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299 Results Found

  • Article
  • Open Access
2 Citations
1,915 Views
20 Pages

28 February 2021

In recent years, cache-enabled vehicles have been introduced to improve the efficiency of content delivery in vehicular networks. However, because of the high dynamic of network topology, it is a big challenge to increase the success probability of c...

  • Article
  • Open Access
6 Citations
2,685 Views
26 Pages

18 February 2024

With the popularity of smart devices and the growth of high-bandwidth applications, the wireless industry is facing an increased surge in data traffic. This challenge highlights the limitations of traditional edge-caching solutions, especially in ter...

  • Article
  • Open Access
13 Citations
2,415 Views
21 Pages

Proactive Caching in D2D Assisted Multitier Cellular Network

  • Fawad Ahmad,
  • Ayaz Ahmad,
  • Irshad Hussain,
  • Ghulam Muhammad,
  • Zahoor Uddin and
  • Salman A. AlQahtani

6 July 2022

Cache-enabled networks suffer hugely from the challenge of content caching and content delivery. In this regard, cache-enabled device-to-device (D2D) assisted multitier cellular networks are expected to relieve the network data pressure and effective...

  • Article
  • Open Access
4 Citations
2,124 Views
27 Pages

27 September 2022

Ubiquitous in-network caching plays an important role in improving the efficiency of content access and distribution in Information-Centric Networks (ICN). Content placement strategies, which determine the location distribution of content replicas in...

  • Article
  • Open Access
36 Citations
1,057 Views
15 Pages

In the context of growing interest in both Mobile-Internet convergence and Web 2.0 social technologies, this article investigates the business opportunities derived from offering Social Applications in the convergent scenario, particularly regarding...

  • Article
  • Open Access
13 Citations
4,914 Views
22 Pages

A PEKS-Based NDN Strategy for Name Privacy

  • Kyi Thar Ko,
  • Htet Htet Hlaing and
  • Masahiro Mambo

Named Data Networking (NDN), where addressable content name is used, is considered as a candidate of next-generation Internet architectures. NDN routers use In-Network cache to replicate and store passing packets to make faster content delivery. Beca...

  • Article
  • Open Access
2 Citations
4,711 Views
16 Pages

Background: Lipid nanoparticles (LNPs) represent one of the most effective non-viral vectors for nucleic acid delivery and have demonstrated clinical success in siRNA therapies and mRNA vaccines. While considerable research has focused on optimizing...

  • Article
  • Open Access
8 Citations
3,070 Views
23 Pages

A Stackelberg Game-Based Caching Incentive Scheme for Roadside Units in VANETs

  • Yang Wang,
  • Yuankun Lin,
  • Lingyu Chen and
  • Jianghong Shi

19 November 2020

As a key technology of intelligent transportation systems (ITS), vehicular ad hoc networks (VANETs) have been promising to provide safety and infotainment for drivers and passengers. To support different applications about traffic safety, traffic eff...

  • Article
  • Open Access
17 Citations
3,910 Views
19 Pages

8 October 2018

In-network caching is one of the key features of information-centric networks (ICN), where forwarding entities in a network are equipped with memory with which they can temporarily store contents and satisfy en route requests. Exploiting in-network c...

  • Article
  • Open Access
4 Citations
3,198 Views
18 Pages

Evaluation of Content Dissemination Strategies in Urban Vehicular Networks

  • Gonçalo Pessoa,
  • Lucas Guardalben,
  • Miguel Luís,
  • Carlos Senna and
  • Susana Sargento

19 March 2020

The main drivers for the continuous development of Vehicular ad-hoc Networks (VANETs) are safety applications and services. However, in recent years, new interests have emerged regarding the introduction of new applications and services for non-urgen...

  • Article
  • Open Access
49 Citations
4,571 Views
22 Pages

Compound Popular Content Caching Strategy in Named Data Networking

  • Muhammad Ali Naeem,
  • Shahrudin Awang Nor,
  • Suhaidi Hassan and
  • Byung-Seo Kim

The aim of named data networking (NDN) is to develop an efficient data dissemination approach by implementing a cache module within the network. Caching is one of the most prominent modules of NDN that significantly enhances the Internet architecture...

  • Review
  • Open Access
93 Citations
20,140 Views
13 Pages

Wound management, in addition to presenting a significant burden to patients and their families, also contributes significantly to a country’s healthcare costs. Treatment strategies are numerous, but in most cases not ideal. Hydrogels, three-di...

