1 November 2026
Antimicrobial susceptibility testing (AST) is evolving from conventional culture-based methods toward rapid phenotypic, molecular, sequencing, and artificial intelligence-assisted approaches. This narrative review examines current and emerging strate...
1 November 2026
Background: Systemic antifungal treatment in intensive care units (ICUs) is frequently initiated before microbiological confirmation. Earthquake-affected ICUs provide an important setting for examining antifungal decision-making under sudden patient...
1 November 2026
Background: The inappropriate use of antibiotics contributes to the development and spread of antibiotic resistance. Community education plays an important role in mitigating this threat; however, community-derived data required to inform the co-crea...
31 October 2026
Background: The misuse of antibiotics in aquaculture and clinical settings promotes drug resistance in food-related microbes. Vibrio parahaemolyticus, a global pathogen linked to diarrheal disease and food safety concerns, warrants a systematic asses...
Extensively drug-resistant (XDR) and pandrug-resistant (PDR) Gram-negative bacteria—principally carbapenem-resistant Acinetobacter baumannii (CRAB), carbapenem-resistant Enterobacterales (CRE), and difficult-to-treat resistant (DTR) Pseudomonas...
Background/Objectives: Ceftazidime–avibactam (CZA) resistance in KPC-producing Klebsiella pneumoniae is frequently associated with variant KPC enzymes, but the resulting susceptibility to other β-lactam/β-lactamase inhibitor combinati...
Background/Objectives: The Stenotrophomonas maltophilia complex (Smc) comprises opportunistic bacteria with substantial antimicrobial resistance and genomic diversity. This study investigated the antimicrobial susceptibility and genomic characteristi...
Background: Orthopedic implant-associated infections are difficult to eradicate because of biofilm formation and impaired healing. FK-16 and GF-17 are short synthetic antimicrobial fragments of the human cathelicidin LL-37; FK-16 consists of 16 amino...
Background/Objectives: Farm-level monitoring of antimicrobial use (AMU) is essential for mitigating antimicrobial resistance (AMR) within a One Health framework because aggregated sales data cannot identify farms and production stages with high AMU....
Introduction: Poultry production can serve as an important reservoir of antimicrobial-resistant bacteria. Although surveillance commonly focuses on prevalent organisms such as Clostridium perfringens, less prevalent anaerobic spore-forming bacteria m...
Background: Multidrug-resistant (MDR) Pseudomonas aeruginosa infections are associated with substantial morbidity, mortality and therapeutic uncertainty, particularly in critically ill and immunocompromised patients. Imipenem/cilastatin/relebactam (I...
Background/Objectives: Coinfection with tuberculosis (TB) and respiratory viral infections (RVIs) complicates clinical management due to polypharmacy, potential drug–drug interactions (DDIs), and adverse drug reactions (ADRs). We aimed to evalu...
Background/Objectives: Brassica spp. constitute an important group of edible plants. Over the last century, the important power of these plants as bioactive producers with anticancer, anti-inflammatory, antioxidant or cardioprotective properties has...
Background/Objectives: Essential oils (EOs) are volatile, biologically active compounds naturally extracted from aromatic plants. Known for their broad-spectrum antimicrobial properties, EOs are gaining increasing attention as potential alternative o...
Background/Objectives: Feline otitis externa is less well characterized microbiologically than the canine disease. This retrospective laboratory-based study described cultivable otic microorganisms and antimicrobial resistance among isolates from 112...
Background/Objectives: Stenotrophomonas maltophilia is a common cause of lower respiratory tract infection (LRTI) in critically ill patients, but differences between ventilator-associated tracheobronchitis (VAT) and ventilator- or hospital-acqui...
Background/Objectives: Machine learning applied to MALDI-TOF mass spectra can flag antimicrobial resistance days before conventional susceptibility testing, but models rarely retain accuracy in a new laboratory. We asked whether this failure can be r...
Background/Objectives: Targeting bacterial virulence mechanisms and associated inflammation represents a compelling strategy to disarm pathogens without imposing selective survival pressure. While Euphorbia tirucalli (Pencil Cactus) synthesizes poten...
Background: Early antibiotic administration is a cornerstone of sepsis management, but its survival benefit in septic patients with pre-existing cirrhosis remains unclear. This study evaluated the association between antibiotic timing and short-term...
Background: Antimicrobial resistance (AMR) is a major challenge among hospitalized patients, particularly when bacterial infection coexists with laboratory evidence of organ dysfunction. This study assessed AMR patterns and laboratory abnormality bur...
Background/Objectives: Fluoroquinolones are classified by the World Health Organization as highest-priority critically important antimicrobials, and their use in food-producing animals is a One Health concern. We aimed to map the published literature...
Background: Klebsiella pneumoniae is a leading cause of multidrug-resistant Gram-negative infections worldwide, with carbapenem resistance posing a major therapeutic challenge. Continuous surveillance of antimicrobial resistance is essential to guide...
Background/Objectives: Hospitalized companion animals may act as reservoirs of multidrug-resistant (MDR) Gram-negative bacteria and contribute to the dissemination of clinically important antimicrobial resistance genes. This study investigated gastro...
Healthcare-Associated Infections (HAIs) are among the leading causes of morbidity and mortality in critically ill patients admitted to intensive care units. The growing spread of multidrug-resistant (MDR), extensively drug-resistant (XDR), and totall...
