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Validation of Predicted Virulence Factors in Listeria monocytogenes Identified Using Comparative Genomics

Large-Scale Comparison of Toxin and Antitoxins in Listeria monocytogenes

CENSA National Center for Animal and Plant Health, San José de las Lajas Municipality 32700, Mayabeque, Cuba
SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland
Department of Biology, UniFr University of Fribourg, 1700 Fribourg, Switzerland
Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland
USB University Hospital Basel, 4031 Basel, Switzerland
Author to whom correspondence should be addressed.
Toxins 2020, 12(1), 29;
Received: 27 September 2019 / Revised: 19 December 2019 / Accepted: 20 December 2019 / Published: 2 January 2020
(This article belongs to the Special Issue Toxins and Virulence Factors of Listeria monocytogenes)
Toxin–antitoxin systems (TASs) are widely distributed in prokaryotes and encode pairs of genes involved in many bacterial biological processes and mechanisms, including pathogenesis. The TASs have not been extensively studied in Listeria monocytogenes (Lm), a pathogenic bacterium of the Firmicutes phylum causing infections in animals and humans. Using our recently published TASmania database, we focused on the known and new putative TASs in 352 Listeria monocytogenes genomes and identified the putative core gene TASs (cgTASs) with the Pasteur BIGSdb-Lm database and, by complementarity, the putative accessory gene TAS (acTASs). We combined the cgTASs with those of an additional 227 L. monocytogenes isolates from our previous studies containing metadata information. We discovered that the differences in 14 cgTAS alleles are sufficient to separate the four main lineages of Listeria monocytogenes. Analyzing these differences in more details, we uncovered potentially co-evolving residues in some pairs of proteins in cgTASs, probably essential for protein–protein interactions within the TAS complex. View Full-Text
Keywords: toxin–antitoxin systems; Listeria monocytogenes; co-evolution toxin–antitoxin systems; Listeria monocytogenes; co-evolution
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MDPI and ACS Style

Agüero, J.A.; Akarsu, H.; Aguilar-Bultet, L.; Oevermann, A.; Falquet, L. Large-Scale Comparison of Toxin and Antitoxins in Listeria monocytogenes. Toxins 2020, 12, 29.

AMA Style

Agüero JA, Akarsu H, Aguilar-Bultet L, Oevermann A, Falquet L. Large-Scale Comparison of Toxin and Antitoxins in Listeria monocytogenes. Toxins. 2020; 12(1):29.

Chicago/Turabian Style

Agüero, José Antonio, Hatice Akarsu, Lisandra Aguilar-Bultet, Anna Oevermann, and Laurent Falquet. 2020. "Large-Scale Comparison of Toxin and Antitoxins in Listeria monocytogenes" Toxins 12, no. 1: 29.

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