This paper identifies the major research concepts, techniques, and models covered in the cross-docking literature. A systematic literature review is conducted using the BibExcel bibliometric analysis and Gephi network analysis tools. A research focus...
Recent trends in the management of supply chains have witnessed an increasing implementation of the cross-docking strategy. The cross-docking strategy, being the one that can potentially improve supply chain operations, has received a lot of attentio...
In this paper, the transportation problem of cross-docking network is taken into account. Cross-docking centers differ from distribution centers or warehouses in that the loads are transported from origins to destinations through cross-docking center...
Supply chains have become more time-sensitive in recent years. Delays in supply chain operations may cause significant negative externalities, including lost sales and customers. In order to facilitate the product distribution process within supply c...
A cross-docking system is a kind of facility design for the purpose of enhancing the time efficiency of a distribution center. In this study, we attempt to consider a cross-docking system without temporary storage and obtain great system performance...
In today’s competitive world, it is essential to provide a new method through which maximum efficiency can be created in the production and supply cycle. In many production environments, sending goods directly from the producer to the consumer...
Cross-docking has emerged as a critical logistics strategy to reduce lead times, lower inventory levels, and enhance supply chain responsiveness. However, in high-throughput terminals, efficient coordination of inbound and outbound trailers remains a...
Cross-docking is a new logistics model. The location planning of the crossover center is one of the important issues in logistics management. The location of the cross-docking center is not only a technical issue, but also a management issue. This is...
Cross-docking operations are highly dependent on precise scheduling and timely truck arrivals to ensure streamlined logistics and minimal storage costs. Predicting potential delays in truck arrivals is essential to avoiding disruptions that can propa...
Cross-docking is an excellent way to reduce the space required to store goods, inventory management costs, and customer order delivery time. This paper focuses on cost optimization, scheduling incoming and outgoing trucks, and green supply chains wit...
The rapid growth of e-commerce and advances in information and communication technologies have placed increasing pressure on last-mile delivery companies to enhance operational productivity. As investments in logistics infrastructure require long-ter...
Background: The logistics network design with cross-docking operations enables shipping service providers to integrate the physical flow of products between vendors and dealers in logistics management. The collective goal is to synchronize the goods...
In the context of supply chain sustainability, Physical Internet (PI or
Cross-docking operations in Eastern and Central European markets face increasing complexity amid persistent uncertainty and inflationary pressures. This study provides the first comprehensive comparative analysis integrating economic efficiency with...
Background: Manufacturing companies optimize logistics network routing to reduce transportation costs and operational costs in order to make profits in an extremely competitive environment. Therefore, the efficiency of logistics management in the sup...
Thedistribution of products stands out as one of the pivotal activities for logistics companies in recent years, particularly in the aftermath of the COVID-19 pandemic and other geopolitical events. Intense competition compels companies to efficientl...
Molecular docking is the most frequently used computational method for studying the interactions between organic molecules and biological macromolecules. In this context, docking allows predicting the preferred pose of a ligand inside a receptor bind...
The paper highlights the potential of cross-docking to reduce storage time and costs. The study addresses evolving market demands that push logistics providers to adopt new technologies for operational efficiency, emphasizing the often-overlooked imp...
The Vehicle-Routing Problem (VRP) represents a critical challenge in logistics, encompassing numerous variations, such as time window considerations, multi-depot systems, two-echelon routing aspects, and Satellite Locations (SL). SLs are intermediate...
Dipeptidyl peptidase-IV (DPP-IV) rapidly breaks down the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). Thus, the use of DPP-IV inhibitors to retard the degradation of endogenous GLP-1 is a possi...
The present consumer behavior is manipulated by “fast fashion”, where purchasing new, trendy, affordable clothes is preferred over recycling old ones. This changing mannerism has escalated the GHG emissions from the fashion industry. Ener...
This study explores the inhibitory potential of the flavonoids resokaempferol and tectochrysin against both wild-type and H1047R mutant forms of PI3Kα, aiming to expand the repertoire of targeted cancer therapies. Employing an array of computat...
Closed-loop supply chains (CLSC) are gaining popularity due to their efficiency in addressing economic, environmental, and social concerns. An important point to ponder in the distribution of CLSC is that imperfect refrigeration and bad road conditio...
A series of 44 hybrid compounds that included in their structure tetrahydroquinoline (THQ) and isoxazole/isoxazoline moieties were synthesized through the 1,3-dipolar cycloaddition reaction (1,3-DC) from the corresponding N-allyl/propargyl THQs, prev...
To enhance safety and efficiency in mixed traffic scenarios, it is crucial to predict freight truck traffic flow accurately. Issues arise due to the interactions between freight trucks and passenger vehicles, leading to problems like traffic congesti...
Pyrazolo[3,4-b]pyridine scaffolds have been heavily exploited in the development of nitrogen-containing heterocycles with numerous therapeutic applications in the field of medicinal and pharmaceutical chemistry. The present work describes the synthes...
By using an ensemble-docking strategy, we undertook a large-scale virtual screening campaign in order to identify new putative hits against the MET kinase target. Following a large molecular dynamics sampling of its conformational space, a set of 45...
