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10,578 Results Found

  • Systematic Review
  • Open Access
9 Citations
5,793 Views
17 Pages

Meta-Analysis of Herbicide Non-Target Effects on Pest Natural Enemies

  • Gabriel Zilnik,
  • Paul E. Bergeron,
  • Angela Chuang,
  • Lauren Diepenbrock,
  • Aldo Hanel,
  • Eric Middleton,
  • Erica Moretti and
  • Rebecca Schmidt-Jeffris

26 September 2023

A critical component of integrated pest management is minimizing disruption of biological control by reducing the use of pesticides with significant non-target effects on natural enemies. Insecticide non-target effects testing for natural enemies has...

  • Review
  • Open Access
27 Citations
6,733 Views
51 Pages

Non-targeted effects (NTE) have been generally regarded as a low-dose ionizing radiation (IR) phenomenon. Recently, regarding long distant abscopal effects have also been observed at high doses of IR) relevant to antitumor radiation therapy. IR is in...

  • Feature Paper
  • Review
  • Open Access
6 Citations
3,979 Views
20 Pages

Non-Targeted Effects of Synchrotron Radiation: Lessons from Experiments at the Australian and European Synchrotrons

  • Cristian Fernandez-Palomo,
  • Zacharenia Nikitaki,
  • Valentin Djonov,
  • Alexandros G. Georgakilas and
  • Olga A. Martin

17 February 2022

Studies have been conducted at synchrotron facilities in Europe and Australia to explore a variety of applications of synchrotron X-rays in medicine and biology. We discuss the major technical aspects of the synchrotron irradiation setups, paying spe...

  • Review
  • Open Access
1,366 Views
60 Pages

Radiation Without Borders: Unraveling Bystander and Non-Targeted Effects in Oncology

  • Madhi Oli Ramamurthy,
  • Poorvi Subramanian,
  • Sivaroopan Aravindan,
  • Loganayaki Periyasamy and
  • Natarajan Aravindan

11 November 2025

Radiotherapy (RT) remains a cornerstone of cancer treatment, offering spatially precise cytotoxicity against malignant cells. However, emerging evidence reveals that ionizing radiation (IR) exerts biological effects beyond the targeted tumor volume,...

  • Review
  • Open Access
22 Citations
19,688 Views
42 Pages

17 November 2023

It is well established that cells, tissues, and organisms exposed to low doses of ionizing radiation can induce effects in non-irradiated neighbors (non-targeted effects or NTE), but the mechanisms remain unclear. This is especially true of the initi...

  • Article
  • Open Access
2 Citations
3,369 Views
10 Pages

Nitric Oxide Is Involved in Heavy Ion-Induced Non-Targeted Effects in Human Fibroblasts

  • Megumi Hada,
  • Premkumar B. Saganti and
  • Francis A. Cucinotta

4 September 2019

Previously, we investigated the dose response for chromosomal aberration (CA) for exposures corresponding to less than one particle traversal per cell nucleus by high energy and charge (HZE) particles, and showed that the dose responses for simple ex...

  • Article
  • Open Access
37 Citations
5,275 Views
25 Pages

Phenotypic and Functional Characteristics of Exosomes Derived from Irradiated Mouse Organs and Their Role in the Mechanisms Driving Non-Targeted Effects

  • Seda Tuncay Cagatay,
  • Ammar Mayah,
  • Mariateresa Mancuso,
  • Paola Giardullo,
  • Simonetta Pazzaglia,
  • Anna Saran,
  • Amuthachelvi Daniel,
  • Damien Traynor,
  • Aidan D. Meade and
  • Fiona Lyng
  • + 2 authors

9 November 2020

Molecular communication between irradiated and unirradiated neighbouring cells initiates radiation-induced bystander effects (RIBE) and out-of-field (abscopal) effects which are both an example of the non-targeted effects (NTE) of ionising radiation...

