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Viruses 2019, 11(1), 84; https://doi.org/10.3390/v11010084

Meta-Analysis of Human IgG anti-HEV Seroprevalence in Industrialized Countries and a Review of Literature

1
EA7310 BIOSCOPE, Laboratoire de Virologie, Université de Corse-Inserm, 20250 Corte, France
2
Unité des Virus Emergents (UVE), Aix-Marseille Université, IRD 190, INSERM 1207, IHU Méditerranée Infection, 13005 Marseille, France
3
Emerging Pathogens Institute, University of Florida, Gainesville, FL 32611, USA
*
Authors to whom correspondence should be addressed.
Received: 13 December 2018 / Revised: 16 January 2019 / Accepted: 18 January 2019 / Published: 20 January 2019
(This article belongs to the Special Issue Hepatitis E Virus)
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Abstract

Although Hepatitis E is increasingly described as a major cause of liver disease in industrialized countries, the epidemiology is far from being fully elucidated. We provide here a comprehensive review of documented clusters of cases, and of serological studies conducted in populations with distinct types of exposure. Seroprevalence rates range from <5% to >50% depending on the countries and the groups of population. Such discrepancies can be attributed to the type of serological assay used, but this solves only a part of the problem. We performed a meta-analysis of studies performed with the broadly used Wantai HEV-IgG ELISA and found striking differences that remain difficult to understand with the current knowledge of transmission pathways. View Full-Text
Keywords: epidemiology; Hepatitis E virus; Meta-analysis; seroprevalence; industrialized countries epidemiology; Hepatitis E virus; Meta-analysis; seroprevalence; industrialized countries
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Capai, L.; Falchi, A.; Charrel, R. Meta-Analysis of Human IgG anti-HEV Seroprevalence in Industrialized Countries and a Review of Literature. Viruses 2019, 11, 84.

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