Search Results (3,843)

Digital technology adoption can be beneficial for sustainable development of firms. This study seeks to illuminate how it works, based on the contingent affordance actualization theory that emphasizes both action potential and achievement context of technology. Specifically, it considers supply chain innovation as the underexplored mechanism and environmental munificence as the context factor. With the matched multisource data of 157 human resources service firms in China, the empirical findings show that supply chain innovation mediates the relationship between digital technology adoption and sustainable performance. Additionally, environmental munificence, the extent of the resources available in an environment, weakens this indirect relationship. By demonstrating these relations, this study provides firms with insights that allow them to utilize both the functional and coordinated action potentials of digital technology to conduct supply chain innovation, which in turn enhances sustainable performance. During this process, firms are further advised to be watchful to cope with organizational inertia when environmental munificence is high. Full article

Oral mucosal wound healing is a rapid, precisely regulated process distinct from cutaneous repair due to the specialized anatomical, microbial, and physiological features of the oral cavity. This review outlines the sequential healing phases—hemostasis, inflammation, proliferation, and remodeling—and examines the coordinated roles of keratinocytes, fibroblasts, endothelial cells, and immune cell subsets in tissue restoration. Central molecular pathways, including PI3K/Akt, JAK/STAT, Ras/MAPK, TGF-β/SMAD, and Wnt/β-catenin, along with growth factors such as TGF-β, FGF, EGF, and VEGF, are discussed in relation to their regulatory influence on cell behavior and extracellular matrix dynamics. Unique intraoral factors—namely saliva-derived histatins and a distinct resident microbiota—promote accelerated re-epithelialization and attenuated fibrosis. Systemic conditions such as diabetes, aging, and tobacco exposure are identified as key modulators that compromise repair efficiency. Emerging therapeutic strategies, including stem-cell-based interventions, microbiota modulation, bioengineered scaffolds, and photobiomodulation, offer translational potential to enhance clinical outcomes in oral tissue regeneration. Full article

When young children come to the attention of helping professionals because they are experiencing significant behavioral or emotional challenges, effective solutions frequently involve establishing whether there are strains or ruptures in the child’s coparenting network impeding functional communication about the child. Coparenting refers to the shared—and ideally, mutual—parenting efforts of adults working together to socialize, care for, and raise children for whom they share responsibility. Among the most important aims in understanding and strengthening the family’s coparenting alliance is evaluating who the various adults are comprising the functional coparenting network. As part of a coordinated effort to provide guidance in best practices for evaluating coparenting, an International Coparenting Collaborative (ICC) has highlighted the use of a pictoral mapping tool—a child-centered ecomap—as one effective means of assessing coparental engagement and learning more about existing levels of child-related teamwork and conflict. Completed ecomaps provided by multiple coparenting adults in the same family also provide an opening to highlight and explore child focus and to facilitate pivotal information sharing among the multiple caregivers. In this article, we examine the use of child-centered ecomaps in a variety of family-centered cases seen in four different collaborating sites and services partnering in the ICC. The cases highlight the unique value of an assessment tool that goes beyond simply illuminating the nature of the child’s coparenting system to afford the interventionist with a means of refocusing coparents’ attention on the perspective of the child. Closing reflections focus on the child-centered ecomap’s advantages, both as a method for learning more about coparenting in the family and for setting a stage for subsequent child-centered work with the family through more comprehensive and nuanced case conceptualization. Full article

