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4,609 Results Found

  • Article
  • Open Access
2 Citations
2,612 Views
15 Pages

SiC Doping Impact during Conducting AFM under Ambient Atmosphere

  • Christina Villeneuve-Faure,
  • Abdelhaq Boumaarouf,
  • Vishal Shah,
  • Peter M. Gammon,
  • Ulrike Lüders and
  • Rosine Coq Germanicus

1 August 2023

The characterization of silicon carbide (SiC) by specific electrical atomic force microscopy (AFM) modes is highly appreciated for revealing its structure and properties at a nanoscale. However, during the conductive AFM (C-AFM) measurements, the str...

  • Review
  • Open Access
6 Citations
1,836 Views
19 Pages

AFM for Studying the Functional Activity of Enzymes

  • Irina A. Ivanova,
  • Anastasia A. Valueva,
  • Maria O. Ershova and
  • Tatiana O. Pleshakova

12 April 2025

The conventional approach to investigating enzyme systems involves the simultaneous investigation of a large number of molecules and observing ensemble-averaged properties. However, modern science allows us to study the properties of single molecules...

  • Proceeding Paper
  • Open Access
4 Citations
1,530 Views
5 Pages

Unbundling SWCNT Mechanically via Nanomanipulation Using AFM

  • Ahmed Kreta,
  • Mohamed A. Swillam,
  • Albert Guirguis and
  • Abdou Hassanien

26 October 2023

Carbon nanotubes (CNTs) are cylindrical nanostructures fabricated from carbon atoms that seem like seamless cylinders composed of rolled sheets of graphite. Owing to the unique properties of single-walled carbon nanotubes (SWCNTs), they are a promisi...

  • Article
  • Open Access
6 Citations
4,093 Views
12 Pages

Brownian Motion Influence on AFM Exosomes’ Size Measurements

  • Katarzyna Życieńska,
  • Beata Pszczółkowska,
  • Beata Brzozowska,
  • Maciej Kamiński,
  • Tomasz Lorenc,
  • Wioletta Olejarz,
  • Sławomir Sęk and
  • Józef Ginter

3 September 2022

Extracellular vesicles are evaluated by nanoparticle tracking analysis (NTA), providing information on their hydrodynamic diameters, and by atomic force microscopy (AFM) to calculate their geometric diameters. The aim of this study is to explore the...

  • Article
  • Open Access
13 Citations
5,870 Views
13 Pages

Photocatalytic Nanofabrication and Intracellular Raman Imaging of Living Cells with Functionalized AFM Probes

  • Takayuki Shibata,
  • Hiromi Furukawa,
  • Yasuharu Ito,
  • Masahiro Nagahama,
  • Terutake Hayashi,
  • Miho Ishii-Teshima and
  • Moeto Nagai

Atomic force microscopy (AFM) is an effective platform for in vitro manipulation and analysis of living cells in medical and biological sciences. To introduce additional new features and functionalities into a conventional AFM system, we investigated...

  • Article
  • Open Access
14 Citations
11,460 Views
14 Pages

Nano-Electrochemistry and Nano-Electrografting with an Original Combined AFM-SECM

  • Achraf Ghorbal,
  • Federico Grisotto,
  • Julienne Charlier,
  • Serge Palacin,
  • Cédric Goyer,
  • Christophe Demaille and
  • Ammar Ben Brahim

17 May 2013

This study demonstrates the advantages of the combination between atomic force microscopy and scanning electrochemical microscopy. The combined technique can perform nano-electrochemical measurements onto agarose surface and nano-electrografting of n...

  • Feature Paper
  • Review
  • Open Access
58 Citations
9,275 Views
28 Pages

7 November 2020

In this review several scanning probe microscopy techniques are briefly discussed as valuable assets for corrosionists to study corrosion susceptibility and inhibition of metals and alloys at sub-micrometer resolution. At the beginning, the review pr...

