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Open AccessArticle

Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria

1
Department of Microbiology, University of Helsinki, Viikinkaari 9, FI-00014 Helsinki, Finland
2
Institute of Biotechnology, University of Helsinki, Viikinkaari 5D, FI-00014 Helsinki, Finland
3
Center for Nuclear Energy in Agriculture, University of São Paulo, Avenida Centenário 303, 13400-970 Piracicaba, São Paulo, Brazil
4
Centre for Pharmacy, Department of Clinical Science, University of Bergen, P.O. Box 7804, 5020 Bergen, Norway
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Toxins 2020, 12(1), 12; https://doi.org/10.3390/toxins12010012
Received: 3 December 2019 / Revised: 20 December 2019 / Accepted: 21 December 2019 / Published: 24 December 2019
Cyanobacteria are photosynthetic organisms that produce a large diversity of natural products with interesting bioactivities for biotechnological and pharmaceutical applications. Cyanobacterial extracts exhibit toxicity towards other microorganisms and cancer cells and, therefore, represent a source of potentially novel natural products for drug discovery. We tested 62 cyanobacterial strains isolated from various Brazilian biomes for antileukemic and antimicrobial activities. Extracts from 39 strains induced selective apoptosis in acute myeloid leukemia (AML) cancer cell lines. Five of these extracts also exhibited antifungal and antibacterial activities. Chemical and dereplication analyses revealed the production of nine known natural products. Natural products possibly responsible for the observed bioactivities and five unknown, chemically related chlorinated compounds present only in Brazilian cyanobacteria were illustrated in a molecular network. Our results provide new information on the vast biosynthetic potential of cyanobacteria isolated from Brazilian environments. View Full-Text
Keywords: natural products; mass spectrometry; leukemia; antifungal; antibacterial; cyanotoxins; Nostoc natural products; mass spectrometry; leukemia; antifungal; antibacterial; cyanotoxins; Nostoc
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Shishido, T.K.; Popin, R.V.; Jokela, J.; Wahlsten, M.; Fiore, M.F.; Fewer, D.P.; Herfindal, L.; Sivonen, K. Dereplication of Natural Products with Antimicrobial and Anticancer Activity from Brazilian Cyanobacteria. Toxins 2020, 12, 12.

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