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521 Results Found

  • Article
  • Open Access
9 Citations
3,107 Views
19 Pages

Cinco de Bio: A Low-Code Platform for Domain-Specific Workflows for Biomedical Imaging Research

  • Colm Brandon,
  • Steve Boßelmann,
  • Amandeep Singh,
  • Stephen Ryan,
  • Alexander Schieweck,
  • Eanna Fennell,
  • Bernhard Steffen and
  • Tiziana Margaria

Background: In biomedical imaging research, experimental biologists generate vast amounts of data that require advanced computational analysis. Breakthroughs in experimental techniques, such as multiplex immunofluorescence tissue imaging, enable deta...

  • Article
  • Open Access
6 Citations
2,873 Views
9 Pages

24 December 2021

Biomedical terms extracted using Word2vec, the most popular word embedding model in recent years, serve as the foundation for various natural language processing (NLP) applications, such as biomedical information retrieval, relation extraction, and r...

  • Review
  • Open Access
39 Citations
7,939 Views
26 Pages

Biomedical-named entity recognition (bNER) is critical in biomedical informatics. It identifies biomedical entities with special meanings, such as people, places, and organizations, as predefined semantic types in electronic health records (EHR). bNE...

  • Article
  • Open Access
6 Citations
3,568 Views
14 Pages

9 August 2021

Relation extraction (RE) is an essential task in natural language processing. Given a context, RE aims to classify an entity-mention pair into a set of pre-defined relations. In the biomedical field, building an efficient and accurate RE system is cr...

  • Review
  • Open Access
6 Citations
3,582 Views
22 Pages

30 October 2023

C1q domain-containing proteins (C1qDC proteins) unexpectedly turned out to be widespread molecules among a variety of invertebrates, despite their lack of an integral complement system. Despite the wide distribution in the genomes of various inverteb...

  • Article
  • Open Access
41 Citations
6,409 Views
15 Pages

Feasibility of a Wearable Reflectometric System for Sensing Skin Hydration

  • Raissa Schiavoni,
  • Giuseppina Monti,
  • Emanuele Piuzzi,
  • Luciano Tarricone,
  • Annarita Tedesco,
  • Egidio De Benedetto and
  • Andrea Cataldo

16 May 2020

One of the major goals of Health 4.0 is to offer personalized care to patients, also through real-time, remote monitoring of their biomedical parameters. In this regard, wearable monitoring systems are crucial to deliver continuous appropriate care....

  • Article
  • Open Access
3 Citations
4,576 Views
11 Pages

Web Interface of NER and RE with BERT for Biomedical Text Mining

  • Yeon-Ji Park,
  • Min-a Lee,
  • Geun-Je Yang,
  • Soo Jun Park and
  • Chae-Bong Sohn

21 April 2023

The BioBERT Named Entity Recognition (NER) model is a high-performance model designed to identify both known and unknown entities. It surpasses previous NER models utilized by text-mining tools, such as tmTool and ezTag, in effectively discovering no...

  • Review
  • Open Access
10 Citations
4,856 Views
14 Pages

13 January 2022

For all research data collected, data descriptions and information about the corresponding variables are essential for data analysis and reuse. To enable cross-study comparisons and analyses, semantic interoperability of metadata is one of the most i...

  • Article
  • Open Access
3 Citations
4,185 Views
25 Pages

24 January 2020

The hallmarks of cancer represent an essential concept for discovering novel knowledge about cancer and for extracting the complexity of cancer. Due to the lack of topic analysis frameworks optimized specifically for cancer data, the studies on topic...

  • Systematic Review
  • Open Access
4 Citations
12,280 Views
29 Pages

Retrieval-Augmented Generation (RAG) in Healthcare: A Comprehensive Review

  • Fnu Neha,
  • Deepshikha Bhati and
  • Deepak Kumar Shukla

11 September 2025

Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating external knowledge retrieval to improve factual consistency and reduce hallucinations. Despite growing interest, its use in healthcare remains fragmented. This...