Background: Childhood cancer survivors (CCSs) are at heightened risk of long-term neurocognitive and emotional difficulties that can affect educational attainment, social participation, and overall quality of life. These outcomes vary across developmental stages and are influenced by treatment modality, age at diagnosis, and central nervous system (CNS) involvement. Methods: A comprehensive literature search was conducted in PubMed, Scopus, PsycINFO, and Web of Science for articles published between January 2000 and June 2024. Search terms included combinations of “childhood cancer survivors,” “neurocognitive outcomes,” “executive function,” “emotional regulation,” and related MeSH terms. Inclusion criteria required peer-reviewed studies assessing CCS using standardized neuropsychological or emotional measures. Results: Evidence indicates persistent deficits in processing speed, working memory, and higher-order executive functions, with additional challenges in attention and memory. Emotional difficulties, including anxiety, depression, and social withdrawal, were prevalent and often co-occurred with cognitive impairments. Developmental timing of cancer and treatment was a key determinant of outcome. Family functioning, school reintegration support, and broader social environments emerged as important moderators of resilience. Conclusions: CCSs face complex, interrelated cognitive and emotional challenges that warrant early identification and ongoing, developmentally tailored intervention. Integrated approaches combining cognitive remediation and psychosocial support appear most effective. Future research should prioritize longitudinal designs, multi-informant assessments, and culturally sensitive frameworks to inform targeted prevention and rehabilitation strategies. Our synthesis highlights that deficits in processing speed and working memory are most pronounced following CNS-directed therapies during early developmental stages, whereas emotional vulnerabilities such as anxiety and social withdrawal often emerge later in adolescence. Interventions combining cognitive remediation, targeted psychosocial support, and structured school reintegration show the strongest evidence for improving adaptive outcomes. Coordinated survivorship care across healthcare, educational, and family systems is essential to sustain developmental recovery. Full article

Cancer-related pain remains one of the most frequent and burdensome symptoms in oncology, significantly impairing patients’ quality of life and functional status. Despite advances in treatment and the availability of evidence-based guidelines, pain continues to be undertreated worldwide. In Italy, legislative efforts such as Law 38/2010 have not fully translated into consistent clinical practice. On 28 March 2025, a national roundtable held in Rome, Italy, brought together experts from medical oncology, radiation oncology, palliative care, anesthesiology, and pain medicine, representing the main Italian scientific societies involved in oncology and supportive care, to examine the current status of cancer pain management and develop a consensus on actionable priorities. Four key gaps were identified: insufficient education and training of healthcare providers in pain management; fragmented care pathways and limited interdisciplinary integration; lack of clarity regarding professional roles; and challenges in implementing shared diagnostic and therapeutic care pathways (Percorsi Diagnostico Terapeutici Assistenziali). The roundtable proposed coordinated strategies to address these gaps, including expanding interdisciplinary educational initiatives and integrating pain management into undergraduate and specialty curricula; establishing local oncology orientation centers to provide joint, patient-centered assessments; promoting cross-specialty collaboration through congress sessions, educational activities, and practical workshops; and developing adaptable therapeutic frameworks to ensure standardized yet context-sensitive care delivery. This congress report formalizes a joint framework aimed at embedding pain management within comprehensive cancer care. Its implementation will require sustained advocacy, structured education, and alignment of clinical practice with policy support. By addressing these barriers through pragmatic, evidence-informed actions, the proposed strategies aim to optimize timely, integrated, and effective pain care, ultimately improving outcomes for patients with cancer. Full article

Participation in cancer prevention programs is suboptimal. Socioeconomic backgrounds play a role in cancer awareness and prevention programs. We conducted a narrative review, summarizing the evidence on the integration of cancer prevention extended to non-occupational risk factors at the workplace. Cancer prevention programs include screenings (colonoscopy, mammography, Pap-test), vaccinations (anti-HPV, anti-HBV), and interventions focused on lifestyle changes. Such strategies may face several barriers related to individual or environmental factors. The workplace is potentially an ideal setting for implementing extended cancer prevention strategies because (i) occupational health surveillance (OHS) targets adults, including hard-to-reach subgroups; (ii) it is structured, with health records and exams for risk assessment; (iii) it offers a key chance to promote cancer awareness and prevention through direct worker–physician interaction. Such an innovative approach requires a coordinated effort to build professional networks and manage high-risk workers. Its successful implementation depends on financial support and the active involvement of physicians, employers, and workers. Occupational-based cancer prevention represents a novel and promising strategy, though its feasibility and cost-effectiveness need to be assessed through large-scale studies. Full article

