Next Article in Journal
Anticancer and Antifungal Compounds from Aspergillus, Penicillium and Other Filamentous Fungi
Previous Article in Journal
Revealing the Properties of Plant Defensins through Dynamics
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(9), 11327-11337;

Dillapiole, Isolated from Peperomia pellucida, Shows Gastroprotector Activity against Ethanol-Induced Gastric Lesions in Wistar Rats

Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Santo Tomás, Delegación Miguel Hidalgo, México D.F., 11340, Mexico
Facultad de Estudios Superiores Zaragoza, UNAM, Batalla del 5 de Mayo Esquina Fuerte de Loreto, Ejército de Oriente, México D.F., 09230, Mexico
Centro de Nanociencias y Micro y Nanotecnologías del Instituto Politécnico Nacional, Unidad Profesional Adolfo López Mateos, Luis Enrique Erro S/N, Zacatenco, México D.F., 07738, Mexico
Universidad Tecnológica de la Selva, Entronque Toniná Carretera Ocosingo-Altamirano, Ocosingo, Estado de Chiapas, 29950, Mexico
Author to whom correspondence should be addressed.
Received: 15 July 2013 / Revised: 4 September 2013 / Accepted: 10 September 2013 / Published: 13 September 2013
Full-Text   |   PDF [221 KB, uploaded 18 June 2014]   |  


Peperomia pellucida is a plant used in traditional medicine to treat gastric ulcers. Although this gastroprotective activity was reported, the active compounds have not been identified. Therefore, the aim herein was to identify the most active compound in the gastroprotective activity of P. pellucida using an ethanol-induced gastric ulcer experimental rat model. A gastroprotective effect was observed when the hexane and dichloromethane extracts were tested, with the higher effect being obtained with the dichloromethane extract (82.3 ± 5.6%) at 100 mg/kg. Dillapiole was identified as the most active compound in this extract. Although there have been previous reports on dillapiole, this is the first on its gastroprotective activity. Rats treated with this compound at 3, 10, 30 and 100 mg/kg showed 23.1, 56.1, 73.2 and 85.5% gastroprotection, respectively. The effect elicited by dillapiole at 100 mg/kg was not attenuated by pretreatment with indomethacin (10 mg/kg, s.c.), a prostaglandin synthesis blocker, NG-nitro-l-arginine methyl ester (70 mg/kg, i.p.), a nitric oxide (NO) synthase inhibitor, or N-ethylmaleimide (10 mg/kg, s.c.), a blocker of sulfhydryl groups. This suggests that the gastroprotective mechanism of action of dillapiole does not involve prostaglandins, NO or sulfhydryl groups. View Full-Text
Keywords: Peperomia pellucida; dillapiole; gastroprotection; medicinal plants Peperomia pellucida; dillapiole; gastroprotection; medicinal plants

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Rojas-Martínez, R.; Arrieta, J.; Cruz-Antonio, L.; Arrieta-Baez, D.; Velázquez-Méndez, A.M.; Sánchez-Mendoza, M.E. Dillapiole, Isolated from Peperomia pellucida, Shows Gastroprotector Activity against Ethanol-Induced Gastric Lesions in Wistar Rats. Molecules 2013, 18, 11327-11337.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top