  • Article
  • Open Access
32 Citations
6,154 Views
22 Pages

A Deep Learning Approach for Molecular Classification Based on AFM Images

  • Jaime Carracedo-Cosme,
  • Carlos Romero-Muñiz and
  • Rubén Pérez

24 June 2021

In spite of the unprecedented resolution provided by non-contact atomic force microscopy (AFM) with CO-functionalized and advances in the interpretation of the observed contrast, the unambiguous identification of molecular systems solely based on AFM...

  • Article
  • Open Access
6 Citations
2,463 Views
18 Pages

Selection of Aptamers for Use as Molecular Probes in AFM Detection of Proteins

  • Maria O. Ershova,
  • Amir Taldaev,
  • Petr V. Konarev,
  • Georgy S. Peters,
  • Anastasia A. Valueva,
  • Irina A. Ivanova,
  • Sergey V. Kraevsky,
  • Andrey F. Kozlov,
  • Vadim S. Ziborov and
  • Tatyana O. Pleshakova
  • + 2 authors

12 December 2023

Currently, there is great interest in the development of highly sensitive bioanalytical systems for diagnosing diseases at an early stage, when pathological biomarkers are present in biological fluids at low concentrations and there are no clinical m...

  • Article
  • Open Access
6 Citations
4,632 Views
14 Pages

10 February 2024

Any 3D AFM image is a convolution of the geometry of the AFM tip and the profile of the scanned sample, especially when the dimensions of the scanned sample are comparable to those of the AFM tip shape. The precise profile of the scanned sample can b...

  • Proceeding Paper
  • Open Access
1 Citations
1,056 Views
5 Pages

7 November 2023

The electrochemical cell is designed with a conductive substrate (working electrode) where deposition takes place within a three-electrode cell. In order to complete the electrochemical circuit, the cell has been equipped with a counter electrode (CE...

  • Article
  • Open Access
4 Citations
3,514 Views
24 Pages

PeakForce AFM Analysis Enhanced with Model Reduction Techniques

  • Xuyang Chang,
  • Simon Hallais,
  • Kostas Danas and
  • Stéphane Roux

13 May 2023

PeakForce quantitative nanomechanical AFM mode (PF-QNM) is a popular AFM technique designed to measure multiple mechanical features (e.g., adhesion, apparent modulus, etc.) simultaneously at the exact same spatial coordinates with a robust scanning f...

  • Article
  • Open Access
3 Citations
3,507 Views
11 Pages

Hydration Dynamics and the Future of Small-Amplitude AFM Imaging in Air

  • Sergio Santos,
  • Tuza A. Olukan,
  • Chia-Yun Lai and
  • Matteo Chiesa

23 November 2021

Here, we discuss the effects that the dynamics of the hydration layer and other variables, such as the tip radius, have on the availability of imaging regimes in dynamic AFM—including multifrequency AFM. Since small amplitudes are required for...

  • Article
  • Open Access
8 Citations
6,207 Views
10 Pages

In situ Stiffness Adjustment of AFM Probes by Two Orders of Magnitude

  • Marcel Lambertus Cornelis De Laat,
  • Héctor Hugo Pérez Garza and
  • Murali Krishna Ghatkesar

12 April 2016

The choice on which type of cantilever to use for Atomic Force Microscopy (AFM) depends on the type of the experiment being done. Typically, the cantilever has to be exchanged when a different stiffness is required and the entire alignment has to be...

  • Abstract
  • Open Access
792 Views
2 Pages

Design of a Multiplex Sensing Platform: AFM as a Nanolithographic Tool

  • Silvia Maria Cristina Rotondi,
  • Paolo Canepa,
  • Maurizio Canepa and
  • Ornella Cavalleri

Coupling spectroscopic ellipsometry (SE), quartz crystal microbalance with dissipation (QCM-D), X-ray photoemission spectroscopy (XPS), and atomic force microscopy (AFM), we developed a multi-technique approach to characterize the surface immobilizat...