Amid the rapid evolution of the digital economy reshaping global competitiveness, China has advanced regional coordination through the Digital China initiative and the “Data Elements ×” Three-Year Action Plan (2024–2026). To further integrate digital transformation with high-quality growth in the urban agglomerations of the middle and lower Yellow River, this study aims to strengthen regional competitiveness, expand digital industries, foster new productivity, refine the development pathway, and safeguard balanced economic, social, and ecological progress. Taking the Yellow River urban clusters as the research object, a comprehensive assessment framework encompassing seven subsystems is established. By employing a mixed-weighting approach, entropy-based TOPSIS, hotspot analysis, coupling coordination models, spatial gravity shift techniques, and grey relational methods, this study investigates the spatiotemporal dynamics between the digital economy and high-quality development. The findings reveal that: (1) temporally, the coupling–coordination process evolves through three distinct phases—initial fluctuation and divergence (1990–2005), synergy consolidation (2005–2015), and high-level stabilization (2015–2022)—with the average coordination index rising from 0.21 to 0.41; (2) spatially, a persistent “core–periphery” structure emerges, while subsystem coupling consistently surpasses coordination levels, reflecting a pattern of “high coupling but insufficient coordination”; (3) hot–cold spot analysis identifies sharp east–west contrasts, with the gravity center shift and ellipse trajectory showing weaker directional stability but greater dispersion; and (4) grey correlation results indicate that key drivers have transitioned from economic scale and infrastructure inputs to green innovation performance and data resource allocation. Overall, this study interprets the empirical results in both temporal and spatial dimensions, offering insights for policymakers seeking to narrow the digital divide and advance sustainable, high-quality development in the Yellow River region. Full article

This study takes 22 megacities and super-large cities in China as research subjects, systematically exploring the coupled system relationship between digital maturity and resilient cities. Using methods such as information entropy theory, coupling coordination degree model, and grey relational coefficient measurement, it conducts comprehensive evaluation analysis, coupling coordination analysis, and factor contribution analysis. The results indicate that digital maturity and resilient cities exhibit a mutually reinforcing relationship. The positive interaction and coupling between digital maturity and resilient cities development have further promoted innovation in China’s urban governance and contributed to the long-term sustainable development of cities. Although the digital maturity and resilience levels of these cities show a fluctuating upward trend, they have not yet reached an ideal state, and significant differences exist among different urban clusters and regions. Megacities and super-large cities demonstrate high coupling characteristics among their internal subsystems, but their coordination level remains relatively low. Key factors such as digital governance policies, digital economy, and disaster-resistant infrastructure play a crucial role in advancing the sustainable development of resilient cities. Therefore, it is urgent to improve the coupling coordination mechanism to enhance sustainable development capacity. Full article

The building sector represents a major frontier in the global response to climate change, accounting for approximately one-third of global energy consumption and a comparable share of energy-related carbon dioxide emissions. This review conducts a PRISMA-ScR–based scoping synthesis of technological, behavioural, and policy pathways to achieve energy efficiency and deep decarbonization in buildings. It systematically examines passive design principles, high-performance envelopes, efficient HVAC and lighting systems, renewable energy integration, building energy modelling, and retrofit strategies. The study also addresses the role of regulatory instruments, energy codes, and certification schemes in accelerating sectoral transformation. The synthesis identifies three cross-cutting drivers of decarbonization: integrated design across building systems, digitalization enabling predictive and adaptive operation, and robust policy frameworks ensuring large-scale implementation. The review concludes that while most technologies required to reach zero-emission buildings are already available, their potential remains underutilized due to fragmented policies, limited retrofit rates, and behavioural barriers. Coordinated implementation across technology, governance, and user engagement is essential to realise a net-zero building sector. Full article