  • Article
  • Open Access
2 Citations
2,089 Views
17 Pages

17 January 2025

2,6-Dichloro-1,4-benzoquinone (2,6-DCBQ) is an emerging chlorinated disinfection byproduct (DBP) in bodies of water. However, this compound poses an unknown toxic effect on cyanobacteria. In this study, the toxicological mechanisms of 2,6-DCBQ in Mic...

  • Review
  • Open Access
7 Citations
3,234 Views
19 Pages

21 September 2022

The role of signalling in initiating and perpetuating effects triggered by deposition of ionising radiation energy in parts of a system is very clear. Less clear are the very early steps involved in converting energy to chemical and biological effect...

  • Article
  • Open Access
12 Citations
3,938 Views
23 Pages

Hidden Host Mortality from an Introduced Parasitoid: Conventional and Molecular Evaluation of Non-Target Risk

  • James R. Hepler,
  • Kacie Athey,
  • David Enicks,
  • Paul K. Abram,
  • Tara D. Gariepy,
  • Elijah J. Talamas and
  • Elizabeth Beers

23 November 2020

Hidden trophic interactions are important in understanding food web ecology and evaluating the ecological risks and benefits associated with the introduction of exotic natural enemies in classical biological control programs. Although non-target risk...

  • Article
  • Open Access
8 Citations
4,265 Views
13 Pages

Effects of Bioinsecticidal Aegerolysin-Based Cytolytic Complexes on Non-Target Organisms

  • Anastasija Panevska,
  • Gordana Glavan,
  • Anita Jemec Kokalj,
  • Veronika Kukuljan,
  • Tomaž Trobec,
  • Monika Cecilija Žužek,
  • Milka Vrecl,
  • Damjana Drobne,
  • Robert Frangež and
  • Kristina Sepčić

30 June 2021

Aegerolysin proteins ostreolysin A6 (OlyA6), pleurotolysin A2 (PlyA2) and erylysin A (EryA) produced by the mushroom genus Pleurotus bind strongly to an invertebrate-specific membrane sphingolipid, and together with a protein partner pleurotolysin B...

  • Article
  • Open Access
26 Citations
6,592 Views
19 Pages

Classification of Human Motions Using Micro-Doppler Radar in the Environments with Micro-Motion Interference

  • Xiaolin Ma,
  • Running Zhao,
  • Xinhua Liu,
  • Hailan Kuang and
  • Mohammed A. A. Al-qaness

7 June 2019

Human motion classification based on micro-Doppler effect has been widely used in various fields. However, the motion classification performance would be greatly degraded if the wireless environment has non-target micro-motion interference. In this c...

  • Article
  • Open Access
371 Views
19 Pages

Terpenoid Mixtures as Repellents Against the American Cockroach: Their Synergy and Low Toxicity Against Non-Target Species

  • Hataichanok Passara,
  • Tanapoom Moungthipmalai,
  • Chamroon Laosinwattana,
  • Sirawut Sittichok,
  • Kouhei Murata and
  • Mayura Soonwera

5 January 2026

The repellent activities (Periplaneta americana) of lone and binary mixtures of terpenoids—geranial, trans-anethole, and trans-cinnamaldehyde—against adult American cockroaches were evaluated in this study. The respective efficacies of th...

  • Article
  • Open Access
826 Views
11 Pages

13 August 2025

Regulating tumor invasion and metastasis is pivotal for improving cancer patient prognosis. While cell migration is a key factor in these processes, the non-targeted effects of chemoradiotherapy on cell motility remain poorly understood. In this stud...

  • Article
  • Open Access
45 Citations
6,984 Views
14 Pages

Can Anastatus bifasciatus Be Used for Augmentative Biological Control of the Brown Marmorated Stink Bug in Fruit Orchards?

  • Judith M. Stahl,
  • Dirk Babendreier,
  • Cristina Marazzi,
  • Stefano Caruso,
  • Elena Costi,
  • Lara Maistrello and
  • Tim Haye

15 April 2019

The generalist egg parasitoid Anastatus bifasciatus (Geoffroy) (Hymenoptera: Eupelmidae) is the most prevalent egg parasitoid of the invasive Halyomorpha halys (Stål) (Hemiptera: Pentatomidae) in Europe. To assess its efficacy against the pest...

