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566 Results Found

  • Article
  • Open Access
2 Citations
2,132 Views
21 Pages

This study examines the relationship between undergraduates’ learning environment perception, achievement goals, and the deep learning approach in a research-oriented Chinese university with a longitudinal mediation model. A total of 260 underg...

  • Article
  • Open Access
1 Citations
1,488 Views
16 Pages

30 August 2025

Background/Objectives: Drug discovery is a lengthy and expensive process, taking an average of 10 years and more than USD 2 billion from target discovery to drug approval. It is even more challenging in complex diseases due to disease heterogeneity a...

  • Article
  • Open Access
1 Citations
3,295 Views
14 Pages

15 March 2024

This article investigates how cultural context and theological ideas shape the integration of digital media in religious practices. Focusing on Poland and Northern Ireland/The Republic of Ireland, we explore the diverse strategies employed by religio...

  • Article
  • Open Access
3 Citations
2,735 Views
14 Pages

11 October 2024

CRISPR/Cas9 has been applied to edit the genome of various organisms, but our understanding of editing outcomes at specific sites after Cas9-mediated DNA cleavage is still limited. Several deep learning-based methods have been proposed for repair out...

  • Article
  • Open Access
5 Citations
4,349 Views
14 Pages

Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic Reprogramming

  • Byung Geun Ha,
  • Sung Suk Jung,
  • You Kyung Jang,
  • Byong Yeob Jeon and
  • Yun Hee Shon

27 October 2019

Metabolic disorders such as diabetes and obesity are serious global health issues. These diseases are accelerated by mineral deficiencies, emphasizing the importance of addressing these deficiencies in disease management plans. Lactate metabolism is...

  • Article
  • Open Access
12 Citations
3,587 Views
14 Pages

Mesenchymal Stem Cell-Mediated Deep Tumor Delivery of Gold Nanorod for Photothermal Therapy

  • Wan Su Yun,
  • Man Kyu Shim,
  • Seungho Lim,
  • Sukyung Song,
  • Jinseong Kim,
  • Suah Yang,
  • Hee Sook Hwang,
  • Mi Ra Kim,
  • Hong Yeol Yoon and
  • Dong-Kwon Lim
  • + 2 authors

28 September 2022

Gold nanoparticles (AuNPs) with various sizes and morphologies have been extensively investigated for effective photothermal therapy (PTT) against multiple cancer types. However, a highly dynamic and complex tumor microenvironment (TME) considerably...

  • Review
  • Open Access
23 Citations
5,181 Views
28 Pages

Deep Eutectic Solvent-Mediated Electrocatalysts for Water Splitting

  • Chenyun Zhang,
  • Yongqi Fu,
  • Wei Gao,
  • Te Bai,
  • Tianyi Cao,
  • Jianjiao Jin and
  • Bingwei Xin

21 November 2022

As green, safe, and cheap solvents, deep eutectic solvents (DESs) provide tremendous opportunities to open up attractive perspectives for electrocatalysis. In this review, the achievement of DESs in the preparation of catalysts for electrolytic water...

  • Review
  • Open Access
20 Citations
4,084 Views
23 Pages

22 August 2022

Nickel-based electrocatalysts have been widely used to catalyze electrocatalytic water splitting. In order to obtain high-performance nickel-based electrocatalysts, using ionic liquids and deep eutectic solvents mediated their preparation has receive...

  • Review
  • Open Access
92 Citations
8,989 Views
17 Pages

31 January 2019

Enthusiasm for photodynamic therapy (PDT) as a potential therapeutic intervention for cancer has increased exponentially in recent decades. Photodynamic therapy constitutes a clinically approved, minimally invasive treatment modality that uses a phot...

