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Viruses 2019, 11(1), 80; https://doi.org/10.3390/v11010080

The Importance of Being Non-Defective: A Mini Review Dedicated to the Memory of Jan Svoboda

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Received: 27 December 2018 / Revised: 15 January 2019 / Accepted: 16 January 2019 / Published: 18 January 2019
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Abstract

Jan Svoboda triggered investigations on non-defective avian sarcoma viruses. These viruses were a critical factor in the genetic understanding of retroviruses. They provided the single and unique access to the field and facilitated the discovery of the first oncogene src and of the cellular origin of retroviral oncogenes. They continue to be of importance as singularly effective expression vectors that have provided insights into the molecular functions of numerous oncogenes. Combined with the contributions to the validation of the provirus hypothesis, Jan Svoboda’s investigations of non-defective avian sarcoma viruses have shaped a large and important part of retrovirology. View Full-Text
Keywords: Prague strain of Rous sarcoma virus; oncogenesis in mammalian cells; avian leukosis and sarcoma virus; viral genetics; oncogenes; expression vectors Prague strain of Rous sarcoma virus; oncogenesis in mammalian cells; avian leukosis and sarcoma virus; viral genetics; oncogenes; expression vectors
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Vogt, P.K. The Importance of Being Non-Defective: A Mini Review Dedicated to the Memory of Jan Svoboda. Viruses 2019, 11, 80.

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