Progress in clinical diagnosis increasingly relies on innovative technologies and advanced disease biomarker detection methods. While cell labeling remains a well-established technique, label-free approaches offer significant advantages, including re...
The biophysical properties of therapeutic antibodies influence their manufacturability, efficacy, and safety. To develop an anti-cancer antibody, we previously generated a human monoclonal antibody (Ab417) that specifically binds to L1 cell adhesion...
Progress in the design of G-quadruplex (G4) binding ligands relies on the availability of approaches that assess the binding mode and nature of the interactions between G4 forming sequences and their putative ligands. The experimental approaches used...
Over the years, there have been many developments and advances in the field of integral membrane protein research. As important pharmaceutical targets, it is paramount to understand the mechanisms of action that govern their structure–function...
Protected areas (PAs) are a key strategy to reverse global biodiversity declines, but they are under increasing pressure from anthropogenic activities and concomitant effects. Thus, the heterogeneous landscapes within PAs, containing a number of diff...
This study evaluates cultural ecosystem services (CESs) provided by coastal beaches in Korea using two valuation methods: choice experiments (CEs) and the energy method (EM). CESs, which include non-material benefits like recreation and esthetic enjo...
Radiative transfer models predicting the bidirectional reflectance factor (BRF) of leaf canopies are powerful tools that relate biophysical parameters such as leaf area index (LAI), fractional vegetation cover fV and the fraction of photosyntheticall...
26 November 2019
Purpose: to compare different methods to assess the arm stroke efficiency (
A range of remote sensing platforms provide high spatial and temporal resolution insights which are useful for monitoring vegetation growth. Very few studies have focused on fruit orchards, largely due to the inherent complexity of their structure. F...
Ribosome assembly is one of the most fundamental processes of gene expression and has served as a playground for investigating the molecular mechanisms of how protein–RNA complexes (RNPs) assemble. A bacterial ribosome is composed of around 50...
Identifying the relationships between ecosystem services (ESs) and land use change is crucial for ES management and sustainable regional development. The Manas region in China has witnessed dramatic reclamation activities in its desert areas that res...
We developed an automated pattern recognition code that is particularly well suited to extract one-dimensional curvilinear features from two-dimensional digital images. A former version of this Oriented Coronal Curved Loop Tracing (OCCULT) code was a...
The aim of this work was the evaluation of the physico-chemical properties of a new type of liposomes that are composed of DPPC and bioconjugates of anisic acid with phosphatidylcholine. In particular, the impact of modified anisic acid phospholipids...
An effective therapy for advanced melanoma, a skin cancer with the highest mortality, has not yet been developed. The endocannabinoid system is considered to be an attractive target for cancer treatment. The use of endocannabinoids, such as anandamid...
Overexpression of the 14-3-3ε protein is associated with suppression of apoptosis in cutaneous squamous cell carcinoma (cSCC). This antiapoptotic activity of 14-3-3ε is dependent on its binding to CDC25A; thus, inhibiting 14-3-3&epsil...
Sarcoendoplasmic reticulum calcium ATPase (SERCA), a member of the P-type ATPase family of ion and lipid pumps, is responsible for the active transport of Ca2+ from the cytoplasm into the sarcoplasmic reticulum lumen of muscle cells, into the endopla...
Rapid and accurate estimation of maize biomass is critical for predicting crop productivity. The launched Sentinel-1 (S-1) synthetic aperture radar (SAR) and Sentinel-2 (S-2) missions offer a new opportunity to map biomass. The selection of appropria...
In this article, we describe the use of diagnostic timescales as simple tools for illuminating how aquatic ecosystems work, with a focus on coastal systems such as estuaries, lagoons, tidal rivers, reefs, deltas, gulfs, and continental shelves. Inten...
Starch is the major component of cereal grains and starchy foods, and changes in its biophysical and biochemical properties (e.g., amylose, amylopectin, pasting, gelatinization, viscosity) will have a direct effect on its end use properties (e.g., br...
In this paper we present a framework for modelling potential species distribution (PSD) of balsam fir [bF; Abies balsamea (L.) Mill.] as a function of landscape-level descriptions of: (i) growing degree days (GDD: a temperature related index), (ii) l...
The goal of this study was to propose and validate a method for predicting cropland suitability based on biophysical variables and machine learning according to an FAO land suitability standard using soybean (Glycine max L.) as a representative crop,...
Cas9 is a site-specific RNA-guided endonuclease (RGEN) that can be used for precise genome editing in various cell types from multiple species. Ribonucleoprotein (RNP) complexes, which contains the Cas9 protein in complex with a guide RNA, are suffic...
In preparation for new-generation imaging spectrometer missions and the accompanying unprecedented inflow of hyperspectral data, optimized models are needed to generate vegetation traits routinely. Hybrid models, combining radiative transfer models w...
The review highlights how protein–protein interactions (PPIs) have determining roles in most life processes and how interactions between protein partners are involved in various human diseases. The study of PPIs and binding interactions as well...
Microbial resistance to conventional antibiotics is one of the most outstanding medical and scientific challenges of our times. Despite the recognised need for new anti-infective agents, however, very few new drugs have been brought to the market and...