  • Article
  • Open Access
816 Views
18 Pages

Time-domain (TD) diffuse reflectance can be modeled using diffusion theory (DT) to non-invasively estimate optical transport coefficients of biological media, which serve as markers of tissue physiology. We employ an optimized N-layer DT solver in cy...

  • Feature Paper
  • Review
  • Open Access
36 Citations
7,933 Views
38 Pages

Broadband Time Domain Diffuse Optical Reflectance Spectroscopy: A Review of Systems, Methods, and Applications

  • Sanathana Konugolu Venkata Sekar,
  • Pranav Lanka,
  • Andrea Farina,
  • Alberto Dalla Mora,
  • Stefan Andersson-Engels,
  • Paola Taroni and
  • Antonio Pifferi

12 December 2019

This review presents recent developments and a wide overview of broadband time domain diffuse optical spectroscopy (TD-DOS). Various topics including physics of photon migration, advanced instrumentation, methods of analysis, applications covering mu...

  • Article
  • Open Access
8 Citations
3,941 Views
15 Pages

Investigation of an Ultra Wideband Noise Sensor for Health Monitoring

  • Xuezhi Zeng,
  • Joakim Robakowski,
  • Mikael Persson,
  • Albert Monteith and
  • Andreas Fhager

14 February 2020

Quick on-scene assessment and early intervention is the key to reduce the mortality of stroke and trauma patients, and it is highly desirable to develop ambulance-based diagnostic and monitoring devices in order to provide additional support to the m...

  • Article
  • Open Access
7 Citations
8,684 Views
12 Pages

An ultra-low voltage sixth-order low pass filter topology, suitable for sensing the T-wave signal in an electrocardiogram (ECG), is presented in this paper. This is realized using a cascade connection of second-order building blocks constructed from...

  • Review
  • Open Access
35 Citations
10,087 Views
30 Pages

Time-Gated Single-Photon Detection in Time-Domain Diffuse Optics: A Review

  • Alberto Dalla Mora,
  • Laura Di Sieno,
  • Rebecca Re,
  • Antonio Pifferi and
  • Davide Contini

6 February 2020

This work reviews physical concepts, technologies and applications of time-domain diffuse optics based on time-gated single-photon detection. This particular photon detection strategy is of the utmost importance in the diffuse optics field as it unle...

  • Feature Paper
  • Review
  • Open Access
1,801 Views
13 Pages

Sherpabodies are a novel class of antibody-mimetic proteins and represent the third generation of SH3 domain-based targeting scaffolds. Sherpabodies have several advantageous biophysical properties, and molecular libraries based on this scaffold prov...

  • Article
  • Open Access
986 Views
19 Pages

The Specialist’s Paradox: Generalist AI May Better Organize Medical Knowledge

  • Carlo Galli,
  • Maria Teresa Colangelo,
  • Marco Meleti and
  • Elena Calciolari

21 July 2025

This study investigates the ability of six pre-trained sentence transformers to organize medical knowledge by performing unsupervised clustering on 70 high-level Medical Subject Headings (MeSH) terms across seven medical specialties. We evaluated mod...

  • Review
  • Open Access
106 Citations
10,343 Views
28 Pages

THz Pulsed Imaging in Biomedical Applications

  • Annalisa D’Arco,
  • Marta Di Fabrizio,
  • Valerio Dolci,
  • Massimo Petrarca and
  • Stefano Lupi

Recent advances in technology have allowed the production and the coherent detection of sub-ps pulses of terahertz (THz) radiation. Therefore, the potentialities of this technique have been readily recognized for THz spectroscopy and imaging in biome...

  • Article
  • Open Access
3 Citations
2,695 Views
12 Pages

2 December 2023

Named Entity Recognition (NER) is an important task used to extract relevant information from biomedical texts. Recently, pre-trained language models have made great progress in this task, particularly in English language. However, the performance of...

  • Article
  • Open Access
2 Citations
2,016 Views
18 Pages

The fusion of machine learning and biomedical research offers novel ways to understand, diagnose, and treat various health conditions. However, the complexities of biomedical data, coupled with the intricate process of developing and deploying machin...