  • Article
  • Open Access
7 Citations
4,160 Views
34 Pages

13 August 2022

Atomic force microscopy (AFM) has been applied to study the adsorption morphology of various collectors, i.e., potassium ethyl xanthate (KEX) and potassium amyl xanthate (PAX) and Cytec Aerofloat 238 (sodium dibutyl dithiophosphate), on chalcocite in...

  • Article
  • Open Access
14 Citations
3,475 Views
15 Pages

Morphological and Mechanical Characterization of DNA SAMs Combining Nanolithography with AFM and Optical Methods

  • Giulia Pinto,
  • Paolo Canepa,
  • Claudio Canale,
  • Maurizio Canepa and
  • Ornella Cavalleri

27 June 2020

The morphological and mechanical properties of thiolated ssDNA films self-assembled at different ionic strength on flat gold surfaces have been investigated using Atomic Force Microscopy (AFM). AFM nanoshaving experiments, performed in hard tapping m...

  • Article
  • Open Access
9 Citations
6,216 Views
18 Pages

Advanced Surface Probing Using a Dual-Mode NSOM–AFM Silicon-Based Photosensor

  • Matityahu Karelits,
  • Emanuel Lozitsky,
  • Avraham Chelly,
  • Zeev Zalevsky and
  • Avi Karsenty

16 December 2019

A feasibility analysis is performed for the development and integration of a near-field scanning optical microscope (NSOM) tip–photodetector operating in the visible wavelength domain of an atomic force microscope (AFM) cantilever, involving si...

  • Article
  • Open Access
24 Citations
9,997 Views
19 Pages

10 March 2015

Measurement of force on a micro- or nano-Newton scale is important when exploring the mechanical properties of materials in the biophysics and nanomechanical fields. The atomic force microscope (AFM) is widely used in microforce measurement. The cant...

  • Abstract
  • Open Access
1 Citations
1,538 Views
3 Pages

Fabrication of 3D Nanostructures via AFM-Based Nanolithography

  • Lorenzo Vincenti,
  • Paolo Pellegrino,
  • Isabella Farella,
  • Mariafrancesca Cascione,
  • Valeria De Matteis,
  • Fabio Quaranta and
  • Rosaria Rinaldi

The increasing use of nanomaterials in high-tech devices has posed an exciting challenge for the scientific community to develop new, easy, high-throughput nanofabrication approaches. Here, we present an easy AFM-based nanofabrication approach based...

  • Review
  • Open Access
48 Citations
10,804 Views
47 Pages

3 February 2020

Electrochemical atomic force microscopy (EC-AFM), a branch of a scanning probe microscopy (SPM), can image substrate topography with high resolution. Since its inception, it was extended to a wide range of research areas through continuous improvemen...

  • Article
  • Open Access
3 Citations
3,316 Views
17 Pages

18 April 2023

AFM has a wide range of applications in nanostructure scanning imaging and fabrication. The wear of AFM probes has a significant impact on the accuracy of nanostructure measurement and fabrication, which is particularly significant in the process of...

  • Proceeding Paper
  • Open Access
1 Citations
1,824 Views
3 Pages

Investigations on Long-Range AFM Scans Using a Nanofabrication Machine (NFM-100)

  • Jaqueline Stauffenberg,
  • Ingo Ortlepp,
  • Christoph Reuter,
  • Mathias Holz,
  • Denis Dontsov,
  • Christoph Schäffel,
  • Steffen Strehle,
  • Jens-Peter Zöllner,
  • Ivo W. Rangelow and
  • Eberhard Manske

The focus of this work lies on investigations on a new Nano Fabrication Machine (NFM-100) with a mounted atomic force microscope (AFM). This installed tip-based measuring system uses self-sensing and self-actuated microcantilevers, which can be used...

  • Communication
  • Open Access
21 Citations
8,118 Views
11 Pages

Examination of Polymer Blends by AFM Phase Images

  • Enrico Werner,
  • Uwe Güth,
  • Bennet Brockhagen,
  • Christoph Döpke and
  • Andrea Ehrmann

Atomic force microscopy (AFM) belongs to the high-resolution surface morphology investigation methods. Since it can, in many cases, be applied in air, samples can more easily be inspected than by a scanning electron microscope (SEM). In addition, sev...

