Viruses, Volume 11, Issue 1 (January 2019) – 90 articles
Cover Story (view full-size image): KDEL receptors, a family of seven-transmembrane proteins, retrieve chaperones such as GRP78 containing the C-terminal tetra peptide sequence KDEL (Lys-Asp-Glu-Leu) in the ER, and thus regulate the maturation and fate of other proteins. KDEL receptor over-expression disturbs this sensitive equilibrium between chaperones available for newly synthesized proteins and retrieved chaperones, and impairs measles virus replication by reducing the transport of viral envelope proteins to the cell surface. View Paper here.
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