The strategic relevance of innovation and scientific research has amplified the attention towards the definition of quality in research practice. However, despite the proliferation of evaluation metrics and procedures, there is a need to go beyond bi...
Public open spaces have recently attracted significant attention in the national development programs aimed at improving urban livability and quality of life in Saudi Arabia. While many studies have examined the design quality of public open spaces i...
A robust manufacturing process and the relationship between intermediate quality attributes (IQAs), critical quality attributes (CQAs), and critical process parameters (CPPs) for high-shear wet granulation was determined in this study. Based on quali...
Buildings exert a profound influence on the environment, with the design phase recognized as the pivotal determinant of a building’s overall performance. Green building design, in particular, introduces heightened complexity, where the attribut...
Hydrogel-based drug delivery systems are of interest to researchers for many reasons, such as biocompatibility, high diversity, and the possibility of administration from different routes. Despite these advantages, there are challenges, such as contr...
Extrusion-based 3D-printing is an easy-to-use, cheap manufacturing technique that could be used to produce tailored precision medicines. The technique has an almost unlimited versatility since a multitude of print parameters can easily be adapted. Un...
In recent years, the “quality by design” (QbD) approach has been used for developing pharmaceutical formulations. This is particularly important for complex dosage forms such as topical semisolid products. The first step for developing a...
Mucoadhesive buccal films have found increased popularity in pharmaceutical drug delivery due to the several advantages that they possess. The present study strives to develop and optimize chitosan-based mucoadhesive buccal films by relying on qualit...
The Process Analytical Technology initiative and Quality by Design paradigm have led to changes in the guidelines and views of how to develop drug manufacturing processes. On this occasion the concept of the design space, which describes the impact o...
Although various quality by design (QbD) approaches have been used to establish a design space to obtain robust drug formulation and process parameters, the effect of excipient variability on the design space and drug product quality is unclear. In t...
Background/Objectives: Traditional Quality by Testing (QbT) strategies rely heavily on end-product testing and offer limited insight into how critical process parameters (CPPs) influence product quality. This increases the risk of variability and inc...
In this study, we developed a control strategy for a drug product prepared by high-shear wet granulation and roller compaction using integrated quality by design (QbD). During the first and second stages, we optimized the process parameters through t...
The present article exemplifies the application of the concept of quality by design (QbD) for the systematic development of a nanoparticulate imiquimod (IMQ) emulsion gel formulation as an investigational medicinal product (IMP) for evaluation in an...
Various frameworks and methods, such as quality by design (QbD), real time release test (RTRT), and continuous process verification (CPV), have been introduced to improve drug product quality in the pharmaceutical industry. The methods recognize that...
In the past several decades, polymeric microparticles (MPs) have emerged as viable solutions to address the limitations of standard pharmaceuticals and their corresponding delivery methods. While there are many preclinical studies that utilize polyme...
Drug nanocrystals are nanosized solid drug particles, the most important application of which is the improvement of solubility properties of poorly soluble drug materials. Drug nanocrystals can be produced by many different techniques, but the mostly...
Hydrophobic ion pairing (HIP) complexation was found to be an efficient approach in modulating the release and enhancing the stability and encapsulation of hydrophilic macromolecules such as proteins in hydrophobic nano/microcarriers. The present wor...
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The purpose of the present study was to identify the customer requirements and engineering attribute expectations of an innovative product to which a Kano’s model and quality function deployment (QFD) analysis was applied. In order to accomplis...
High-quality concept design is a key factor of successful product performance and efficiency. Conventional conceptual design morphological chart serves to combine product concept designs. Nevertheless, the huge number of combined concept designs and...
The design characteristics of urban parks’ pathways are important in facilitating leisure walking and maintaining the minimum rate of physical activity, thus improving public health. This study examined and explored the relationships between de...
Topical corticosteroids are used to treat a variety of skin conditions such as allergic reactions, eczema, and psoriasis. Niosomes are a novel surfactant-based delivery system that may be used to deliver desoximetasone via topical product application...
Lamivudine (3TC) and zidovudine (AZT) are antiretroviral agents used to manage HIV/AIDS infection. A wet media milling top-down approach was used to develop and produce nano co-crystals of 3TC and AZT. Micro co-crystals were prepared by solvent evapo...
The current studies entail quality by design (QbD)-enabled development of a simple, rapid, precise, accurate, and cost-effective high-performance liquid chromatographic method for estimation of metformin hydrochloride (M-HCl). Design of experiments (...
Applications of analytical quality by design (QbD) approach for developing HPLC (High Performance Liquid Chromatography) methods for food components assays, and separations of complex natural product mixtures, are still limited. The current study dev...
The goal of this study was to apply the principles of analytical quality by design (AQbD) to the analytical method for determining the radiochemical purity (PQR) of the radiopharmaceutical sodium iodide 131I oral solution, utilizing thin-layer chroma...