Bcl-2 protein is involved in cell apoptosis and is considered an interesting target for anti-cancer therapy. The present study aims to understand the stability and conformational changes of Bcl-2 upon interaction with the inhibitor venetoclax, and to...
Posidonia oceanica is an endemic Mediterranean seagrass used as a ‘biological quality element’ in monitoring programmes of the EU Water Framework Directive, providing information about coastal ecosystems status. The regression of P. oceanica meadows...
Nanobodies provide important advantages over traditional antibodies, including their smaller size and robust biochemical properties such as high thermal stability, high solubility, and the ability to be bioengineered into novel multivalent, multi-spe...
Despite recent developments in protein structure prediction, the process of the structure formation, folding, remains poorly understood. Notably, folding of multidomain proteins, which involves multiple steps of segmental folding, is one of the bigge...
Estimating confidence intervals in small or noisy datasets is a recurring challenge in biomolecular research, particularly when data contain outliers or exhibit high variability. This study introduces a robust statistical method that combines a hybri...
Expansive growth is a culmination of many biological processes. It is fundamental to volume growth, development, morphogenesis, sensory responses, and environmental responses of plants, fungi, and algae. Expansive growth of walled cells and plant tis...
Biophysical properties are widely used to detect pathophysiological processes of vascular diseases or clinical states. For early detection of cardiovascular diseases, it is necessary to simultaneously measure multiple biophysical properties in a micr...
22 January 2015
The Sunda Banda Seascape (SBS), located in the center of the Coral Triangle, is a global center of marine biodiversity and a conservation priority. We proposed the first biophysical environmental delineation of the SBS using globally available satell...
Molecular assembly in a complex cellular environment is vital for understanding underlying biological mechanisms. Biophysical parameters (such as single-molecule cluster density, cluster-area, pairwise distance, and number of molecules per cluster) r...
In the post-genome era, pathologies become associated with specific gene expression profiles and defined molecular lesions can be identified. The traditional therapeutic strategy is to block the identified aberrant biochemical activity. However, an a...
Pumpkins are a nutritious and globally enjoyed fruit for their rich and earthy flavor. The biophysical properties of pumpkins play an important role in determining their yield. However, manual in-field techniques for monitoring these properties can b...
The extracellular matrix (ECM) is a pericellular network of proteins and other molecules that provides mechanical support to organs and tissues. ECM biophysical properties such as topography, elasticity and porosity strongly influence cell proliferat...
Remote sensing has been applied to map the extent and biophysical properties of mangroves. However, the impact of several critical factors, such as the fractional cover and leaf-to-total area ratio of mangroves, on their canopy reflectance have rarel...
The overexpression of atypical protein kinase C-iota (PKC-ι) is a biomarker for carcinogenesis in various cell types, such as glioma, ovarian, renal, etc., manifesting as a potential drug target. In previous in vitro studies, ICA-1S and ICA-1T,...
Protein intrinsic disorder is increasingly recognized for its biological and disease-driven functions. However, it represents significant challenges for biophysical studies due to its high conformational flexibility. In addressing these challenges, w...
Current numerical methods for simulating biophysical processes in aquatic environments are typically constructed in a grid-based Eulerian framework or as an individual-based model in a particle-based Lagrangian framework. Often, the biogeochemical pr...
Label-free imaging is becoming ever more important, especially in modern molecular biophysics. This method allows observation of biological structures and dynamics without the alteration caused by dyes or genetic labels. Coherent Anti-Stokes Raman Sc...
Methods for accurately measuring biophysical parameters are a key component for quantitative evaluation regarding to various forest applications. Conventional in situ measurements of these parameters take time and expense, encountering difficultness...
Different pigmented corn and sorghum types were evaluated to characterize their biophysical, nutraceutical, and technofunctional properties for the first time. Commercially pigmented (blue, purple, red, black, and yellow) popcorn (Zea mays var. evert...
Cellular mechanical properties are critical for tissue and organ homeostasis, which are associated with many diseases and are very promising non-labeled biomarkers. Over the past two decades, many research tools based on microfluidic methods have bee...
Some amphiphilic molecules are able to interact with the lipid matrix of plant plasma membranes and trigger the immune response in plants. This original mode of perception is not yet fully understood and biophysical approaches could help to obtain mo...
The estimation of forest biophysical attributes improves when airborne laser scanning (ALS) is integrated. Individual tree detection methods (ITD) and traditional area-based approaches (ABA) are the two main alternatives in ALS-based forest inventory...
The biophysical effect of land cover changes (LCC) on local temperature is currently a hot topic. This work selects one of the nine agricultural divisions in China, the Sichuan Basin and surrounding regions, as the study area. By combining long-term...
Over the past decade intrinsically disordered proteins (IDPs) have emerged as a biologically important class of proteins, many of which are of therapeutic relevance. Here, we investigated the interactions between a model IDP system, tau K18, and nine...
(1) Background: Our aim is to reveal the influence of the geometry designs on biophysical stimuli and healing patterns. The design guidelines for dental implants can then be provided. (2) Methods: A two-dimensional axisymmetric finite element model w...
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