Background/Objectives: The cerebellum is essential for motor coordination and has recently been implicated in sleep-related disorders. However, the neural mechanisms linking sleep disruption to motor dysfunction remain poorly understood. This study aimed to elucidate the roles of the deep cerebellar nuclei (DCN), particularly the lateral nucleus, in motor dysfunction induced by chronic sleep disruption (CSD). Methods: Using a validated mouse model of CSD with periodic sleep fragmentation induced by an orbital shaker during the light phase, we assessed neuronal activation via c-Fos immunostaining and performed chemogenetic manipulation of glutamatergic neurons within the lateral nucleus. Behavioral performance was evaluated using open-field and rotarod tests. Results: CSD selectively increased c-Fos expression in the lateral nucleus, with no significant changes observed in other DCN subregions. Chemogenetic activation or ablation of glutamatergic neurons in the lateral nucleus decreased locomotor activity in the open-field test and shortened latency to fall in the rotarod task. Conversely, chemogenetic inhibition of these neurons attenuated CSD-induced impairments, restoring locomotor performance toward control levels. Conclusions: Our findings provide direct experimental evidence that glutamatergic neurons in the lateral nucleus play a crucial role in mediating CSD-induced motor dysfunction. These results highlight the cerebellar contribution to the interplay between sleep and motor control and identify a potential target for therapeutic intervention in sleep-related motor disorders. Full article

Skeletal muscle is increasingly recognized as a dynamic endocrine organ whose secretome—particularly myokines—serves as a central hub for the coordination of systemic metabolic health, inflammation, and tissue adaptation. This review integrates molecular, cellular, and physiological evidence to elucidate how myokine signaling translates mechanical and metabolic stimuli from exercise into biochemical pathways that regulate glucose homeostasis, lipid oxidation, mitochondrial function, and immune modulation. We detail the duality and context-dependence of cytokine and myokine actions, emphasizing the roles of key mediators such as IL-6, irisin, SPARC, FGF21, and BAIBA in orchestrating cross-talk between muscle, adipose tissue, pancreas, liver, bone, and brain. Distinctions between resistance and endurance training are explored, highlighting how each modality shapes the myokine milieu and downstream metabolic outcomes through differential activation of AMPK, mTOR, and PGC-1α axes. The review further addresses the hormetic role of reactive oxygen species, the importance of satellite cell dynamics, and the interplay between anabolic and catabolic signaling in muscle quality control and longevity. We discuss the clinical implications of these findings for metabolic syndrome, sarcopenia, and age-related disease, and propose that the remarkable plasticity of skeletal muscle and its secretome offers a powerful, multifaceted target for lifestyle interventions and future therapeutic strategies. An original infographic is presented to visually synthesize the complex network of myokine-mediated muscle–organ interactions underpinning exercise-induced metabolic health. Full article

Background/Objectives: Working memory (WM) performance relies on the coordination of updating and inhibition functions within the central executive system. However, their interaction under varying cognitive loads, particularly across sensory modalities, remains unclear. Methods: This study examined how sensory modality modulates flanker interference under increasing WM loads. Twenty-two participants performed a visual n-back task at three load levels (1-, 2-, and 3-back) while ignoring visual (within-modality) or auditory (cross-modality) flankers. Results: Behaviorally, increased WM load (2- and 3-back) led to reduced accuracy (AC) and prolonged reaction times (RTs) in both conditions. In addition, flanker interference was observed under the 2-back condition in both the visual within-modality (VM) and audiovisual cross-modality (AVM) tasks. However, performance impairment emerged at a lower load (2-back) in the VM condition, whereas in the AVM condition, it only emerged at the highest load (3-back). Significant performance impairment in the AVM condition occurred at higher WM loads, suggesting that greater WM load is required to trigger interference. Event-related potential (ERP) results showed that N200 amplitudes increased significantly for incongruent flankers under the highest WM load (3-back) in the visual within-modality condition, reflecting greater inhibitory demands. In the cross-modality condition, enhanced N200 was not observed across all loads and even reversed at low load (1-back). Moreover, the results also showed that P300 amplitude increased with load in the within-modality condition but decreased in the cross-modality condition. Conclusions: These results demonstrated that the interaction between updating and inhibition is shaped by both WM load and sensory modality, further supporting a sensory modality-specific resource allocation mechanism. The cross-modality configurations may enable more efficient distribution of cognitive resources under high load, reducing interference between concurrent executive demands. Full article