  • Article
  • Open Access
6 Citations
8,628 Views
20 Pages

A Novel Dog-Bone Oscillating AFM Probe with Thermal Actuation and Piezoresistive Detection

  • Zhuang Xiong,
  • Estelle Mairiaux,
  • Benjamin Walter,
  • Marc Faucher,
  • Lionel Buchaillot and
  • Bernard Legrand

31 October 2014

In order to effectively increase the resonance frequency and the quality factor of atomic force microscope (AFM) probes, a novel oscillating probe based on a dog-bone shaped MEMS resonator was conceived, designed, fabricated and evaluated. The novel...

  • Article
  • Open Access
7 Citations
10,982 Views
9 Pages

31 January 2005

The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolym...

  • Article
  • Open Access
11 Citations
4,603 Views
16 Pages

6 September 2018

In this study, a new approach, “dynamic wettability”, and atomic force microscopy (AFM) imaging analysis techniques were successfully used to characterize the hydrophobization mechanism of the collector dodecylamine (DDA) on muscovite and...

  • Review
  • Open Access
973 Views
24 Pages

Corrosion is a complex, surface-initiated process that demands nanoscale, real-time characterization to understand its initiation and propagation. Atomic force microscopy (AFM) and scanning Kelvin probe force microscopy (SKPFM) have emerged as powerf...

  • Article
  • Open Access
8 Citations
4,061 Views
13 Pages

AFM Characterization of Temperature Effect on the SU-8 Mechanical and Tribological Properties

  • Marius Pustan,
  • Corina Birleanu,
  • Rodica Voicu and
  • Raluca Muller

2 March 2022

This study presents the effect of temperature on the mechanical and tribological properties of SU-8 polymer. The temperature of investigated samples increasing during testing and the variation of mechanical and tribological properties were monitored....

  • Article
  • Open Access
12 Citations
4,280 Views
12 Pages

Influence of Thin Film Deposition on AFM Cantilever Tips in Adhesion and Young’s Modulus of MEMS Surfaces

  • Pedram Heidari,
  • Majid Salehi,
  • Behrooz Ruhani,
  • Violeta Purcar and
  • Simona Căprărescu

12 March 2022

Adhesion is a critical factor in microelectromechanical systems (MEMSs) and is influenced by many parameters. In important fields, such as microassembly, an improved understanding of adhesion can result in higher precision. This study examines the in...

  • Article
  • Open Access
15 Citations
11,063 Views
15 Pages

25 September 2008

A study of the frequency response of AFM microcantilevers in liquid media contained in a commercial fluid cell is presented. Such systems exhibit complicated dynamics which are often not well described by available theories. Their dynamic behavior ha...

  • Article
  • Open Access
8 Citations
2,805 Views
17 Pages

A New Elementary Method for Determining the Tip Radius and Young’s Modulus in AFM Spherical Indentations

  • Stylianos Vasileios Kontomaris,
  • Andreas Stylianou,
  • Georgios Chliveros and
  • Anna Malamou

31 August 2023

Atomic force microscopy (AFM) is a powerful tool for characterizing biological materials at the nanoscale utilizing the AFM nanoindentation method. When testing biological materials, spherical indenters are typically employed to reduce the possibilit...

  • Article
  • Open Access
2 Citations
1,392 Views
12 Pages

Qualitative Research of Composite Graphene Membranes Using the Electric Mode in SEM and AFM

  • Grzegorz Romaniak,
  • Konrad Dybowski,
  • Łukasz Kołodziejczyk and
  • Paulina Kowalczyk

3 January 2025

The development of new graphene-based materials necessitates the application of suitable material imaging techniques, especially for the identification of defects in the graphene structure and its continuity. For this purpose, it is natural to use on...