  • Article
  • Open Access
6 Citations
2,522 Views
20 Pages

Comparative Validation of Scintillator Materials for X-Ray-Mediated Neuronal Control in the Deep Brain

  • Mercedes Hildebrandt,
  • Masanori Koshimizu,
  • Yasuki Asada,
  • Kansai Fukumitsu,
  • Mahito Ohkuma,
  • Na Sang,
  • Takashi Nakano,
  • Toshiaki Kunikata,
  • Kai Okazaki and
  • Noriaki Kawaguchi
  • + 4 authors

22 October 2024

When exposed to X-rays, scintillators emit visible luminescence. X-ray-mediated optogenetics employs scintillators for remotely activating light-sensitive proteins in biological tissue through X-ray irradiation. This approach offers advantages over t...

  • Review
  • Open Access
33 Citations
7,329 Views
18 Pages

Green Synthesis of Nanoparticles Mediated by Deep Eutectic Solvents and Their Applications in Water Treatment

  • Sebastian Ponce,
  • Herman A. Murillo,
  • Frank Alexis,
  • José Alvarez-Barreto and
  • José R. Mora

17 June 2023

The use of environmentally friendly deep eutectic solvents (DES) in green synthesis of different types of nanoparticles has garnered increasing interest in recent years. The application of these materials in water treatment, mainly by adsorption or d...

  • Review
  • Open Access
33 Citations
5,874 Views
14 Pages

15 December 2021

Chitin, the second most abundant biopolymer on earth, is utilised in a wide range of applications including wastewater treatment, drug delivery, wound healing, tissue engineering, and stem cell technology among others. This review compares the most p...

  • Article
  • Open Access
17 Citations
12,140 Views
18 Pages

Genotype-Phenotype Comparison in POGZ-Related Neurodevelopmental Disorders by Using Clinical Scoring

  • Dóra Nagy,
  • Sarah Verheyen,
  • Kristen M. Wigby,
  • Artem Borovikov,
  • Artem Sharkov,
  • Valerie Slegesky,
  • Austin Larson,
  • Christina Fagerberg,
  • Charlotte Brasch-Andersen and
  • Maria Kibæk
  • + 12 authors

15 January 2022

POGZ-related disorders (also known as White-Sutton syndrome) encompass a wide range of neurocognitive abnormalities and other accompanying anomalies. Disease severity varies widely among POGZ patients and studies investigating genotype-phenotype asso...

  • Brief Report
  • Open Access
3 Citations
2,194 Views
14 Pages

10 November 2023

Virus coat protein (CP)-mediated resistance is considered an effective antiviral defense strategy that has been used to develop robust resistance to viral infection. Rice stripe virus (RSV) causes significant losses in rice production in eastern Asia...

  • Feature Paper
  • Article
  • Open Access
1 Citations
3,590 Views
15 Pages

InsuLock: A Weakly Supervised Learning Approach for Accurate Insulator Prediction, and Variant Impact Quantification

  • Shushrruth Sai Srinivasan,
  • Yanwen Gong,
  • Siwei Xu,
  • Ahyeon Hwang,
  • Min Xu,
  • Matthew J. Girgenti and
  • Jing Zhang

30 March 2022

Mapping chromatin insulator loops is crucial to investigating genome evolution, elucidating critical biological functions, and ultimately quantifying variant impact in diseases. However, chromatin conformation profiling assays are usually expensive,...

  • Article
  • Open Access
1,829 Views
18 Pages

Mediation CNN (Med-CNN) Model for High-Dimensional Mediation Data

  • Yao Li,
  • Zhongyuan (Jasper) Zhang,
  • Olli Saarela,
  • Divya Sharma and
  • Wei Xu

20 February 2025

Complex biological features such as the human microbiome and gene expressions play a crucial role in human health by mediating various biomedical processes that influence disease progression, such as immune responses and metabolic processes. Understa...

  • Review
  • Open Access
4 Citations
3,631 Views
40 Pages

19 August 2025

Polymer inclusion membranes (PIMs) have undergone substantial advancements in their selectivity and efficiency, driven by their increasing deployment in separation processes, environmental remediation, and sensing applications. This review presents r...

