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Antibiotics, Volume 12, Issue 6

June 2023 - 136 articles

Cover Story: As part of our search for new antimicrobials and antibiotic enhancers, a series of naphthyl- and biphenyl-substituted polyamine conjugates have been synthesized. The structurally diverse library of compounds incorporated variation in the capping end groups and in the length of polyamine cores. Longer chain variants containing naphthyl capping groups exhibited more pronounced intrinsic antimicrobial properties against methicillin-resistant Staphylococcus aureus and the fungus Cryptococcus neoformans. Closer mechanistic study of one of these analogues identified it as a bactericide. In contrast to the previously reported diarylacyl-substituted polyamines, several examples in the current set were able to enhance the antibiotic action of doxycycline and/or erythromycin towards the Gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli. View this paper
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Articles (136)

  • Review
  • Open Access
20 Citations
4,535 Views
17 Pages

The Epidemiology of Animal-Associated Methicillin-Resistant Staphylococcus aureus

  • Martyna Kasela,
  • Mateusz Ossowski,
  • Ewelina Dzikoń,
  • Katarzyna Ignatiuk,
  • Łukasz Wlazło and
  • Anna Malm

Methicillin-resistant Staphylococcus aureus (MRSA) remains an important etiological factor of human and animal infectious diseases, causing significant economic losses not only in human healthcare but also in the large-scale farming sector. The const...

  • Communication
  • Open Access
14 Citations
3,906 Views
12 Pages

The Use of Phage Cocktail and Various Antibacterial Agents in Combination to Prevent the Emergence of Phage Resistance

  • Hoang Minh Duc,
  • Yu Zhang,
  • Son Minh Hoang,
  • Yoshimitsu Masuda,
  • Ken-Ichi Honjoh and
  • Takahisa Miyamoto

Bacterial food poisoning cases due to Salmonella and E. coli O157:H7 have been linked with the consumption of a variety of food products, threatening public health around the world. This study describes the combined effects of a phage cocktail (STG2,...

  • Article
  • Open Access
6 Citations
2,687 Views
10 Pages

Delafloxacin (DLX) is a recently approved fluoroquinolone with broad activity against common cystic fibrosis (CF) pathogens, including multidrug-resistant Pseudomonas aeruginosa (MDR-Psa). Delafloxacin has been previously shown to have excellent lung...

  • Article
  • Open Access
4 Citations
2,416 Views
16 Pages

Ether Derivatives of Naringenin and Their Oximes as Factors Modulating Bacterial Adhesion

  • Anna Duda-Madej,
  • Joanna Kozłowska,
  • Dagmara Baczyńska and
  • Paweł Krzyżek

Because of the close connection between adhesion and many vital cellular functions, the search for new compounds modulating the adhesion of bacteria belonging to the intestinal microbiota is a great challenge and a clinical need. Based on our previou...

  • Review
  • Open Access
31 Citations
8,200 Views
19 Pages

CRISPR-Cas9 System: A Prospective Pathway toward Combatting Antibiotic Resistance

  • Muhammad Uzair Javed,
  • Muhammad Tahir Hayat,
  • Hamid Mukhtar and
  • Kalman Imre

Antibiotic resistance is rising to dangerously high levels throughout the world. To cope with this problem, scientists are working on CRISPR-based research so that antibiotic-resistant bacteria can be killed and attacked almost as quickly as antibiot...

  • Perspective
  • Open Access
16 Citations
4,502 Views
13 Pages

Insights on Current Strategies to Decolonize the Gut from Multidrug-Resistant Bacteria: Pros and Cons

  • Natalia Roson-Calero,
  • Clara Ballesté-Delpierre,
  • Javier Fernández and
  • Jordi Vila

In the last decades, we have witnessed a steady increase in infections caused by multidrug-resistant (MDR) bacteria. These infections are associated with higher morbidity and mortality. Several interventions should be taken to reduce the emergence an...

  • Review
  • Open Access
21 Citations
5,074 Views
17 Pages

Treatment of Periodontal Infections, the Possible Role of Hydrogels as Antibiotic Drug-Delivery Systems

  • Adelaide Mensah,
  • Aoife M. Rodgers,
  • Eneko Larrañeta,
  • Lyndsey McMullan,
  • Murtaza Tambuwala,
  • John F. Callan and
  • Aaron J. Courtenay

With the advancement of biomedical research into antimicrobial treatments for various diseases, the source and delivery of antibiotics have attracted attention. In periodontal diseases, antibiotics are integral in positive treatment outcomes; however...

  • Review
  • Open Access
12 Citations
4,494 Views
21 Pages

Use of Newer and Repurposed Antibiotics against Gram-Negative Bacteria in Neonates

  • Angeliki Kontou,
  • Maria Kourti,
  • Elias Iosifidis,
  • Kosmas Sarafidis and
  • Emmanuel Roilides

Antimicrobial resistance has become a significant public health problem globally with multidrug resistant Gram negative (MDR-GN) bacteria being the main representatives. The emergence of these pathogens in neonatal settings threatens the well-being o...

  • Article
  • Open Access
3 Citations
3,902 Views
12 Pages

Effect of Phenylalanine–Arginine Beta-Naphthylamide on the Values of Minimum Inhibitory Concentration of Quinolones and Aminoglycosides in Clinical Isolates of Acinetobacter baumannii

  • Stefany Plasencia-Rebata,
  • Saul Levy-Blitchtein,
  • Juana del Valle-Mendoza,
  • Wilmer Silva-Caso,
  • Isaac Peña-Tuesta,
  • William Vicente Taboada,
  • Fernando Barreda Bolaños and
  • Miguel Angel Aguilar-Luis

(1) Background: Acinetobacter baumannii has become the most important pathogen responsible for nosocomial infections in health systems. It expresses several resistance mechanisms, including the production of β-lactamases, changes in the cell mem...

  • Article
  • Open Access
2 Citations
1,918 Views
12 Pages

Insight into the Clonal Lineage and Antimicrobial Resistance of Staphylococcus aureus from Vascular Access Infections before and during the COVID-19 Pandemic

  • Chih-Chen Kao,
  • Chi-Hsiang Lai,
  • Min-Yi Wong,
  • Tsung-Yu Huang,
  • Yuan-Hsi Tseng,
  • Chu-Hsueh Lu,
  • Chien-Chao Lin and
  • Yao-Kuang Huang

Patients receiving hemodialysis are at risk of vascular access infections (VAIs) and are particularly vulnerable to the opportunistic pathogen Staphylococcus aureus. Hemodialysis patients were also at increased risk of infection during the COVID-19 p...

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Antibiotics - ISSN 2079-6382