  • Article
  • Open Access
8 Citations
8,908 Views
14 Pages

28 February 2017

Atomic force microscopy (AFM) has been used extensively in nanoscience research since its invention. Recently, many teaching laboratories in colleges, undergraduate institutions, and even high schools incorporate AFM as an effective teaching tool for...

  • Review
  • Open Access
6 Citations
3,854 Views
27 Pages

2 June 2025

This review explores recent advances in data processing for atomic force microscopy (AFM) nanoindentation on soft samples, with a focus on “apparent” or “average” Young’s modulus distributions used for cancer diagnosis a...

  • Article
  • Open Access
4 Citations
2,917 Views
9 Pages

Methodic Approach of Atomic-Force Microscopy (AFM) to Study Morphological Changes of Cells and Model Systems

  • Vladimir Binyukov,
  • Elena Mil,
  • Ludmila Matienko,
  • Anastasia Albantova and
  • Alexander Goloshchapov

28 March 2023

For the first time AFM (atomic-force microscopy) was used to record significant changes in the geometric parameters of the image of erythrocytes in vitro under conditions of glycolytic starvation (ATP (Adenosine triphosphate) deficiency). The differe...

  • Article
  • Open Access
9 Citations
4,393 Views
13 Pages

Statistical Analysis of Nanofiber Mat AFM Images by Gray-Scale-Resolved Hurst Exponent Distributions

  • Tomasz Blachowicz,
  • Krzysztof Domino,
  • Michał Koruszowic,
  • Jacek Grzybowski,
  • Tobias Böhm and
  • Andrea Ehrmann

9 March 2021

Two-dimensional structures, either periodic or random, can be classified by diverse mathematical methods. Quantitative descriptions of such surfaces, however, are scarce since bijective definitions must be found to measure unique dependency between d...

  • Review
  • Open Access
14 Citations
3,596 Views
19 Pages

14 December 2022

The unique functions of intrinsically disordered proteins (IDPs) depend on their dynamic protean structure that often eludes analysis. High-speed atomic force microscopy (HS-AFM) can conduct this difficult analysis by directly visualizing individual...

  • Article
  • Open Access
7 Citations
3,243 Views
14 Pages

AFM Analysis of a Three-Point Flexure Tested, 3D Printing Definitive Restoration Material for Dentistry

  • Maximilian N. Sandmair,
  • Christoph Kleber,
  • Dragan A. Ströbele and
  • Constantin von See

Background: Three-dimensional printing is a rapidly developing technology across all industries. In medicine recent developments include 3D bioprinting, personalized medication and custom prosthetics and implants. To ensure safety and long-term usabi...

  • Article
  • Open Access
6 Citations
3,521 Views
13 Pages

Quantitative Elasticity of Flexible Polymer Chains Using Interferometer-Based AFM

  • Vikhyaat Ahlawat,
  • Surya Pratap S. Deopa and
  • Shivprasad Patil

3 February 2022

We estimate the elasticity of single polymer chains using atomic force microscope (AFM)-based oscillatory experiments. An accurate estimate of elasticity using AFM is limited by assumptions in describing the dynamics of an oscillating cantilever. Her...

  • Article
  • Open Access
4 Citations
2,603 Views
13 Pages

DNA Sensing Platforms: Novel Insights into Molecular Grafting Using Low Perturbative AFM Imaging

  • Silvia Maria Cristina Rotondi,
  • Paolo Canepa,
  • Elena Angeli,
  • Maurizio Canepa and
  • Ornella Cavalleri

8 May 2023

By using AFM as a nanografting tool, we grafted micrometer-sized DNA platforms into inert alkanethiol SAMs. Tuning the grafting conditions (surface density of grafting lines and scan rate) allowed us to tailor the molecular density of the DNA platfor...

  • Review
  • Open Access
16 Citations
6,480 Views
34 Pages

AFM Nanotribomechanical Characterization of Thin Films for MEMS Applications

  • Corina Bîrleanu,
  • Marius Pustan,
  • Florina Șerdean and
  • Violeta Merie

25 December 2021

Nanotribological studies of thin films are needed to develop a fundamental understanding of the phenomena that occur to the interface surfaces that come in contact at the micro and nanoscale and to study the interfacial phenomena that occur in microe...