  • Feature Paper
  • Article
  • Open Access
44 Citations
12,336 Views
17 Pages

Transfer Learning for Named Entity Recognition in Financial and Biomedical Documents

  • Sumam Francis,
  • Jordy Van Landeghem and
  • Marie-Francine Moens

26 July 2019

Recent deep learning approaches have shown promising results for named entity recognition (NER). A reasonable assumption for training robust deep learning models is that a sufficient amount of high-quality annotated training data is available. Howeve...

  • Proceeding Paper
  • Open Access
1 Citations
1,175 Views
4 Pages

27 February 2024

The electrocardiogram is a widely used clinical diagnostic tool and is studied in biomedical engineering and electrophysiology courses. Modern electrocardiograms are complex, requiring some knowledge in many domains of engineering to comprehend their...

  • Review
  • Open Access
21 Citations
6,171 Views
39 Pages

25 May 2021

The collagen hydrolysate, a proteinic biopeptide, is used for various key functionalities in humans and animals. Numerous reviews explained either individually or a few of following aspects: types, processes, properties, and applications. In the rece...

  • Article
  • Open Access
168 Citations
21,086 Views
40 Pages

Deep Learning in the Biomedical Applications: Recent and Future Status

  • Ryad Zemouri,
  • Noureddine Zerhouni and
  • Daniel Racoceanu

12 April 2019

Deep neural networks represent, nowadays, the most effective machine learning technology in biomedical domain. In this domain, the different areas of interest concern the Omics (study of the genome—genomics—and proteins—transcriptom...

  • Editorial
  • Open Access
5 Citations
2,869 Views
3 Pages

Recent Advancements in Biological Microelectromechanical Systems (BioMEMS) and Biomimetic Coatings

  • Song-Jeng Huang,
  • Ming-Tzer Lin,
  • Chao-Ching Chiang,
  • Kavya Arun Dwivedi and
  • Aqeel Abbas

23 November 2022

Biomimetic micro- and nanotechnology have substantially grown in recent years, contributing to significant progress in the pharmaceutical and biomedical domains [...]

  • Article
  • Open Access
21 Citations
3,684 Views
19 Pages

7 June 2022

The large availability of clinical natural language documents, such as clinical narratives or diagnoses, requires the definition of smart automatic systems for their processing and analysis, but the lack of annotated corpora in the biomedical domain,...

  • Systematic Review
  • Open Access
3,482 Views
31 Pages

eXplainable Artificial Intelligence (XAI): A Systematic Review for Unveiling the Black Box Models and Their Relevance to Biomedical Imaging and Sensing

  • Nadeesha Hettikankanamage,
  • Niusha Shafiabady,
  • Fiona Chatteur,
  • Robert M. X. Wu,
  • Fareed Ud Din and
  • Jianlong Zhou

30 October 2025

Artificial Intelligence (AI) has achieved immense progress in recent years across a wide array of application domains, with biomedical imaging and sensing emerging as particularly impactful areas. However, the integration of AI in safety-critical fie...

  • Article
  • Open Access
10 Citations
3,605 Views
21 Pages

The increasing expansion of biomedical documents has increased the number of natural language textual resources related to the current applications. Meanwhile, there has been a great interest in extracting useful information from meaningful coherent...

  • Article
  • Open Access
12 Citations
4,588 Views
16 Pages

20 August 2020

Various tasks in natural language processing (NLP) suffer from lack of labelled training data, which deep neural networks are hungry for. In this paper, we relied upon features learned to generate relation triples from the open information extraction...

  • Article
  • Open Access
1 Citations
1,368 Views
21 Pages

9 September 2025

Monte Carlo Path Tracing (MCPT) provides highly realistic visualization of biomedical volumes, but its computational cost limits real-time interaction. The Advanced Realistic Rendering Technique (AR2T) adapts MCPT to enable interactive exploration th...