  • Article
  • Open Access
18 Citations
4,724 Views
17 Pages

Cytosolic Release of Mitochondrial DNA and Associated cGAS Signaling Mediates Radiation-Induced Hematopoietic Injury of Mice

  • Hua Guan,
  • Wen Zhang,
  • Dafei Xie,
  • Yuehua Nie,
  • Shi Chen,
  • Xiaoya Sun,
  • Hongling Zhao,
  • Xiaochang Liu,
  • Hua Wang and
  • Xin Huang
  • + 4 authors

16 February 2023

Mitochondrion is an important organelle of eukaryotic cells and a critical target of ionizing radiation (IR) outside the nucleus. The biological significance and mechanism of the non-target effect originating from mitochondria have received much atte...

  • Article
  • Open Access
4 Citations
3,327 Views
17 Pages

Anise and Fennel Essential Oils and Their Combination as Natural and Safe Housefly Repellents

  • Hataichanok Passara,
  • Sirawut Sittichok,
  • Cheepchanok Puwanard,
  • Jirisuda Sinthusiri,
  • Tanapoom Moungthipmalai,
  • Kouhei Murata and
  • Mayura Soonwera

29 December 2024

Essential oils (EOs) are effective repellents and eco-friendly alternatives. We tested single and combination EOs of fennel and anise for repellency and stability against houseflies. All treatments were stored at 27 °C for up to 360 days. Efficac...

  • Review
  • Open Access
5 Citations
4,581 Views
30 Pages

11 August 2021

Purpose: A major issue in radiotherapy is the relative resistance of hypoxic cells to radiation. Historic approaches to this problem include the use of oxygen mimetic compounds to sensitize tumour cells, which were unsuccessful. This review looks at...

  • Article
  • Open Access
5 Citations
2,890 Views
17 Pages

Proton Compared to X-Irradiation Induces Different Protein Profiles in Oral Cancer Cells and Their Derived Extracellular Vesicles

  • Inga Solgård Juvkam,
  • Olga Zlygosteva,
  • Mateusz Sitarz,
  • Bernd Thiede,
  • Brita Singers Sørensen,
  • Eirik Malinen,
  • Nina Jeppesen Edin,
  • Tine Merete Søland and
  • Hilde Kanli Galtung

30 November 2023

Extracellular vesicles (EVs) are membrane-bound particles released from cells, and their cargo can alter the function of recipient cells. EVs from X-irradiated cells have been shown to play a likely role in non-targeted effects. However, EVs derived...

  • Article
  • Open Access
1 Citations
1,943 Views
21 Pages

Synergistic Larvicidal and Pupicidal Effects of Monoterpene Mixtures Against Aedes aegypti with Low Toxicity to Guppies and Honeybees

  • Sirawut Sittichok,
  • Hataichanok Passara,
  • Tanapoom Moungthipmalai,
  • Jirisuda Sinthusiri,
  • Kouhei Murata and
  • Mayura Soonwera

18 July 2025

The present study evaluated the larvicidal and pupicidal activities of pure and mixed monoterpene formulations—eucalyptol, geranial, trans-anethole, and trans-cinnamaldehyde—against Aedes aegypti and compared them with 1% (w/w) temephos....

  • Article
  • Open Access
4 Citations
2,940 Views
10 Pages

26 November 2021

The non-targeted effects of radiation have been known to induce significant alternations in cell survival. Although the effects might govern the progression of tumor sites following advanced radiotherapy, the impacts on the intercellular control of t...

  • Editorial
  • Open Access
13 Citations
4,618 Views
5 Pages

7 February 2020

Complex samples such as botanical extracts contain hundreds of compounds. Since we can only identify compounds that are stable, extractable, separable and detectable from complex botanical extracts, minimal sample treatment and different detection me...

  • Review
  • Open Access
3 Citations
3,073 Views
29 Pages

23 October 2022

The present paper reviews a non-targeted effect in radiobiology known as the Radiation-Induced Rescue Effect (RIRE) and insights gained from previous microbeam experiments on RIRE. RIRE describes the mitigation of radiobiological effects in targeted...