  • Article
  • Open Access
14 Citations
5,305 Views
10 Pages

Miscibility and Phase Separation in PMMA/SAN Blends Investigated by Nanoscale AFM-IR

  • Julia Resch,
  • Julia Dreier,
  • Christian Bonten and
  • Marc Kreutzbruck

4 November 2021

The miscibility and phase separation of poly(methyl methacrylate) (PMMA) and styrene-acrylonitrile (SAN) have already been investigated using various methods. However, these methods have limitations that often result in inconsistent characterization....

  • Communication
  • Open Access
11 Citations
3,896 Views
12 Pages

Size Matters: Rethinking Hertz Model Interpretation for Cell Mechanics Using AFM

  • Katarína Mendová,
  • Martin Otáhal,
  • Mitja Drab and
  • Matej Daniel

Cell mechanics are a biophysical indicator of cell state, such as cancer metastasis, leukocyte activation, and cell cycle progression. Atomic force microscopy (AFM) is a widely used technique to measure cell mechanics, where the Young modulus of a ce...

  • Review
  • Open Access
20 Citations
6,752 Views
28 Pages

27 January 2024

Membrane fouling presents a significant challenge in the treatment of wastewater. Several detection methods have been used to interpret membrane fouling processes. Compared with other analysis and detection methods, atomic force microscopy (AFM) is w...

  • Article
  • Open Access
8 Citations
4,747 Views
11 Pages

Integration of Fluorescent, NV-Rich Nanodiamond Particles with AFM Cantilevers by Focused Ion Beam for Hybrid Optical and Micromechanical Devices

  • Mateusz Ficek,
  • Maciej J. Głowacki,
  • Krzysztof Gajewski,
  • Piotr Kunicki,
  • Ewelina Gacka,
  • Krystian Sycz,
  • Mariusz Mrózek,
  • Adam M. Wojciechowski,
  • Teodor P. Gotszalk and
  • Robert Bogdanowicz
  • + 1 author

29 October 2021

In this paper, a novel fabrication technology of atomic force microscopy (AFM) probes integrating cantilever tips with an NV-rich diamond particle is presented. Nanomanipulation techniques combined with the focused electron beam-induced deposition (F...

  • Article
  • Open Access
9 Citations
4,680 Views
18 Pages

Conjugates of Gold Nanoparticles and Antitumor Gold(III) Complexes as a Tool for Their AFM and SERS Detection in Biological Tissue

  • Aleksandra M. Bondžić,
  • Andreja R. Leskovac,
  • Sandra Ž. Petrović,
  • Dragana D. Vasić Anićijević,
  • Marco Luce,
  • Lara Massai,
  • Amanda Generosi,
  • Barbara Paci,
  • Antonio Cricenti and
  • Vesna M. Vasić
  • + 1 author

13 December 2019

Citrate-capped gold nanoparticles (AuNPs) were functionalized with three distinct antitumor gold(III) complexes, e.g., [Au(N,N)(OH)2][PF6], where (N,N)=2,2′-bipyridine; [Au(C,N)(AcO)2], where (C,N)=deprotonated 6-(1,1-dimethylbenzyl)-pyridine;...

  • Communication
  • Open Access
5 Citations
3,101 Views
14 Pages

Stearic Acid as an Atomic Layer Deposition Inhibitor: Spectroscopic Insights from AFM-IR

  • Saumya Satyarthy,
  • Md Hasan Ul Iqbal,
  • Fairoz Abida,
  • Ridwan Nahar,
  • Adam J. Hauser,
  • Mark Ming-Cheng Cheng and
  • Ayanjeet Ghosh

6 October 2023

Modern-day chip manufacturing requires precision in placing chip materials on complex and patterned structures. Area-selective atomic layer deposition (AS-ALD) is a self-aligned manufacturing technique with high precision and control, which offers co...

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