Childhood neuroblastoma (NB) is a malignant tumour that is a member of a class of embryonic tumours that have their origins in sympathoadrenal progenitor cells. There are five stages in the clinical NB staging system: 1, 2A, 2B, 3, 4S, and 4. For tho...
The growing demand for bottled beverages has led to the search for optimal configurations that represent the lowest costs. Using crossdocking techniques reduces storage costs, these costs being the main ones in the logistics of distribution of produc...
Sphingolipidoses, a subgroup of lysosomal storage diseases (LSDs), are rare and debilitating disorders caused by defects in sphingolipid metabolism. Despite advancements in treatment, therapeutic options remain limited. Miglustat, a glucosylceramide...
In spacecraft rendezvous and docking, traditional methods that rely on inertial navigation and sensor data face challenges due to sensor inaccuracies, noise, and a lack of multi-approach assurance. Focusing on exploring a new approach as assistance,...
Suzuki-Miyaura cross-coupling of 6-bromo-2-styrylquinazolin-4(3H)-ones with arylboronic acids afforded a series of novel 6-aryl-2-styrylquinazolin-4(3H)-ones. These compounds were evaluated for potential anticancer properties against the human renal...
Background/Objectives: Influenza A viruses—including highly pathogenic H5N1—remain a global threat due to rapid evolution, zoonoses, and pandemic potential. Strain-specific vaccines targeting variable antigens often yield limited, short-l...
Water molecules play an important role in modeling protein-ligand interactions. However, traditional molecular docking methods often ignore the impact of the water molecules by removing them without any analysis or keeping them as a static part of th...
The selection of the appropriate distribution channel is crucial for the success of any business dealing with physical goods. When dealing with this selection, it is crucial to have an effective decision support system (DSS) that can assist with such...
β-Secretase (BACE-1) constitutes an important target for search of anti-Alzheimer’s drugs. The first inhibitors of this enzyme were peptidic compounds with high molecular weight and low bioavailability. Therefore, the search for new efficient non-pep...
Many goods require certain conditions for their storage, such as temperature, humidity and arrangement, which are strictly specific. These include dangerous goods, medicines and goods with a limited shelf life. Servicing them in warehouses is an impo...
P21-activated kinase 4 (PAK4) plays a crucial role in the proliferation and metastasis of various cancers. However, developing selective PAK4 inhibitors remains challenging due to the high homology within the PAK family. Therefore, developing highly...
In innovative city logistics systems, there are three main node types: consolidation centers, cross-docks, and concentrated loading areas. Since the latter has an essential role in the future urban freight transport, and they are significant parts of...
Ribavirin, 1-(β-D-Ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, which is included in the list of drugs recommended in the guidelines for the diagnosis and treatment of SARS-CoV-2 infection, has been the subject of experimental and theoretical...
The solid-state structural analysis and docking studies of three adamantane-linked 1,2,4-triazole derivatives are presented. Crystal structure analyses revealed that compound 2 crystallizes in the triclinic P-1 space group, while compounds 1 and 3 cr...
Background: Hydroxycarboxylic acid receptor 3 (HCAR3) is a receptor that is mainly expressed in human adipose tissue. It can inhibit lipolysis through the inhibition of adenylyl cyclase; thus, it is closely related to the regulation of lipids in the...
This research proposes a new distribution system of goods in the historical center of the city of Santiago, Chile. For the design of the urban logistic system, the methodology city logistics and last mile are used. This design incorporates to the fre...
Space and labor are the two internal resources within a warehouse or cross-dock center which seek attention. Meaningful efforts in optimizing these two resources can reduce the operational cost or time of the goods delivery. The timely allocation of...
After more than 40 years of biopolymer development, the current research is still based on conventional laboratory techniques, which require a large number of experiments. Therefore, finding new research methods are required to accelerate and...
Blood coagulation is an essential physiological process for hemostasis; however, abnormal coagulation can lead to various potentially fatal disorders, generally known as thromboembolic disorders, which are a major cause of mortality in the modern wor...
Recently, the direct thrombin (thr) inhibitor dabigatran has proven to be beneficial in animal models of Alzheimer’s disease (AD). Aiming at discovering novel multimodal agents addressing thr and AD-related targets, a selection of previously and newl...
The implementation of chemo- and bioinformatics tools is a crucial step in the design of structure-based drugs, enabling the identification of more specific and effective molecules against cancer without side effects. In this study, three new compoun...
In this paper, we describe the synthesis of the 5-styryltetrazolo[1,5-c]quinazolines substituted at the 9-position with a 4-fluorophenyl ring directly or via a conjugated π-spacer (C=C or C≡C bond) based on the 6-bromo-4-chloro-2-styrylquinazoline sc...
Factor XIII (FXIII) is a predominant determinant of clot stability, strength, and composition. Plasma FXIII circulates as a pro-transglutaminase with two catalytic A subunits and two carrier-protective B subunits in a heterotetramer (FXIII-A2B2). FXI...
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