  • Review
  • Open Access
4,162 Views
33 Pages

Diatom Biosilica: A Useful Natural Material for Biomedical Engineering

  • Daehyeon Yoo,
  • Minyoung Lee,
  • Yoseph Seo,
  • Jinwook Yoon,
  • Eunseok Jang,
  • Gaeun Lee,
  • Daeryul Kwon,
  • Sang Deuk Lee,
  • Junhong Min and
  • Taek Lee

11 August 2025

Silica-based materials are recognized as effective functional materials across diverse industrial fields, including biomedicine (e.g., drug delivery systems (DDS), biosensors, and tissue engineering), owing to their excellent stability and physicoche...

  • Perspective
  • Open Access
2,183 Views
36 Pages

13 December 2024

During the last decade, artificial intelligence (AI) was applied to nearly all domains of human activity, including scientific research. It is thus warranted to ask whether AI thinking should be durably involved in biomedical research. This problem w...

  • Systematic Review
  • Open Access
33 Citations
9,871 Views
21 Pages

Automatic Text Summarization of Biomedical Text Data: A Systematic Review

  • Andrea Chaves,
  • Cyrille Kesiku and
  • Begonya Garcia-Zapirain

19 August 2022

In recent years, the evolution of technology has led to an increase in text data obtained from many sources. In the biomedical domain, text information has also evidenced this accelerated growth, and automatic text summarization systems play an essen...

  • Review
  • Open Access
24 Citations
12,444 Views
26 Pages

11 January 2024

Biomedical image segmentation plays a pivotal role in medical imaging, facilitating precise identification and delineation of anatomical structures and abnormalities. This review explores the application of the Denoising Diffusion Probabilistic Model...

  • Review
  • Open Access
261 Citations
20,127 Views
25 Pages

Versatility of Hydrogels: From Synthetic Strategies, Classification, and Properties to Biomedical Applications

  • Zubair Ahmad,
  • Saad Salman,
  • Shahid Ali Khan,
  • Abdul Amin,
  • Zia Ur Rahman,
  • Youssef O. Al-Ghamdi,
  • Kalsoom Akhtar,
  • Esraa M. Bakhsh and
  • Sher Bahadar Khan

7 March 2022

Hydrogels are three-dimensional, cross-linked, and supramolecular networks that can absorb significant volumes of water. Hydrogels are one of the most promising biomaterials in the biological and biomedical fields, thanks to their hydrophilic propert...

  • Editorial
  • Open Access
1,294 Views
3 Pages

27 September 2023

Molecular probes, specialized tools or substances meticulously designed to bind to specific molecules or biomarkers within cells, tissues, or biological samples, play a pivotal role in various domains such as biomedical research, diagnostics, and med...

  • Article
  • Open Access
1 Citations
1,695 Views
23 Pages

Semantic web technologies (SWT) represent data in a format that is easier for machines to understand. Validating the knowledge in data graphs created using SWT is critical to ensure that the axioms accurately represent the so-called “real&rdquo...

  • Communication
  • Open Access
13 Citations
7,429 Views
13 Pages

Biomedical signals carry valuable physiological information and many researchers have difficulty interpreting and analyzing long-term, one-dimensional, quasi-periodic biomedical signals. Traditionally, biomedical signals are analyzed and visualized u...

  • Review
  • Open Access
193 Citations
36,252 Views
46 Pages

Brain-Computer Interface: Advancement and Challenges

  • M. F. Mridha,
  • Sujoy Chandra Das,
  • Muhammad Mohsin Kabir,
  • Aklima Akter Lima,
  • Md. Rashedul Islam and
  • Yutaka Watanobe

26 August 2021

Brain-Computer Interface (BCI) is an advanced and multidisciplinary active research domain based on neuroscience, signal processing, biomedical sensors, hardware, etc. Since the last decades, several groundbreaking research has been conducted in this...

  • Review
  • Open Access
72 Citations
7,424 Views
29 Pages

26 July 2021

Polyelectrolyte multilayers are versatile materials that are used in a large number of domains, including biomedical and environmental applications. The fabrication of polyelectrolyte multilayers using the layer-by-layer technique is one of the simpl...