  • Article
  • Open Access
318 Views
11 Pages

Ligand Functionality-Dependent Performance of Organotin Carboxylate Resists

  • Xiaofei Liu,
  • Tianren Liu,
  • Kaixin Su,
  • Jingxin Lei,
  • Yuanfu Chen,
  • Yuan Chen and
  • Dongxu Yang

19 December 2025

As metal-containing resists attract increasing research interest in high-resolution lithography, gaining insights into the photochemical mechanisms, particularly in relation to the ligand functionality, is actively demanded. In this work, a controlle...

  • Article
  • Open Access
1 Citations
2,175 Views
19 Pages

Amino Acid-Based Protein-Mimic Hydrogel Incorporating Pro-Regenerative Lipid Mediator and Microvascular Fragments Promotes the Healing of Deep Burn Wounds

  • Yan Lu,
  • Shanchun Su,
  • Chih-Chang Chu,
  • Yuichi Kobayashi,
  • Abdul-Razak Masoud,
  • Hongying Peng,
  • Nathan Lien,
  • Mingyu He,
  • Christopher Vuong and
  • Ryan Tran
  • + 1 author

26 September 2024

Pro-regenerative lipid mediator 1 (PreM1) is a specialized pro-resolving lipid mediator that promotes wound healing and regenerative functions of mesenchymal stem cells (MSCs), endothelial cells, and macrophages. The healing of third-degree (3°)...

  • Article
  • Open Access
27 Citations
2,331 Views
25 Pages

The phosphorylation of different sites produces a significant effect on the conformational dynamics of KRAS. Gaussian accelerated molecular dynamics (GaMD) simulations were combined with deep learning (DL) to explore the molecular mechanism of the ph...

  • Article
  • Open Access
5 Citations
2,070 Views
17 Pages

11 November 2024

As urban aging issues intensify, the impact of the built environment in urban neighborhoods on the physical and mental health of elderly residents has garnered increasing attention. Previous studies have demonstrated that the built environment is rel...

  • Article
  • Open Access
8 Citations
3,537 Views
23 Pages

DeepsmirUD: Prediction of Regulatory Effects on microRNA Expression Mediated by Small Molecules Using Deep Learning

  • Jianfeng Sun,
  • Jinlong Ru,
  • Lorenzo Ramos-Mucci,
  • Fei Qi,
  • Zihao Chen,
  • Suyuan Chen,
  • Adam P. Cribbs,
  • Li Deng and
  • Xia Wang

18 January 2023

Aberrant miRNA expression has been associated with a large number of human diseases. Therefore, targeting miRNAs to regulate their expression levels has become an important therapy against diseases that stem from the dysfunction of pathways regulated...

  • Article
  • Open Access
12 Citations
5,536 Views
15 Pages

This study examined the effect of service employees’ resilience on deep acting in the job demands–resources model (JD-R model). It set and verified person–job fit and work engagement as double-mediation factors between service emplo...

  • Article
  • Open Access
8 Citations
4,369 Views
16 Pages

10 December 2021

The ongoing COVID-19 pandemic has dealt a significant blow to the restaurant industry, with many restaurants suspending operations or closing altogether. This study was aimed to investigate the effects of emotional labor on employees’ well-bein...

  • Article
  • Open Access
13 Citations
3,713 Views
14 Pages

19 October 2022

Ginger extracts have been shown to have health-promoting pharmacological activity and beneficial effects, including antioxidant and anticancer properties. The extraction of ginger by natural deep eutectic solvents (NaDES) has been shown to enhance bi...

  • Feature Paper
  • Article
  • Open Access
20 Citations
6,504 Views
15 Pages

In order to survive the fiercer competition, more and more service firms emphasize front-line employees’ role of creating excellent customer experience by displaying positive emotions during the service interactions. However, the underlying mec...

  • Article
  • Open Access
7 Citations
10,757 Views
13 Pages

The Role of Play and Objects in Children’s Deep-Level Learning in Early Childhood Education

  • Ole Johan Sando,
  • Ellen Beate Hansen Sandseter and
  • Mariana Brussoni

This research investigates the significance of the physical environment in early childhood education and care (ECEC) institutions as a facilitator of deep-level learning. Building upon Laevers’ concept of deep-level learning, this study explore...