Background: The ever-growing emergence of antibiotic resistance associated with tuberculosis (TB) has become a global challenge. In 2012, the USFDA gave expedited approval to bedaquiline (BDQ) as a new treatment for drug-resistant TB in adults when n...
Low aqueous solubility and poor oral bioavailability are limiting factors in the oral delivery of voxelotor, an antisickling agent. To overcome these limitations, a voxelotor self-nanoemulsifying drug delivery system was developed. Various oils, surf...
A better understanding of passenger perceived quality helps urban rail transit managers adopt better strategies to improve the service quality of urban rail transit, which is beneficial to the sustainable development of an urban rail transit system i...
Nanoparticles can be used as drug carriers in various applications (e.g., in pulmonary drug delivery and mucosal vaccination). For further investigations, such as drug release studies, as well as for cell and tissue targeting, particles with defined...
Background/Objectives: Quality-by-Design (QbD) is a proactive, risk-based, regulatory-endorsed approach to the development and manufacture of medicinal products but is rarely applied to medicines compounded by pharmacists. This study aims to apply th...
The Electronic Health Record (EHR) has brought numerous challenges since its inception that have prevented a unified implementation from being carried out in Colombia. Within these challenges, we find a lack of security, auditability, and interoperab...
For intensified global environmental and societal challenges, the Sustainable Development Goals (SDGs) have come to the forefront as a pivotal framework for corresponding action. For SDGs, the role of commercial spatial design and planning gains uniq...
This research aimed to develop miconazole-based microemulsions using oleic acid as a natural lipophilic phase and a stabilizer mixture comprising Tween 20 and PEG 400 to solubilize miconazole as an antifungal agent known for its activity in oral cand...
As the leading platform of online education, MOOCs provide learners with rich course resources, but course designers are still faced with the challenge of how to accurately improve the quality of courses. Current research mainly focuses on learners&r...
The rapid development of information technology and the diffusion of Internet-only banks have made mobile banking an essential service in Korea. Meanwhile, the spread of non-face-to-face services triggered by the COVID-19 pandemic is encouraging cont...
Since the early 20th century, silviculturists have recognized the importance of planting seedlings with desirable attributes, and that these attributes are associated with successful seedling survival and growth after outplanting. Over the ensuing ce...
Kindergarten’s physical and social environment influences preschoolers’ physical activity (PA) and impacts their development. This study aimed first to describe the quality of the opportunities provided by the physical attributes and soci...
Household waste sorting at the source is an essential part of the waste management system in many countries. Correct sorting of this waste, including food packaging waste, is cost-effective, it facilitates the recycling process and enhances the quali...
Wet media milling is a fully industrialized technology for the manufacturing of drug nanocrystal suspensions. This work describes the development of an advanced control strategy and an associated design space for a manufacturing process at a commerci...
The development of efficient mass transit systems that provide quality of service is a major challenge for modern societies. To meet this challenge, it is essential to understand user demand. This article proposes using new time-dependent attributes...
In the recent consumer market, eyewear has gone beyond the improvement of visual function and is used for the individual style and the symbolization of social standing. Consequently, the aesthetic design of eyewear influences consumer purchasing deci...
Multi-domain image-to-image translation with the desired attributes is an important approach for modifying single or multiple attributes of a face image, but is still a challenging task in the computer vision field. Previous methods were based on eit...
Background: Experiential learning is a vital component of health-professional education. It provides students with the opportunity to apply their knowledge in real-life settings before becoming licensed practitioners. Preceptors (i.e., practice educa...
The purpose of this study was to apply the Quality by Design (QbD) approach to the electrospinning of fibres loaded with the nonsteroidal anti-inflammatory drugs (NSAIDs) indomethacin (INDO) and diclofenac sodium (DICLO). A Quality Target Product Pro...
Quality monitoring of manufacturing processes is a field where data analytics can thrive. The attributes of the data, denoted with the famous ‘7V’, can be used to potentially measure different aspects of the fact that data analytics may b...
Many industries are labor-intensive and energy- and resource-consuming. A sustainable development plan is necessary for the industries as industrial structures have been changing recently. Taiwan’s shoe industry also has experienced such changes and...
Various architectures can be applied in software design. The aim of this research is to examine a typical implementation of Jakarta EE monolithic and microservice software architectures in the context of software quality attributes. Software quality...
Indoor radon constitutes a public health issue in various regions across the United States as the second leading cause of lung cancer following tobacco smoke. The U.S. Environmental Protection Agency advises radon mitigation interventions for residen...
With the intensification of population aging and the increasing awareness of public health protection in the post-epidemic era, the renewal of the old urban community neighborhood space is facing many new challenges and problems. Neighborhood Public...
This work aims at providing the assumptions to assist the sustainable development of cream formulations. Specifically, it envisions to rationalize and predict the effect of formulation and process variability on a 1% hydrocortisone cream quality prof...
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