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Open AccessEditorial

Hyphenated TLC as a Tool in the Effect-Directed Discovery of Bioactive Natural Products

1
Department of Pharmaceutical and Toxicological Chemistry Named after Arzamastsev of the Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia
2
School of Pharmacy and Biomedical Sciences, La Trobe Institute for Molecular Sciences, La Trobe University, Edwards Rd, Bendigo 3550, Australia
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2020, 10(3), 1123; https://doi.org/10.3390/app10031123
Received: 29 January 2020 / Accepted: 5 February 2020 / Published: 7 February 2020
(This article belongs to the Special Issue Medicinal Chemistry and Drug Discovery)
Complex samples such as botanical extracts contain hundreds of compounds. Since we can only identify compounds that are stable, extractable, separable and detectable from complex botanical extracts, minimal sample treatment and different detection methods are essential. A combination of high-performance thin-layer chromatography (HPTLC) with non-targeted screening via bioassays (enzymes), microchemical and biological (microorganisms) detection allows for the fast and quantitative bioprofiling of complex samples. Further hyphenation of HPTLC with spectroscopic methods of identification enables targeted identification of bioactive natural products via Effect Directed Analysis (EDA). View Full-Text
Keywords: HPTLC; Effect Directed Analysis; bioassays; hyphenation; non-targeted screening HPTLC; Effect Directed Analysis; bioassays; hyphenation; non-targeted screening
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MDPI and ACS Style

Agatonovic-Kustrin, S.; Morton, D.W. Hyphenated TLC as a Tool in the Effect-Directed Discovery of Bioactive Natural Products. Appl. Sci. 2020, 10, 1123. https://doi.org/10.3390/app10031123

AMA Style

Agatonovic-Kustrin S, Morton DW. Hyphenated TLC as a Tool in the Effect-Directed Discovery of Bioactive Natural Products. Applied Sciences. 2020; 10(3):1123. https://doi.org/10.3390/app10031123

Chicago/Turabian Style

Agatonovic-Kustrin, Snezana; Morton, David W. 2020. "Hyphenated TLC as a Tool in the Effect-Directed Discovery of Bioactive Natural Products" Appl. Sci. 10, no. 3: 1123. https://doi.org/10.3390/app10031123

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