  • Article
  • Open Access
32 Citations
6,495 Views
15 Pages

10 October 2018

Despite an enduring interest in emotional labor, the effects of social capital on the emotional regulation process remain relatively underexplored. Using the job demands-resources model, we propose that social capital provides employees with the job...

  • Article
  • Open Access
6 Citations
3,086 Views
11 Pages

This study investigated the effects of workplace ostracism on emotional labor and burnout among current nursing staff during the COVID-19 pandemic, as well as the relationship between the surface acting and deep acting of emotional labor as the media...

  • Article
  • Open Access
9 Citations
3,486 Views
13 Pages

11 September 2023

The objective of this study was to investigate the effect of job satisfaction on psychological well-being through emotional labor for Taiwanese home-care workers. A total of 316 home-care workers who worked in Chiayi, Taiwan, were recruited in this s...

  • Article
  • Open Access
6 Citations
3,081 Views
21 Pages

Emotional labor exerts a significant impact on employees’ physical and mental health as a unique form of labor. This study aims to explore the multilevel mechanism of multifoci service orientation on emotional labor from the social capital pers...

  • Article
  • Open Access
21 Citations
9,286 Views
18 Pages

29 November 2019

Since bank employees are prone to high psychological pressure, it is key to explore the influencing mechanism of their emotional labor so as to relieve their pressure, as well as improve organizational performance and service quality. This study aime...

  • Article
  • Open Access
762 Views
17 Pages

17 March 2025

The enhancement of local market size is an important element of sustainable economic development. The core purpose of the article is to prove that the increase of local market size has the attribute of industrial and spatial coupling, and that the de...

  • Article
  • Open Access
22 Citations
5,300 Views
12 Pages

16 February 2022

Teacher burnout is a psychological syndrome affecting many teachers across the globe. Therefore, numerous studies have investigated antecedents of teacher burnout in order to provide recommendations to alleviate it. Although the studies pay attention...

  • Feature Paper
  • Article
  • Open Access
8 Citations
3,887 Views
15 Pages

Drawing on both the organization identification and impression management theories, we propose that perceived external prestige of frontline employees influences their emotional labor through organizational identification and impression management mo...

  • Article
  • Open Access
10 Citations
3,529 Views
16 Pages

15 September 2023

External and internal accountabilities and emotional labor are possible factors triggering teacher burnout, but the relationships between the constructs have not been fully addressed. Thus, this study aimed to construct and test a chain mediation mod...

  • Proceeding Paper
  • Open Access
7,693 Views
8 Pages

The ‘Myth of the cave’ is one of the topic of philosophical knowledge and a most debated object of study among philosophical scholars and authors. It is also a core-content knowledge of the philosophical school curriculum in high schools. The ‘Myth o...

  • Article
  • Open Access
37 Citations
7,167 Views
17 Pages

16 August 2021

The literature suggests that teacher burnout is influenced by the market and hierarchy cultures of school management and teachers’ emotional labor strategies of surface and deep acting. However, studies have suggested that school management cultures...

  • Article
  • Open Access
5 Citations
3,842 Views
15 Pages

Resilience of Colombian Entrepreneurships during COVID-19 Pandemic Crisis

  • Oscar Leonardo Acevedo,
  • Manuel Méndez-Pinzón and
  • Adela Margarita Vélez-Rolón

27 February 2023

MSMEs were facing major challenges driven by uncontrollable macro-environmental factors caused by the COVID-19 pandemic. This paper shows the strategies that a sample of Colombian start-ups developed for their survival in the first months of the COVI...

  • Article
  • Open Access
28 Citations
7,160 Views
13 Pages

20 August 2022

With the deep integration of ICT into education and teaching, the effect of technology acceptance on students’ self-directed learning has been one of the key concerns in the education field. This study examines the relationship between technolo...