  • Article
  • Open Access
5 Citations
6,198 Views
13 Pages

Bacillus thuringiensis Maize Expressing a Fusion Gene Cry1Ab/Cry1AcZM Does Not Harm Valued Pollen Feeders

  • Xiaowei Xie,
  • Zhifu Cui,
  • Yanan Wang,
  • Yuanyuan Wang,
  • Fengqin Cao,
  • Jörg Romeis,
  • Yufa Peng and
  • Yunhe Li

26 December 2018

The ladybird Propylea japonica, adults of the green lacewing Chrysoperla nipponensis and the honey bee Apis mellifera are common pollen feeders in many crop systems. They could therefore be directly exposed to Cry proteins in Bacillus thuringiensis (...

  • Review
  • Open Access
99 Citations
15,238 Views
34 Pages

20 August 2020

The present system of radiation protection assumes that exposure at low doses and/or low dose-rates leads to health risks linearly related to the dose. They are evaluated by a combination of epidemiological data and radiobiological models. The latter...

  • Article
  • Open Access
5 Citations
2,815 Views
13 Pages

18 October 2022

A simple food chain (plant, insect pests, and predatory arthropods) in an agro-ecosystem was set up here as a model system to elucidate the potential effect of transgenic Bacillus thuringiensis (Bt) cotton on non-target organisms. The system included...

  • Article
  • Open Access
11 Citations
6,905 Views
17 Pages

Revealing the Extent of Pesticide Runoff to the Surface Water in Agricultural Watersheds

  • Young-Eun Kim,
  • Darae Jeon,
  • Hyeri Lee,
  • Yujeong Huh,
  • Soohyung Lee,
  • Jong Guk Kim and
  • Hyoung Seop Kim

16 November 2023

Pesticides are beneficial in protecting crops from pests and improving agricultural productivity; however, concerns on pesticide pollution in water have increased due to their indiscriminate use and lack of adequate regulations. Many studies have foc...

  • Article
  • Open Access
10 Citations
4,516 Views
16 Pages

Glyphosate-Based Herbicide Formulations and Their Relevant Active Ingredients Affect Soil Springtails Even Five Months after Application

  • Anna Altmanninger,
  • Verena Brandmaier,
  • Bernhard Spangl,
  • Edith Gruber,
  • Eszter Takács,
  • Mária Mörtl,
  • Szandra Klátyik,
  • András Székács and
  • Johann G. Zaller

11 December 2023

Glyphosate is the most widely used active ingredient (AI) in glyphosate-based herbicides (GBHs) worldwide and is also known to affect a variety of soil organisms. However, we know little about how the effects of glyphosate AIs differ from those of GB...

  • Review
  • Open Access
168 Citations
16,799 Views
59 Pages

13 October 2021

Until recently, radiation effects have been considered to be mainly due to nuclear DNA damage and their management by repair mechanisms. However, molecular biology studies reveal that the outcomes of exposures to ionizing radiation (IR) highly depend...

  • Article
  • Open Access
17 Citations
5,173 Views
23 Pages

Mango Endophyte and Epiphyte Microbiome Composition during Fruit Development and Post-Harvest Stages

  • Malick Bill,
  • Lizyben Chidamba,
  • Jarishma Keriuscia Gokul and
  • Lise Korsten

The influence of the development stage and post-harvest handling on the microbial composition of mango fruit plays a central role in fruit health. Hence, the composition of fungal and bacterial microbiota on the anthoplane, fructoplane, stems and ste...

  • Article
  • Open Access
3 Citations
3,893 Views
21 Pages

Proteins Marking the Sequence of Genotoxic Signaling from Irradiated Mesenchymal Stromal Cells to CD34+ Cells

  • Vanessa Kohl,
  • Oliver Drews,
  • Victor Costina,
  • Miriam Bierbaum,
  • Ahmed Jawhar,
  • Henning Roehl,
  • Christel Weiss,
  • Susanne Brendel,
  • Helga Kleiner and
  • Johanna Flach
  • + 6 authors

Non-targeted effects (NTE) of ionizing radiation may initiate myeloid neoplasms (MN). Here, protein mediators (I) in irradiated human mesenchymal stromal cells (MSC) as the NTE source, (II) in MSC conditioned supernatant and (III) in human bone marro...

