13 September 2026
Background: Monitoring antibiotic consumption represents an important objective for antimicrobial stewardship programs in hospitals. The aim of this study was to analyze antibiotic consumption patterns in three Romanian hospitals. Methods: A five-yea...
12 September 2026
Background. Rational design of phage cocktails typically relies on the lytic spectrum. However, susceptibility criteria vary widely among studies, ranging from qualitative lysis in spot tests to quantitative endpoints based on serial-dilution titrati...
12 September 2026
Background/Objectives: Antimicrobial resistance (AMR) is an urgent global threat, with bacteria developing resistance against most antibiotics currently in clinical use. Non-traditional antibacterials—including bacteriophages, antimicrobial pep...
Background/Objectives: Antibiotic resistance is a growing global health challenge, especially with tricky bacteria like Pseudomonas aeruginosa. Anthranilate, previously identified as a signaling molecule in P. aeruginosa, modulates various pathogenic...
Background/Objectives: Environmental bacterial isolates with contrasting, previously established antimicrobial-susceptibility phenotypes may differ in growth under antibiotic-free conditions, but such differences can reflect strain background and tem...
Background/Objectives: Prompt identification of bloodborne pathogens and their antimicrobial resistance is critical for effective sepsis management. Direct molecular testing of blood offers faster results than blood culture; however, its clinical uti...
Background/Objectives: Antimicrobial resistance (AMR) constitutes a major public health and economic burden in contemporary society. This work aims to identify the patterns and temporal trends of Klebsiella pneumoniae resistance to carbapenems across...
Background/Objectives: Streptococcus parasuis is an under-recognized member of the Streptococcus suis complex that can be misidentified by routine diagnostic methods. Human clinical isolates remain sparsely characterized. This study investigated...
Background/Objectives: Routine local gentamicin irrigation has been used during artificial urinary sphincter (AUS) implantation despite limited procedure-specific evidence. We evaluated early outcomes after its calendar-defined discontinuation. Metho...
Background/Objectives: Trunk injection of oxytetracycline (OTC) can suppress Candidatus Liberibacter asiaticus (CLas) and improve the productivity of citrus trees affected by huanglongbing (HLB), a devastating bacterial disease, but conventional acid...
Clinical guidelines for antimicrobial pharmacotherapy are crucial tools, built upon extensive research and expert consensus, designed to optimize the treatment of infections [...]
Background/Objectives: Shiga toxin-producing Escherichia coli (STEC) are important zoonotic pathogens associated with gastrointestinal infections and hemolytic–uremic syndrome (HUS). Increasing serotype diversity, emergence of hybrid strains, a...
Background/Objectives: Bovine mastitis is a common infection in cattle causing significant economic losses globally in the dairy industry. While bacterial profiles and antimicrobial resistance (AMR) patterns are generally consistent worldwide, compre...
Background/Objectives: Currently, readily available data on antimicrobial resistance in bacteria colonizing farmed Atlantic salmon (Salmo salar L.) are limited. Recent data indicate that the gastrointestinal tract mucosa of adult Atlantic salmon farm...
Widespread antibiotic use in aquaculture has increased selective pressure on resident bacterial communities, accelerating the emergence of resistance in key pathogens and raising concerns for animal health, environmental microbiomes, and food-chain s...
Background: Porphyromonas gingivalis is a Gram-negative, anaerobic keystone pathogen strongly implicated in the pathogenesis of periodontitis. Its pathogenicity is mediated through virulence factors, such as lipopolysaccharides (PG-LPS), which have b...
The rise in carbapenem resistance is well documented, but a less conspicuous trend has received far less attention: the gradual upward shift in minimum inhibitory concentration (MIC) values among isolates that remain phenotypically “susceptible...
Background/Objectives: Skin and soft tissue infections (SSTIs) remain a major clinical challenge due to the increasing prevalence of antimicrobial resistance and biofilm-associated pathogens. Conventional antibiotics are often limited by reduced effi...
The rise of multidrug-resistant (MDR) pathogens in the pediatric population represents a significant global health challenge, compounded by a historically stagnant antibiotic pipeline for children. While several novel antibiotics have been approved f...
Background/Objectives: The prescription of aerosolized antimicrobial agents for lower respiratory tract infections varies significantly among clinicians. This study investigated the practices and perceptions of clinicians regarding aerosolized antimi...
The treatment of infective endocarditis (IE) in patients who inject drugs (PWID) is complex and challenging. These patients face stigma in the healthcare system, as well as higher mortality, longer length of hospital stay, higher rates of recurrent i...
Antimicrobial peptides (AMPs) are increasingly regarded as next-generation antimicrobial agents because of their broad-spectrum activity, rapid killing, antibiofilm potential, immunomodulatory properties, and mechanisms of action that differ from tho...
Background/Objectives: Serratia marcescens is an opportunistic pathogen that causes severe hospital-acquired infections, notable for its biofilm formation abilities and development of extensive antibiotic resistance. Here, we aim to evaluate the effi...
Background/Objectives: Antimicrobial resistance (AMR) and virulence represent co-evolving dimensions of microbial pathogenic potential whose ecological organization in building-scale wastewater systems remains poorly understood. Methods: Using shotgu...
Background: Adults who undergo blood-culture sampling in the emergency department (ED) may be discharged before results are finalized and later found bacteremic. Factors identifying which patients require readmission are not well defined. We sought p...
