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Toxins, Volume 12, Issue 1

January 2020 - 60 articles

Cover Story: Fumagillin is a mycotoxin produced by the pathogenic filamentous fungus Aspergillus fumigatus, which is important because of its role in the fungal infection process. This review offers a complete overview of all the information currently related to this mycotoxin and its applications, notably in oncology, as an anti-tumor molecule, in the treatment of infectious diseases like HIV or in the treatment of different parasitosis, like microsporidiosis, with a special focus on beekeeping. View this paper.
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Articles (60)

  • Article
  • Open Access
14 Citations
5,414 Views
11 Pages

A Structural Study on the Listeria Monocytogenes Internalin A—Human E-cadherin Interaction: A Molecular Tool to Investigate the Effects of Missense Mutations

  • Luca Dellafiora,
  • Virginia Filipello,
  • Chiara Dall’Asta,
  • Guido Finazzi,
  • Gianni Galaverna and
  • Marina Nadia Losio

20 January 2020

Listeria monocytogenes is a widespread foodborne pathogen of high concern and internalin A is an important virulence factor that mediates cell invasion upon the interaction with the host protein E-cadherin. Nonsense mutations of internalin A are know...

  • Article
  • Open Access
6 Citations
3,891 Views
13 Pages

Gas Chromatography–Mass Spectrometry Profiling of Volatile Compounds Reveals Metabolic Changes in a Non-Aflatoxigenic Aspergillus flavus Induced by 5-Azacytidine

  • Fengqin Song,
  • Qingru Geng,
  • Xuewei Wang,
  • Xiaoqing Gao,
  • Xiaona He,
  • Wei Zhao,
  • Huahui Lan,
  • Jun Tian,
  • Kunlong Yang and
  • Shihua Wang

19 January 2020

Aspergillus flavus is one of the most opportunistic pathogens invading many important oilseed crops and foodstuffs with such toxic secondary metabolites as aflatoxin (AF) and Cyclopiazonic acid. We previously used the DNA methylation inhibitor 5-azac...

  • Review
  • Open Access
53 Citations
7,074 Views
12 Pages

19 January 2020

The protein-bound uremic toxins, indoxyl sulfate (IS) and p-cresyl sulfate (PCS), are considered to be harmful vascular toxins. Arterial media calcification, or the deposition of calcium phosphate crystals in the arteries, contributes significantly t...

  • Article
  • Open Access
41 Citations
6,670 Views
10 Pages

Patulin Mycotoxin in Mango and Orange Fruits, Juices, Pulps, and Jams Marketed in Pakistan

  • Shabbir Hussain,
  • Muhammad Rafique Asi,
  • Mazhar Iqbal,
  • Nisha Khalid,
  • Syed Wajih-ul-Hassan and
  • Agustín Ariño

16 January 2020

The objective of the study was to explore the incidence of patulin (PAT) mycotoxin in mango and orange fruits and derived products marketed in Pakistan. A total of 274 samples, including 70 mango fruits, 63 mango-based products (juices, pulp, and jam...

  • Article
  • Open Access
23 Citations
7,289 Views
16 Pages

Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics

  • Chunfang Xie,
  • Julien Slagboom,
  • Laura-Oana Albulescu,
  • Ben Bruyneel,
  • Kristina B. M. Still,
  • Freek J. Vonk,
  • Govert W. Somsen,
  • Nicholas R. Casewell and
  • Jeroen Kool

16 January 2020

Venomous snakebite is one of the world’s most lethal neglected tropical diseases. Animal-derived antivenoms are the only standardized specific therapies currently available for treating snakebite envenoming, but due to venom variation, often th...

  • Article
  • Open Access
13 Citations
6,774 Views
13 Pages

Venomics and Cellular Toxicity of Thai Pit Vipers (Trimeresurus macrops and T. hageni)

  • Supeecha Kumkate,
  • Lawan Chanhome,
  • Tipparat Thiangtrongjit,
  • Jureeporn Noiphrom,
  • Panithi Laoungboa,
  • Orawan Khow,
  • Taksa Vasaruchapong,
  • Siravit Sitprija,
  • Narongsak Chaiyabutr and
  • Onrapak Reamtong

16 January 2020

The two venomous pit vipers, Trimeresurus macrops and T. hageni, are distributed throughout Thailand, although their abundance varies among different areas. No species-specific antivenom is available for their bite victims, and the only recorded trea...

  • Article
  • Open Access
17 Citations
3,982 Views
14 Pages

16 January 2020

Previous studies by us or others have shown that endoplasmic reticulum (ER) stress was activated by fumonisin 1 (FB1) exposure, which is considered to be a critical event in the FB1-induced toxic effect. However, the detailed mechanisms underlying FB...

  • Article
  • Open Access
11 Citations
5,198 Views
17 Pages

16 January 2020

Aflatoxins (AF) are highly toxic compounds produced by Aspergillus section Flavi. They spoil food crops and present a serious global health hazard to humans and livestock. The aim of this study was to examine the phylogenetic relationships among afla...

  • Review
  • Open Access
37 Citations
5,640 Views
21 Pages

Ciguatera Fish Poisoning: The Risk from an Aotearoa/New Zealand Perspective

  • Lesley L. Rhodes,
  • Kirsty F. Smith,
  • J. Sam Murray,
  • Tomohiro Nishimura and
  • Sarah C. Finch

15 January 2020

Gambierdiscus and Fukuyoa species have been identified in Aotearoa/New Zealand’s coastal waters and G. polynesiensis, a known producer of ciguatoxins, has been isolated from Rangitāhua/Kermadec Islands (a New Zealand territory). The warming of...

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Toxins - ISSN 2072-6651