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Open AccessArticle

Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic Reprogramming

1
Biomedical Research Institute, Kyungpook National University Hospital, 50 Samduk 2ga Jung-gu, Daegu 41944, Korea
2
QBM Co., Ltd., Seoul 06752, Korea
*
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(11), 611; https://doi.org/10.3390/md17110611
Received: 22 September 2019 / Revised: 22 October 2019 / Accepted: 25 October 2019 / Published: 27 October 2019
(This article belongs to the Special Issue Deep-Sea Natural Products II)
Metabolic disorders such as diabetes and obesity are serious global health issues. These diseases are accelerated by mineral deficiencies, emphasizing the importance of addressing these deficiencies in disease management plans. Lactate metabolism is fundamentally linked to glucose metabolism, and several clinical studies have reported that blood lactate levels are higher in obese and diabetic patients than in healthy subjects. Balanced deep-sea water contains various minerals and exhibits antiobesity and antidiabetic activities in mice; however, the impact of balanced deep-sea water on lactate metabolism is unclear. Thus, we evaluated the effects of balanced deep-sea water on lactate metabolism in C2C12 myotubes, and found that balanced deep-sea water mediated lactate metabolism by regulating the gene expression levels of lactate dehydrogenases A and B, a monocarboxylate transporter, and a mitochondrial pyruvate carrier. The activities of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) and signaling molecules involved in PGC-1α activation were also upregulated by treatment with balanced deep-sea water. These results suggest that balanced deep-sea water, which can mediate lactate metabolism, may be used to prevent or treat obesity and diabetes mellitus. View Full-Text
Keywords: C2C12 myotubes; deep-sea water; lactate metabolism; metabolic disorders; mineral deficiency; PGC-1α C2C12 myotubes; deep-sea water; lactate metabolism; metabolic disorders; mineral deficiency; PGC-1α
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MDPI and ACS Style

Ha, B.G.; Jung, S.S.; Jang, Y.K.; Jeon, B.Y.; Shon, Y.H. Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic Reprogramming. Mar. Drugs 2019, 17, 611.

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