  • Communication
  • Open Access
4 Citations
3,366 Views
7 Pages

Imidacloprid Movement into Fungal Conidia Is Lethal to Mycophagous Beetles

  • Robin A. Choudhury,
  • Andrew M. Sutherland,
  • Matt J. Hengel,
  • Michael P. Parrella and
  • W. Douglas Gubler

3 August 2020

Applications of systemic pesticides can have unexpected direct and indirect effects on nontarget organisms, producing ecosystem-level impacts. We investigated whether a systemic insecticide (imidacloprid) could be absorbed by a plant pathogenic fungu...

  • Article
  • Open Access
12 Citations
4,254 Views
18 Pages

22 February 2022

Black pheromone-baited traps are commonly used for monitoring Monochamus galloprovincialis, a vector of Bursaphelenchus xylophilus, although few studies have been conducted on its response to color (black, white, and clear). The objective of our stud...

  • Article
  • Open Access
6 Citations
3,139 Views
14 Pages

18 January 2024

Mosquitoes, as disease vectors causing global morbidity and mortality through diseases like malaria, dengue, and Zika, necessitate mosquito population control methods. This study investigated the efficacy of nano-formulated insecticide-based sugar ba...

  • Article
  • Open Access
15 Citations
6,729 Views
12 Pages

The present paper studied the X-ray-induced targeted effect in irradiated zebrafish embryos (Danio rerio), as well as a non-targeted effect in bystander naïve embryos partnered with irradiated embryos, and examined the influence of exogenous nitric o...

  • Review
  • Open Access
80 Citations
14,869 Views
35 Pages

Physiological Effects of Neonicotinoid Insecticides on Non-Target Aquatic Animals—An Updated Review

  • Nemi Malhotra,
  • Kelvin H.-C. Chen,
  • Jong-Chin Huang,
  • Hong-Thih Lai,
  • Boontida Uapipatanakul,
  • Marri Jmelou M. Roldan,
  • Allan Patrick G. Macabeo,
  • Tzong-Rong Ger and
  • Chung-Der Hsiao

4 September 2021

In this paper, we review the effects of large-scale neonicotinoid contaminations in the aquatic environment on non-target aquatic invertebrate and vertebrate species. These aquatic species are the fauna widely exposed to environmental changes and che...

  • Article
  • Open Access
17 Citations
3,872 Views
14 Pages

Non-Target Effects of dsRNA Molecules in Hemipteran Insects

  • Arinder K. Arora,
  • Seung Ho Chung and
  • Angela E. Douglas

12 March 2021

Insect pest control by RNA interference (RNAi)-mediated gene expression knockdown can be undermined by many factors, including small sequence differences between double-stranded RNA (dsRNA) and the target gene. It can also be compromised by effects t...

  • Article
  • Open Access
2,002 Views
21 Pages

27 February 2023

Herbicide resistance is an important weed management issue. Glyphosate is the most dominant herbicide, which controls a broad spectrum of weeds, including grasses such as Lolium rigidum. Lolium rigidum is a major weed of winter crops in Australia tha...

  • Article
  • Open Access
7 Citations
2,436 Views
12 Pages

21 January 2021

To evaluate the effect of Bt maize expressing Cry1Ie protein on non-target soil Collembola, a two-year field study was conducted in Northeast China. Bt maize line IE09S034 and its near isoline Zong 31 were selected as experimental crops; we investiga...

  • Review
  • Open Access
25 Citations
10,071 Views
19 Pages

27 February 2015

The biological effects of high-dose total body ionizing irradiation [(thereafter, irradiation (IR)] are attributed to primary oxidative breakage of biomolecule targets, mitotic, apoptotic and necrotic cell death in the dose-limiting tissues, clastoge...

