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From SARS to MERS, Thrusting Coronaviruses into the Spotlight
Open AccessReview

Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain

1
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China
2
Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, China
3
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
4
Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(1), 60; https://doi.org/10.3390/v11010060
Received: 15 December 2018 / Revised: 8 January 2019 / Accepted: 10 January 2019 / Published: 14 January 2019
(This article belongs to the Special Issue MERS-CoV)
Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is an infectious virus that was first reported in 2012. The MERS-CoV genome encodes four major structural proteins, among which the spike (S) protein has a key role in viral infection and pathogenesis. The receptor-binding domain (RBD) of the S protein contains a critical neutralizing domain and is an important target for development of MERS vaccines and therapeutics. In this review, we describe the relevant features of the MERS-CoV S-protein RBD, summarize recent advances in the development of MERS-CoV RBD-based vaccines and therapeutic antibodies, and illustrate potential challenges and strategies to further improve their efficacy. View Full-Text
Keywords: Coronavirus; MERS-CoV; spike protein; receptor-binding domain; vaccines; therapeutics Coronavirus; MERS-CoV; spike protein; receptor-binding domain; vaccines; therapeutics
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MDPI and ACS Style

Zhou, Y.; Yang, Y.; Huang, J.; Jiang, S.; Du, L. Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain. Viruses 2019, 11, 60.

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