Background/Objectives: Carbapenem overuse contributes to antimicrobial resistance, but pragmatic stewardship models for high-complexity Internal Medicine wards remain underreported. We evaluated the feasibility and stewardship impact of a carbapenem-...
Background: The vaginal microbiota of healthy women is predominantly composed of lactic acid bacteria (LAB), particularly species from the lactobacilli group, which contribute to the maintenance of vaginal health through multiple protective mechanism...
Vibriosis causes substantial losses in marine and brackish-water aquaculture, while increasing antimicrobial resistance limits the effectiveness of conventional antibiotic treatment. Biofilm formation and quorum-sensing-controlled virulence further c...
Background: Dental caries is a biofilm-associated disease in which Streptococcus mutans plays a central role. This study evaluated HT-2-1-3, a Vespidae venom-derived antimicrobial peptide, as a potential topical anti-caries lead. Methods: Candidate p...
Background. Osteoarticular infections (OAI)—including prosthetic joint infections (PJI), fracture-related infections (FRI), and osteomyelitis—are challenging to cure because bacterial biofilm on implant surfaces confers up to 1000-fold an...
Antimicrobial stewardship (AMS) is often framed as a set of prescribing-focused interventions aimed at optimizing antibiotic selection, dose, route of administration, and duration. In practice, AMS also functions as a systems discipline. Embedded wit...
Background: The emergence of multidrug-resistant (MDR) uropathogenic Escherichia coli (UPEC) poses a significant public health challenge, and alternative treatments are urgently needed. Methods: Here, we identified clinical MDR-UPEC strains AT82 and...
Objectives: The study determined antimicrobial resistance profiles of surgical wound multidrug-resistant (MDR) isolates belonging to the ESKAPE group and evaluated antibacterial and antibiofilm activities of geraniol (G), carvacrol (C) and eugenol (E...
Introduction: Antibiotic-associated diarrhea (AAD) is a common complication of antibiotic therapy, while evidence supporting Saccharomyces boulardii for its prevention among hospitalized adults in resource-constrained settings remains limited. We eva...
Background/Objectives: Enterococcus species are important causes of healthcare-associated infections, particularly multidrug-resistant (MDR) and vancomycin-resistant enterococci (VRE). This study characterized antimicrobial susceptibility, biofilm fo...
Background/Objectives: Colistin is a last-resort agent against multidrug-resistant Gram-negative infections and is administered predominantly to complex, comorbid inpatients in whom mortality is high. We aimed to identify independent baseline predict...
Background/Objectives: The application of organic soil amendments constitutes an important source of antibiotic residues in agricultural soils. However, studies have mainly focused on a few parent tetracyclines, whereas information on their transform...
Background/Objectives: Bacillus spp. are often isolated from airborne microbiota. Five Bacillus strains (AD12–16) isolated from dust during a sandstorm in Kuwait were characterized for their potential to produce antimicrobial compounds, biosurf...
Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) is a major nosocomial pathogen; bacteriophage therapy is a promising alternative, but its principal challenge is the rapid emergence of phage resistance. Cocktails counter this yet they...
Background/Objectives: This prospective cross-sectional study quantified veterinary antimicrobial residues in soils from 27 commercial beef feedlots across multiple regions of Argentina and production scales. Methods: Using a validated Ultra-Fast Liq...
Objectives: The collaborative “Stop Hospital Infection 2.0”, implemented in Portugal between 2023 and 2025, aimed to reduce the incidence of catheter-associated urinary tract infection (CAUTI), ventilator-associated pneumonia (VAP) and ce...
Background/Objectives: Pseudomonas aeruginosa is an opportunistic Gram-negative bacterium and a major cause of healthcare-associated infections worldwide, exhibiting intrinsic antimicrobial resistance and readily acquiring novel resistance mecha...
Background/Objectives: Antimicrobial resistance threatens public health globally, and critical access hospitals (CAHs) serving rural communities face structural barriers to implementing antibiotic stewardship programs (ASPs). This study evaluated whe...
Background/Objectives: Antimicrobial resistance (AMR) can be influenced by the interconnection of human, animal and environmental compartments, making wildlife-based surveillance an important component of One Health surveillance. The red fox (Vulpes ...
Background/Objectives: Antibiotics are widely used in clinical practice, yet their potential effects on endocrine homeostasis remain insufficiently recognized. This review summarizes endocrine adverse effects associated with selected antibacterial ag...
Background/Objectives: Infectious keratitis and eye injuries, despite being well-recognized ophthalmological diseases, continue to pose diagnostic and therapeutic challenges in clinical practice; therefore, this study was conducted to assess the sali...
Background: Sepsis is a time-sensitive, serious condition; therefore, early recognition and prompt initiation of therapy are critical to improving outcomes in patients with infection. We sought to evaluate whether prehospital antibiotic administratio...
Background/Objectives: Screening for carriage of antibiotic-resistant bacteria (ARB) upon hospital admission and isolating carriers can prevent nosocomial spread of ARB. Screening typically targets patients at high risk of ARB carriage because of rec...
Background/Objectives: The rapid emergence of antimicrobial resistance has created an urgent need for new chemotypes with activity against bacterial, fungal, and mycobacterial pathogens. Rhodanine-based compounds are recognized as privileged scaffold...
Objectives: This retrospective study aimed to estimate vancomycin area under the curve over 24 h (AUC24) at steady state for pediatric patients from 1 month to 18 years to update the dose recommendations in a tertiary hospital. Methods: A total of 46...