Background/Objectives: Colistin, previously of limited clinical relevance in human medicine, has become one of the last-line antimicrobials for infections caused by multidrug-resistant Gram-negative bacteria and was classified by the World Health Org...
Background: Determining infection eradication before reimplantation remains challenging during two-stage revision for chronic periprosthetic joint infections (PJI). This exploratory study investigated the association between serial postoperative C-re...
Background: Beta-lactam antibiotic allergy is one of the most frequently reported drug hypersensitivities. True allergy is rarely confirmed. Inaccurate labeling leads to unnecessary avoidance of beta-lactams, antimicrobial resistance, and increased h...
Acinetobacter baumannii (AB) is recognized as a major opportunistic nosocomial pathogen. Its success largely depends on the ability to adhere to and colonize both biotic and abiotic surfaces, survive under adverse environmental conditions, and acquir...
Background/Objectives: Dermatophytosis is a common superficial mycosis of keratinized tissues caused predominantly by species of the genera Epidermophyton, Microsporum, and Trichophyton. The present study aimed to investigate the antidermatophytic ef...
Background/Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) remains an important One Health challenge, yet its combined human, animal, and environmental correlates remain incompletely understood. This study examined associations of huma...
Background/Objectives: Resistance and toxicity limit topical agents for infected burns. We evaluated biogenic silver nanoparticles (bio-AgNPs) combined with Brazilian stingless bee Scaptotrigona bipunctata honey (SB honey). Methods: Bio-AgNPs and hon...
Background/Objectives: Bacterial resistance to antimicrobials has become a public health problem worldwide, limiting the effectiveness of conventional treatments. Therefore, combination antimicrobial therapy has been proposed as a strategy to combat...
Background/Objectives: The proliferation of antibiotic resistance genes (ARGs) in agricultural soils poses a growing One Health threat. However, how hydrological fluctuations in paddy–upland rotations shape the soil resistome remains unclear. T...
Background/Objectives: Tuberculosis (TB) in older adults represents an increasing clinical challenge, although this population remains underrepresented in clinical studies. We compared outcomes and permanent regimen modification between age groups in...
Background/Objectives: Peripheral intravenous catheters (PIVCs) are frequently used in neonatal intensive care units (NICUs) and can become major conduits of nosocomial infections, often colonized with clinically important bacteria, including methici...
Background/Objectives: Curcumin is a food-grade (E100) photosensitiser with promising antimicrobial properties, but its applicability is limited due to low water-solubility. Complexation of curcumin with hydroxypropyl-γ-cyclodextrin (HP-γ...
Latent tuberculosis infection constitutes the principal reservoir from which tuberculosis (TB) disease emerges, yet the molecular transition from durable containment to reactivation remains incompletely resolved. Reactivation is not a single bacteria...
Plant-derived phytochemicals are being investigated as antibacterial agents and antibiotic adjuvants, but disruption of bacterial redox homeostasis does not invariably lead to sustained killing. This critical narrative review examines how bacterial r...
Objective: The primary goal of this study was to determine the rate of occult fracture-related infection associated with nonunion of upper extremity fractures following open reduction internal fixation (ORIF). Methods: We performed a retrospective an...
Background/Objectives: Antimicrobials are regularly prescribed in general practice, yet the infrastructure to support routine review of prescribing in this setting remains limited. Integrated antimicrobial stewardship (AMS) interventions combining au...
Background: Bedaquiline (BDQ) is critical for multidrug-resistant tuberculosis (MDR-TB) treatment, but emerging resistance threatens its efficacy. Detection of BDQ resistance relies on slow phenotypic drug-susceptibility testing (pDST), delaying trea...
Fungal diseases range from common superficial infections to life-threatening invasive mycoses, yet treatment options remain constrained by host toxicity, drug interactions, pharmacokinetic limitations and antifungal resistance. This review provides a...
Background: Procalcitonin (PCT) may support decision-making in abdominal and emergency surgery when infection is difficult to distinguish from non-infectious inflammation. Its interpretation remains challenging because clinical settings, sampling sch...
Background: Hospital drainage systems represent an important interface between healthcare facilities and urban wastewater networks and may contribute distinct microbial inputs to downstream aquatic environments. This issue is particularly relevant in...
Background/Objectives: Antimicrobial resistance (AMR) is a major One Health challenge affecting both human and animal health. Comparative studies investigating resistance patterns across reservoirs remain limited in Morocco. This study compared antim...
Background/Objectives: The Acinetobacter baumannii–calcoaceticus (Acb) complex comprises opportunistic pathogens of increasing relevance in human and veterinary medicine due to their capacity to acquire multidrug resistance. colistin, a last-re...
Background: The inflammation of the mammary gland, known as bovine mastitis, is a major challenge for the dairy cattle industry globally. The main organisms responsible for mastitis are bacteria, classified as either contagious, such as Staphylococcu...
Antimicrobial resistance (AMR) is a global public health challenge with remarkable impacts on human, animal, and environmental health within the One Health framework. Among the pathogens most frequently associated with healthcare-associated infection...
In the published article [...]
Background: Antimicrobial administration is a major contributor to healthcare-associated waste. We evaluated the environmental impact of changing the default metronidazole dosing frequency from three-times-daily (TID) to twice-daily (BID) administrat...
