cacao production in Latin America, and sustainable control alternatives remain limited. This study aimed to evaluate the antifungal potential of essential oils (EOs) from Piper s...

  • Article
  • Open Access
9 Citations
4,124 Views
11 Pages

Anticariogenic Activity of Three Essential Oils from Brazilian Piperaceae

  • Êni S. Carvalho,
  • Vanessa F. S. Ayres,
  • Midiã R. Oliveira,
  • Geone M. Corrêa,
  • Renata Takeara,
  • Anderson C. Guimarães,
  • Mariana B. Santiago,
  • Thaís A. S. Oliveira,
  • Carlos H. G. Martins and
  • Eliane O. Silva
  • + 1 author

6 August 2022

The current trend toward using natural food additives, cosmetics, and medicines has motivated industries to substitute synthetic compounds for natural products. Essential oils (EOs) from medicinal plants are a well-known source of chemical compounds...

  • Article
  • Open Access
3 Citations
2,861 Views
14 Pages

Crithmum maritimum L.—Study on the Histochemical Localization of Essential Oil

  • Velina Dzhoglova,
  • Kalin Ivanov,
  • Niko Benbassat,
  • Yoana Georgieva-Dimova,
  • Rayna Ardasheva,
  • Diana Karcheva-Bahchevanska and
  • Stanislava Ivanova

17 February 2024

Crithmum maritimum L. is a perennial halophyte plant that is a medicinal herb known by people from different cultures since ancient times. However, the therapeutic potential of this halophyte has not been completely investigated, and the scientific d...

  • Article
  • Open Access
2 Citations
2,177 Views
20 Pages

Triphenylphosphine Derivatives of Allylbenzenes Express Antitumor and Adjuvant Activity When Solubilized with Cyclodextrin-Based Formulations

  • Igor D. Zlotnikov,
  • Sergey S. Krylov,
  • Marina N. Semenova,
  • Victor V. Semenov and
  • Elena V. Kudryashova

26 November 2023

Allylbenzenes (apiol, dillapiol, myristicin and allyltetramethoxybenzene) are individual components of plant essential oils that demonstrate antitumor activity and can enhance the antitumor activity of cytotoxic drugs, such as paclitaxel, doxorubicin...

  • Article
  • Open Access
23 Citations
6,855 Views
22 Pages

Phenolics and Volatile Compounds of Fennel (Foeniculum vulgare) Seeds and Their Sprouts Prevent Oxidative DNA Damage and Ameliorates CCl4-Induced Hepatotoxicity and Oxidative Stress in Rats

  • Hassan Barakat,
  • Ibrahim Ali Alkabeer,
  • Thamer Aljutaily,
  • Mona S. Almujaydil,
  • Reham M. Algheshairy,
  • Raghad M. Alhomaid,
  • Abdulkarim S. Almutairi and
  • Ahmed Mohamed

23 November 2022

Researchers recently focused on studying the nutritional and functional qualities of sprouts generated from seeds. The current study investigated the total phenolic content (TPC), total flavonoids (TF), total flavonols (TFL), antioxidant activity (AO...

  • Article
  • Open Access
2 Citations
1,774 Views
28 Pages

New Derivatives of Chalcones, Chromenes, and Stilbenoids, Complexed with Methyl-β-Cyclodextrin with Antioxidant Properties and Antibacterial Synergism with Antibiotics

  • Igor D. Zlotnikov,
  • Sergey S. Krylov,
  • Natalya G. Belogurova,
  • Alexander N. Blinnikov,
  • Victor E. Kalugin and
  • Elena V. Kudryashova

13 December 2024

Cyclodextrins (CDs) are natural cyclic oligosaccharides with the ability to form inclusion complexes with various organic substances. In this paper, we investigate the potential of CD complex formation to enhance the antibacterial activity and antiox...