  • Article
  • Open Access
18 Citations
7,534 Views
20 Pages

Predicting Proteolysis in Complex Proteomes Using Deep Learning

  • Matiss Ozols,
  • Alexander Eckersley,
  • Christopher I. Platt,
  • Callum Stewart-McGuinness,
  • Sarah A. Hibbert,
  • Jerico Revote,
  • Fuyi Li,
  • Christopher E. M. Griffiths,
  • Rachel E. B. Watson and
  • Jiangning Song
  • + 2 authors

Both protease- and reactive oxygen species (ROS)-mediated proteolysis are thought to be key effectors of tissue remodeling. We have previously shown that comparison of amino acid composition can predict the differential susceptibilities of proteins t...

  • Article
  • Open Access
13 Citations
3,152 Views
18 Pages

Design of an L-Valine-Modified Nanomicelle-Based Drug Delivery System for Overcoming Ocular Surface Barriers

  • Huimin Wu,
  • Yuchen Xu,
  • Mengru Cai,
  • Longtai You,
  • Jing Liu,
  • Xiaoxv Dong,
  • Xingbin Yin,
  • Jian Ni and
  • Changhai Qu

The incidence of ocular surface disease (OSD) is increasing, with a trend towards younger ages. However, it is difficult for drugs to reach the deep layers of the cornea due to ocular surface barriers, and bioavailability is less than 5%. In this stu...

  • Article
  • Open Access
317 Views
17 Pages

Talaporfin Sodium as a Clinically Translatable Radiosensitizer in Radiodynamic Therapy

  • Junko Takahashi,
  • Junkoh Yamamoto,
  • Kohei Suzuki,
  • Shohei Nagasaka,
  • Kaizhen Yang,
  • Haobo Zhao and
  • Teppei Yamaoka

18 December 2025

Talaporfin sodium (mono-L-aspartyl chlorin e6; NPe6), a second-generation photosensitizer, is clinically used in photodynamic therapy (PDT). It accumulates preferentially in tumors and exhibits deep tissue penetration, rapid systemic clearance, and m...

  • Feature Paper
  • Article
  • Open Access
6 Citations
2,863 Views
12 Pages

The aim of present study was to examine the mediating effect of presenteeism on the relationship between emotional labor and work engagement of coaches for disability sports. A total of 198 coaches in Korea participated in this study. Participants re...

  • Review
  • Open Access
19 Citations
4,426 Views
12 Pages

22 June 2021

Transparent exopolymer particles (TEP) are a class of abundant gel-like particles that are omnipresent in seawater. While versatile roles of TEP in the regulation of carbon cycles have been studied extensively over the past three decades, investigato...

  • Article
  • Open Access
4 Citations
4,544 Views
22 Pages

24 December 2020

Interpersonal trust mediates multiple socio-technical systems and has implications for personal and societal well-being. Consequently, it is crucial to devise novel machine learning methods to infer interpersonal trust automatically using mobile sens...

  • Article
  • Open Access
6 Citations
3,832 Views
14 Pages

4 August 2023

This study investigates the specific pathways through which mindfulness influences task performance, focusing on the sequential mediating roles of psychological resilience, customer-oriented behavior, and deep acting. Structural equation modeling is...

  • Article
  • Open Access
15 Citations
4,356 Views
12 Pages

Laccase Mediator Cocktail System as a Sustainable Skin Whitening Agent for Deep Eumelanin Decolorization

  • Valeria Gigli,
  • Davide Piccinino,
  • Daniele Avitabile,
  • Riccarda Antiochia,
  • Eliana Capecchi and
  • Raffaele Saladino

The overproduction of eumelanin leads to a panel of unaesthetic hyper-pigmented skin diseases, including melasma and age spots. The treatment of these diseases often requires the use of tyrosinase inhibitors, which act as skin whitening agents by inh...

  • Review
  • Open Access
14 Citations
5,116 Views
25 Pages

This review paper provides an extensive analysis of the rapidly evolving convergence of deep learning and long non-coding RNAs (lncRNAs). Considering the recent advancements in deep learning and the increasing recognition of lncRNAs as crucial compon...

  • Article
  • Open Access
20 Citations
4,838 Views
14 Pages

3 June 2022

The sustainable development of early childhood institutions in aging China calls for the sustainable development of early childhood teachers, which should attend to the balanced development between male and female teachers. Yet this issue has not bee...

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