  • Review
  • Open Access
17 Citations
4,352 Views
14 Pages

Exploiting the Opportunity to Use Plant-Derived Nanoparticles as Delivery Vehicles

  • Vincenza Tinnirello,
  • Nima Rabienezhad Ganji,
  • Carine De Marcos Lousa,
  • Riccardo Alessandro and
  • Stefania Raimondo

7 March 2023

The scientific community has become increasingly interested in plant-derived nanoparticles (PDNPs) over the past ten years. Given that they possess all the benefits of a drug carrier, including non-toxicity, low immunogenicity, and a lipid bilayer th...

  • Case Report
  • Open Access
4 Citations
3,940 Views
13 Pages

This case report outlines the strategies underpinning the adaptation of professionalism and ethics strand (P&E) teaching for remote delivery on a Pharmacy programme in response to COVID-19 restrictions. In line with national and University guidan...

  • Article
  • Open Access
13 Citations
5,273 Views
16 Pages

With the rapid development of cloud computing, big data, and Internet of Things, Information-Centric Networking (ICN) has become a novel hotspot in the field of future Internet architecture, and new problems have appeared. In particular, more researc...

  • Article
  • Open Access
8 Citations
2,178 Views
15 Pages

10 May 2023

With the continuous development of intelligent vehicles, people’s demand for services has also rapidly increased, leading to a sharp increase in wireless network traffic. Edge caching, due to its location advantage, can provide more efficient t...

  • Feature Paper
  • Article
  • Open Access
4 Citations
3,210 Views
11 Pages

Design and Construction of pH-Selective Self-Lytic Liposome System

  • Ayumi Kashiwada,
  • Kana Namiki and
  • Haruka Mori

24 November 2020

Liposomes are well-investigated drug or gene delivery vehicles for chemotherapy, used by taking advantage of their biocompatibility and biodegradability. A central question on the construction of intracellular liposomal delivery systems is to entrap...

  • Article
  • Open Access
17 Citations
3,442 Views
29 Pages

Towards Intelligent Zone-Based Content Pre-Caching Approach in VANET for Congestion Control

  • Khola Nazar,
  • Yousaf Saeed,
  • Abid Ali,
  • Abeer D. Algarni,
  • Naglaa F. Soliman,
  • Abdelhamied A. Ateya,
  • Mohammed Saleh Ali Muthanna and
  • Faisal Jamil

25 November 2022

In vehicular ad hoc networks (VANETs), content pre-caching is a significant technology that improves network performance and lowers network response delay. VANET faces network congestion when multiple requests for the same content are generated. Loca...

  • Review
  • Open Access
7 Citations
4,429 Views
22 Pages

26 October 2022

Extracellular vesicles (EVs), including exosomes, mediate intercellular communication by delivering their contents, such as nucleic acids, proteins, and lipids, to distant target cells. EVs play a role in the progression of several diseases. In parti...

  • Review
  • Open Access
66 Citations
7,684 Views
47 Pages

Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems

  • Ernesto J. Delgado-Pujol,
  • Guillermo Martínez,
  • David Casado-Jurado,
  • Juan Vázquez,
  • Jesús León-Barberena,
  • David Rodríguez-Lucena,
  • Yadir Torres,
  • Ana Alcudia and
  • Belén Begines

Conventional drug delivery approaches, including tablets and capsules, often suffer from reduced therapeutic effectiveness, largely attributed to inadequate bioavailability and difficulties in ensuring patient adherence. These challenges have driven...

  • Article
  • Open Access
1,109 Views
20 Pages

Liposomal Tubacin: Strategies for the Formulation of a Highly Hydrophobic Anticancer Drug

  • Cindy Schelker,
  • Léa Revaclier,
  • Gerrit Borchard and
  • Patrycja Nowak-Sliwinska

Background: Clear-cell renal cell carcinoma (ccRCC) is the most prevalent form of kidney cancer, accounting for over 75% of cases worldwide. Histone deacetylase inhibitors (HDACIs) have emerged as promising agents for ccRCC treatment, particularly in...

  • Review
  • Open Access
42 Citations
7,859 Views
23 Pages

Drug Loading in Chitosan-Based Nanoparticles

  • Yedi Herdiana,
  • Ellin Febrina,
  • Siti Nurhasanah,
  • Dolih Gozali,
  • Khaled M. Elamin and
  • Nasrul Wathoni

Chitosan nanoparticles (CSNPs) are promising vehicles for targeted and controlled drug release. Recognized for their biodegradability, biocompatibility, low toxicity, and ease of production, CSNPs represent an effective approach to drug delivery. Enc...