Renewable energy sources (RESs) such as photovoltaic (PV) and fuel cells (FCs) introduce variability that complicates reliable, loss-aware operation of distributed power-flow systems (DPFSs) in smart homes. Frequent charge/discharge cycling of energy storage systems (ESSs) can inflate losses and jeopardize user comfort when generation and demand are mismatched. This paper addresses the gap in multi-load, multi-source coordination under fluctuating RESs by proposing a Multiple-Load Power-Flow Assignment (MPFA) framework that explicitly minimizes storage-related losses while maintaining demand satisfaction. We evaluate four logical interconnection scenarios among generators (PGs), loads (PLs), and storage (PSs), and compare three control algorithms—total-demand-based (TDPF), adaptive-demand-based (ADPF), and grid-based (GBPF). Using measured PV/FC data across seasons, MPFA consistently reduces storage-related losses as interconnections increase, with GBPF guaranteeing full daily demand satisfaction by flexibly supplementing local generation with grid power. ADPF performs strongly when grid support is limited by prioritizing critical loads and optimizing storage utilization. The results provide actionable guidance for designing smart-home energy management that emphasizes sustainability, reliability, and user comfort. Full article

Floods are among the most frequent and damaging natural hazards in the Mekong River Basin, where the interplay of monsoon-driven climate variability, complex topography, and rapid socio-economic change creates high exposure and vulnerability. This study presents a comprehensive assessment of flood disaster patterns, loss distribution, and regional disparities across five countries in the Lower Mekong Basin—Cambodia, Laos, Myanmar, Thailand, and Vietnam. Using multivariate spatiotemporal analysis based on EM-DAT, MRC, and national government datasets, the study quantifies flood frequency, casualties, and affected population to reveal cross-country differences in disaster impact and timing. Results show that while Vietnam and Thailand experience high flood frequency and storm-induced events, Laos and Cambodia face riverine flooding under constrained economic and infrastructural conditions. The findings highlight a basin-wide increase in flood frequency over recent decades, driven by climate change, land use transitions, and uneven development. The analysis identifies critical gaps in adaptive governance, particularly the need for dynamic policy frameworks that can adjust to spatial disparities in flood typologies (e.g., Vietnam’s storm floods vs. Cambodia’s riverine floods) and improve transboundary coordination of reservoir operations. Despite the region’s extensive reservoir capacity, most infrastructure prioritizes hydropower over flood mitigation. The study evaluates the role of regional cooperation frameworks such as the Lancang–Mekong Cooperation (LMC), demonstrating how strengthened institutional flexibility and knowledge-sharing mechanisms could enhance progress toward Sustainable Development Goals (SDGs) related to water governance (SDG 6), resilient infrastructure (SDG 9), and disaster risk reduction (SDG 11). By constructing the first integrated national-level flood disaster database for the basin and conducting comparative analysis across countries, this research provides empirical evidence to support differentiated yet coordinated flood risk governance strategies at both national and transboundary levels. Full article

Background: The National Institutes of Health (NIH) established the Research Centers in Minority Institutions (RCMI) Program in response to the Congressional language in House Report 98-911 to establish research centers in predominantly minority institutions that offered doctoral degrees in the health professions and/or health-related sciences. The National Institute on Minority Health and Health Disparities (NIMHD) recognizes the critical role of the RCMI in conducting biomedical research and providing healthcare to communities impacted by health disparities. The RCMI Coordinating Center (RCMI-CC) supports the Consortium of 23 competitively funded RCMI Centers, with a collaborative infrastructure, to stimulate research partnerships and harness the research talents of the many gifted scientists and health professionals to collectively support investigator development, and advance health disparities research. Objectives: This manuscript presents the national and public health impact of the RCMI-CC as it works to help RCMI achieve their primary goals. Methods: We describe the organization of the RCMI Consortium and evaluate the impact of the overall RCMI Program, as measured by highly competitive NIH awards, high-impact publications, and other metrics. Results/Impact: In addition to the competitive research R01 and equivalent awards, publications, and patents, RCMI-CC implementation of the National Research Mentoring Network (NRMN), and health services research in RCMI–clinical research networks, collectively highlight the national and public health impact, as measured by collaborative scientific excellence, investigator development, and community engagement. Conclusions: The RCMI-CC and RCMI Consortium collectively demonstrate national and public health impact, with externally validated quantifiable metrics and return on investment. Full article