  • Review
  • Open Access
14 Citations
6,312 Views
24 Pages

1 November 2022

Coffee is a very popular beverage worldwide. However, its composition and characteristics are affected by a number of factors, such as geographical and botanical origin, harvesting and roasting conditions, and brewing method used. As coffee consumpti...

  • Article
  • Open Access
10 Citations
3,006 Views
14 Pages

26 November 2020

Increasing areas of artificial afforestation and poplar monoculture in China have led to serious problems with insect pests. The development of genetic engineering technology, such as transgenic modification with Bacillus thuringiensis (Bt) genes, pr...

  • Article
  • Open Access
4 Citations
2,806 Views
12 Pages

25 October 2024

Metabolic dysfunction-associated steatohepatitis (MASH), characterized by progressive inflammation and fibrosis, evolves from metabolic dysfunction-associated steatotic liver disease and significantly heightens the risk of cirrhosis and hepatocellula...

  • Article
  • Open Access
1 Citations
2,426 Views
13 Pages

Evaluation of the Morphological, Physiological and Biochemical Effects Induced by Coragen 20 SC in Some Non-Target Species

  • Cristina Maria Ponepal,
  • Liliana Cristina Soare,
  • Oana-Alexandra Drăghiceanu,
  • Cristina Florina Mihăescu,
  • Nicoleta Anca Șuțan,
  • Monica Marilena Țânțu and
  • Alina Păunescu

17 July 2023

Coragen 20 SC is an insecticide based on chlorantraniliprole that is applied on many crops. Considered an effective product with an incremental cost-benefit ratio, it has been widely used globally. Residual pesticides affect non-target organisms, so...

  • Article
  • Open Access
3 Citations
2,059 Views
13 Pages

14 October 2024

The effects of pirimiphos-methyl have previously been assessed on blood-sucking insect species, pollinating insects, and target crop pest species. The sensitivity of non-target zoophagous and saprophage species to this insecticide remains largely uns...

  • Review
  • Open Access
598 Views
20 Pages

Sublethal Effects of Neonicotinoids: How Physiological and Behavioral Disruptions in Non-Target Insects Threaten Biodiversity and Ecosystem Services

  • Sarah K. Spence,
  • Shorooq A. M. Alharbi,
  • Afure Ejomah,
  • Feizollah A. Maleki,
  • Michael S. Wolfin and
  • Mônica F. Kersch-Becker

24 December 2025

Neonicotinoid insecticides were initially hailed as safer alternatives to organochlorine and organophosphate pesticides due to their perceived lower toxicity to non-target organisms. However, it has been recently discovered that sublethal exposure to...

  • Article
  • Open Access
752 Views
14 Pages

2 September 2025

Although traditional genetically modified (GM) cotton has reduced lepidopteran pests, secondary pests such as Adelphocoris suturalis Jakovlev (Hemiptera: Miridae) have become increasingly problematic. RNA interference (RNAi)-based insect-resistant pl...

  • Review
  • Open Access
21 Citations
4,890 Views
25 Pages

23 August 2019

Non-targeted effects (NTE) such as bystander effects or genomic instability have been known for many years but their significance for radiotherapy or medical diagnostic radiology are far from clear. Central to the issue are reported differences in th...

  • Article
  • Open Access
6 Citations
5,273 Views
19 Pages

Pesticides affect biota inside and outside agricultural fields due to their intrinsic mode of action. This study investigated whether pesticide active substances (AS) approved for conventional agriculture in Europe differ in their ecotoxicity from AS...

  • Article
  • Open Access
26 Citations
4,035 Views
12 Pages

Radiation-Induced Bystander Effect Mediated by Exosomes Involves the Replication Stress in Recipient Cells

  • Mateusz Smolarz,
  • Łukasz Skoczylas,
  • Marta Gawin,
  • Monika Krzyżowska,
  • Monika Pietrowska and
  • Piotr Widłak

Exosomes released by irradiated cells mediate the radiation-induced bystander effect, which is manifested by DNA breaks detected in recipient cells; yet, the specific mechanism responsible for the generation of chromosome lesions remains unclear. In...

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