  • Review
  • Open Access
29 Citations
7,065 Views
32 Pages

Adipocyte-Based Cell Therapy in Oncology: The Role of Cancer-Associated Adipocytes and Their Reinterpretation as Delivery Platforms

  • Raluca Munteanu,
  • Anca Onaciu,
  • Cristian Moldovan,
  • Alina-Andreea Zimta,
  • Diana Gulei,
  • Angelo V. Paradiso,
  • Vladimir Lazar and
  • Ioana Berindan-Neagoe

Cancer-associated adipocytes have functional roles in tumor development through secreted adipocyte-derived factors and exosomes and also through metabolic symbiosis, where the malignant cells take up the lactate, fatty acids and glutamine produced by...

  • Article
  • Open Access
39 Citations
12,508 Views
18 Pages

Using Interactive Online Pedagogical Approaches to Promote Student Engagement

  • Tracey Muir,
  • Isabel Wang,
  • Allison Trimble,
  • Casey Mainsbridge and
  • Tracy Douglas

The COVID-19 outbreak in late 2019 required a complete shift to online learning across all educational institutions, including universities. The rapid transition to online learning globally meant that many educators were suddenly tasked with adapting...

  • Article
  • Open Access
7 Citations
4,742 Views
19 Pages

26 August 2021

This study aims towards identifying and modelling the significant factors which act as enablers for the branded content to be used strategically by marketers as a marketing tool in the COVID-19 era. A qualitative approach was adopted for this study,...

  • Article
  • Open Access
2,361 Views
12 Pages

A Capacitated House Allocation Game for the Energy Efficient Relays Selection in 5G Multicast Context

  • Francesco Chiti,
  • Romano Fantacci,
  • Benedetta Picano and
  • Laura Pierucci

18 September 2020

The upcoming fifth generation (5G) wireless networks making use of higher-frequency spectrum bands suffer from serious propagation issues due to high path loss and beam directivity requirements. This promotes the device-to-device communications to bo...

  • Review
  • Open Access
16 Citations
5,474 Views
16 Pages

What physical activity (PA) training do current and future healthcare professionals (HCPs) receive in the UK? How is PA training delivered to them? The present scoping review looks at existing evidence to respond these questions. Seven databases were...

  • Article
  • Open Access
1 Citations
1,472 Views
16 Pages

20 September 2025

Genetic engineering of macrophages, particularly for chimeric antigen receptor macrophage (CAR-M) therapy, holds great promise for immunotherapy, yet is constrained by the challenge of efficient gene delivery into primary macrophages, which are notor...

  • Article
  • Open Access
20 Citations
10,860 Views
10 Pages

Fortifier and Cream Improve Fat Delivery in Continuous Enteral Infant Feeding of Breast Milk

  • Mika Tabata,
  • Khaled Abdelrahman,
  • Amy B. Hair,
  • Keli M. Hawthorne,
  • Zhensheng Chen and
  • Steven A. Abrams

11 February 2015

Premature and high-risk infants require accurate delivery of nutrients to promote appropriate growth. Continuous enteral feeding methods may result in significant fat and micronutrient loss. This study evaluated fat loss in enteral nutrition using cu...

  • Article
  • Open Access
2 Citations
1,237 Views
16 Pages

18 December 2024

Single and dual-drug delivery systems (DDSs) based on linear choline polymers were designed through the controlled polymerization of a pharmaceutically functionalized monomer, i.e., [2-(methacryloyloxy)ethyl]trimethylammonium, with counterions of clo...

  • Article
  • Open Access
771 Views
24 Pages

Background/Objectives: Citrus × paradisi Macfad., Rutaceae. peel is a rich source of naringin (NR), but its poor solubility and low bioavailability limit applications. This study aimed to improve NR delivery by comparing microencapsulation, lip...

  • Article
  • Open Access
41 Citations
4,782 Views
17 Pages

HPMC- and PLGA-Based Nanoparticles for the Mucoadhesive Delivery of Sitagliptin: Optimization and In Vivo Evaluation in Rats

  • Anroop B. Nair,
  • Nagaraja Sreeharsha,
  • Bandar E. Al-Dhubiab,
  • Jagadeesh G. Hiremath,
  • Pottathil Shinu,
  • Mahesh Attimarad,
  • Katharigatta N. Venugopala and
  • Mohamed Mutahar

17 December 2019

Mucoadhesive nanoparticles represent a potential drug delivery strategy to enhance the therapeutic efficacy in oral therapy. This study assessed the prospective of developing HPMC- and PLGA-based nanoparticles using a nanospray drier as a mucoadhesiv...

