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Open AccessArticle

Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway

by Jiajia Chang 1,2,†, Xiaoqin He 2,3,4,†, Jingmei Hu 2,3,†, Peter Muiruri Kamau 2,5,6, Ren Lai 2,3,6,7,8,9, Dingqi Rao 10,* and Lei Luo 2,*
1
College of Life Sciences, Anhui Normal University, Wuhu 241000, China
2
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, National & Local Joint Engineering Laboratory of Natural Peptides, Kunming Institute of Zoology, Kunming 650223, China
3
College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China
4
Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China
5
University of Chinese Academy of Sciences, Beijing 100049, China
6
Sino-African Joint Research Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
7
KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
8
Institute for Drug Discovery and Development, Chinese Academy of Sciences, Shanghai 201203, China
9
Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430207, China
10
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this paper.
Toxins 2020, 12(1), 15; https://doi.org/10.3390/toxins12010015
Received: 2 December 2019 / Revised: 25 December 2019 / Accepted: 27 December 2019 / Published: 29 December 2019
(This article belongs to the Special Issue Animal Venoms and Their Components: Molecular Mechanisms of Action)
Prokineticins are highly conserved small peptides family expressed in all vertebrates, which contain a wide spectrum of functions. In this study, a prokineticin homolog (Bv8-AJ) isolated from the venom of frog Amolops jingdongensis was fully characterized. Bv8-AJ accelerated full-thickness wounds healing of mice model by promoting the initiation and the termination of inflammatory phase. Moreover, Bv8-AJ exerted strong proliferative effect on fibroblasts and keratinocytes isolated from newborn mice by activating interleukin (IL)-1 production. Our findings indicate that Bv8 is a potent wound healing regulator and may reveal the mechanism of rapid wound-healing in amphibian skins. View Full-Text
Keywords: Bv8; Amolops jingdongensis; wound healing; Interleukin-1; keratinocytes; fibroblasts Bv8; Amolops jingdongensis; wound healing; Interleukin-1; keratinocytes; fibroblasts
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MDPI and ACS Style

Chang, J.; He, X.; Hu, J.; Kamau, P.M.; Lai, R.; Rao, D.; Luo, L. Bv8-Like Toxin from the Frog Venom of Amolops jingdongensis Promotes Wound Healing via the Interleukin-1 Signaling Pathway. Toxins 2020, 12, 15.

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