  • Review
  • Open Access
6 Citations
4,476 Views
20 Pages

Trustworthy AI Guidelines in Biomedical Decision-Making Applications: A Scoping Review

  • Marçal Mora-Cantallops,
  • Elena García-Barriocanal and
  • Miguel-Ángel Sicilia

Recently proposed legal frameworks for Artificial Intelligence (AI) depart from some frameworks of concepts regarding ethical and trustworthy AI that provide the technical grounding for safety and risk. This is especially important in high-risk appli...

  • Article
  • Open Access
1 Citations
2,587 Views
17 Pages

Semantic Data Visualisation for Biomedical Database Catalogues

  • Arnaldo Pereira,
  • João Rafael Almeida,
  • Rui Pedro Lopes and
  • José Luís Oliveira

15 November 2022

Biomedical databases often have restricted access policies and governance rules. Thus, an adequate description of their content is essential for researchers who wish to use them for medical research. A strategy for publishing information without disc...

  • Article
  • Open Access
1,059 Views
17 Pages

10 June 2025

Despite remarkable advances in neural language models, a substantial gap remains in precisely interpreting the complex semantics of Electronic Medical Records (EMR). We propose Contrastive Representations Pre-Training (CRPT) to address this gap, repl...

  • Review
  • Open Access
11 Citations
7,227 Views
21 Pages

This work presents methods of obtaining polymeric hollow-fiber membranes produced via the dry–wet phase inversion method that were published in renowned specialized membrane publications in the years 2010–2020. Obtaining hollow-fiber memb...

  • Article
  • Open Access
4 Citations
3,450 Views
14 Pages

6 April 2020

Micromixers are significant segments inside miniaturized scale biomedical frameworks. Numerical investigation of the effects of galloping cylinder characteristics inside a microchannel Newtonian, incompressible fluid in nonstationary condition is per...

  • Review
  • Open Access
1,112 Views
32 Pages

Biomedical ontologies are critical for structuring domain knowledge and enabling integrative analyses in the life sciences. Traditional ontology development is labor-intensive, requiring extensive expert curation. Recent advances in artificial intell...

  • Article
  • Open Access
5 Citations
7,090 Views
28 Pages

Leveraging Large Language Models for Enhancing Literature-Based Discovery

  • Ikbal Taleb,
  • Alramzana Nujum Navaz and
  • Mohamed Adel Serhani

The exponential growth of biomedical literature necessitates advanced methods for Literature-Based Discovery (LBD) to uncover hidden, meaningful relationships and generate novel hypotheses. This research integrates Large Language Models (LLMs), parti...

  • Article
  • Open Access
1 Citations
2,326 Views
18 Pages

A Linked Data Application for Harmonizing Heterogeneous Biomedical Information

  • Nicola Capuano,
  • Pasquale Foggia,
  • Luca Greco and
  • Pierluigi Ritrovato

16 September 2022

In the biomedical field, there is an ever-increasing number of large, fragmented, and isolated data sources stored in databases and ontologies that use heterogeneous formats and poorly integrated schemes. Researchers and healthcare professionals find...

  • Article
  • Open Access
6 Citations
3,163 Views
10 Pages

Molecular Recognition of Methacryllysine and Crotonyllysine by the AF9 YEATS Domain

  • Nurgül Bilgin,
  • Laust Moesgaard,
  • Mohammad M. Rahman,
  • Vildan A. Türkmen,
  • Jacob Kongsted and
  • Jasmin Mecinović

Histone lysine methacrylation and crotonylation are epigenetic marks that play important roles in human gene regulation. Here, we explore the molecular recognition of histone H3 peptides possessing methacryllysine and crotonyllysine at positions 18 a...

  • Article
  • Open Access
6 Citations
4,167 Views
14 Pages

Confidence Measures for Deep Learning in Domain Adaptation

  • Simone Bonechi,
  • Paolo Andreini,
  • Monica Bianchini,
  • Akshay Pai and
  • Franco Scarselli

29 May 2019

In recent years, Deep Neural Networks (DNNs) have led to impressive results in a wide variety of machine learning tasks, typically relying on the existence of a huge amount of supervised data. However, in many applications (e.g., bio–medical im...

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