  • Review
  • Open Access
14 Citations
5,902 Views
19 Pages

Exosomes Highlight Future Directions in the Treatment of Acute Kidney Injury

  • Xiaoyu Zhang,
  • Jing Wang,
  • Jing Zhang,
  • Yuwei Tan,
  • Yiming Li and
  • Zhiyong Peng

25 October 2023

Acute kidney injury (AKI) is a severe health problem associated with high morbidity and mortality rates. It currently lacks specific therapeutic strategies. This review focuses on the mechanisms underlying the actions of exosomes derived from differe...

  • Review
  • Open Access
14 Citations
4,038 Views
24 Pages

Clinical Translation of Long-Acting Drug Delivery Systems for Posterior Capsule Opacification Prophylaxis

  • Xinyang Li,
  • Chen Liang,
  • Yexuan Guo,
  • Jing Su,
  • Xi Chen,
  • Robert B. Macgregor,
  • Rui Xue Zhang and
  • Hong Yan

Posterior capsule opacification (PCO) remains the most common cause of vision loss post cataract surgery. The clinical management of PCO formation is limited to either physical impedance of residual lens epithelial cells (LECs) by implantation of spe...

  • Article
  • Open Access
360 Views
11 Pages

4 December 2025

Mobile Microlearning (MML) has emerged as a sustainable digital learning strategy capable of improving cognitive efficiency, reducing learner fatigue, and supporting scalable instructional delivery. This study investigates how MML compares with conve...

  • Perspective
  • Open Access
3 Citations
3,022 Views
6 Pages

19 January 2022

Background and objectives: There is a lack of good quality evidence regarding the effectiveness of transcutaneous electrical nerve stimulation (TENS) for chronic musculoskeletal pain, including chronic low back pain. High quality randomised controlle...

  • Article
  • Open Access
4 Citations
2,217 Views
14 Pages

23 October 2023

Bioactive linear choline-based copolymers were developed as micellar carriers for drug delivery systems (DDSs). The polymethacrylates containing trimethylammonium groups with p-aminosalicylate anions (PAS-based copolymers: series 1) or chloride anion...

  • Review
  • Open Access
47 Citations
5,131 Views
25 Pages

Exploiting the Natural Properties of Extracellular Vesicles in Targeted Delivery towards Specific Cells and Tissues

  • Pablo Lara,
  • Alan B. Chan,
  • Luis J. Cruz,
  • Andrew F. G. Quest and
  • Marcelo J. Kogan

Extracellular vesicles (EVs) are important mediators of intercellular communication that participate in many physiological/pathological processes. As such, EVs have unique properties related to their origin, which can be exploited for drug delivery a...

  • Feature Paper
  • Review
  • Open Access
101 Citations
12,269 Views
17 Pages

13 November 2020

Conductive hydrogel, with electroconductive properties and high water content in a three-dimensional structure is prepared by incorporating conductive polymers, conductive nanoparticles, or other conductive elements, into hydrogel systems through var...

  • Article
  • Open Access
58 Citations
12,848 Views
20 Pages

The New EU Forest Strategy for 2030: A New Understanding of Sustainable Forest Management?

  • Markus Lier,
  • Michael Köhl,
  • Kari T. Korhonen,
  • Stefanie Linser,
  • Kit Prins and
  • Andrzej Talarczyk

5 February 2022

Two decades after the pan-European set of indicators for sustainable forest management was adopted, the European Commission published the New EU Forest Strategy for 2030. We compared the documents on the basis of a content analysis to determine wheth...

  • Article
  • Open Access
3 Citations
1,769 Views
13 Pages

Iron Deficiency in Tomatoes Reversed by Pseudomonas Strains: A Synergistic Role of Siderophores and Plant Gene Activation

  • Belén Montero-Palmero,
  • Jose A. Lucas,
  • Blanca Montalbán,
  • Ana García-Villaraco,
  • Javier Gutierrez-Mañero and
  • Beatriz Ramos-Solano

22 December 2024

An alkaline pH in soils reduces Fe availability, limiting Fe uptake, compromising plant growth, and showing chlorosis due to a decrease in chlorophyll content. To achieve proper Fe homeostasis, dicotyledonous plants activate a battery of strategies i...

  • Article
  • Open Access
5 Citations
6,936 Views
22 Pages

Strategy Pattern Creation in Forest Planning in Swedish Forest-Owning Companies

  • Malin Nilsson,
  • Ljusk Ola Eriksson and
  • Dianne Staal Wästerlund

10 July 2013

Forest-owning companies in Sweden have both a goal to yield a good short-term rate of return on their forest and a goal to maintain a high long-term rate of return by maintaining the production of wood-based products. Both these objectives are taken...

  • Article
  • Open Access
21 Citations
3,257 Views
23 Pages

OPMSS: Optimal Producer Mobility Support Solution for Named Data Networking

  • Muktar Hussaini,
  • Muhammad Ali Naeem and
  • Byung-Seo Kim

29 April 2021

Named data networking (NDN) is designed as a clean-slate Internet architecture to replace the current IP Internet architecture. The named data networking was proposed to offer vast advantages, especially with the advent of new content distributions i...

  • Article
  • Open Access
2 Citations
4,199 Views
22 Pages

Telco content delivery networks (CDNs) have envisioned building highly distributed and cloudified sites to provide a high-quality CDN service in the 5G era. However, there are still two open problems to be addressed. First, telco CDNs are operated up...

  • Review
  • Open Access
19 Citations
10,160 Views
19 Pages

Respect for Religiosity: Review of Faith Integration in Health and Wellbeing Interventions with Muslim Minorities

  • Helen McLaren,
  • Emi Patmisari,
  • Mohammad Hamiduzzaman,
  • Michelle Jones and
  • Renee Taylor

27 August 2021

Integration of religion in community health and wellbeing interventions is important for achieving a good life among faith-based populations. In countries hosting Muslim-minorities, however, relatively little is reported in academic literature on pro...

  • Review
  • Open Access
1 Citations
864 Views
46 Pages

Niosomes as Vesicular Carriers: From Formulation Strategies to Stimuli-Responsive Innovative Modulations for Targeted Drug Delivery

  • Andra Ababei-Bobu,
  • Bianca-Ștefania Profire,
  • Andreea-Teodora Iacob,
  • Oana-Maria Chirliu,
  • Florentina Geanina Lupașcu and
  • Lenuța Profire

Niosomes (NIOs), a class of nanovesicular drug delivery system, have garnered significant attention due to their unique architecture, resulting from the self-assembly of non-ionic surfactants (with or without cholesterol) in aqueous media. This bilay...

  • Review
  • Open Access
7 Citations
2,520 Views
13 Pages

Measures of Patient-Reported Expectations, Acceptance, and Satisfaction Using Automated Insulin Delivery Systems: A Review

  • Marco Marigliano,
  • Enza Mozzillo,
  • Valentina Mancioppi,
  • Francesca Di Candia,
  • Francesco Maria Rosanio,
  • Annalisa Antonelli,
  • Ilaria Nichelatti,
  • Claudio Maffeis,
  • Stefano Tumini and
  • Roberto Franceschi

22 June 2023

In people with type 1 diabetes, Automated Insulin Delivery (AID) systems adjust insulin delivery in response to sensor glucose data and consist of three components: an insulin pump, a continuous glucose sensor, and an algorithm that determines insuli...

  • Article
  • Open Access
1 Citations
2,624 Views
14 Pages

A Novel Preparation Technique for Human Nasal Respiratory Mucosa to Disclose Its Glycosylation Pattern for Bioadhesive Drug Delivery

  • Julia Clara Gausterer,
  • Michael Schlager,
  • Navid Ahmadi,
  • Michael Nieratschker,
  • Valerie Dahm,
  • Michael Wirth,
  • Christoph Arnoldner,
  • Clemens Honeder and
  • Franz Gabor

To shed some light on glycotargeting as a potential strategy for nasal drug delivery, a reliable preparation method for human nasal mucosa samples and a tool to investigate the carbohydrate building blocks of the glycocalyx of the respiratory epithel...

  • Review
  • Open Access
9 Citations
4,289 Views
27 Pages

Boosting Lipofection Efficiency Through Enhanced Membrane Fusion Mechanisms

  • Rais V. Pavlov,
  • Sergey A. Akimov,
  • Erdem B. Dashinimaev and
  • Pavel V. Bashkirov

18 December 2024

Gene transfection is a fundamental technique in the fields of biological research and therapeutic innovation. Due to their biocompatibility and membrane-mimetic properties, lipid vectors serve as essential tools in transfection. The successful delive...

  • Article
  • Open Access
35 Citations
6,968 Views
17 Pages

12 January 2023

With the emergence of intelligent terminals, the Internet of Vehicles (IoV) has been drawing great attention by taking advantage of mobile communication technologies. However, high computation complexity, collaboration communication overhead and limi...

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